{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:23:03Z","timestamp":1790770983387,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100016148","name":"Department of Pharmaceutical Chemistry, University of Kansas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016148","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.ejmech.2025.118168","type":"journal-article","created":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T10:02:32Z","timestamp":1757757752000},"page":"118168","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Modulating glucose homeostasis via expression of PPAR-\u03b3 TF: Pharmacological insights into quinolone-based hydrazones"],"prefix":"10.1016","volume":"300","author":[{"given":"Naik Jui","family":"Pravin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1149-3819","authenticated-orcid":false,"given":"Rohini S.","family":"Kavalapure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shankar","family":"Gharge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shankar G.","family":"Alegaon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shriram D.","family":"Ranade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Koli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.R.","family":"Prashantha Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Gudasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilas Gowda","family":"K B","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramith","family":"Ramu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2025.118168_bib1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3390\/diabetology2020004","article-title":"Diabetes Mellitus: insights from epidemiology, biochemistry, risk factors, diagnosis, complications and comprehensive management","volume":"2","author":"Alam","year":"2021","journal-title":"Diabetology"},{"key":"10.1016\/j.ejmech.2025.118168_bib2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/1520-7560(200105\/06)17:3<181::AID-DMRR197>3.0.CO;2-1","article-title":"Clinical importance of insulin secretion and its interaction with insulin resistance in the treatment of type 2 diabetes mellitus and its complications","volume":"17","author":"Porte","year":"2001","journal-title":"Diabetes Metab Res Rev"},{"key":"10.1016\/j.ejmech.2025.118168_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252413294","article-title":"Systemic and cardiac microvascular dysfunction in hypertension","volume":"25","author":"Durante","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2025.118168_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107966","article-title":"Expression of PPAR-\u03b3 TF by newly synthesized thiazolidine-2, 4-diones to manage glycemic control: insights from in silico, in vitro and experimental pharmacology in wistar rats","volume":"153","author":"Gharge","year":"2024","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2025.118168_bib5","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.2174\/1389450119666180727142902","article-title":"Current strategies and drug targets in the management of type 2 diabetes mellitus","volume":"19","author":"Kaur","year":"2018","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.ejmech.2025.118168_bib6","doi-asserted-by":"crossref","first-page":"4525","DOI":"10.2147\/DMSO.S492626","article-title":"Acupuncture and drug combination therapy for abnormal glucose metabolism: exploring synergistic enhancement and reduced toxicity mechanisms","volume":"31","author":"Tian","year":"2024","journal-title":"Diabetes, Metabolic Syndrome and Obesity"},{"key":"10.1016\/j.ejmech.2025.118168_bib7","first-page":"2181","article-title":"The nuclear hormone receptor PPAR\u03b3 as a therapeutic target in major diseases","volume":"10","author":"Schmidt","year":"2010","journal-title":"Sci. World"},{"key":"10.1016\/j.ejmech.2025.118168_bib8","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/cbdd.14129","article-title":"A comprehensive review of recent advances in the biological activities of quinazolines","volume":"100","author":"Gomaa","year":"2022","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.ejmech.2025.118168_bib9","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1080\/17460441.2017.1319357","article-title":"An overview of quinoline as a privileged scaffold in cancer drug discovery","volume":"12","author":"Musiol","year":"2017","journal-title":"Expert Opin Drug Dis"},{"key":"10.1016\/j.ejmech.2025.118168_bib10","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.2174\/092986711795328382","article-title":"Quinoline as a privileged scaffold in cancer drug discovery","volume":"18","author":"Solomon V","year":"2011","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118168_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2024.129770","article-title":"Synthesis of a new 2-prenylated quinoline as potential drug for metabolic syndrome with pan-PPAR activity and anti-inflammatory effects","volume":"106","author":"Villarroel-Vicente","year":"2024","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2025.118168_bib12","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1248\/cpb.c20-00841","article-title":"Synthesis and evaluation of a novel series of 2, 7-substituted-6-tetrazolyl-1, 2, 3, 4-tetrahydroisoquinoline derivatives as selective peroxisome proliferator-activated receptor \u03b3 partial agonists","volume":"69","author":"Morishita","year":"2021","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.ejmech.2025.118168_bib13","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1002\/jhet.4271","article-title":"Visible light induced nano copper catalyzed one pot synthesis of novel quinoline bejeweled thiobarbiturates as potential hypoglycemic agents","volume":"58","author":"Angajala","year":"2021","journal-title":"J. Heterocycl. Chem."