{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:51:37Z","timestamp":1792601497539,"version":"4.5.0"},"reference-count":274,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:00:00Z","timestamp":1758931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005420","name":"Dezhou University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005420","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2024YQ024"],"award-info":[{"award-number":["ZR2024YQ024"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2024QH560"],"award-info":[{"award-number":["ZR2024QH560"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.ejmech.2025.118195","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T02:51:32Z","timestamp":1758941492000},"page":"118195","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["HSP90 inhibitors in cancer immunotherapy: Therapeutic opportunities and challenges"],"prefix":"10.1016","volume":"301","author":[{"given":"Chao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenying","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2025.118195_bib1","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/s41417-025-00886-9","article-title":"MDSC checkpoint blockade therapy: a new breakthrough point overcoming immunosuppression in cancer immunotherapy","volume":"32","author":"Ibrahim","year":"2025","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.ejmech.2025.118195_bib2","first-page":"451","article-title":"Immune checkpoint inhibitors: breakthroughs in cancer treatment","volume":"21","author":"Kong","year":"2024","journal-title":"Cancer Biol. Med."},{"key":"10.1016\/j.ejmech.2025.118195_bib3","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s40425-017-0212-y","article-title":"Immunotherapy resistance: the answers lie ahead - not in front - of us","volume":"5","author":"Andrews","year":"2017","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.ejmech.2025.118195_bib4","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/s41419-022-05373-9","article-title":"HSP90 mediates the connection of multiple programmed cell death in diseases","volume":"13","author":"Peng","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejmech.2025.118195_bib5","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/s41580-023-00640-9","article-title":"Structural and functional complexity of HSP90 in cellular homeostasis and disease","volume":"24","author":"Chiosis","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejmech.2025.118195_bib6","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1021\/acsmedchemlett.4c00550","article-title":"Design, synthesis, and biological evaluation of chiral-Proline derivatives as novel HSP90 inhibitors","volume":"16","author":"Zhang","year":"2025","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2025.118195_bib7","doi-asserted-by":"crossref","first-page":"5263","DOI":"10.18632\/oncotarget.3029","article-title":"Identification of epipolythiodioxopiperazines HDN-1 and chaetocin as novel inhibitor of heat shock protein 90","volume":"6","author":"Song","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejmech.2025.118195_bib8","first-page":"275","article-title":"HSP90: enabler of cancer adaptation","volume":"3","author":"Jaeger","year":"2019","journal-title":"Annu. Rev. Cell Biol."},{"key":"10.1016\/j.ejmech.2025.118195_bib9","first-page":"17","article-title":"HSP90 is essential for Jak-STAT signaling in classical Hodgkin lymphoma cells, Cell Commun","volume":"7","author":"Schoof","year":"2009","journal-title":"Signal."},{"key":"10.1016\/j.ejmech.2025.118195_bib10","first-page":"402","article-title":"The JAK\/STAT signaling pathway: from bench to clinic, Signal. Transd. Target","volume":"6","author":"Hu","year":"2021","journal-title":"Ther"},{"key":"10.1016\/j.ejmech.2025.118195_bib11","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-22788-8","article-title":"Expression of membrane Hsp90 is a molecular signature of T cell activation","volume":"12","author":"Scarneo","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2025.118195_bib12","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.molimm.2010.12.014","article-title":"HSP90 is crucial for regulation of LAT expression in activated T cells","volume":"48","author":"Hayashi","year":"2011","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.ejmech.2025.118195_bib13","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.immuni.2018.11.013","article-title":"Fever promotes T lymphocyte trafficking via a thermal sensory pathway involving heat shock protein 90 and \u03b14 integrins","volume":"50","author":"Lin","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.ejmech.2025.118195_bib14","article-title":"HSP90B1 regulates autophagy via PI3K\/AKT\/mTOR signaling, mediating HNSC biological behaviors","volume":"12","author":"Li","year":"2024","journal-title":"PeerJ"},{"key":"10.1016\/j.ejmech.2025.118195_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2025.114448","article-title":"MYG1 interacts with HSP90 to promote breast cancer progression through Wnt\/\u03b2-catenin and Notch signaling pathways","volume":"446","author":"Liu","year":"2025","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ejmech.2025.118195_bib16","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1186\/s13287-023-03453-x","article-title":"HSP90, as a functional target antigen of a mAb 11C9, promotes stemness and tumor progression in hepatocellular carcinoma","volume":"14","author":"Liu","year":"2023","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.ejmech.2025.118195_bib17","doi-asserted-by":"crossref","first-page":"105","DOI":"10.7150\/thno.63788","article-title":"A novel C-terminal heat shock protein 90 inhibitor that overcomes STAT3-Wnt-\u03b2-catenin signaling-mediated drug resistance and adverse effects","volume":"12","author":"Lee","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.ejmech.2025.118195_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellimm.2020.104188","article-title":"Regulation of an adaptor protein STING by Hsp90\u03b2 to enhance innate immune responses against microbial infections","volume":"356","author":"Sato","year":"2020","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.ejmech.2025.118195_bib19","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1073\/pnas.0711365105","article-title":"Heat-shock protein 90 associates with N-terminal extended peptides and is required for direct and indirect antigen presentation","volume":"105","author":"Callahan","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejmech.2025.118195_bib20","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.imbio.2014.08.001","article-title":"Hsp90-peptide complexes stimulate antigen presentation through the class II pathway after binding scavenger receptor SREC-I","volume":"219","author":"Murshid","year":"2014","journal-title":"Immunobiology"},{"key":"10.1016\/j.ejmech.2025.118195_bib21","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.4049\/jimmunol.172.7.4195","article-title":"Glucose-regulated protein 94\/glycoprotein 96 elicits bystander activation of CD4+ T cell Th1 cytokine production in vivo","volume":"172","author":"Baker-LePain","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejmech.2025.118195_bib22","article-title":"Heat shock proteins 90 kDa: Immunomodulators and adjuvants in vaccine design against infectious diseases","volume":"8","author":"Corigliano","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.ejmech.2025.118195_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/s41418-025-01502-x","article-title":"Enhancement of colorectal cancer therapy through interruption of the HSF1-HSP90 axis by p53 activation or cell cycle inhibition","author":"Isermann","year":"2025","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ejmech.2025.118195_bib24","doi-asserted-by":"crossref","first-page":"15968","DOI":"10.1021\/acs.jmedchem.4c00966","article-title":"Targeting HSP90 for cancer therapy: current progress and emerging prospects","volume":"67","author":"Liang","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118195_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0114506","article-title":"Heat