{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:33:08Z","timestamp":1792427588281,"version":"4.5.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100011324","name":"Qingdao University","doi-asserted-by":"publisher","award":["22-3-3-hygg-25-hy"],"award-info":[{"award-number":["22-3-3-hygg-25-hy"]}],"id":[{"id":"10.13039\/501100011324","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.ejmech.2025.118062","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T06:20:39Z","timestamp":1755498039000},"page":"118062","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Development of cell-permeable and plasma-stable peptidomimetic inhibitors against PSD-95\/nNOS interaction as potential anti-ischemic stroke agents"],"prefix":"10.1016","volume":"299","author":[{"given":"Jiacheng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiguo","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujiao","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiya","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8623-0146","authenticated-orcid":false,"given":"Mingxin","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2025.118062_bib1","doi-asserted-by":"crossref","first-page":"e897","DOI":"10.1016\/S2468-2667(21)00228-0","article-title":"Temporal trend and attributable risk factors of stroke burden in China, 1990-2019: an analysis for the Global Burden of Disease Study 2019","volume":"6","author":"Ma","year":"2021","journal-title":"Lancet Public Health"},{"key":"10.1016\/j.ejmech.2025.118062_bib2","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0140-6736(07)60149-4","article-title":"Thrombolysis with alteplase for acute ischaemic stroke in the safe implementation of thrombolysis in stroke-monitoring study (SITS-MOST): an observational study","volume":"369","author":"Wahlgren","year":"2007","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.ejmech.2025.118062_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/jcm13195826","article-title":"The changing landscape of intravenous thrombolysis for acute ischaemic stroke","volume":"13","author":"Donaldson","year":"2024","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.ejmech.2025.118062_bib4","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/s00415-025-13081-5","article-title":"Risk of intracerebral haemorrhage with tenecteplase versus alteplase in acute ischaemic stroke: a meta-analysis","volume":"272","author":"Tao","year":"2025","journal-title":"J. Neurol."},{"key":"10.1016\/j.ejmech.2025.118062_bib5","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6687386","article-title":"Neuroprotective phytochemicals in experimental ischemic stroke: mechanisms and potential clinical applications","volume":"2021","author":"Xu","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ejmech.2025.118062_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115251","article-title":"Discovery of phenylcarbamoyl xanthone derivatives as potent neuroprotective agents for treating ischemic stroke","volume":"251","author":"Chen","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118062_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115871","article-title":"Discovery of benzyloxy benzamide derivatives as potent neuroprotective agents against ischemic stroke","volume":"261","author":"Chen","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118062_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2023.117236","article-title":"Design and synthesis of novel GluN2A NMDAR positive allosteric modulators via scaffold hopping strategy as anti-stroke therapeutic agents","volume":"83","author":"Chen","year":"2023","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118062_bib9","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.pneurobio.2013.11.006","article-title":"Excitotoxicity and stroke: identifying novel targets for neuroprotection","volume":"115","author":"Lai","year":"2014","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.ejmech.2025.118062_bib10","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1161\/STROKEAHA.115.009314","article-title":"Therapeutic targets for cerebral ischemia based on the signaling pathways of the GluN2B C terminus","volume":"46","author":"Sun","year":"2015","journal-title":"Stroke"},{"key":"10.1016\/j.ejmech.2025.118062_bib11","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1385\/MN:24:1-3:107","article-title":"Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death","volume":"24","author":"Sattler","year":"2001","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ejmech.2025.118062_bib12","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.brainresrev.2006.11.003","article-title":"Molecular targets in cerebral ischemia for developing novel therapeutics","volume":"54","author":"Mehta","year":"2007","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.ejmech.2025.118062_bib13","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1126\/science.2567056","article-title":"The role of excitatory amino acids and NMDA receptors in traumatic brain injury","volume":"244","author":"Faden","year":"1989","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.ejmech.2025.118062_bib14","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1021\/jm801220a","article-title":"Discovery of highly potent and selective inhibitors of neuronal nitric oxide synthase by fragment hopping","volume":"52","author":"Ji","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118062_bib15","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s004150200065","article-title":"Treatment of acute ischaemic stroke with the low-affinity, use-dependent NMDA antagonist AR-R15896AR. A safety and tolerability study","volume":"249","author":"Diener","year":"2002","journal-title":"J. Neurol."