{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:27:45Z","timestamp":1777865265582,"version":"3.51.4"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515010642"],"award-info":[{"award-number":["2024A1515010642"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073689"],"award-info":[{"award-number":["82073689"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973183"],"award-info":[{"award-number":["81973183"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273762"],"award-info":[{"award-number":["82273762"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People&apos;s Republic of China","doi-asserted-by":"publisher","award":["2022YFC2304203"],"award-info":[{"award-number":["2022YFC2304203"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.ejmech.2025.117762","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T10:55:11Z","timestamp":1747220111000},"page":"117762","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Ellipticine derivatives as Toll-like receptor 3 inhibitor for treating acute hepatitis"],"prefix":"10.1016","volume":"294","author":[{"given":"Zhuoxian","family":"Cao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meixin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingze","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxiao","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4136-2070","authenticated-orcid":false,"given":"Kui","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2025.117762_bib1","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.immuni.2024.03.004","article-title":"Decoding toll-like receptors: recent insights and perspectives in innate immunity","volume":"57","author":"Kawai","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.ejmech.2025.117762_bib2","article-title":"TLR1\/2 specific small-molecule agonist suppresses leukemia cancer cell growth by stimulating cytotoxic T lymphocytes","volume":"6","author":"Cen","year":"2019","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.ejmech.2025.117762_bib3","doi-asserted-by":"crossref","first-page":"3782","DOI":"10.1016\/j.apsb.2023.05.034","article-title":"Discovery of novel aporphine alkaloid derivative as potent TLR2 antagonist reversing macrophage polarization and neutrophil infiltration against acute inflammation","volume":"13","author":"Yang","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.ejmech.2025.117762_bib4","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41577-019-0215-7","article-title":"DAMP-Sensing receptors in sterile inflammation and inflammatory diseases","volume":"20","author":"Gong","year":"2020","journal-title":"Nat. Rev. Immunol."},{"issue":"2024","key":"10.1016\/j.ejmech.2025.117762_bib5","article-title":"Toll-like receptors in health and disease","volume":"5","author":"Wang","year":"2020","journal-title":"MedComm"},{"key":"10.1016\/j.ejmech.2025.117762_bib6","doi-asserted-by":"crossref","first-page":"142","DOI":"10.3390\/pharmaceutics13020142","article-title":"TLR agonists as vaccine adjuvants targeting cancer and infectious diseases","volume":"13","author":"Luchner","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejmech.2025.117762_bib7","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/s41401-021-00766-6","article-title":"Pharmacological inhibition of MyD88 suppresses inflammation in tubular epithelial cells and prevents diabetic nephropathy in experimental mice","volume":"43","author":"Zhang","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ejmech.2025.117762_bib8","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s40364-025-00739-5","article-title":"Toll-like receptor 3: a double-edged sword","volume":"13","author":"Hsieh","year":"2025","journal-title":"Biomark. Res."},{"key":"10.1016\/j.ejmech.2025.117762_bib9","article-title":"Roles of toll-like receptor 3 in human tumors","volume":"12","author":"Zheng","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejmech.2025.117762_bib10","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/s41392-023-01543-z","article-title":"Extracellular RNAs-TLR3 signaling contributes to cognitive impairment after chronic neuropathic pain in mice","volume":"8","author":"Zhang","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.ejmech.2025.117762_bib11","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.molimm.2017.03.002","article-title":"Regulation of airway inflammation and remodeling in asthmatic mice by TLR3\/TRIF signal pathway","volume":"85","author":"Yang","year":"2017","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.ejmech.2025.117762_bib12","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1161\/CIRCULATIONAHA.122.063481","article-title":"Toll-like receptor 3 mediates aortic stenosis through a conserved mechanism of calcification","volume":"147","author":"Gollmann-Tepek\u00f6yl\u00fc","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.ejmech.2025.117762_bib13","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1084\/jem.20081370","article-title":"TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events","volume":"205","author":"Cavassani","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ejmech.2025.117762_bib14","doi-asserted-by":"crossref","first-page":"3764","DOI":"10.1021\/ja111312h","article-title":"Small-molecule inhibitors of the TLR3\/dsRNA complex","volume":"133","author":"Cheng","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2025.117762_bib15","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1016\/j.bmcl.2017.02.048","article-title":"1-ethyl-3-(6-methylphenanthridine-8-il) urea modulates TLR3\/9 activation and induces selective pro-inflammatory cytokine expression in vitro","volume":"27","author":"Teofilovi\u0107","year":"2017","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2025.117762_bib16","first-page":"145","article-title":"Meroterpenes with toll-like receptor 3 regulating activity from the endophytic fungus Guignardia mangiferae","volume":"81","author":"Han","year":"2015","journal-title":"Planta Med."