shock protein-90 inhibitors enhance antigen expression on melanomas and increase T cell recognition of tumor cells","volume":"9","author":"Haggerty","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ejmech.2025.118195_bib26","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1158\/2326-6066.CIR-24-0713","article-title":"The HSP90 inhibitor pimitespib targets regulatory T cells in the tumor microenvironment","volume":"13","author":"Tsuge","year":"2025","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.ejmech.2025.118195_bib27","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2023-007625","article-title":"Caspase-9 inhibition triggers Hsp90-based chemotherapy-mediated tumor intrinsic innate sensing and enhances antitumor immunity","volume":"11","author":"Li","year":"2023","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.ejmech.2025.118195_bib28","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1158\/2326-6066.CIR-15-0057","article-title":"Targeting heat-shock protein 90 (HSP90) as a complementary strategy to immune checkpoint blockade for cancer therapy","volume":"3","author":"Proia","year":"2015","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.ejmech.2025.118195_bib29","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1002\/ijc.32227","article-title":"Inhibition of HSP90 overcomes resistance to chemotherapy and radiotherapy in pancreatic cancer","volume":"145","author":"Nagaraju","year":"2019","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ejmech.2025.118195_bib30","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/s41419-023-06337-3","article-title":"Co-targeting HSP90 alpha and CDK7 overcomes resistance against HSP90 inhibitors in BCR-ABL1+ leukemia cells","volume":"14","author":"Vogt","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejmech.2025.118195_bib31","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1126\/science.aaf5023","article-title":"Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase","volume":"352","author":"Verba","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2025.118195_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116736","article-title":"Extracellular heat shock protein 90 alpha (eHsp90\u03b1)'s role in cancer progression and the development of therapeutic strategies","volume":"277","author":"Reynolds","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118195_bib33","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ymeth.2004.08.004","article-title":"Regulatory interfaces between the stress protein response and other gene expression programs in the cell","volume":"35","author":"Calderwood","year":"2005","journal-title":"Methods"},{"key":"10.1016\/j.ejmech.2025.118195_bib34","article-title":"HSP70 and HSP90 in cancer: cytosolic, endoplasmic reticulum and mitochondrial chaperones of tumorigenesis, front","volume":"12","author":"Albakova","year":"2022","journal-title":"Oncology"},{"key":"10.1016\/j.ejmech.2025.118195_bib35","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.gene.2015.08.063","article-title":"HSP90AB1: helping the good and the bad","volume":"575","author":"Haase","year":"2016","journal-title":"Gene"},{"key":"10.1016\/j.ejmech.2025.118195_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114516","article-title":"Pan- and isoform-specific inhibition of Hsp90: design strategy and recent advances","volume":"238","author":"Yu","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118195_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/biom12091166","article-title":"Cytosolic Hsp90 isoform-specific functions and clinical significance","volume":"12","author":"Maiti","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.ejmech.2025.118195_bib38","first-page":"8252","article-title":"Heat shock protein 90-\u03b2 over-expression is associated with poor survival in stage I lung adenocarcinoma patients","volume":"8","author":"Wu","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.ejmech.2025.118195_bib39","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.bbamcr.2011.10.013","article-title":"GRP94: an HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulum","volume":"1823","author":"Marzec","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejmech.2025.118195_bib40","doi-asserted-by":"crossref","first-page":"8309","DOI":"10.1074\/jbc.M115.688374","article-title":"Endoplasmic reticulum-resident heat shock protein 90 (HSP90) isoform glucose-regulated protein 94 (GRP94) regulates cell polarity and cancer cell migration by affecting intracellular transport","volume":"291","author":"Ghosh","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejmech.2025.118195_bib41","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.celrep.2014.06.061","article-title":"Deletion of the mitochondrial chaperone TRAP-1 uncovers global reprogramming of metabolic networks","volume":"8","author":"Lisanti","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.ejmech.2025.118195_bib42","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.bbamcr.2011.08.007","article-title":"TRAP-1, the mitochondrial Hsp90","volume":"1823","author":"Altieri","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejmech.2025.118195_bib43","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/nature04716","article-title":"Crystal structure of an Hsp90-nucleotide-p23\/Sba1 closed chaperone complex","volume":"440","author":"Ali","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2025.118195_bib44","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.jmb.2004.09.055","article-title":"Independent ATPase activity of Hsp90 subunits creates a flexible assembly platform","volume":"344","author":"McLaughlin","year":"2004","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.ejmech.2025.118195_bib45","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/nchembio.2111","article-title":"Cooperation of local motions in the Hsp90 molecular chaperone ATPase mechanism","volume":"12","author":"Schulze","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.ejmech.2025.118195_bib46","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/s41586-021-04252-1","article-title":"Structure of Hsp90-Hsp70-Hop-GR reveals the Hsp90 client-loading mechanism","volume":"601","author":"Wang","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2025.118195_bib47","doi-asserted-by":"crossref","first-page":"7161","DOI":"10.1074\/jbc.M512406200","article-title":"Modulation of chaperone function and cochaperone interaction by novobiocin in the C-terminal domain of Hsp90: evidence that coumarin antibiotics disrupt Hsp90 dimerization","volume":"281","author":"Allan","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejmech.2025.118195_bib48","doi-asserted-by":"crossref","first-page":"554","DOI":"10.7150\/thno.27213","article-title":"Evaluation of [(11)C]NMS-E973 as a PET tracer for in vivo visualisation of HSP90","volume":"9","author":"Vermeulen","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.ejmech.2025.118195_bib49","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1111\/cas.14881","article-title":"Proteomic analysis of urinary and tissue-exudative extracellular vesicles to discover novel bladder cancer biomarkers","volume":"112","author":"Tomiyama","year":"2021","journal-title":"Cancer Sci."},{"key":"10.1016\/j.ejmech.2025.118195_bib50","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2022.982593","article-title":"Targeting extracellular Hsp90: a unique frontier against cancer","volume":"9","author":"Sager","year":"2022","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.ejmech.2025.118195_bib51","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1073\/pnas.83.10.3121","article-title":"A mouse tumor-specific transplantation antigen is a heat shock-related protein","volume":"83","author":"Ullrich","year":"1986","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejmech.2025.118195_bib52","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1111\/j.1349-7006.2007.00561.x","article-title":"Extracellular heat shock protein 90: a role for a molecular chaperone in cell motility and cancer metastasis","volume":"98","author":"Tsutsumi","year":"2007","journal-title":"Cancer Sci."