},{"key":"10.1016\/j.ejmech.2025.118062_bib16","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S1474-4422(02)00164-3","article-title":"Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?","volume":"1","author":"Ikonomidou","year":"2002","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ejmech.2025.118062_bib17","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1126\/science.1072873","article-title":"Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactions","volume":"298","author":"Aarts","year":"2002","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.ejmech.2025.118062_bib18","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1083\/jcb.200407024","article-title":"The PSD95-nNOS interface: a target for inhibition of excitotoxic p38 stress-activated protein kinase activation and cell death","volume":"168","author":"Cao","year":"2005","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ejmech.2025.118062_bib19","doi-asserted-by":"crossref","first-page":"9901","DOI":"10.1523\/JNEUROSCI.1464-07.2007","article-title":"PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors","volume":"27","author":"Cui","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejmech.2025.118062_bib20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.neures.2016.09.002","article-title":"Neuroprotective efficacy of poly-arginine R18 and NA-1 (TAT-NR2B9c) peptides following transient middle cerebral artery occlusion in the rat","volume":"114","author":"Milani","year":"2017","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.ejmech.2025.118062_bib21","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/S0140-6736(20)30258-0","article-title":"Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial","volume":"395","author":"Hill","year":"2020","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.ejmech.2025.118062_bib22","doi-asserted-by":"crossref","first-page":"9685","DOI":"10.1002\/anie.200904741","article-title":"Design and synthesis of highly potent and plasma-stable dimeric inhibitors of the PSD-95-NMDA receptor interaction","volume":"48","author":"Bach","year":"2009","journal-title":"Angew. Chem."},{"key":"10.1016\/j.ejmech.2025.118062_bib23","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1073\/pnas.1113761109","article-title":"A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage","volume":"109","author":"Bach","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.ejmech.2025.118062_bib24","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1021\/acs.jmedchem.2c01803","article-title":"Development of a potent cyclic peptide inhibitor of the nNOS\/PSD-95 interaction","volume":"66","author":"Balboa","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118062_bib25","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1021\/jm1013924","article-title":"Cell-permeable and plasma-stable peptidomimetic inhibitors of the postsynaptic density-95\/N-methyl-D-aspartate receptor interaction","volume":"54","author":"Bach","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118062_bib26","doi-asserted-by":"crossref","first-page":"4243","DOI":"10.1016\/j.apsb.2024.06.019","article-title":"Transformation of peptides to small molecules in medicinal chemistry: challenges and opportunities","volume":"14","author":"Han","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.ejmech.2025.118062_bib27","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1136\/svn-2022-002156","article-title":"Preclinical evaluation of ZL006-05, a new antistroke drug with fast-onset antidepressant and anxiolytic effects","volume":"8","author":"Wu","year":"2023","journal-title":"Stroke Vasc. Neurol."},{"key":"10.1016\/j.ejmech.2025.118062_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/srep12157","article-title":"Biochemical investigations of the mechanism of action of small molecules ZL006 and IC87201 as potential inhibitors of the nNOS-PDZ\/PSD-95-PDZ interactions","volume":"5","author":"Bach","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2025.118062_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/adtp.201800143","article-title":"PDZ domains as drug targets","volume":"2","author":"Christensen","year":"2019","journal-title":"Adv. Therapeut."},{"key":"10.1016\/j.ejmech.2025.118062_bib30","doi-asserted-by":"crossref","first-page":"6450","DOI":"10.1021\/jm800836w","article-title":"Modified peptides as potent inhibitors of the postsynaptic density-95\/N-methyl-D-aspartate receptor interaction","volume":"51","author":"Bach","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118062_bib31","doi-asserted-by":"crossref","first-page":"19932","DOI":"10.1021\/acs.jmedchem.4c00110","article-title":"Unnatural amino acids: strategies, designs, and applications in medicinal chemistry and drug discovery","volume":"67","author":"Sharma","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118062_bib32","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1039\/C5MD00445D","article-title":"Design and synthesis of triazole-based peptidomimetics of a PSD-95 PDZ domain inhibitor","volume":"7","author":"Bach","year":"2016","journal-title":"MedChemComm"},{"key":"10.1016\/j.ejmech.2025.118062_bib33","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1478-811X-8-8","article-title":"PDZ domains and their binding partners: structure, specificity, and modification","volume":"8","author":"Lee","year":"2010","journal-title":"Cell Commun. Signal. : CCS"},{"key":"10.1016\/j.ejmech.2025.118062_bib34","doi-asserted-by":"crossref","first-page":"15773","DOI":"10.1021\/acs.jmedchem.0c01528","article-title":"Cyclic peptidyl inhibitors against CAL\/CFTR interaction for treatment of cystic fibrosis","volume":"63","author":"Dougherty","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118062_bib35","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1038\/nm.2245","article-title":"Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95","volume":"16","author":"Zhou","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejmech.2025.118062_bib36","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/0896-6273(89)90043-3","article-title":"Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress","volume":"2","author":"Murphy","year":"1989","journal-title":"Neuron"},{"key":"10.1016\/j.ejmech.2025.118062_bib37","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s00709-019-01439-2","article-title":"Ischemic