{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T04:23:28Z","timestamp":1783052608134,"version":"3.54.6"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013254","name":"National College Students Innovation and Entrepreneurship Training Program","doi-asserted-by":"publisher","award":["S202410555027"],"award-info":[{"award-number":["S202410555027"]}],"id":[{"id":"10.13039\/501100013254","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2024JJ8141"],"award-info":[{"award-number":["2024JJ8141"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["242300421194"],"award-info":[{"award-number":["242300421194"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009020","name":"University of South China","doi-asserted-by":"publisher","award":["5524GC003"],"award-info":[{"award-number":["5524GC003"]}],"id":[{"id":"10.13039\/501100009020","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009020","name":"University of South China","doi-asserted-by":"publisher","award":["5524BH006"],"award-info":[{"award-number":["5524BH006"]}],"id":[{"id":"10.13039\/501100009020","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009020","name":"University of South China","doi-asserted-by":"publisher","award":["5524GC001"],"award-info":[{"award-number":["5524GC001"]}],"id":[{"id":"10.13039\/501100009020","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.ejmech.2025.118139","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T15:31:01Z","timestamp":1756999861000},"page":"118139","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Discovery of novel xanthotoxin-pyridine quaternary ammonium derivatives with membrane-targeting mode of action as potential antimicrobials against methicillin-resistant Staphylococcus aureus"],"prefix":"10.1016","volume":"300","author":[{"given":"Shengnan","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaomiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruige","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2227-8276","authenticated-orcid":false,"given":"Yong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ejmech.2025.118139_bib1","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1080\/21505594.2021.1878688","article-title":"Pathogenicity and virulence of Staphylococcus aureus","volume":"12","author":"Cheung","year":"2021","journal-title":"Virulence"},{"issue":"1","key":"10.1016\/j.ejmech.2025.118139_bib2","article-title":"The impact of the COVID-19 pandemic on Staphylococcus aureus infections in pediatric patients admitted with community acquired pneumonia","volume":"14","author":"Ai","year":"2024","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.ejmech.2025.118139_bib3","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41579-018-0147-4","article-title":"Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research","volume":"17","author":"Turner","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ejmech.2025.118139_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.113056","article-title":"Potentials of nanotechnology in treatment of methicillin-resistant Staphylococcus aureus","volume":"213","author":"Gao","year":"2021","journal-title":"Eur. J. Med. Chem."},{"issue":"5","key":"10.1016\/j.ejmech.2025.118139_bib5","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1183\/09031936.00007709","article-title":"What is MRSA?","volume":"34","author":"Pantosti","year":"2009","journal-title":"Eur. Respir. J."},{"issue":"12","key":"10.1016\/j.ejmech.2025.118139_bib6","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1016\/j.jiph.2021.10.020","article-title":"Antibiotic resistance in microbes: history, mechanisms, therapeutic strategies and future prospects","volume":"14","author":"Uddin","year":"2021","journal-title":"J. Infect. Public Health"},{"issue":"19","key":"10.1016\/j.ejmech.2025.118139_bib7","doi-asserted-by":"crossref","DOI":"10.1172\/JCI185824","article-title":"Intertwining clonality and resistance: staphylococcus aureus in the antibiotic era","volume":"134","author":"Chambers","year":"2024","journal-title":"J. Clin. Investig."},{"issue":"3","key":"10.1016\/j.ejmech.2025.118139_bib8","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/cpt.726","article-title":"The nephrotoxicity of Vancomycin","volume":"102","author":"Filippone","year":"2017","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ejmech.2025.118139_bib9","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.jare.2023.11.005","article-title":"Discovery of new quaternized norharmane dimers as potential anti-MRSA agents","volume":"63","author":"Dai","year":"2024","journal-title":"J. Adv. Res."