},{"key":"10.1016\/j.ejmech.2025.118195_bib53","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.796493","article-title":"The HSP immune network in cancer","volume":"12","author":"Albakova","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejmech.2025.118195_bib54","doi-asserted-by":"crossref","first-page":"21288","DOI":"10.1073\/pnas.0908151106","article-title":"The regulatory mechanism of Hsp90alpha secretion and its function in tumor malignancy","volume":"106","author":"Wang","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejmech.2025.118195_bib55","doi-asserted-by":"crossref","first-page":"4588","DOI":"10.3390\/ijms20184588","article-title":"Roles of extracellular HSPs as biomarkers in immune surveillance and immune evasion","volume":"20","author":"Taha","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2025.118195_bib56","doi-asserted-by":"crossref","first-page":"787","DOI":"10.32604\/or.2023.030081","article-title":"HSP90AA1 promotes lymphatic metastasis of hypopharyngeal squamous cell carcinoma by regulating epithelial-mesenchymal transition","volume":"31","author":"Tang","year":"2023","journal-title":"Oncol. Res."},{"key":"10.1016\/j.ejmech.2025.118195_bib57","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1007\/s12094-023-03143-3","article-title":"A comprehensive analysis of immunogenic cell death and its key gene HSP90AA1 in bladder cancer","volume":"25","author":"Song","year":"2023","journal-title":"Clin. Transl. Oncol."},{"key":"10.1016\/j.ejmech.2025.118195_bib58","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/s00432-024-05779-2","article-title":"Identification of immunogenic cell death-related damage-related molecular patterns (DAMPs) to predict outcomes in patients with head and neck squamous cell carcinoma","volume":"150","author":"Zhang","year":"2024","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.ejmech.2025.118195_bib59","first-page":"1876","article-title":"HSP90 expression is associated with outcome in pulmonary carcinoid tumor patients, Transl","volume":"12","author":"Niinim\u00e4ki","year":"2023","journal-title":"Lung Cancer Res"},{"key":"10.1016\/j.ejmech.2025.118195_bib60","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/2148253","article-title":"Heat shock protein 90 family isoforms as Prognostic biomarkers and their correlations with immune infiltration in breast cancer","volume":"2020","author":"Lin","year":"2020","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.ejmech.2025.118195_bib61","doi-asserted-by":"crossref","first-page":"7526","DOI":"10.3390\/ijms241512476","article-title":"Cytokine-induced killer cells in combination with heat shock protein 90 inhibitors functioning via the Fas\/FasL Axis provides rationale for a potential clinical benefit in Burkitt's lymphoma","volume":"24","author":"Ge","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2025.118195_bib62","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/s41419-021-03426-z","article-title":"Hsp90-stabilized MIF supports tumor progression via macrophage recruitment and angiogenesis in colorectal cancer","volume":"12","author":"Klemke","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejmech.2025.118195_bib63","first-page":"3","article-title":"Emerging functions of the EGFR in cancer, Mol","volume":"12","author":"Sigismund","year":"2018","journal-title":"Oncology"},{"key":"10.1016\/j.ejmech.2025.118195_bib64","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s10020-021-00384-2","article-title":"Hsp90 up-regulates PD-L1 to promote HPV-positive cervical cancer via HER2\/PI3K\/AKT pathway","volume":"27","author":"Zeng","year":"2021","journal-title":"Mol. Med."},{"key":"10.1016\/j.ejmech.2025.118195_bib65","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/s41419-023-05976-w","article-title":"circSLC4A7 accelerates stemness and progression of gastric cancer by interacting with HSP90 to activate NOTCH1 signaling pathway","volume":"14","author":"Hui","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejmech.2025.118195_bib66","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202302025","article-title":"HSP90\u03b2 impedes STUB1-induced ubiquitination of YTHDF2 to drive sorafenib resistance in hepatocellular carcinoma","volume":"10","author":"Liao","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.ejmech.2025.118195_bib67","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1016\/j.bcp.2009.01.014","article-title":"Regulators of endothelial and epithelial barrier integrity and function in acute lung injury","volume":"77","author":"Lucas","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejmech.2025.118195_bib68","doi-asserted-by":"crossref","first-page":"129","DOI":"10.4142\/jvs.2017.18.2.129","article-title":"Apoptosis in response to heat stress is positively associated with heat-shock protein 90 expression in chicken myocardial cells in vitro","volume":"18","author":"Zhang","year":"2017","journal-title":"J. Vet. Sci."},{"key":"10.1016\/j.ejmech.2025.118195_bib69","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3390\/cells11020229","article-title":"Extracellular HSP90\u03b1 induces MyD88-IRAK complex-associated IKK\u03b1\/\u03b2-NF-\u03baB\/IRF3 and JAK2\/TYK2-STAT-3 signaling in macrophages for tumor-promoting M2-polarization","volume":"11","author":"Fan","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.ejmech.2025.118195_bib70","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1038\/nsmb.2114","article-title":"Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53","volume":"18","author":"Hagn","year":"2011","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.ejmech.2025.118195_bib71","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3390\/cells12020212","article-title":"Protein kinase D3 (PKD3) requires Hsp90 for stability and promotion of prostate cancer cell migration","volume":"12","author":"Varga","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.ejmech.2025.118195_bib72","doi-asserted-by":"crossref","first-page":"7526","DOI":"10.3390\/ijms21207526","article-title":"TRAP1 regulates Wnt\/\u03b2-catenin pathway through LRP5\/6 receptors expression modulation","volume":"21","author":"Lettini","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2025.118195_bib73","doi-asserted-by":"crossref","first-page":"227","DOI":"10.31083\/j.fbl2809227","article-title":"Inhibition of TRAP1 accelerates the DNA damage response, activation of the heat shock response and metabolic reprogramming in colon cancer cells","volume":"28","author":"Bhasin","year":"2023","journal-title":"Front. Biosci."},{"key":"10.1016\/j.ejmech.2025.118195_bib74","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.bbrc.2005.03.225","article-title":"Stabilization of integrin-linked kinase by binding to Hsp90","volume":"331","author":"Aoyagi","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejmech.2025.118195_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2019.113771","article-title":"AT-533, a novel Hsp90 inhibitor, inhibits breast cancer growth and HIF-1\u03b1\/VEGF\/VEGFR-2-mediated angiogenesis in vitro and in vivo","volume":"172","author":"Zhang","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejmech.2025.118195_bib76","first-page":"5351","article-title":"Non-canonical approaches to targeting hypoxic tumors","volume":"12","author":"Zhao","year":"2022","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.ejmech.2025.118195_bib77","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.bbamcr.2011.09.009","article-title":"Secreted heat shock protein-90 (Hsp90) in wound healing and cancer","volume":"1823","author":"Li","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejmech.2025.118195_bib78","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.3390\/cells11182778","article-title":"Targeting HSP90 as a novel therapy for cancer: mechanistic insights and translational relevance","volume":"11","author":"Zhang","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.ejmech.2025.118195_bib79","doi-asserted-by":"crossref","first-page":"4794","DOI":"10.1158\/0008-5472.CAN-20-3150","article-title":"Targeting the extracellular HSP90 Co-chaperone Morgana inhibits cancer cell migration and promotes anticancer immunity","volume":"81","author":"Secl\u00ec","year":"2021","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejmech.2025.118195_bib80","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1038\/s41416-023-02435-3","article-title":"Heat-shock protein 90\u03b1 protects NME1 against degradation and suppresses metastasis of breast cancer","volume":"129","author":"Zhang","year":"2023","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ejmech.2025.118195_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116234","article-title":"Macrocycles and macrocyclization in anticancer drug discovery: Important pieces of the puzzle","volume":"268","author":"Zhang","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118195_bib82","first-page":"191","article-title":"Chapter Eight - HSP90 and immune modulation in cancer","author":"Graner","year":"2016","journal-title":"Adv. Cancer Res."