{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T20:31:56Z","timestamp":1793997116910,"version":"4.8.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFA0907800"],"award-info":[{"award-number":["2020YFA0907800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.ejmech.2025.117564","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T03:10:47Z","timestamp":1742872247000},"page":"117564","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["A highly active angiotensin I-converting enzyme inhibitory peptide KAKW designed based on the role of C-terminal residue, and its antihypertensive effects on spontaneously hypertensive rats"],"prefix":"10.1016","volume":"290","author":[{"given":"Yangting","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dewei","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xujun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4666-4019","authenticated-orcid":false,"given":"Jingli","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2025.117564_bib1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.foodchem.2017.10.087","article-title":"Immunomodulatory and anticancer protein hydrolysates (peptides) from food proteins: a review","volume":"245","author":"Chalamaiah","year":"2018","journal-title":"Food Chem."},{"key":"10.1016\/j.ejmech.2025.117564_bib2","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.tifs.2014.02.004","article-title":"Bioinformatics approaches, prospects and challenges of food bioactive peptide research","volume":"36","author":"Udenigwe","year":"2014","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.ejmech.2025.117564_bib3","doi-asserted-by":"crossref","first-page":"3825","DOI":"10.1111\/1541-4337.12651","article-title":"Bioactive peptides from food fermentation: a comprehensive review of their sources, bioactivities, applications, and future development","volume":"19","author":"Chai","year":"2020","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"10.1016\/j.ejmech.2025.117564_bib4","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ejmech.2019.07.009","article-title":"Discovery, synthesis, and in vitro evaluation of a novel bioactive peptide for ACE and DPP-IV inhibitory activity","volume":"180","author":"Ashok","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117564_bib5","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1080\/10408398.2018.1528206","article-title":"Recently isolated antidiabetic hydrolysates and peptides from multiple food sources: a review","volume":"60","author":"Kehinde","year":"2018","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.ejmech.2025.117564_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2021.104680","article-title":"Collagen peptides and the related synthetic peptides: a review on improving skin health","volume":"86","author":"Zhao","year":"2021","journal-title":"J. Funct.Foods"},{"key":"10.1016\/j.ejmech.2025.117564_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116797","article-title":"Discovery of AMPs from random peptides via deep learning-based model and biological activity validation","volume":"277","author":"Du","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117564_bib8","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.ejmech.2017.10.052","article-title":"Discovery of a head-to-tail cyclic peptide as the Keap1-Nrf2 protein-protein interaction inhibitor with high cell potency","volume":"143","author":"Lu","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117564_bib9","doi-asserted-by":"crossref","first-page":"12510","DOI":"10.1039\/D2FO02223K","article-title":"Peptides and protein hydrolysates exhibiting anti-inflammatory activity: sources, structural features and modulation mechanisms","volume":"13","author":"Rivera-Jim\u00e9nez","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.ejmech.2025.117564_bib10","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.canlet.2014.05.002","article-title":"Peptide-based cancer therapy: opportunity and challenge","volume":"351","author":"Wu","year":"2014","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ejmech.2025.117564_bib11","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.1002\/jsfa.7697","article-title":"Food-derived immunomodulatory peptides","volume":"96","author":"Santiago\u2010L\u00f3pez","year":"2016","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.ejmech.2025.117564_bib12","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1089\/jmf.2014.0028","article-title":"Research progress in structure-activity relationship of bioactive peptides","volume":"18","author":"Li","year":"2015","journal-title":"J. Med. Food"},{"key":"10.1016\/j.ejmech.2025.117564_bib13","doi-asserted-by":"crossref","first-page":"75400","DOI":"10.1039\/C6RA12738J","article-title":"Learnings from quantitative structure-activity relationship (QSAR) studies with respect to food protein-derived bioactive peptides: a review","volume":"6","author":"Nongonierma","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejmech.2025.117564_bib14","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1080\/10408398.2021.1964433","article-title":"Advancement and prospects of production, transport, functional activity and structure-activity relationship of food-derived angiotensin converting enzyme (ACE) inhibitory peptides","volume":"63","author":"Xiang","year":"2021","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.ejmech.2025.117564_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116623","article-title":"Synthesis of thiazolidine-2,4-dione tethered 1,2,3-triazoles as \u03b1-amylase inhibitors: In vitro approach coupled with QSAR, molecular docking, molecular dynamics and ADMET