{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T17:21:29Z","timestamp":1794244889798,"version":"4.9.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100019018","name":"Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","doi-asserted-by":"publisher","award":["2021-I2M-1-069"],"award-info":[{"award-number":["2021-I2M-1-069"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016798","name":"Natural Science Foundation of Yangzhou Municipality","doi-asserted-by":"publisher","award":["YZ2023074"],"award-info":[{"award-number":["YZ2023074"]}],"id":[{"id":"10.13039\/100016798","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010023","name":"Natural Science Research of Jiangsu Higher Education Institutions of China","doi-asserted-by":"publisher","award":["22KJB350011"],"award-info":[{"award-number":["22KJB350011"]}],"id":[{"id":"10.13039\/501100010023","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011176","name":"Peking Union Medical College","doi-asserted-by":"publisher","award":["3332023153"],"award-info":[{"award-number":["3332023153"]}],"id":[{"id":"10.13039\/501100011176","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission, Adminitrative Commission of Zhongguancun Science Park","doi-asserted-by":"publisher","award":["Z221100007922045"],"award-info":[{"award-number":["Z221100007922045"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003345","name":"Chinese Academy of Meteorological Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003345","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008235","name":"Peking Union Medical College Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008235","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.ejmech.2025.117731","type":"journal-article","created":{"date-parts":[[2025,5,11]],"date-time":"2025-05-11T13:39:42Z","timestamp":1746970782000},"page":"117731","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Discovery of novel triphenylphosphonium conjugated pleuromutilin with enhanced anti-MRSA effect and broaden antibacterial spectrum"],"prefix":"10.1016","volume":"294","author":[{"given":"Bo","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huabin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangxu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianlei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2025.117731_bib1","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1080\/22221751.2022.2030196","article-title":"Antibiotic resistance in hospital-acquired ESKAPE-E infections in low- and lower-middle-income countries: a systematic review and meta-analysis","volume":"11","author":"Ayobami","year":"2022","journal-title":"Emerg. Microb. Infect."},{"key":"10.1016\/j.ejmech.2025.117731_bib2","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","article-title":"Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis","volume":"399","author":"Antimicrobial Resistance","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.ejmech.2025.117731_bib3","doi-asserted-by":"crossref","first-page":"10174","DOI":"10.1021\/jacs.2c04708","article-title":"Synthesis of pleuromutilin","volume":"144","author":"Foy","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2025.117731_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2021.116138","article-title":"Design, synthesis and biological evaluation of novel pleuromutilin derivatives as potent anti-MRSA agents targeting the 50S ribosome","volume":"38","author":"Huang","year":"2021","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117731_bib5","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a027110","article-title":"Pleuromutilins: potent drugs for resistant bugs-mode of action and resistance","volume":"7","author":"Paukner","year":"2017","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.ejmech.2025.117731_bib6","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.2174\/15680266113136660217","article-title":"Efficient antibacterial agents: a review of the synthesis, biological evaluation and mechanism of pleuromutilin derivatives","volume":"13","author":"Shang","year":"2013","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117731_bib7","doi-asserted-by":"crossref","first-page":"855","DOI":"10.2165\/00003495-200868060-00008","article-title":"Retapamulin: a review of its use in the management of impetigo and other uncomplicated superficial skin infections","volume":"68","author":"Yang","year":"2008","journal-title":"Drugs"},{"key":"10.1016\/j.ejmech.2025.117731_bib8","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/joim.13378","article-title":"Clinical use of lefamulin: a first-in-class semisynthetic pleuromutilin antibiotic","volume":"291","author":"Covvey","year":"2022","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.ejmech.2025.117731_bib9","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1128\/AAC.50.2.765-769.2006","article-title":"Single- and multistep resistance selection studies on the activity of retapamulin compared to other agents against Staphylococcus aureus and streptococcus pyogenes. Antimicrob","volume":"50","author":"Kosowska-Shick","year":"2006","journal-title":"Agents Chemother."},{"key":"10.1016\/j.ejmech.2025.117731_bib10","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1038\/s41467-022-29493-0","article-title":"Collateral sensitivity to pleuromutilins in vancomycin-resistant Enterococcus faecium","volume":"13","author":"Li","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2025.117731_bib11","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1038\/s41557-022-01027-7","article-title":"Total synthesis of structurally diverse pleuromutilin antibiotics","volume":"14","author":"Goethe","year":"2022","journal-title":"Nat. Chem."