},{"key":"10.1016\/j.ejmech.2025.118195_bib83","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.3390\/cells10102626","article-title":"The pathophysiological role of heat shock response in autoimmunity: a literature review","volume":"10","author":"Androvitsanea","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.ejmech.2025.118195_bib84","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.3390\/cancers14071681","article-title":"Dual effect of immune cells within Tumour microenvironment: pro- and anti-tumour effects and their triggers","volume":"14","author":"Pe\u00f1a-Romero","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.ejmech.2025.118195_bib85","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.161","article-title":"Heat shock proteins: biological functions, pathological roles, and therapeutic opportunities","volume":"3","author":"Hu","year":"2022","journal-title":"MedComm"},{"key":"10.1016\/j.ejmech.2025.118195_bib86","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3389\/fimmu.2016.00171","article-title":"Heat shock protein-peptide and HSP-based immunotherapies for the treatment of cancer","volume":"7","author":"Shevtsov","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejmech.2025.118195_bib87","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1586\/14760584.7.3.383","article-title":"Heat-shock protein-based vaccines for cancer and infectious disease","volume":"7","author":"Binder","year":"2008","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.ejmech.2025.118195_bib88","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1436973","article-title":"HSP90 multi-functionality in cancer","volume":"15","author":"Albakova","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejmech.2025.118195_bib89","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.4049\/jimmunol.1200593","article-title":"Heat shock protein 90 is critical for regulation of phenotype and functional activity of human T lymphocytes and NK cells","volume":"190","author":"Bae","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejmech.2025.118195_bib90","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1016\/j.molimm.2009.05.185","article-title":"Enhanced interaction between Hsp90 and raptor regulates mTOR signaling upon T cell activation","volume":"46","author":"Delgoffe","year":"2009","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.ejmech.2025.118195_bib91","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1182\/blood.V112.11.674.674","article-title":"Enhanced interaction between Hsp90 and raptor regulates mTOR signaling upon T cell activation","volume":"112","author":"Delgoffe","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.ejmech.2025.118195_bib92","doi-asserted-by":"crossref","first-page":"6995","DOI":"10.1158\/0008-5472.CAN-08-4511","article-title":"Heat shock protein 90 inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin enhances EphA2+ tumor cell recognition by specific CD8+ T cells","volume":"69","author":"Kawabe","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejmech.2025.118195_bib93","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.1158\/0008-5472.CAN-12-0538","article-title":"Combination therapy with HSP90 inhibitor 17-DMAG reconditions the tumor microenvironment to improve recruitment of therapeutic T cells","volume":"72","author":"Rao","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejmech.2025.118195_bib94","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-004702","article-title":"Novel peptide-based vaccine targeting heat shock protein 90 induces effective antitumor immunity in a HER2+ breast cancer murine model","volume":"10","author":"Kang","year":"2022","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.ejmech.2025.118195_bib95","doi-asserted-by":"crossref","first-page":"20847","DOI":"10.1074\/jbc.M200425200","article-title":"The endoplasmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the Toll-like receptor 2\/4 pathway","volume":"277","author":"Vabulas","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejmech.2025.118195_bib96","article-title":"Interaction of toll-like receptors with the molecular chaperone Gp96 is essential for its activation of cytotoxic T lymphocyte response","volume":"11","author":"Liu","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ejmech.2025.118195_bib97","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.1002\/1878-0261.12851","article-title":"Targeting immunogenic cell death in cancer","volume":"14","author":"Ahmed","year":"2020","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.ejmech.2025.118195_bib98","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/onc.2015.82","article-title":"Hyperthermic intraperitoneal chemotherapy leads to an anticancer immune response via exposure of cell surface heat shock protein 90","volume":"35","author":"Zunino","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.ejmech.2025.118195_bib99","doi-asserted-by":"crossref","first-page":"16363","DOI":"10.1073\/pnas.1108372108","article-title":"Heat shock protein 90 (HSP90) contributes to cytosolic translocation of extracellular antigen for cross-presentation by dendritic cells","volume":"108","author":"Imai","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejmech.2025.118195_bib100","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.4049\/jimmunol.1000821","article-title":"Essential role of endogenous heat shock protein 90 of dendritic cells in antigen cross-presentation","volume":"185","author":"Ichiyanagi","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejmech.2025.118195_bib101","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.immuni.2006.03.015","article-title":"Hsp90alpha chaperones large C-terminally extended proteolytic intermediates in the MHC class I antigen processing pathway","volume":"24","author":"Kunisawa","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.ejmech.2025.118195_bib102","doi-asserted-by":"crossref","first-page":"3851","DOI":"10.4049\/jimmunol.1103269","article-title":"Heat shock protein 90-mediated peptide-selective presentation of cytosolic tumor antigen for direct recognition of tumors by CD4(+) T cells","volume":"188","author":"Tsuji","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejmech.2025.118195_bib103","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.3390\/cells11162556","article-title":"Targeting heat-shock protein 90 in cancer: an update on combination therapy","volume":"11","author":"Ren","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.ejmech.2025.118195_bib104","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1006\/mgme.1998.2774","article-title":"The benzoquinone ansamycin geldanamycin stimulates proteolytic degradation of focal adhesion kinase","volume":"66","author":"Ochel","year":"1999","journal-title":"Mol. Genet. Metabol."