studies","volume":"275","author":"Singh","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117564_bib16","doi-asserted-by":"crossref","first-page":"10020","DOI":"10.1021\/acs.jafc.7b04043","article-title":"High-throughput and rapid screening of novel ACE inhibitory peptides from sericin source and inhibition mechanism by using in silico and in vitro prescriptions","volume":"65","author":"Sun","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejmech.2025.117564_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0197644","article-title":"Identification, structure-activity relationship and in silico molecular docking analyses of five novel angiotensin I-converting enzyme (ACE)-inhibitory peptides from stone fish (Actinopyga lecanora) hydrolysates","volume":"14","author":"Auwal","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.ejmech.2025.117564_bib18","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1080\/87559129.2021.1936005","article-title":"Understanding the mechanism for the structure-activity relationship of food-derived ACEI peptides","volume":"39","author":"Ding","year":"2021","journal-title":"Food Rev. Int."},{"key":"10.1016\/j.ejmech.2025.117564_bib19","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.idairyj.2013.10.009","article-title":"Screening milk-derived antihypertensive peptides using quantitative structure activity relationship (QSAR) modelling and in vitro\/in vivo studies on their bioactivity","volume":"35","author":"Jing","year":"2014","journal-title":"Int. Dairy J."},{"key":"10.1016\/j.ejmech.2025.117564_bib20","doi-asserted-by":"crossref","DOI":"10.1002\/minf.201600157","article-title":"Studies on the bioactivities of ACE\u2010inhibitory peptides with phenylalanine C\u2010terminus using 3D\u2010QSAR, molecular docking and in vitro evaluation","volume":"36","author":"Qi","year":"2017","journal-title":"Mol. Inf."},{"key":"10.1016\/j.ejmech.2025.117564_bib21","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.foodchem.2012.09.092","article-title":"A new QSAR model, for angiotensin I-converting enzyme inhibitory oligopeptides","volume":"136","author":"Sagardia","year":"2013","journal-title":"Food Chem."},{"key":"10.1016\/j.ejmech.2025.117564_bib22","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jff.2017.03.008","article-title":"Novel angiotensin I-converting enzyme inhibitory peptides from protease hydrolysates of Qula casein: quantitative structure-activity relationship modeling and molecular docking study","volume":"32","author":"Lin","year":"2017","journal-title":"J. Funct.Foods"},{"key":"10.1016\/j.ejmech.2025.117564_bib23","doi-asserted-by":"crossref","DOI":"10.1111\/jfbc.12572","article-title":"Molecular interactions, bioavailability, and cellular mechanisms of angiotensin-converting enzyme inhibitory peptides","volume":"43","author":"Fan","year":"2019","journal-title":"J. Food Biochem."},{"key":"10.1016\/j.ejmech.2025.117564_bib24","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0271-5317(04)00058-2","article-title":"Angiotensin I-converting enzyme inhibitory peptides derived from food proteins and their physiological and pharmacological effects","volume":"24","author":"Li","year":"2004","journal-title":"Nutr. Res."},{"key":"10.1016\/j.ejmech.2025.117564_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.730809","article-title":"The role of short-chain fatty acids of gut microbiota origin in hypertension","volume":"12","author":"Wu","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ejmech.2025.117564_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.111156","article-title":"A cross-talk between gut microbiome, salt and hypertension","volume":"134","author":"Naqvi","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejmech.2025.117564_bib27","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40168-016-0222-x","article-title":"Gut microbiota dysbiosis contributes to the development of hypertension","volume":"5","author":"Li","year":"2017","journal-title":"Microbiome"},{"key":"10.1016\/j.ejmech.2025.117564_bib28","doi-asserted-by":"crossref","DOI":"10.1080\/10641963.2023.2195135","article-title":"Gut microbiota and hypertension: association, mechanisms and treatment","volume":"45","author":"Yang","year":"2023","journal-title":"Clin. Exp. Hypertens."},{"key":"10.1016\/j.ejmech.2025.117564_bib29","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1002\/jsfa.13907","article-title":"Walnut peptide relieves hypertension and associated kidney and heart injury by regulating the renin\u2013angiotensin\u2013aldosterone system and intestinal microbiota","volume":"105","author":"Chen","year":"2024","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.ejmech.2025.117564_bib30","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1039\/D1FO03570C","article-title":"The effects of angiotensin I-converting enzyme inhibitory peptide VGINYW and the hydrolysate of \u03b1-lactalbumin on blood pressure, oxidative stress and gut microbiota of spontaneously hypertensive rats","volume":"13","author":"Xie","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.ejmech.2025.117564_bib31","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.3390\/nu14153207","article-title":"Why should pistachio be a regular food in our diet?","volume":"14","author":"Mateos","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.ejmech.2025.117564_bib32","doi-asserted-by":"crossref","first-page":"4705","DOI":"10.1021\/jf0606959","article-title":"Chemical composition of selected edible nut seeds","volume":"54","author":"Venkatachalam","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejmech.2025.117564_bib33","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.procbio.2014.02.007","article-title":"In vitro and in vivo ACE inhibitory of pistachio hydrolysates and in silico mechanism of identified peptide binding with ACE","volume":"49","author":"Li","year":"2014","journal-title":"Process Biochem."