stroke and mitochondria: mechanisms and targets","volume":"257","author":"Andrabi","year":"2020","journal-title":"Protoplasma"},{"key":"10.1016\/j.ejmech.2025.118062_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2009.06.059","article-title":"Mechanism of glutamate-induced neurotoxicity in HT22 mouse hippocampal cells","volume":"617","author":"Fukui","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejmech.2025.118062_bib39","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/s41392-022-01129-1","article-title":"Correction to: signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions","volume":"7","author":"Qin","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.ejmech.2025.118062_bib40","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1021\/acschemneuro.2c00757","article-title":"Effect of P-Glycoprotein on the blood\u2013brain barrier transport of the major active constituents of Salvia miltiorrhiza based on the MDCK-MDR1 cell model","volume":"14","author":"Fang","year":"2023","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.ejmech.2025.118062_bib41","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.ijpharm.2004.10.007","article-title":"Evaluation of the MDR-MDCK cell line as a permeability screen for the blood-brain barrier","volume":"288","author":"Wang","year":"2005","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejmech.2025.118062_bib42","first-page":"204","volume":"vol. 4","author":"Li","year":"2021"},{"key":"10.1016\/j.ejmech.2025.118062_bib43","first-page":"3445","article-title":"Animal models of ischemic stroke and their application in clinical research","volume":"9","author":"Fluri","year":"2015","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.ejmech.2025.118062_bib44","doi-asserted-by":"crossref","first-page":"5211","DOI":"10.1021\/acs.jmedchem.4c01710","article-title":"Engineered cyclotide blocks neuronal excitotoxicity","volume":"68","author":"Ariawan","year":"2025","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118062_bib45","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1096\/fj.201601209R","article-title":"Combination therapy with liposomal neuroprotectants and tissue plasminogen activator for treatment of ischemic stroke","volume":"31","author":"Fukuta","year":"2017","journal-title":"FASEB J."},{"key":"10.1016\/j.ejmech.2025.118062_bib46","first-page":"109","article-title":"Safety and efficacy of edaravone combined with alteplase for patients with acute ischemic stroke: a systematic review and meta-analysis","volume":"76","author":"Hu","year":"2021","journal-title":"Pharmazie"},{"key":"10.1016\/j.ejmech.2025.118062_bib47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0311231","article-title":"Synergistic effects of neuroprotective drugs with intravenous recombinant tissue plasminogen activator in acute ischemic stroke: a Bayesian network meta-analysis","volume":"19","author":"Dang","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.ejmech.2025.118062_bib48","article-title":"Organocatalytic enantioselective 1,12-Addition of alkynyl biphenyl quinone methides formed in situ","volume":"63","author":"Wang","year":"2024","journal-title":"Angew. Chem."},{"key":"10.1016\/j.ejmech.2025.118062_bib49","doi-asserted-by":"crossref","DOI":"10.1002\/pro.4792","article-title":"UCSF ChimeraX: tools for structure building and analysis","volume":"32","author":"Meng","year":"2023","journal-title":"Protein Sci."},{"key":"10.1016\/j.ejmech.2025.118062_bib50","first-page":"1710","article-title":"Molecular complexes at a glance: automated generation of two-dimensional complex diagrams","volume":"22","author":"Stierand","year":"2006","journal-title":"Bioinformatics (Oxford, England)"},{"key":"10.1016\/j.ejmech.2025.118062_bib51","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/jcc.20291","article-title":"GROMACS: fast, flexible, and free","volume":"26","author":"Van Der Spoel","year":"2005","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.ejmech.2025.118062_bib52","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","article-title":"GROMACS: high performance molecular simulations through multi-level parallelism from laptops to supercomputers","volume":"1\u20132","author":"Abraham","year":"2015","journal-title":"SoftwareX"},{"key":"10.1016\/j.ejmech.2025.118062_bib53","unstructured":"T. Lu, Sobtop, Version [dev3.1], http:\/\/sobereva.com\/soft\/Sobtop\/(accessed on May 18, 2025)."},{"key":"10.1016\/j.ejmech.2025.118062_bib54","doi-asserted-by":"crossref","first-page":"3696","DOI":"10.1021\/acs.jctc.5b00255","article-title":"ff14SB: improving the accuracy of protein side chain and backbone parameters from ff99SB","volume":"11","author":"Maier","year":"2015","journal-title":"J. Chem. Theor. Comput."},{"key":"10.1016\/j.ejmech.2025.118062_bib55","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1021\/acs.jmedchem.4c02772","article-title":"Discovery of HZS60 as a novel brain penetrant NMDAR\/TRPM4 interaction interface inhibitor with improved activity and pharmacokinetic properties for the treatment of cerebral ischemia","volume":"68","author":"Sun","year":"2025","journal-title":"J. Med. Chem."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S022352342500827X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S022352342500827X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T14:53:45Z","timestamp":1772808825000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S022352342500827X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":55,"alternative-id":["S022352342500827X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2025.118062","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of cell-permeable and plasma-stable peptidomimetic inhibitors against PSD-95\/nNOS interaction as potential anti-ischemic stroke agents","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2025.118062","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118062"}}