},{"key":"10.1016\/j.ejmech.2025.118195_bib105","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1177\/15353702221142614","article-title":"The value of serum TRAP1 in diagnosing small cell lung cancer and tumor immunity","volume":"248","author":"Tan","year":"2023","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.ejmech.2025.118195_bib106","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/onc.2012.130","article-title":"The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies","volume":"32","author":"Luo","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.ejmech.2025.118195_bib107","doi-asserted-by":"crossref","first-page":"20","DOI":"10.18632\/oncoscience.554","article-title":"HSP90 as an emerging barrier to immune checkpoint blockade therapy","volume":"9","author":"Tang","year":"2022","journal-title":"Oncoscience"},{"key":"10.1016\/j.ejmech.2025.118195_bib108","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.chembiol.2020.10.005","article-title":"HSP90 inhibition enhances cancer immunotherapy by modulating the surface expression of multiple immune checkpoint proteins","volume":"28","author":"Zavareh","year":"2021","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.ejmech.2025.118195_bib109","doi-asserted-by":"crossref","first-page":"20852","DOI":"10.1073\/pnas.0810958105","article-title":"Oncogenic kinase NPM\/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)","volume":"105","author":"Marzec","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejmech.2025.118195_bib110","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1158\/0008-5472.CAN-21-3917","article-title":"HSP90 mediates IFN\u03b3-induced adaptive resistance to anti-PD-1 immunotherapy","volume":"82","author":"Liu","year":"2022","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejmech.2025.118195_bib111","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2022.2068488","article-title":"Targeting HSP90 sensitizes pancreas carcinoma to PD-1 blockade","volume":"11","author":"Liu","year":"2022","journal-title":"Oncoimmunol"},{"key":"10.1016\/j.ejmech.2025.118195_bib112","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3892\/or.2022.8443","article-title":"HSP90 inhibitors and cancer: prospects for use in targeted therapies","volume":"49","author":"Li","year":"2023","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.ejmech.2025.118195_bib113","article-title":"Mechanisms of regulatory T cell infiltration in tumors: implications for innovative immune precision therapies","volume":"9","author":"Nishikawa","year":"2021","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.ejmech.2025.118195_bib114","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00262-025-03973-w","article-title":"Revealing the role of regulatory b cells in cancer: development, function and treatment significance","volume":"74","author":"Ye","year":"2025","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.ejmech.2025.118195_bib115","doi-asserted-by":"crossref","first-page":"317","DOI":"10.5114\/ceji.2016.63133","article-title":"Heat shock proteins (HSPs) in the homeostasis of regulatory T cells (Tregs)","volume":"41","author":"Koli\u0144ski","year":"2016","journal-title":"Cent. Eur. J. Immunol."},{"key":"10.1016\/j.ejmech.2025.118195_bib116","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s40425-019-0646-5","article-title":"Tumor-released autophagosomes induces CD4(+) T cell-mediated immunosuppression via a TLR2-IL-6 cascade","volume":"7","author":"Chen","year":"2019","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.ejmech.2025.118195_bib117","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nri2448","article-title":"Exploring the full spectrum of macrophage activation","volume":"8","author":"Mosser","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ejmech.2025.118195_bib118","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/s41419-019-1435-2","article-title":"Cancer-associated fibroblasts enhance tumor-associated macrophages enrichment and suppress NK cells function in colorectal cancer","volume":"10","author":"Zhang","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejmech.2025.118195_bib119","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/s41590-017-0022-x","article-title":"Myeloid-derived suppressor cells coming of age","volume":"19","author":"Veglia","year":"2018","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ejmech.2025.118195_bib120","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-005551","article-title":"HSP90\u03b1 induces immunosuppressive myeloid cells in melanoma via TLR4 signaling","volume":"10","author":"Arkhypov","year":"2022","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.ejmech.2025.118195_bib121","first-page":"515","article-title":"HSP90 at the hub of protein homeostasis: emerging mechanistic insights, Nature reviews","volume":"11","author":"Taipale","year":"2010","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.ejmech.2025.118195_bib122","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.893137","article-title":"Aberrant HSP90 expression in lymphocytes and HSP90 response to anti-PD-1 therapy in lymphoma patients","volume":"13","author":"Albakova","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejmech.2025.118195_bib123","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1756-9966-33-16","article-title":"Geldanamycin-mediated inhibition of heat shock protein 90 partially activates dendritic cells, but interferes with their full maturation, accompanied by impaired upregulation of RelB","volume":"33","author":"Trojandt","year":"2014","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.ejmech.2025.118195_bib124","doi-asserted-by":"crossref","first-page":"7730","DOI":"10.4049\/jimmunol.178.12.7730","article-title":"Phenotypic and functional effects of heat shock protein 90 inhibition on dendritic cell","volume":"178","author":"Bae","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejmech.2025.118195_bib125","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1074\/jbc.M509901200","article-title":"The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons","volume":"281","author":"Shang","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejmech.2025.118195_bib126","first-page":"68","article-title":"Inhibiting HSP90 prevents the induction of myeloid-derived suppressor cells by melanoma cells, Cell","volume":"327","author":"Janssen","year":"2018","journal-title":"Immunol. Ser."},{"key":"10.1016\/j.ejmech.2025.118195_bib127","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3109\/08923973.2015.1119159","article-title":"Heat shock protein 90 inhibitors induce functional inhibition of human natural killer cells in a dose-dependent manner","volume":"38","author":"Huyan","year":"2016","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.ejmech.2025.118195_bib128","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.21873\/invivo.13687","article-title":"17-AAG induces endoplasmic reticulum stress-mediated apoptosis in breast cancer cells, possibly through PERK\/eIF2\u03b1 up-regulation","volume":"38","author":"Suwannalert","year":"2024","journal-title":"Vivo"},{"key":"10.1016\/j.ejmech.2025.118195_bib129","doi-asserted-by":"crossref","first-page":"4385","DOI":"10.4049\/jimmunol.0901797","article-title":"Heat shock protein-90 inhibitors increase MHC class I-related chain A and B ligand expression on multiple myeloma cells and their ability to trigger NK cell degranulation","volume":"183","author":"Fionda","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejmech.2025.118195_bib130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0063566","article-title":"Heat shock protein 90 inhibitors repress latent membrane protein 1 (LMP1) expression and proliferation of Epstein-Barr virus-positive natural killer cell lymphoma","volume":"8","author":"Murata","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ejmech.2025.118195_bib131","first-page":"513","article-title":"HSP90-regulated CHIP\/TRIM21\/p21 Axis Involves in the senescence of osteosarcoma cells, protein Pept","volume":"30","author":"Xu","year":"2023","journal-title":"Letture"},{"key":"10.1016\/j.ejmech.2025.118195_bib132","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1158\/1078-0432.CCR-10-1689","article-title":"Heat shock protein 90-sheltered overexpression of insulin-like