},{"key":"10.1016\/j.ejmech.2025.117564_bib34","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0021-9673(02)00052-3","article-title":"Improved method for direct high-performance liquid chromatography assay of angiotensin-converting enzyme-catalyzed reactions","volume":"950","author":"Wu","year":"2002","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.ejmech.2025.117564_bib35","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1021\/acs.jafc.7b04294","article-title":"Antihypertensive effects, molecular docking study, and isothermal titration calorimetry assay of angiotensin I-converting enzyme inhibitory peptides from Chlorella vulgaris","volume":"66","author":"Xie","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejmech.2025.117564_bib36","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.procbio.2024.02.008","article-title":"Anti-hypertensive and gut microbiota regulatory effects of yeast protein hydrolysate on spontaneous hypertensive rat","volume":"140","author":"Wang","year":"2024","journal-title":"Process Biochem."},{"key":"10.1016\/j.ejmech.2025.117564_bib37","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nature01370","article-title":"Crystal structure of the human angiotensin-converting enzyme-lisinopril complex","volume":"421","author":"Natesh","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2025.117564_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.lwt.2021.112984","article-title":"In vitro-in silico screening strategy and mechanism of angiotensin I-converting enzyme inhibitory peptides from \u03b1-lactalbumin","volume":"156","author":"Xie","year":"2022","journal-title":"LWT--Food Sci. Technol."},{"key":"10.1016\/j.ejmech.2025.117564_bib39","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/1541-4337.12051","article-title":"Food\u2010originating ACE inhibitors, including antihypertensive peptides, as preventive food components in blood pressure reduction","volume":"13","author":"Iwaniak","year":"2014","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"10.1016\/j.ejmech.2025.117564_bib40","doi-asserted-by":"crossref","first-page":"11234","DOI":"10.1021\/jf202902r","article-title":"Inhibition strength of short peptides derived from an ACE inhibitory peptide","volume":"59","author":"Terashima","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejmech.2025.117564_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0037077","article-title":"Inhibition mechanism and model of an angiotensin I-converting enzyme (ACE)-inhibitory hexapeptide from yeast (Saccharomyces cerevisiae)","volume":"7","author":"Ni","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ejmech.2025.117564_bib42","doi-asserted-by":"crossref","first-page":"12122","DOI":"10.1021\/ja061755u","article-title":"Solvent-induced effects: self-association of positively charged \u03c0 systems","volume":"128","author":"Buisine","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2025.117564_bib43","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.foodchem.2017.10.095","article-title":"Exploration of the molecular interactions between angiotensin-I-converting enzyme (ACE) and the inhibitory peptides derived from hazelnut (Corylus heterophylla Fisch.)","volume":"245","author":"Liu","year":"2018","journal-title":"Food Chem."},{"key":"10.1016\/j.ejmech.2025.117564_bib44","doi-asserted-by":"crossref","first-page":"13414","DOI":"10.1021\/acs.jafc.8b04303","article-title":"Studies on the interaction between angiotensin-converting enzyme (ACE) and ACE inhibitory peptide from Saurida elongata","volume":"66","author":"Lan","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejmech.2025.117564_bib45","doi-asserted-by":"crossref","first-page":"7015","DOI":"10.1021\/acs.jafc.8b01558","article-title":"Isolation and characterization of angiotensin I-converting enzyme (ACE) inhibitory peptides from the enzymatic hydrolysate of carapax Trionycis (the shell of the turtle Pelodiscus sinensis)","volume":"66","author":"Liao","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejmech.2025.117564_bib46","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1016\/j.fshw.2022.06.021","article-title":"Structural requirements and interaction mechanisms of ACE inhibitory peptides: molecular simulation and thermodynamics studies on LAPYK and its modified peptides","volume":"11","author":"Zhang","year":"2022","journal-title":"Food Sci. Hum. Wellness"},{"key":"10.1016\/j.ejmech.2025.117564_bib47","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1007\/s00467-005-1854-4","article-title":"Ventricular arrhythmia following short-acting nifedipine administration","volume":"20","author":"Castaneda","year":"2005","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.ejmech.2025.117564_bib48","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/mnfr.201100381","article-title":"Acute effect of whey peptides upon blood pressure of hypertensive rats, and relationship with their angiotensin\u2010converting enzyme inhibitory activity","volume":"56","author":"Tavares","year":"2012","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.ejmech.2025.117564_bib49","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/nrcardio.2016.165","article-title":"Lower or higher blood-pressure targets for high-risk patients?","volume":"13","author":"Zanchetti","year":"2016","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.ejmech.2025.117564_bib50","doi-asserted-by":"crossref","first-page":"845","DOI":"10.3389\/fphys.2017.00845","article-title":"Gut-brain axis in regulation of blood pressure","volume":"8","author":"Yang","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ejmech.2025.117564_bib51","doi-asserted-by":"crossref","DOI":"10.1111\/1750-3841.17617","article-title":"A peptide from Boletus griseus-Hypomyces chrysospermus protects against hypertension and associated cardiac and renal damage through modulating RAAS and intestinal microbiota","volume":"90","author":"Huan","year":"2025","journal-title":"J. Food Sci."