{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:48:10Z","timestamp":1763038090405,"version":"build-2065373602"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.ejmech.2025.117867","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T19:30:15Z","timestamp":1749843015000},"page":"117867","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Rational design of CZL-S092: A novel indazole-based PLK4 inhibitor targeting neuroblastoma through virtual screening and fragment-based drug design strategies"],"prefix":"10.1016","volume":"296","author":[{"given":"Nian","family":"liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ningyuan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cunzheng","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minghui","family":"Tong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengkun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuyi","family":"Mu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zehui","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenqiang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixiang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zixuan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5156-6125","authenticated-orcid":false,"given":"Dongmei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maosheng","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2025.117867_bib1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.semcdb.2021.03.020","article-title":"Human centrosome organization and function in interphase and mitosis","volume":"117","author":"Vasquez-Limeta","year":"2021","journal-title":"Semin. Cell Dev. Biol."},{"issue":"6067","key":"10.1016\/j.ejmech.2025.117867_bib2","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1126\/science.1209037","article-title":"The centrosome in cells and organisms","volume":"335","author":"Bornens","year":"2012","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.ejmech.2025.117867_bib3","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/nrd4504","article-title":"The history and future of targeting cyclin-dependent kinases in cancer therapy","volume":"14","author":"Asghar","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"issue":"9","key":"10.1016\/j.ejmech.2025.117867_bib4","doi-asserted-by":"crossref","first-page":"6390","DOI":"10.1021\/acs.jmedchem.1c02064","article-title":"From structure modification to drug launch: a systematic review of the ongoing development of cyclin-dependent kinase inhibitors for multiple cancer therapy","volume":"65","author":"Shi","year":"2022","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117867_bib5","doi-asserted-by":"crossref","unstructured":"Rocha Lima C. M. S., Roberts P. J., Priego V. M., Divers S. G., Thomas M. B., Boccia R. V., Stabler K., Andrews E., Malik R. K., Aljumaily R., Hamm J. T., Chiu V. K., Richards D. A., Nikolinakos P., Hussein M. A., Schuster S. R., Hoyer R. J., Shapiro G., Dragnev K. H., Owonikoko T. K. Trilaciclib (G1T28): a cyclin dependent kinase 4\/6 inhibitor, in combination with etoposide and carboplatin (EP) for extensive stage small cell lung cancer (ES-SCLC)\u2014Phase 1b results [J]. J. Clin. Oncol., 35(15_suppl) : 8568-8568.","DOI":"10.1200\/JCO.2017.35.15_suppl.8568"},{"key":"10.1016\/j.ejmech.2025.117867_bib6","doi-asserted-by":"crossref","unstructured":"Littman S. J., Knudsen E. S., Witkiewicz A., Hyslop T., Lewis N., Pillai M. V., Brus C., Mitchell E. P. A phase II study of PD-0332991 in patients with advanced hepatocellular cancer [J]. J. Clin. Oncol., 31(4_suppl) : 321-321.","DOI":"10.1200\/jco.2013.31.4_suppl.321"},{"issue":"6","key":"10.1016\/j.ejmech.2025.117867_bib7","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1002\/med.21399","article-title":"Aurora\u2010A kinase: a potent oncogene and target for cancer therapy","volume":"36","author":"Yan","year":"2016","journal-title":"Med. Res. Rev."},{"issue":"1","key":"10.1016\/j.ejmech.2025.117867_bib8","first-page":"17","article-title":"The NEK family of serine\/threonine kinases as a biomarker for cancer","volume":"23","author":"Panchal","year":"2023","journal-title":"Clin. Exp. Med."},{"issue":"8","key":"10.1016\/j.ejmech.2025.117867_bib9","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/nrd3184","article-title":"Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy","volume":"9","author":"Strebhardt","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"issue":"17","key":"10.1016\/j.ejmech.2025.117867_bib10","doi-asserted-by":"crossref","first-page":"7697","DOI":"10.1021\/acs.jmedchem.9b00353","article-title":"Discovery of inhibitors of Aurora\/PLK targets as anticancer agents","volume":"62","author":"Qi","year":"2019","journal-title":"J. Med. Chem."