},{"issue":"17","key":"10.1016\/j.ejmech.2025.118139_bib10","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.1016\/j.bmc.2019.07.023","article-title":"Natural product derived promising anti-MRSA drug leads: a review","volume":"27","author":"Gatadi","year":"2019","journal-title":"Bioorg. Med. Chem."},{"issue":"6","key":"10.1016\/j.ejmech.2025.118139_bib11","doi-asserted-by":"crossref","first-page":"3495","DOI":"10.1021\/acs.chemrev.0c00922","article-title":"Ethnobotany and the role of plant natural products in antibiotic drug discovery","volume":"121","author":"Porras","year":"2021","journal-title":"Chem. Rev."},{"issue":"3","key":"10.1016\/j.ejmech.2025.118139_bib12","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural products as sources of new drugs over the nearly four decades from 01\/1981 to 09\/2019","volume":"83","author":"Newman","year":"2020","journal-title":"J. Nat. Prod."},{"issue":"10","key":"10.1016\/j.ejmech.2025.118139_bib13","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1002\/ptr.7577","article-title":"Xanthotoxin (8-methoxypsoralen): a review of its chemistry, pharmacology, pharmacokinetics, and toxicity","volume":"36","author":"Wu","year":"2022","journal-title":"Phytother Res."},{"issue":"7","key":"10.1016\/j.ejmech.2025.118139_bib14","doi-asserted-by":"crossref","first-page":"3605","DOI":"10.1111\/ejn.16119","article-title":"Mechanisms involved in the antinociceptive and anti\u2010inflammatory effects of xanthotoxin","volume":"58","author":"Zhu","year":"2023","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ejmech.2025.118139_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.121129","article-title":"Xanthotoxin modulates oxidative stress, inflammation, and MAPK signaling in a rotenone-induced Parkinson's disease model","volume":"310","author":"Sayed","year":"2022","journal-title":"Life Sci."},{"issue":"5","key":"10.1016\/j.ejmech.2025.118139_bib16","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1021\/acschemneuro.8b00011","article-title":"Scopolamine-induced memory impairment is alleviated by xanthotoxin: role of acetylcholinesterase and oxidative stress processes","volume":"9","author":"Skalicka-Wozniak","year":"2018","journal-title":"ACS Chem. Neurosci."},{"issue":"1","key":"10.1016\/j.ejmech.2025.118139_bib17","doi-asserted-by":"crossref","first-page":"856","DOI":"10.3390\/cimb46010055","article-title":"Methoxyfuranocoumarins of natural origin\u2013updating biological activity research and searching for new directions\u2014a review","volume":"46","author":"Bartnik","year":"2024","journal-title":"Curr. Issues Mol. Biol."},{"issue":"10","key":"10.1016\/j.ejmech.2025.118139_bib18","doi-asserted-by":"crossref","first-page":"5659","DOI":"10.3390\/ijms23105659","article-title":"Pyridine compounds with antimicrobial and antiviral activities","volume":"23","author":"Marinescu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.ejmech.2025.118139_bib19","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1097\/INF.0000000000004807","article-title":"A phase 3 study of the safety and efficacy of tedizolid phosphate in patients <12 years of age with acute bacterial skin and skin structure infections","volume":"44","author":"Mngqibisa","year":"2025","journal-title":"Pediatr. Infect. Dis. J."},{"issue":"6","key":"10.1016\/j.ejmech.2025.118139_bib20","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1093\/cid\/ciy600","article-title":"Delafloxacin: a new anti\u2013methicillin-resistant staphylococcus aureus fluoroquinolone","volume":"68","author":"Saravolatz","year":"2019","journal-title":"Clin. Infect. Dis."},{"issue":"3","key":"10.1016\/j.ejmech.2025.118139_bib21","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1080\/14787210.2019.1573671","article-title":"A review of preclinical and clinical efficacy","volume":"17","author":"Vila","year":"2019","journal-title":"Expert Rev. Anti Infect. Ther."},{"issue":"20","key":"10.1016\/j.ejmech.2025.118139_bib22","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.2165\/00003495-200464200-00006","article-title":"Moxifloxacin: a review of its use in the management of bacterial infections","volume":"64","author":"Keating","year":"2004","journal-title":"Drugs"},{"issue":"2023","key":"10.1016\/j.ejmech.2025.118139_bib23","article-title":"Recent advances in pyridine scaffold: focus on chemistry, synthesis, and antibacterial activities","volume":"1","author":"Islam","year":"2023","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.ejmech.2025.118139_bib24","article-title":"Enhanced antimicrobial performance of D-A covalent organic framework with pyridinium and quaternary ammonium groups and ROS activity","volume":"62","author":"Ma","year":"2025","journal-title":"Surf. Interfaces"},{"key":"10.1016\/j.ejmech.2025.118139_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2019.118776","article-title":"Enhancing the solubility of natural compound xanthotoxin by modulating stability via cocrystallization engineering","volume":"572","author":"Chen","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejmech.2025.118139_bib26","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.ejmech.2017.06.005","article-title":"Drug development against tuberculosis: impact of alkaloids","volume":"137","author":"Mishra","year":"2017","journal-title":"Eur. J. Med. Chem."