},{"key":"10.1016\/j.ejmech.2025.117564_bib52","doi-asserted-by":"crossref","first-page":"4410","DOI":"10.1073\/pnas.1215927110","article-title":"Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation","volume":"110","author":"Pluznick","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejmech.2025.117564_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110503","article-title":"Gut microbiota-derived short-chain fatty acids and hypertension: mechanism and treatment","volume":"130","author":"Yang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejmech.2025.117564_bib54","article-title":"Effect of dietary protein and processing on gut microbiota-a systematic review","volume":"14","author":"Wu","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.ejmech.2025.117564_bib55","doi-asserted-by":"crossref","DOI":"10.1186\/s12866-021-02202-5","article-title":"Changes of gut microbiome composition and metabolites associated with hypertensive heart failure rats","volume":"21","author":"Li","year":"2021","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.ejmech.2025.117564_bib56","doi-asserted-by":"crossref","DOI":"10.1186\/s12866-023-02967-x","article-title":"Gut microbiome profile of Chinese hypertension patients with and without type 2 diabetes mellitus","volume":"23","author":"Ding","year":"2023","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.ejmech.2025.117564_bib57","first-page":"513","article-title":"Molecular characterization of alterations in the intestinal microbiota of patients with grade 3 hypertension","volume":"44","author":"Mushtaq","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.ejmech.2025.117564_bib58","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3390\/metabo14090497","article-title":"Functional muffins exert bifidogenic effects along with highly product-specific effects on the human gut microbiota ex vivo","volume":"14","author":"Deyaert","year":"2024","journal-title":"Metabolites"},{"key":"10.1016\/j.ejmech.2025.117564_bib59","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12866-019-1494-7","article-title":"Changes in the gut microbiome and fermentation products concurrent with enhanced longevity in acarbose-treated mice","volume":"19","author":"Smith","year":"2019","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.ejmech.2025.117564_bib60","doi-asserted-by":"crossref","first-page":"12896","DOI":"10.1039\/D2FO03366F","article-title":"Dietary methionine restriction improves gut microbiota composition and prevents cognitive impairment in d-galactose-induced aging mice","volume":"13","author":"Xu","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.ejmech.2025.117564_bib61","doi-asserted-by":"crossref","first-page":"8051","DOI":"10.1039\/D0FO01770A","article-title":"Sacha inchi (Plukenetia volubilis L.) shell extract alleviates hypertension in association with the regulation of gut microbiota","volume":"11","author":"Li","year":"2020","journal-title":"Food Funct."},{"key":"10.1016\/j.ejmech.2025.117564_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119097","article-title":"Exercise and food supplement of vitamin C ameliorate hypertension through improvement of gut microflora in the spontaneously hypertensive rats","volume":"269","author":"Li","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.ejmech.2025.117564_bib63","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3389\/fcimb.2017.00381","article-title":"Alterations of the gut microbiome in hypertension","volume":"7","author":"Yan","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.ejmech.2025.117564_bib64","doi-asserted-by":"crossref","first-page":"641","DOI":"10.3390\/foods13050641","article-title":"Oral administration of fermented milk from co-starter containing Lactobacillus plantarum Y44 shows an ameliorating effect on hypertension in spontaneously hypertensive rats","volume":"13","author":"Yu","year":"2024","journal-title":"Foods"},{"key":"10.1016\/j.ejmech.2025.117564_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111334","article-title":"Link between microbiota and hypertension: focus on LPS\/TLR4 pathway in endothelial dysfunction and vascular inflammation, and therapeutic implication of probiotics","volume":"137","author":"Grylls","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejmech.2025.117564_bib66","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1161\/HYPERTENSIONAHA.122.18558","article-title":"Short-chain fatty acid receptors and blood pressure regulation: council on hypertension mid-career award for research excellence 2021","volume":"79","author":"Xu","year":"2022","journal-title":"Hypertension"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523425003290?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523425003290?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:24:17Z","timestamp":1745454257000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523425003290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":66,"alternative-id":["S0223523425003290"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2025.117564","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A highly active angiotensin I-converting enzyme inhibitory peptide KAKW designed based on the role of C-terminal residue, and its antihypertensive effects on spontaneously hypertensive rats","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2025.117564","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117564"}}