growth factor 1 receptor contributes to malignancy of thymic epithelial tumors","volume":"17","author":"Breinig","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ejmech.2025.118195_bib133","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-73394-9","article-title":"HSP90 promotes tumor associated macrophage differentiation during triple-negative breast cancer progression","volume":"14","author":"Hong","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2025.118195_bib134","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/s41467-017-00449-z","article-title":"HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genes","volume":"8","author":"Mbofung","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2025.118195_bib135","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1182\/blood-2016-06-721423","article-title":"HSP90 promotes Burkitt lymphoma cell survival by maintaining tonic B-cell receptor signaling","volume":"129","author":"Walter","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.ejmech.2025.118195_bib136","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/s13046-023-02785-z","article-title":"Mutant p53-ENTPD5 control of the calnexin\/calreticulin cycle: a druggable target for inhibiting integrin-\u03b15-driven metastasis","volume":"42","author":"Pavlakis","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.ejmech.2025.118195_bib137","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/s41467-019-14259-y","article-title":"HSP90A inhibition promotes anti-tumor immunity by reversing multi-modal resistance and stem-like property of immune-refractory tumors","volume":"11","author":"Song","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2025.118195_bib138","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.217354","article-title":"HSP90 inhibitor AUY922 suppresses tumor growth and modulates immune response through YAP1-TEAD pathway inhibition in gastric cancer","volume":"610","author":"Yoshimura","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ejmech.2025.118195_bib139","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2024.1334876","article-title":"Hsp90 inhibition leads to an increase in surface expression of multiple immunological receptors in cancer cells","volume":"11","author":"Wickenberg","year":"2024","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.ejmech.2025.118195_bib140","doi-asserted-by":"crossref","first-page":"5108","DOI":"10.1158\/1078-0432.CCR-09-0213","article-title":"Heat shock protein 90 inhibitor BIIB021 (CNF2024) depletes NF-kappaB and sensitizes Hodgkin's lymphoma cells for natural killer cell-mediated cytotoxicity","volume":"15","author":"B\u00f6ll","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ejmech.2025.118195_bib141","first-page":"3","article-title":"BIIB021, an Hsp90 inhibitor: a promising therapeutic strategy for blood malignancies","volume":"40","author":"He","year":"2018","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.ejmech.2025.118195_bib142","doi-asserted-by":"crossref","first-page":"5016","DOI":"10.1158\/1078-0432.CCR-12-3510","article-title":"A purine scaffold HSP90 inhibitor BIIB021 has selective activity against KSHV-associated primary effusion lymphoma and blocks vFLIP K13-induced NF-\u03baB","volume":"19","author":"Gopalakrishnan","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ejmech.2025.118195_bib143","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.3892\/etm.2014.1651","article-title":"BIIB021, an Hsp90 inhibitor, effectively kills a myelodysplastic syndrome cell line via the activation of caspases and inhibition of PI3K\/Akt and NF-\u03baB pathway proteins","volume":"7","author":"Lin","year":"2014","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.ejmech.2025.118195_bib144","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1038\/aps.2013.124","article-title":"Hsp90 inhibitor BIIB021 enhances triptolide-induced apoptosis of human T-cell acute lymphoblastic leukemia cells in vitro mainly by disrupting p53-MDM2 balance","volume":"34","author":"Li","year":"2013","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ejmech.2025.118195_bib145","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1182\/blood.V88.2.645.bloodjournal882645","article-title":"Primary effusion lymphoma: a distinct clinicopathologic entity associated with the Kaposi's sarcoma-associated herpes virus","volume":"88","author":"Nador","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.ejmech.2025.118195_bib146","doi-asserted-by":"crossref","first-page":"280","DOI":"10.3389\/fmicb.2015.00280","article-title":"The heat shock protein 90 inhibitor BIIB021 suppresses the growth of T and natural killer cell lymphomas","volume":"6","author":"Suzuki","year":"2015","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ejmech.2025.118195_bib147","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1038\/onc.2016.494","article-title":"HSP90 stabilizes B-cell receptor kinases in a multi-client interactome: PU-H71 induces CLL apoptosis in a cytoprotective microenvironment","volume":"36","author":"Guo","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.ejmech.2025.118195_bib148","doi-asserted-by":"crossref","first-page":"viii244","DOI":"10.1093\/neuonc\/noae165.0967","article-title":"Exth-36. shifting from epigenetics to the epichaperome: HSP90 as a therapeutic target for H3K27M diffuse midline glioma (DMG)","volume":"26","author":"Sbergio","year":"2024","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.ejmech.2025.118195_bib149","doi-asserted-by":"crossref","first-page":"6392","DOI":"10.1158\/1078-0432.CCR-19-0596","article-title":"Rebalancing protein homeostasis enhances tumor antigen presentation","volume":"25","author":"Jaeger","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ejmech.2025.118195_bib150","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1002\/mc.23706","article-title":"JD-02, a novel Hsp90 inhibitor, induces ROS\/SRC axis-dependent cytoprotective autophagy in colorectal cancer cells","volume":"63","author":"Lan","year":"2024","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.ejmech.2025.118195_bib151","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.108308","article-title":"Enniatin A inhibits the chaperone Hsp90 and unleashes the immune system against triple-negative breast cancer","volume":"26","author":"Eisa","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.ejmech.2025.118195_bib152","doi-asserted-by":"crossref","first-page":"4740","DOI":"10.1002\/ptr.7943","article-title":"Targeting HSP90 with picropodophyllin suppresses gastric cancer tumorigenesis by disrupting the association of HSP90 and AKT","volume":"37","author":"Li","year":"2023","journal-title":"Phytother Res."},{"key":"10.1016\/j.ejmech.2025.118195_bib153","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1218467","article-title":"Artesunate, as an Hsp90 inhibitor, inhibits the proliferation of Burkitt's lymphoma cells by inhibiting AKT and ERK","volume":"14","author":"Yuan-Ce","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejmech.2025.118195_bib154","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1007\/s12272-024-01494-1","article-title":"Combination therapy involving HSP90 inhibitors for combating cancer: an overview of clinical and preclinical progress","volume":"47","author":"Liu","year":"2024","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.ejmech.2025.118195_bib155","doi-asserted-by":"crossref","first-page":"6709","DOI":"10.1158\/1078-0432.CCR-21-1929","article-title":"TAS-116 (pimitespib), an oral HSP90 inhibitor, in combination with nivolumab in patients with colorectal cancer and other solid tumors: an open-label, dose-finding, and expansion phase Ib trial (EPOC1704)","volume":"27","author":"Kawazoe","year":"2021","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ejmech.2025.118195_bib156","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.annonc.2022.05.518","article-title":"Pimitespib in patients with advanced gastrointestinal stromal tumor (CHAPTER-GIST-301): a randomized, double-blind, placebo-controlled phase III trial","volume":"33","author":"Kurokawa","year":"2022","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.ejmech.2025.118195_bib157","doi-asserted-by":"crossref","first-page":"3745","DOI":"10.1002\/cncr.35447","article-title":"Cardiovascular safety of pimitespib in patients with advanced solid tumors: an open-label, nonrandomized, phase 1 study","volume":"130","author":"Naoki","year":"2024","journal-title":"Cancer"},{"key":"10.1016\/j.ejmech.2025.118195_bib158","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1111\/cas.15204","article-title":"TAS-116 (pimitespib), a heat shock protein 90 inhibitor, shows efficacy in preclinical models of adult T-cell leukemia","volume":"113","author":"Ikebe","year":"2022","journal-title":"Cancer Sci."