},{"issue":"12","key":"10.1016\/j.ejmech.2025.118139_bib27","doi-asserted-by":"crossref","first-page":"5269","DOI":"10.1021\/acs.biomac.0c01330","article-title":"Screening and matching amphiphilic cationic polymers for efficient antibiosis","volume":"21","author":"Zhao","year":"2020","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.ejmech.2025.118139_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.142098","article-title":"Regulatory effects of different spacer alkyl chains on the in vitro antioxidant and antibacterial activities of chitosan quaternary ammonium\/phosphonium salt derivatives","volume":"307","author":"Su","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"issue":"6531","key":"10.1016\/j.ejmech.2025.118139_bib29","doi-asserted-by":"crossref","DOI":"10.1126\/science.aba0862","article-title":"Clinically relevant mutations in core metabolic genes confer antibiotic resistance","volume":"371","author":"Lopatkin","year":"2021","journal-title":"Science"},{"issue":"7922","key":"10.1016\/j.ejmech.2025.118139_bib30","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/s41586-022-05019-y","article-title":"Teixobactin kills bacteria by a two-pronged attack on the cell envelope","volume":"608","author":"Shukla","year":"2022","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.ejmech.2025.118139_bib31","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.1021\/acsinfecdis.4c00292","article-title":"Plant flavonoids with antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA)","volume":"10","author":"Xu","year":"2024","journal-title":"ACS Infect. Dis."},{"issue":"7","key":"10.1016\/j.ejmech.2025.118139_bib32","doi-asserted-by":"crossref","first-page":"7459","DOI":"10.1021\/acs.jmedchem.4c03167","article-title":"Development of membrane-targeting osthole derivatives containing pyridinium quaternary ammonium moieties with potent anti-methicillin-resistant Staphylococcus aureus properties","volume":"68","author":"Xu","year":"2025","journal-title":"J. Med. Chem."},{"issue":"3","key":"10.1016\/j.ejmech.2025.118139_bib33","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.apsb.2025.02.009","article-title":"Establishment of interpretable cytotoxicity prediction models using machine learning analysis of transcriptome features","volume":"15","author":"Wu","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.ejmech.2025.118139_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116703","article-title":"Design, synthesis of griseofamine a derivatives and development of potent antibacterial agents against MRSA","volume":"276","author":"Ma","year":"2024","journal-title":"Eur. J. Med. Chem."},{"issue":"10","key":"10.1016\/j.ejmech.2025.118139_bib35","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/s41579-022-00682-4","article-title":"Tolerance and resistance of microbial biofilms","volume":"20","author":"Ciofu","year":"2022","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ejmech.2025.118139_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.132454","article-title":"From disinfectants to antibiotics: enhanced biosafety of quaternary ammonium compounds by chemical modification","volume":"460","author":"Mai","year":"2023","journal-title":"J. Hazard. Mater."},{"issue":"3","key":"10.1016\/j.ejmech.2025.118139_bib37","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1002\/ptr.8427","article-title":"Acetylshikonin derived from Arnebia euchroma (Royle) Johnst kills multidrug\u2010resistant gram\u2010positive pathogens in vitro and in vivo","volume":"39","author":"Xiao","year":"2025","journal-title":"Phytother Res."},{"key":"10.1016\/j.ejmech.2025.118139_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116716","article-title":"Development of amphipathic derivatives of thymol and carvacrol as potent broad-spectrum antibacterial agents","volume":"276","author":"Dong","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118139_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114333","article-title":"Novel benzothiazole\u2012urea hybrids: design, synthesis and biological activity as potent anti-bacterial agents against MRSA","volume":"236","author":"Zha","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118139_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116274","article-title":"Novel membrane-targeting isoxanthohumol-amine conjugates for combating methicillin-resistant Staphylococcus aureus (MRSA) infections","volume":"268","author":"Yang","year":"2024","journal-title":"Eur. J. Med. Chem."