{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T19:21:22Z","timestamp":1788808882322,"version":"build-2803163510"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100011447","name":"Science and Technology Department of Henan Province","doi-asserted-by":"publisher","award":["252102311218"],"award-info":[{"award-number":["252102311218"]}],"id":[{"id":"10.13039\/501100011447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004605","name":"Zhengzhou University","doi-asserted-by":"publisher","award":["JSZLQY2021082"],"award-info":[{"award-number":["JSZLQY2021082"]}],"id":[{"id":"10.13039\/501100004605","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.ejmech.2025.117591","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T17:36:44Z","timestamp":1744133804000},"page":"117591","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Synthesis and antimicrobial evaluation of novel quaternary quinolone derivatives with low toxicity and anti-biofilm activity"],"prefix":"10.1016","volume":"291","author":[{"given":"Ye","family":"Qu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruirui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuequan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtao","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanbo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daran","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxwell","family":"Ampomah-Wireko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Na","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4818-756X","authenticated-orcid":false,"given":"En","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2025.117591_bib1","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1126\/science.abg9868","article-title":"Minimizing treatment-induced emergence of antibiotic resistance in bacterial infections","volume":"375","author":"Stracy","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2025.117591_bib2","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/S0140-6736(24)01867-1","article-title":"Global burden of bacterial antimicrobial resistance 1990-2021: a systematic analysis with forecasts to 2050","volume":"404","author":"Murray","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.ejmech.2025.117591_bib3","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41557-019-0378-7","article-title":"Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms","volume":"12","author":"Le","year":"2020","journal-title":"Nat. Chem."},{"key":"10.1016\/j.ejmech.2025.117591_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116219","article-title":"Novel aminothiazoximone-corbelled ethoxycarbonylpyrimidones with antibiofilm activity to conquer Gram-negative bacteria through potential multitargeting effects","volume":"268","author":"Li","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117591_bib5","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.ijbiomac.2020.03.044","article-title":"Antibacterial activity of xanthan-oligosaccharide against Staphylococcus aureus via targeting biofilm and cell membrane","volume":"153","author":"Wang","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejmech.2025.117591_bib6","doi-asserted-by":"crossref","first-page":"47420","DOI":"10.1021\/acsami.2c13166","article-title":"Ultrasound-activatable phase-shift nanoparticle as a targeting antibacterial agent for efficient eradication of Pseudomonas aeruginosa biofilms","volume":"14","author":"Xin","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ejmech.2025.117591_bib7","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nrmicro1557","article-title":"Persister cells, dormancy and infectious disease","volume":"5","author":"Lewis","year":"2007","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ejmech.2025.117591_bib8","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1146\/annurev.micro.112408.134306","article-title":"Persister cells","volume":"64","author":"Lewis","year":"2010","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.ejmech.2025.117591_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114765","article-title":"Antibacterial quaternary ammonium agents: chemical diversity and biological mechanism","volume":"243","author":"Dan","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117591_bib10","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1021\/acsinfecdis.5b00047","article-title":"Quaternary ammonium compounds: an antimicrobial mainstay and platform for innovation to address bacterial resistance","volume":"1","author":"Jennings","year":"2015","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.ejmech.2025.117591_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115373","article-title":"Antibacterial and antibiofilm activity of permanently ionized quaternary ammonium fluoroquinolones","volume":"254","author":"Fedorowicz","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117591_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25094649","article-title":"Advances in the synthesis of biologically active quaternary ammonium compounds","volume":"25","author":"Fedorowicz","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2025.117591_bib13","doi-asserted-by":"crossref","first-page":"10185","DOI":"10.1021\/acs.jmedchem.1c00449","article-title":"Alkyl-aryl-vancomycins: multimodal glycopeptides with weak dependence on the bacterial metabolic state","volume":"64","author":"Sarkar","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117591_bib14","doi-asserted-by":"crossref","first-page":"5061","DOI":"10.1021\/acs.jmedchem.2c02135","article-title":"Discovery of quaternized pyridine-thiazole-pleuromutilin derivatives with broad-spectrum antibacterial and potent anti-MRSA activity","volume":"66","author":"Xia","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117591_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116293","article-title":"Design, synthesis and antibacterial evaluation of low toxicity amphiphilic-cephalosporin derivatives","volume":"268","author":"Chen","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117591_bib16","doi-asserted-by":"crossref","first-page":"5689","DOI":"10.3390\/molecules25235689","article-title":"Bacterial alkyl-4-quinolones: discovery, structural diversity and biological properties","volume":"25","author":"Saalim","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2025.117591_bib17","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.ejmech.2013.01.057","article-title":"Antibacterial action of quinolones: from target to network","volume":"66","author":"Cheng","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117591_bib18","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.ejmech.2019.06.071","article-title":"Synthesis and biological evaluation of hybrid quinolone-based quaternary ammonium antibacterial