},{"key":"10.1016\/j.ejmech.2025.118168_bib14","doi-asserted-by":"crossref","DOI":"10.11131\/2018\/101350","article-title":"Structural and dynamic elucidation of a non-acid PPAR\u03b3 partial agonist: SR1988","volume":"5","author":"Frkic","year":"2018","journal-title":"Nucl. Recept. Res."},{"key":"10.1016\/j.ejmech.2025.118168_bib15","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.70378","article-title":"Decrypting the possible mechanistic role of fenofibrate in alzheimer's disease and type 2 diabetes: the truth and mystery","volume":"29","author":"Alsaleem","year":"2025","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.ejmech.2025.118168_bib16","first-page":"405","volume":"vol. 396","author":"Batiha","year":"2023"},{"key":"10.1016\/j.ejmech.2025.118168_bib17","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1080\/15548627.2024.2367356","article-title":"Dysregulation of pancreatic \u03b2-cell autophagy and the risk of type 2 diabetes","volume":"20","author":"Al-Kuraishy","year":"2024","journal-title":"Autophagy"},{"key":"10.1016\/j.ejmech.2025.118168_bib18","doi-asserted-by":"crossref","first-page":"683","DOI":"10.2174\/1874467214666210902115650","article-title":"Impact of sitagliptin on non-diabetic Covid-19 patients","volume":"15","author":"Al-Kuraishy","year":"2022","journal-title":"Curr. Mol. Pharmacol."},{"key":"10.1016\/j.ejmech.2025.118168_bib19","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/1753-0407.13389","article-title":"Effects of neprilysin and neprilysin inhibitors on glucose homeostasis: controversial points and a promising arena","volume":"15","author":"AlAnazi","year":"2023","journal-title":"J. Diabetes"},{"key":"10.1016\/j.ejmech.2025.118168_bib20","doi-asserted-by":"crossref","first-page":"200","DOI":"10.4103\/JLP.JLP_136_18","article-title":"Renoprotective effect of irbesartan in a rat model of gentamicin-induced nephrotoxicity: role of oxidative stress","volume":"11","author":"Al-Kuraishy","year":"2019","journal-title":"J Lab Physician"},{"key":"10.1016\/j.ejmech.2025.118168_bib21","doi-asserted-by":"crossref","first-page":"16","DOI":"10.4103\/ijpvm.IJPVM_567_18","article-title":"Irbesartan attenuates gentamicin-induced nephrotoxicity in rats through modulation of oxidative stress and endogenous antioxidant capacity","volume":"11","author":"Al-Kuraishy","year":"2020","journal-title":"Int. J. Prev. Med."},{"key":"10.1016\/j.ejmech.2025.118168_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116939","article-title":"Reversal of insulin resistance to combat type 2 Diabetes mellitus by newer thiazolidinedione's in fructose induced insulin resistant rats","volume":"280","author":"Ranade","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118168_bib23","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1039\/D4MD00689E","article-title":"Novel rhodanine\u2013thiazole hybrids as potential antidiabetic agents: a structure-based drug design approach","volume":"16","author":"Gharge","year":"2025","journal-title":"RSC Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118168_bib24","article-title":"Design, synthesis, characterization and Antidiabetic evaluation of 3, 5-substituted thiazolidinediones: evidenced by network pharmacology, Molecular docking, dynamic simulation, in vitro and in vivo assessment","volume":"12","author":"Gharge","year":"2024","journal-title":"Eur. J. Med. Chem. Rep"},{"key":"10.1016\/j.ejmech.2025.118168_bib25","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.1039\/D4MD00344F","article-title":"Quinoline-based Schiff bases as possible antidiabetic agents: ligand-based pharmacophore modeling, 3D QSAR, docking, and molecular dynamics simulations study","volume":"15","author":"Ranade","year":"2024","journal-title":"RSC Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118168_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107783","article-title":"Molecular hybridization, synthesis, in vitro \u03b1-glucosidase inhibition, in vivo antidiabetic activity and computational studies of isatin based compounds","volume":"153","author":"Patil","year":"2024","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2025.118168_bib27","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.sajb.2014.08.001","article-title":"Inhibitory effect of banana (Musa sp. var. Nanjangud rasa bale) flower extract and its constituents Umbelliferone and Lupeol on \u03b1-glucosidase, aldose reductase and glycation at multiple stages","volume":"95","author":"Ramu","year":"2014","journal-title":"S. Afr. J. Bot."},{"key":"10.1016\/j.ejmech.2025.118168_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.103579","article-title":"Synthesis of a 1, 2, 3-bistriazole derivative of embelin and evaluation of its effect on high-fat diet fed-streptozotocin-induced type 2 diabetes in rats and molecular docking studies","volume":"96","author":"Stalin","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2025.118168_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.104207","article-title":"Coumarin-chalcone hybrids targeting insulin receptor: design, synthesis, anti-diabetic activity, and molecular docking","volume":"104","author":"Konidala","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2025.118168_bib30","article-title":"Metabolic syndrome and hypertension resulting from fructose enriched diet in Wistar