},{"key":"10.1016\/j.ejmech.2025.118195_bib159","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.jpha.2023.06.004","article-title":"Ginsenoside Rg5 enhances the radiosensitivity of lung adenocarcinoma via reducing HSP90-CDC37 interaction and promoting client protein degradation","volume":"13","author":"Bai","year":"2023","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.ejmech.2025.118195_bib160","doi-asserted-by":"crossref","first-page":"3692","DOI":"10.1038\/s41598-025-86647-y","article-title":"Assessment of Hsp90\u03b2-selective inhibitor safety and on-target effects","volume":"15","author":"Reynolds","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2025.118195_bib161","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/s41408-021-00450-2","article-title":"HSP90 inhibitor NVP-BEP800 affects stability of SRC kinases and growth of T-cell and B-cell acute lymphoblastic leukemias","volume":"11","author":"Mshaik","year":"2021","journal-title":"Blood Cancer J."},{"key":"10.1016\/j.ejmech.2025.118195_bib162","doi-asserted-by":"crossref","DOI":"10.1016\/j.imbio.2021.152070","article-title":"Selective HSP90\u03b2 inhibition results in TNF and TRAIL mediated HIF1\u03b1 degradation","volume":"226","author":"Heck","year":"2021","journal-title":"Immunobiology"},{"key":"10.1016\/j.ejmech.2025.118195_bib163","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/s41419-020-03288-x","article-title":"The HSP GRP94 interacts with macrophage intracellular complement C3 and impacts M2 profile during ER stress","volume":"12","author":"Chaumonnot","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejmech.2025.118195_bib164","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12943-023-01920-w","article-title":"Identification of HSP90B1 in pan-cancer hallmarks to aid development of a potential therapeutic target","volume":"23","author":"Huang","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.ejmech.2025.118195_bib165","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.bbrc.2012.04.083","article-title":"Heat shock protein gp96 regulates Toll-like receptor 9 proteolytic processing and conformational stability","volume":"421","author":"Brooks","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejmech.2025.118195_bib166","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.3892\/or.2013.2743","article-title":"Mechanism of the inhibition of the STAT3 signaling pathway by EGCG","volume":"30","author":"Wang","year":"2013","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.ejmech.2025.118195_bib167","first-page":"627","article-title":"Epigallocatechin gallate (EGCG), influences a murine WEHI-3 leukemia model in vivo through enhancing phagocytosis of macrophages and populations of T- and B-cells","volume":"27","author":"Huang","year":"2013","journal-title":"Vivo"},{"key":"10.1016\/j.ejmech.2025.118195_bib168","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2023.129325","article-title":"Identification of (-)-Epigallocateshin gallate derivatives promoting innate immune activation via 2',3'-cyclic GMP-AMP-stimulator of interferon genes pathway","volume":"90","author":"Lee","year":"2023","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2025.118195_bib169","doi-asserted-by":"crossref","DOI":"10.3390\/ph14111081","article-title":"EGCG inhibits tumor growth in melanoma by targeting JAK-STAT signaling and its downstream PD-L1\/PD-L2-PD1 Axis in tumors and enhancing cytotoxic T-cell responses","volume":"14","author":"Ravindran Menon","year":"2021","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.ejmech.2025.118195_bib170","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112069","article-title":"EGCG suppresses PD-1 expression of T cells via inhibiting NF-\u03baB phosphorylation and nuclear translocation","volume":"133","author":"Li","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejmech.2025.118195_bib171","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1158\/1078-0432.CCR-12-2528","article-title":"Polyphenol E enhances the antitumor immune response in neuroblastoma by Inactivating myeloid suppressor cells","volume":"19","author":"Santilli","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ejmech.2025.118195_bib172","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110471","article-title":"Heat shock protein 90 C-terminal inhibitor PNSA promotes anticancer immunology of CD8(+) T cells","volume":"121","author":"Zhang","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejmech.2025.118195_bib173","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2023.106721","article-title":"Small-molecule dual inhibitors targeting heat shock protein 90 for cancer targeted therapy","volume":"139","author":"Xie","year":"2023","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2025.118195_bib174","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.2147\/DDDT.S351049","article-title":"Design, synthesis, and biological evaluation of 2-Anilino-4-Triazolpyrimidine derivatives as CDK4\/HDACs inhibitors","volume":"16","author":"Wang","year":"2022","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.ejmech.2025.118195_bib175","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jare.2022.06.009","article-title":"Rational design of synthetically tractable HDAC6\/HSP90 dual inhibitors to destroy immune-suppressive tumor microenvironment","volume":"46","author":"Wu","year":"2023","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.ejmech.2025.118195_bib176","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111725","article-title":"N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-\u03b3 induced PD-L1 expression","volume":"185","author":"Mehndiratta","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118195_bib177","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/s41389-021-00331-0","article-title":"A novel dual HDAC and HSP90 inhibitor, MPT0G449, downregulates oncogenic pathways in human acute leukemia in vitro and in vivo","volume":"10","author":"Wu","year":"2021","journal-title":"Oncogenesis"},{"key":"10.1016\/j.ejmech.2025.118195_bib178","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115459","article-title":"Design, synthesis, and biological activity of dual monoamine oxidase A and heat shock protein 90 inhibitors, N-Methylpropargylamine-conjugated 4-isopropylresorcinol for glioblastoma","volume":"256","author":"Tseng","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118195_bib179","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1021\/acs.jmedchem.3c02053","article-title":"First-in-Class dual EZH2-HSP90 inhibitor eliciting striking antiglioblastoma activity in vitro and in vivo","volume":"67","author":"Sharma","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118195_bib180","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116801","article-title":"HSP90\/LSD1 dual inhibitors against prostate cancer as well as patient-derived colorectal organoids","volume":"278","author":"Tang","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118195_bib181","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/s41401-020-0398-2","article-title":"DCZ5248, a novel dual inhibitor of Hsp90 and autophagy, exerts antitumor activity against colon cancer","volume":"42","author":"Chen","year":"2021","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.ejmech.2025.118195_bib182","doi-asserted-by":"crossref","first-page":"5561","DOI":"10.3390\/molecules27175561","article-title":"Discovery of Quinacrine as a potent Topo II and Hsp90 dual-target inhibitor, Repurposing for cancer therapy","volume":"27","author":"Pan","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2025.118195_bib183","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejmech.2018.10.013","article-title":"Discovery of novel NO-releasing celastrol derivatives with Hsp90 inhibition and cytotoxic activities","volume":"160","author":"Li","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118195_bib184","article-title":"Engineered platelets as targeted protein degraders and application to breast cancer models","author":"Chen","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ejmech.2025.118195_bib185","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2023.1219883","article-title":"Development of the first geldanamycin-based HSP90 degraders","volume":"11","author":"Wurnig","year":"2023","journal-title":"Front. Chem."