agents","volume":"179","author":"Fedorowicz","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117591_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115878","article-title":"Benzopyrone-mediated quinolones as potential multitargeting antibacterial agents","volume":"262","author":"Li","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117591_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116626","article-title":"Synthesis and antibacterial medicinal evaluation of carbothioamido hydrazonyl thiazolylquinolone with multitargeting antimicrobial potential to combat increasingly global resistance","volume":"275","author":"Zang","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117591_bib21","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1007\/s00706-018-2215-x","article-title":"Modifications of quinolones and fluoroquinolones: hybrid compounds and dual-action molecules","volume":"149","author":"Fedorowicz","year":"2018","journal-title":"Monatshefte f\u00fcr Chemie - Chemical Monthly"},{"key":"10.1016\/j.ejmech.2025.117591_bib22","doi-asserted-by":"crossref","first-page":"19077","DOI":"10.1021\/acs.jmedchem.4c01555","article-title":"Inhibition of Pseudomonas aeruginosa carbonic anhydrases, exploring ciprofloxacin functionalization toward new antibacterial agents: an in-depth multidisciplinary study","volume":"67","author":"Marinacci","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117591_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116215","article-title":"Effective ciprofloxacin cationic antibacterial agent against persister bacteria with low hemolytic toxicity","volume":"267","author":"Gao","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117591_bib24","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1021\/jm00400a016","article-title":"Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids","volume":"31","author":"Sanchez","year":"1988","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117591_bib25","doi-asserted-by":"crossref","first-page":"13644","DOI":"10.1002\/anie.201507567","article-title":"Membrane disruption and enhanced inhibition of cell-wall biosynthesis: a synergistic approach to tackle vancomycin-resistant bacteria","volume":"54","author":"Yarlagadda","year":"2015","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.ejmech.2025.117591_bib26","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1007\/s00044-011-9578-4","article-title":"Synthesis, characterization and antimicrobial activity of 4-amino-1-alkyl pyridinium salts","volume":"21","author":"Ilangovan","year":"2012","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.ejmech.2025.117591_bib27","doi-asserted-by":"crossref","first-page":"4970","DOI":"10.1016\/j.ejmech.2009.08.011","article-title":"Dialkylamino and nitrogen heterocyclic analogues of hexadecylphosphocholine and cetyltrimetylammonium bromide: effect of phosphate group and environment of the ammonium cation on their biological activity","volume":"44","author":"Luk\u00e1c","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117591_bib28","series-title":"Performance Standards for Antimicrobial Susceptibility Testing","year":"2015"},{"key":"10.1016\/j.ejmech.2025.117591_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114885","article-title":"Antibacterial efficacy evaluation and mechanism probe of small lysine chalcone peptide mimics","volume":"244","author":"Shen","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117591_bib30","doi-asserted-by":"crossref","first-page":"15349","DOI":"10.1021\/acs.jmedchem.1c01352","article-title":"Tandem repeat of a short human chemerin-derived peptide and its nontoxic d-lysine-containing enantiomer display broad-spectrum antimicrobial and antitubercular activities","volume":"64","author":"Pratap Verma","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117591_bib31","doi-asserted-by":"crossref","first-page":"5898","DOI":"10.1038\/s41467-021-26221-y","article-title":"Addressing MRSA infection and antibacterial resistance with peptoid polymers","volume":"12","author":"Xie","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2025.117591_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.biotechadv.2022.107962","article-title":"Strategies employed in the design of antimicrobial peptides with enhanced proteolytic stability","volume":"59","author":"Lai","year":"2022","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.ejmech.2025.117591_bib33","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.tube.2017.04.010","article-title":"The role of the time-kill kinetics assay as part of a preclinical modeling framework for assessing the activity of anti-tuberculosis drugs","volume":"105","author":"Bax","year":"2017","journal-title":"Tuberculosis"},{"key":"10.1016\/j.ejmech.2025.117591_bib34","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nature17042","article-title":"Antibacterial drug discovery in the resistance era","volume":"529","author":"Brown","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2025.117591_bib35","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1021\/acs.jmedchem.1c01592","article-title":"Natural berberine-derived azolyl ethanols as new structural antibacterial agents against drug-resistant Escherichia coli","volume":"65","author":"Sun","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117591_bib36","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/s41551-022-00950-x","article-title":"A potent antibiotic-loaded bone-cement implant against staphylococcal bone infections","volume":"6","author":"Ghosh","year":"2022","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.ejmech.2025.117591_bib37","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/s41556-022-00920-0","article-title":"Assembly of Tetraspanin-enriched macrodomains contains membrane damage to facilitate repair","volume":"24","author":"Huang","year":"2022","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ejmech.2025.117591_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115773","article-title":"Identification of unique indolylcyanoethylenyl sulfonylanilines as novel structural scaffolds of potential antibacterial agents","volume":"260","author":"Zhou","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117591_bib39","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jare.2023.04.017","article-title":"Antimicrobial activities of lavandulylated flavonoids in Sophora flavences against methicillin-resistant Staphylococcus aureus via membrane disruption","volume":"57","author":"Weng","year":"2024","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.ejmech.2025.117591_bib40","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1128\/AAC.02340-16","article-title":"Intracellular targeting mechanisms by antimicrobial