},{"key":"10.1016\/j.ejmech.2025.117731_bib12","doi-asserted-by":"crossref","first-page":"5061","DOI":"10.1021\/acs.jmedchem.2c02135","article-title":"Discovery of quaternized pyridine-thiazole-pleuromutilin derivatives with broad- spectrum antibacterial and potent anti-MRSA activity","volume":"66","author":"Xia","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117731_bib13","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1021\/acsinfecdis.2c00357","article-title":"Genetic and chemical screening reveals targets and compounds to potentiate Gram-positive antibiotics against Gram-negative bacteria","volume":"8","author":"Klobucar","year":"2022","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.ejmech.2025.117731_bib14","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1038\/s41589-020-00674-6","article-title":"Defining new chemical space for drug penetration into Gram-negative bacteria","volume":"16","author":"Zhao","year":"2020","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.ejmech.2025.117731_bib15","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/nature22308","article-title":"Predictive compound accumulation rules yield a broad-spectrum antibiotic","volume":"545","author":"Richter","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2025.117731_bib16","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1021\/acs.jmedchem.0c01671","article-title":"A novel triphenylphosphonium carrier to target mitochondria without uncoupling oxidative phosphorylation","volume":"64","author":"Kulkarni","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117731_bib17","first-page":"569","article-title":"Triphenylphosphonium-modified mitochondria-targeted paclitaxel nanocrystals for overcoming multidrug resistance","volume":"14","author":"Han","year":"2019","journal-title":"Asian J. Pharm. Sci."},{"key":"10.1016\/j.ejmech.2025.117731_bib18","doi-asserted-by":"crossref","first-page":"3834","DOI":"10.1016\/j.apsb.2023.03.023","article-title":"Brain endothelial cell-derived extracellular vesicles with a mitochondria-targeting photosensitizer effectively treat glioblastoma by hijacking the blood\u2012brain barrier","volume":"13","author":"Nguyen Cao","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.ejmech.2025.117731_bib19","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.apsb.2018.05.006","article-title":"Mitochondria-targeting drug conjugates for cytotoxic, anti-oxidizing and sensing purposes: current strategies and future perspectives","volume":"6","author":"Battogtokh","year":"2018","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.ejmech.2025.117731_bib20","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.apsb.2011.06.007","article-title":"Synthesis of hydroxycinnamic acid derivatives as mitochondria-targeted antioxidants and cytotoxic agents","volume":"1","author":"Li","year":"2017","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.ejmech.2025.117731_bib21","doi-asserted-by":"crossref","first-page":"11309","DOI":"10.1021\/acs.jmedchem.2c00818","article-title":"N-Arylimidazoliums as highly selective biomimetic antimicrobial agents","volume":"65","author":"Kong","year":"2022","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117731_bib22","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1002\/anie.202013975","article-title":"Synthesis and bioactivity of guanidinium-functionalized Pillar[5]arene as a biofilm disruptor","volume":"60","author":"Guo","year":"2021","journal-title":"Angew Chem. Int. Ed. Engl."},{"key":"10.1016\/j.ejmech.2025.117731_bib23","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1039\/C8NP00042E","article-title":"Antibacterial properties and clinical potential of pleuromutilins","volume":"36","author":"Goethe","year":"2019","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.ejmech.2025.117731_bib24","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1021\/acs.accounts.0c00895","article-title":"Facilitating compound entry as a means to discover antibiotics for Gram-negative bacteria","volume":"54","author":"Mu\u00f1oz","year":"2021","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.ejmech.2025.117731_bib25","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41564-019-0604-5","article-title":"Implementation of permeation rules leads to a FabI inhibitor with activity against Gram-negative pathogens","volume":"5","author":"Parker","year":"2020","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.ejmech.2025.117731_bib26","doi-asserted-by":"crossref","first-page":"5102","DOI":"10.1038\/s41467-018-07633-9","article-title":"Efflux pump-mediated resistance to antifungal compounds can be prevented by conjugation with triphenylphosphonium cation","volume":"9","author":"Chang","year":"2018","journal-title":"Nat. Commun."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523425004969?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523425004969?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T05:09:44Z","timestamp":1765602584000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523425004969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":26,"alternative-id":["S0223523425004969"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2025.117731","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of novel triphenylphosphonium conjugated pleuromutilin with enhanced anti-MRSA effect and broaden antibacterial spectrum","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2025.117731","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117731"}}