},{"key":"10.1016\/j.ejmech.2025.117762_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1370042","article-title":"TRIF-dependent signaling and its role in liver diseases","volume":"12","author":"Hu","year":"2024","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ejmech.2025.117762_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2023.105605","article-title":"Hepatoprotective effect of total flavonoids from Carthamus tinctorius L. leaves against carbon tetrachloride-induced chronic liver injury in mice","volume":"171","author":"Ma","year":"2023","journal-title":"Fitoterapia"},{"key":"10.1016\/j.ejmech.2025.117762_bib19","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/hep.31041","article-title":"Mitochondrial double-stranded RNA in exosome promotes Interleukin-17 production through toll-like receptor 3 in alcohol-associated liver injury","volume":"72","author":"Lee","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.ejmech.2025.117762_bib20","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202306483","article-title":"GO-PEG represses the progression of liver inflammation via regulating the M1\/M2 polarization of kupffer cells","volume":"20","author":"Ding","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.ejmech.2025.117762_bib21","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.2174\/1568026616666151120112802","article-title":"HCV inhibitors: role of compounds from botanical sources","volume":"16","author":"Patil","year":"2016","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117762_bib22","doi-asserted-by":"crossref","first-page":"e83","DOI":"10.4142\/jvs.23128","article-title":"Bone marrow stem cells incubated with ellipticine regenerate articular cartilage by attenuating inflammation and cartilage degradation in rabbit model","volume":"24","author":"Hossain","year":"2023","journal-title":"J. Vet. Sci."},{"key":"10.1016\/j.ejmech.2025.117762_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.113992","article-title":"Ellipticine blocks synergistic effects of IL-17A and TNF-\u03b1 in epithelial cells and alleviates severe acute pancreatitis-associated acute lung injury","volume":"177","author":"Li","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejmech.2025.117762_bib24","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s10753-019-01112-z","article-title":"Ellipticine conveys protective effects to lipopolysaccharide-activated macrophages by targeting the JNK\/AP-1 signaling pathway","volume":"43","author":"Tian","year":"2020","journal-title":"Inflammation"},{"key":"10.1016\/j.ejmech.2025.117762_bib25","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2174\/1568009619666190927150131","article-title":"Ellipticine, its derivatives: Re-evaluation of clinical suitability with the aid of drug delivery systems","volume":"20","author":"Dan","year":"2020","journal-title":"Curr. Cancer Drug Targets"},{"key":"10.1016\/j.ejmech.2025.117762_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202400210","article-title":"Bioactivities and action mechanisms of ellipticine derivatives reported prior to 2023","volume":"21","author":"Hou","year":"2024","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.ejmech.2025.117762_bib27","doi-asserted-by":"crossref","first-page":"4802","DOI":"10.1021\/acs.jmedchem.2c01985","article-title":"Design and synthesis of triazole-containing HDAC inhibitors that induce antitumor effects and immune response","volume":"66","author":"Sun","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117762_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114326","article-title":"Dual-acting antitumor agents targeting the A2A adenosine receptor and histone deacetylases: design and synthesis of 4-(furan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine derivatives","volume":"236","author":"Zhang","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117762_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113680","article-title":"Lead optimization to improve the antiviral potency of 2-aminobenzamide derivatives targeting HIV-1 Vif-A3G axis","volume":"224","author":"Zhong","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117762_bib30","doi-asserted-by":"crossref","first-page":"4288","DOI":"10.1021\/jm900230j","article-title":"Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents","volume":"52","author":"Huang","year":"2009","journal-title":"J. Med. Chem."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523425005276?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523425005276?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:07:25Z","timestamp":1777529245000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523425005276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":30,"alternative-id":["S0223523425005276"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2025.117762","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ellipticine derivatives as Toll-like receptor 3 inhibitor for treating acute hepatitis","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2025.117762","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117762"}}