},{"issue":"12","key":"10.1016\/j.ejmech.2025.117867_bib11","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/nrc2964","article-title":"Shared and separate functions of polo-like kinases and aurora kinases in cancer","volume":"10","author":"Lens","year":"2010","journal-title":"Nat. Rev. Cancer"},{"issue":"5","key":"10.1016\/j.ejmech.2025.117867_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/cells11050786","article-title":"Role of polo-like kinases Plk1 and Plk4 in the initiation of centriole duplication-impact on cancer","volume":"11","author":"Hoffmann","year":"2022","journal-title":"Cells"},{"issue":"9","key":"10.1016\/j.ejmech.2025.117867_bib13","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1038\/nsmb.2623","article-title":"Structural basis for the inhibition of Polo-like kinase 1","volume":"20","author":"Xu","year":"2013","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"14","key":"10.1016\/j.ejmech.2025.117867_bib14","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.4161\/cc.10.14.16494","article-title":"From Plk1 to Plk5: functional evolution of polo-like kinases","volume":"10","author":"De","year":"2011","journal-title":"Cell Cycle"},{"issue":"7","key":"10.1016\/j.ejmech.2025.117867_bib15","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nrm3819","article-title":"Polo-like kinases: structural variations lead to multiple functions","volume":"15","author":"Zitouni","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.ejmech.2025.117867_bib16","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1747-1028-5-25","article-title":"Polo-like kinase 4: the odd one out of the family","volume":"5","author":"Sillibourne","year":"2010","journal-title":"Cell Div."},{"issue":"24","key":"10.1016\/j.ejmech.2025.117867_bib17","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1016\/j.cub.2005.11.042","article-title":"SAK\/PLK4 is required for centriole duplication and flagella development","volume":"15","author":"Bettencourt-Dias","year":"2005","journal-title":"Curr. Biol."},{"issue":"11","key":"10.1016\/j.ejmech.2025.117867_bib18","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1038\/s41419-018-1071-2","article-title":"YLT-11, a novel PLK4 inhibitor, inhibits human breast cancer growth via inducing maladjusted centriole duplication and mitotic defect","volume":"9","author":"Lei","year":"2018","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.ejmech.2025.117867_bib19","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ccr.2014.05.006","article-title":"Functional characterization of CFI-400945, a Polo-like kinase 4 inhibitor, as a potential anticancer agent","volume":"26","author":"Mason","year":"2014","journal-title":"Cancer Cell"},{"issue":"8","key":"10.1016\/j.ejmech.2025.117867_bib20","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1073\/pnas.1719760115","article-title":"Polo-like kinase 4 inhibition produces polyploidy and apoptotic death of lung cancers","volume":"115","author":"Kawakami","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.ejmech.2025.117867_bib21","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3892\/ijo.2018.4659","article-title":"High PLK4 expression promotes tumor progression and induces epithelial-mesenchymal transition by regulating the Wnt\/beta-catenin signaling pathway in colorectal cancer","volume":"54","author":"Liao","year":"2019","journal-title":"Int. J. Oncol."},{"issue":"4","key":"10.1016\/j.ejmech.2025.117867_bib22","article-title":"Polo-like kinase 4 (PLK4) is overexpressed in central nervous system neuroblastoma (CNS-NB)","volume":"5","author":"Bailey","year":"2018","journal-title":"Bioengineering (Basel)"},{"issue":"2","key":"10.1016\/j.ejmech.2025.117867_bib23","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.18632\/oncotarget.13619","article-title":"Activity of the novel polo-like kinase 4 inhibitor CFI-400945 in pancreatic cancer patient-derived xenografts","volume":"8","author":"Lohse","year":"2017","journal-title":"Oncotraget"},{"issue":"7825","key":"10.1016\/j.ejmech.2025.117867_bib24","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/s41586-020-2710-1","article-title":"TRIM37 controls cancer-specific vulnerability to PLK4 inhibition","volume":"585","author":"Meitinger","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2025.117867_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.116115","article-title":"Therapeutic potential of targeting polo-like kinase 4","volume":"265","author":"Lei","year":"2024","journal-title":"Eur. J. Med. Chem."