peptides","volume":"61","author":"Le","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2025.117591_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114470","article-title":"Antimicrobial peptides with symmetric structures against multidrug-resistant bacteria while alleviating antimicrobial resistance","volume":"186","author":"Zhong","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejmech.2025.117591_bib42","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.tim.2016.12.008","article-title":"The role of reactive oxygen species in antibiotic-mediated killing of bacteria","volume":"25","author":"Van Acker","year":"2017","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.ejmech.2025.117591_bib43","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.3390\/biom12111545","article-title":"Redox impact on bacterial macromolecule: a promising avenue for discovery and development of novel antibacterials","volume":"12","author":"Aribisala","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.ejmech.2025.117591_bib44","doi-asserted-by":"crossref","first-page":"4881","DOI":"10.1021\/acs.chemrev.8b00626","article-title":"Reactive oxygen species (ROS)-Based nanomedicine","volume":"119","author":"Yang","year":"2019","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejmech.2025.117591_bib45","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.ejmech.2016.09.071","article-title":"Pyrazole derived ultra-short antimicrobial peptidomimetics with potent anti-biofilm activity","volume":"125","author":"Ahn","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117591_bib46","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3390\/metabo9030045","article-title":"An UPLC-MS\/MS assay to measure glutathione as marker for oxidative stress in cultured cells","volume":"9","author":"Herzog","year":"2019","journal-title":"Metabolites"},{"key":"10.1016\/j.ejmech.2025.117591_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115088","article-title":"Benzenesulfonyl thiazoloimines as unique multitargeting antibacterial agents towards Enterococcus faecalis","volume":"248","author":"Zhou","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117591_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154973","article-title":"Evolving biofilm inhibition and eradication in clinical settings through plant-based antibiofilm agents","volume":"119","author":"Silva","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ejmech.2025.117591_bib49","article-title":"Biofilm formation mechanisms of mixed antibiotic-resistant bacteria in water: bacterial interactions and horizontal transfer of antibiotic-resistant plasmids","volume":"481","author":"Xia","year":"2024","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.ejmech.2025.117591_bib50","doi-asserted-by":"crossref","first-page":"7403","DOI":"10.2147\/IJN.S436971","article-title":"Rhamnolipid micelles assist azithromycin in efficiently disrupting Staphylococcus aureus biofilms and impeding their Re-formation","volume":"18","author":"Lin","year":"2023","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.ejmech.2025.117591_bib51","doi-asserted-by":"crossref","first-page":"4074","DOI":"10.1038\/s41467-018-06527-0","article-title":"Prolonged bacterial lag time results in small colony variants that represent a sub-population of persisters","volume":"9","author":"Vulin","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2025.117591_bib52","doi-asserted-by":"crossref","first-page":"eaan4044","DOI":"10.1126\/scitranslmed.aan4044","article-title":"The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms","volume":"10","author":"de Breij","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ejmech.2025.117591_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115551","article-title":"Membrane-active substituted triazines as antibacterial agents against Staphylococcus aureus with potential for low drug resistance and broad activity","volume":"258","author":"Gupta","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117591_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2024.124315","article-title":"Solvation model, Vibrational analysis, Electronic level, Non-Covalent interactions and Molecular docking investigations of 6-Chloro-2-(4-Aminophenyl)-1H-Benzimidazole","volume":"398","author":"Fasiuddin","year":"2024","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.ejmech.2025.117591_bib55","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1021\/acsinfecdis.3c00239","article-title":"Synergy of antibiotics and antibiofilm agents against methicillin-resistant Staphylococcus aureus biofilms","volume":"9","author":"Deusenbery","year":"2023","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.ejmech.2025.117591_bib56","doi-asserted-by":"crossref","first-page":"9028","DOI":"10.1021\/acs.jmedchem.4c00238","article-title":"Cyanomethylquinolones as a new class of potential multitargeting broad-spectrum antibacterial agents","volume":"67","author":"Tan","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117591_bib57","doi-asserted-by":"crossref","first-page":"8932","DOI":"10.1021\/acs.jmedchem.4c00209","article-title":"A unique hybridization route to access hydrazylnaphthalimidols as novel structural scaffolds of multitargeting broad-spectrum antifungal candidates","volume":"67","author":"Wang","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117591_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2022.119853","article-title":"Dielectric relaxation and thermodynamical parameters of hydrogen bonded complexes for Heptanamide and Pentanamide with halogenated phenols in benzene","volume":"363","author":"Basha","year":"2022","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.ejmech.2025.117591_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2023.123368","article-title":"Solvents performance, experimental spectral energies interactions, excitations energies, topological and electrophilic molecular interaction studies on 4?-(bromomethyl)-[1,1?-biphenyl]-2-carbonitrile- antiphobic disorder agent","volume":"391","author":"Kanimozhi","year":"2023","journal-title":"J. Mol. Liq."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523425003563?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523425003563?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T04:55:25Z","timestamp":1778043325000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523425003563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":59,"alternative-id":["S0223523425003563"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2025.117591","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and antimicrobial evaluation of novel quaternary quinolone derivatives with low toxicity and anti-biofilm activity","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2025.117591","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117591"}}