},{"issue":"1","key":"10.1016\/j.ejmech.2025.118139_bib41","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1021\/acs.jmedchem.2c01793","article-title":"Discovery of amphiphilic xanthohumol derivatives as membrane-targeting antimicrobials against methicillin-resistant Staphylococcus aureus","volume":"66","author":"Cheng","year":"2023","journal-title":"J. Med. Chem."},{"issue":"18","key":"10.1016\/j.ejmech.2025.118139_bib42","doi-asserted-by":"crossref","first-page":"16858","DOI":"10.1021\/acs.jmedchem.4c01860","article-title":"Membrane-targeting amphiphilic honokiol derivatives containing an oxazole moiety as potential antibacterials against methicillin-resistant Staphylococcus aureus","volume":"67","author":"Yang","year":"2024","journal-title":"J. Med. Chem."},{"issue":"1","key":"10.1016\/j.ejmech.2025.118139_bib43","doi-asserted-by":"crossref","first-page":"5879","DOI":"10.1038\/s41467-024-49629-8","article-title":"Asymmetric total synthesis of polycyclic xanthenes and discovery of a WalK activator active against MRSA","volume":"15","author":"Cheng","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2025.118139_bib44","article-title":"Development of novel broad-spectrum amphipathic antimicrobial peptides against multidrug-resistant bacteria through a rational combination strategy","author":"Zhang","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.ejmech.2025.118139_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116868","article-title":"Discovery of membrane-targeting amphiphilic honokiol derivatives containing an oxazolethione moiety to combat methicillin-resistant Staphylococcus aureus (MRSA) infections","volume":"279","author":"Yang","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118139_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116625","article-title":"Design and synthesis of unique indole-benzosulfonamide oleanolic acid derivatives as potent antibacterial agents against MRSA","volume":"276","author":"Li","year":"2024","journal-title":"Eur. J. Med. Chem."},{"issue":"1","key":"10.1016\/j.ejmech.2025.118139_bib47","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-75270-8","article-title":"Raw transcriptomics data to gene specific SSRs: a validated free bioinformatics workflow for biologists","volume":"10","author":"Naranpanawa","year":"2020","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.ejmech.2025.118139_bib48","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1038\/s41467-023-37310-5","article-title":"Modulation of MRSA virulence gene expression by the wall teichoic acid enzyme TarO","volume":"14","author":"Lu","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2025.118139_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.117518","article-title":"Synthesis and anti-MRSA activity of quaternized small molecule antimicrobial peptide mimics based on norharmane","volume":"290","author":"Dan","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118139_bib50","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jare.2023.04.017","article-title":"Antimicrobial activities of lavandulylated flavonoids in Sophora flavences against methicillin-resistant Staphylococcus aureus via membrane disruption","volume":"57","author":"Weng","year":"2024","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.ejmech.2025.118139_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.jare.2024.12.044","article-title":"LTX-315 is a novel broad-spectrum antimicrobial peptide against clinical multidrug-resistant bacteria","author":"Tang","year":"2025","journal-title":"J. Adv. Res."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523425009043?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523425009043?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T20:58:52Z","timestamp":1772830732000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523425009043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":51,"alternative-id":["S0223523425009043"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2025.118139","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of novel xanthotoxin-pyridine quaternary ammonium derivatives with membrane-targeting mode of action as potential antimicrobials against methicillin-resistant Staphylococcus aureus","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2025.118139","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118139"}}