},{"issue":"1","key":"10.1016\/j.ejmech.2025.117867_bib26","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1021\/jm500537u","article-title":"The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3 '[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agents","volume":"58","author":"Sampson","year":"2015","journal-title":"J. Med. Chem."},{"issue":"Supplement 1","key":"10.1016\/j.ejmech.2025.117867_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1182\/blood-2020-138822","article-title":"Preliminary results from a phase 1 study of Cfi-400495, a PLK4 inhibitor, in patients with acute myeloid leukemia and high risk MDS","volume":"136","author":"Murphy","year":"2020","journal-title":"Blood"},{"issue":"44","key":"10.1016\/j.ejmech.2025.117867_bib28","doi-asserted-by":"crossref","first-page":"27737","DOI":"10.1039\/C7RA02518A","article-title":"Synthesis and biological evaluation of (E)-4-(3-arylvinyl-1H-indazol-6-yl)pyrimidin-2-amine derivatives as PLK4 inhibitors for the treatment of breast cancer","volume":"7","author":"Liu","year":"2017","journal-title":"RSC Adv."},{"issue":"6239","key":"10.1016\/j.ejmech.2025.117867_bib29","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1126\/science.aaa5111","article-title":"Reversible centriole depletion with an inhibitor of Polo-like kinase 4","volume":"348","author":"Wong","year":"2015","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.ejmech.2025.117867_bib30","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1039\/D3MD00267E","article-title":"Design, synthesis, and biological evaluation of novel pyrimidin-2-amine derivatives as potent PLK4 inhibitors","volume":"14","author":"Xue","year":"2023","journal-title":"RSC Med. Chem."},{"issue":"4","key":"10.1016\/j.ejmech.2025.117867_bib31","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1021\/acs.jmedchem.2c02124","article-title":"Discovery of CZS-241: a potent, selective, and orally available polo-like kinase 4 inhibitor for the treatment of chronic myeloid leukemia","volume":"66","author":"Sun","year":"2023","journal-title":"J. Med. Chem."},{"issue":"12","key":"10.1016\/j.ejmech.2025.117867_bib32","doi-asserted-by":"crossref","first-page":"8200","DOI":"10.1021\/acs.jmedchem.3c00505","article-title":"Discovery of the first potent, selective, and in vivo efficacious polo-like kinase 4 proteolysis targeting chimera degrader for the treatment of TRIM37-Amplified breast cancer","volume":"66","author":"Sun","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.117867_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114424","article-title":"Design, synthesis, and biological evaluation of novel pyrazolo [3,4-d]pyrimidine derivatives as potent PLK4 inhibitors for the treatment of TRIM37-amplified breast cancer","volume":"238","author":"Sun","year":"2022","journal-title":"Eur. J. Med. Chem."},{"issue":"24","key":"10.1016\/j.ejmech.2025.117867_bib34","doi-asserted-by":"crossref","first-page":"4587","DOI":"10.1021\/ol047996t","article-title":"A general palladium-catalyzed coupling of aryl bromides\/triflates and thiols","volume":"6","author":"Itoh","year":"2004","journal-title":"Org. Lett."},{"issue":"9","key":"10.1016\/j.ejmech.2025.117867_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20092112","article-title":"Evaluation of protein kinase inhibitors with PLK4 cross-over potential in a pre-clinical model of cancer","volume":"20","author":"Suri","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"7825","key":"10.1016\/j.ejmech.2025.117867_bib36","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/s41586-020-2690-1","article-title":"Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer","volume":"585","author":"Yeow","year":"2020","journal-title":"Nature"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523425006324?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523425006324?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T14:10:42Z","timestamp":1762265442000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523425006324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":36,"alternative-id":["S0223523425006324"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2025.117867","relation":{},"ISSN":["0223-5234"],"issn-type":[{"type":"print","value":"0223-5234"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rational design of CZL-S092: A novel indazole-based PLK4 inhibitor targeting neuroblastoma through virtual screening and fragment-based drug design strategies","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2025.117867","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117867"}}