rats","volume":"1","author":"Dupas","year":"2017","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.ejmech.2025.118168_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116686","article-title":"Insulin sensitization by Feronia elephantum in fructose-induced hyperinsulinemic rats: insights from computational and experimental","volume":"316","author":"Dwivedi","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejmech.2025.118168_bib32","first-page":"481","article-title":"The influence of insulin on carbohydrate metabolism in the isolated diaphragm muscle of normal and alloxan diabetic rats","volume":"143","author":"Beloff-Chain","year":"1955","journal-title":"Proceedings of the Royal Society of London. Series B-Biological Sciences"},{"key":"10.1016\/j.ejmech.2025.118168_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0184167","article-title":"De novo transcriptome assembly and analysis of differential gene expression in response to drought in European beech","volume":"12","author":"M\u00fcller","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.ejmech.2025.118168_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.118030","article-title":"(+)-Terrein exerts anti-obesity and anti-diabetic effects by regulating the differentiation and thermogenesis of brown adipocytes in mice fed a high-fat diet","volume":"186","author":"Aoki-Saito","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejmech.2025.118168_bib35","article-title":"Phenyl glycine incorporated glitazones as promising novel antidiabetic agents through PPAR\u03b3 agonism: design, synthesis and preclinical studies","volume":"6","author":"Mandal","year":"2022","journal-title":"EJMCR"},{"key":"10.1016\/j.ejmech.2025.118168_bib36","first-page":"937","article-title":"The STRING database in 2017: quality-controlled protein\u2013protein association networks, made broadly accessible","volume":"18","author":"Szklarczyk","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejmech.2025.118168_bib37","article-title":"Green RP-HPLC method for simultaneous quantification of epigallocatechin-3-gallate and rosmarinic acid in lipid-based nanocarriers and biological fluids: quality by design-driven optimization and lean six sigma approach","volume":"11","author":"Koli","year":"2024","journal-title":"GAC"},{"key":"10.1016\/j.ejmech.2025.118168_bib38","first-page":"419","article-title":"Robust high\u2010performance thin\u2010layer chromatography (HPTLC) method for stability assessment and simultaneous quantification of epigallocatechin\u20103\u2010gallate and rosmarinic acid in lipid\u2010based nanoparticles and biological matrices","volume":"35","author":"Koli","year":"2024","journal-title":"PCA."},{"key":"10.1016\/j.ejmech.2025.118168_bib39","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1021\/ja310377d","article-title":"Structural insights into a unique inhibitor binding pocket in kinesin spindle protein","volume":"135","author":"Ulaganathan","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2025.118168_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.medidd.2025.100215","article-title":"Repositioning of rhodanine-thiazole hybrids as aldose reductase inhibitors","volume":"27","author":"Gharge","year":"2025","journal-title":"Med. Drug Discov."},{"key":"10.1016\/j.ejmech.2025.118168_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.amolm.2025.100079","article-title":"Structure-based insights into fatty acid modulation of lipid-sensing nuclear receptors PPAR\u03b4\/\u03b3 for glycemic regulation","volume":"5","author":"Gharge","year":"2025","journal-title":"Aspects of Molecular Medicine"},{"key":"10.1016\/j.ejmech.2025.118168_bib42","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1080\/08927022.2025.2477276","article-title":"Novel quinoline\u2013imidazole derivatives as inhibitors of Mycobacterium tuberculosis: an integrated approach combining molecular dynamics and in-vitro studies","volume":"51","author":"Khebude","year":"2025","journal-title":"Mol. Simul."},{"key":"10.1016\/j.ejmech.2025.118168_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.108306","article-title":"Design, synthesis and molecular dynamics simulations of thiazole-based hydrazones targeting MDA-MB-231 breast cancer cells","volume":"157","author":"Alegaon","year":"2025","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2025.118168_bib44","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1134\/S106816202501011X","article-title":"Thiazolidine based quinazoline hybrids: synthesis, docking, DFT, molecular dynamic study, and in vitro antidiabetic evaluation","volume":"51","author":"Gharge","year":"2025","journal-title":"Russ. J. Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2025.118168_bib45","article-title":"Structure-guided development of Quinoline derivatives targeting kinesin spindle protein","volume":"125","author":"Kavalapure","year":"2025","journal-title":"Bioorg. Med. Chem. Lett."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S022352342500933X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S022352342500933X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T14:16:16Z","timestamp":1762265776000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S022352342500933X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":45,"alternative-id":["S022352342500933X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2025.118168","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modulating glucose homeostasis via expression of PPAR-\u03b3 TF: Pharmacological insights into quinolone-based hydrazones","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2025.118168","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118168"}}