},{"key":"10.1016\/j.ejmech.2025.118195_bib186","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115690","article-title":"Discovery of X10g as a selective PROTAC degrader of Hsp90\u03b1 protein for treating breast cancer","volume":"260","author":"Jiang","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118195_bib187","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116572","article-title":"Novel Hsp90-Targeting PROTACs: enhanced synergy with cisplatin in combination therapy of cervical cancer","volume":"275","author":"Liang","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118195_bib188","doi-asserted-by":"crossref","first-page":"16712","DOI":"10.1021\/acs.jmedchem.4c01518","article-title":"Heat shock protein 90 interactome-mediated proteolysis targeting chimera (HIM-PROTAC) degrading Glutathione peroxidase 4 to trigger ferroptosis","volume":"67","author":"Dong","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118195_bib189","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1021\/acs.jmedchem.2c01648","article-title":"Targeted protein degradation induced by HEMTACs based on HSP90","volume":"66","author":"Li","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118195_bib190","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.114013","article-title":"Discovery of BP3 as an efficacious proteolysis targeting chimera (PROTAC) degrader of HSP90 for treating breast cancer","volume":"228","author":"Liu","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118195_bib191","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2023.106582","article-title":"Development of HSP90 inhibitors-SN38 conjugates for cancer treatment","volume":"137","author":"Cao","year":"2023","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2025.118195_bib192","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1158\/1535-7163.MCT-19-0964","article-title":"Novel Miniaturized drug conjugate Leverages HSP90-driven tumor accumulation to overcome PI3K inhibitor delivery challenges to solid tumors","volume":"19","author":"Perino","year":"2020","journal-title":"Mol. Cancer Therapeut."},{"key":"10.1016\/j.ejmech.2025.118195_bib193","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1158\/1535-7163.MCT-15-0455","article-title":"HSP90 inhibitor-SN-38 conjugate strategy for targeted delivery of topoisomerase I inhibitor to tumors","volume":"14","author":"Proia","year":"2015","journal-title":"Mol. Cancer Therapeut."},{"key":"10.1016\/j.ejmech.2025.118195_bib194","doi-asserted-by":"crossref","first-page":"5421","DOI":"10.1021\/acs.jmedchem.0c00305","article-title":"Design, synthesis, and biological evaluation of HSP90 inhibitor-SN38 conjugates for targeted drug accumulation","volume":"63","author":"Zhu","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118195_bib195","doi-asserted-by":"crossref","first-page":"4784","DOI":"10.1021\/acs.jmedchem.2c01970","article-title":"Design, synthesis, and biological evaluation of androgen receptor (AR) antagonist-heat shock protein 90 (Hsp90) inhibitor conjugates for targeted therapy of castration-resistant prostate cancer","volume":"66","author":"Zhang","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118195_bib196","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.ejmech.2018.03.077","article-title":"A tumor-targeted Ganetespib-zinc phthalocyanine conjugate for synergistic chemo-photodynamic therapy","volume":"151","author":"Huang","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118195_bib197","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s13045-022-01274-8","article-title":"DTX-P7, a peptide-drug conjugate, is highly effective for non-small cell lung cancer","volume":"15","author":"Jiang","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.ejmech.2025.118195_bib198","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.754443","article-title":"Boosting natural killer cell therapies in glioblastoma Multiforme using supramolecular cationic inhibitors of heat shock protein 90","volume":"8","author":"Saha","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.ejmech.2025.118195_bib199","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.7150\/thno.106758","article-title":"CD19-targeted HSP90 inhibitor nanoparticle combined with TKIs reduces tumor burden and enhances T-cell immunity in murine B-cell malignancies","volume":"15","author":"Qin","year":"2025","journal-title":"Theranostics"},{"key":"10.1016\/j.ejmech.2025.118195_bib200","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201900160","article-title":"Multifunctional magnetic nanoplatform eliminates cancer stem cells via inhibiting the secretion of extracellular heat shock protein 90","volume":"8","author":"Liu","year":"2019","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.ejmech.2025.118195_bib201","doi-asserted-by":"crossref","first-page":"4515","DOI":"10.1039\/C9CC00890J","article-title":"Polymer mediated transport of the Hsp90 inhibitor LB76, a polar cyclic peptide, produces an Hsp90 cellular phenotype","volume":"55","author":"Rahimi","year":"2019","journal-title":"Chem. Commun."},{"key":"10.1016\/j.ejmech.2025.118195_bib202","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/s12951-024-02460-1","article-title":"Targeted delivery of HSP90 inhibitors for efficient therapy of CD44-positive acute myeloid leukemia and solid tumor-colon cancer","volume":"22","author":"Jia","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.ejmech.2025.118195_bib203","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.123062","article-title":"Black phosphorus nanosheets activate tumor immunity of glioblastoma by modulating the expression of the immunosuppressive molecule PD-L1","volume":"317","author":"Xiong","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejmech.2025.118195_bib204","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/2518847","article-title":"GP96 and SMP30 protein priming of dendritic cell vaccination induces a more potent CTL response against hepatoma","volume":"2022","author":"Huang","year":"2022","journal-title":"J. Healthc. Eng."},{"key":"10.1016\/j.ejmech.2025.118195_bib205","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.1016\/j.vaccine.2024.04.036","article-title":"Safe plant Hsp90 adjuvants elicit an effective immune response against SARS-CoV2-derived RBD antigen","volume":"42","author":"Ramos-Duarte","year":"2024","journal-title":"Vaccine"},{"key":"10.1016\/j.ejmech.2025.118195_bib206","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e19261","article-title":"Immunoinformatics studies of heat shock proteins 27 and 70: development of potent therapeutic vaccine constructs against human papillomavirus-related cancers","volume":"9","author":"Rezaei","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.ejmech.2025.118195_bib207","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1007\/s12094-021-02570-4","article-title":"A new antisarcoma strategy: multisubtype heat shock protein\/peptide immunotherapy combined with PD-L1 immunological checkpoint inhibitors","volume":"23","author":"Li","year":"2021","journal-title":"Clin. Transl. Oncol."},{"key":"10.1016\/j.ejmech.2025.118195_bib208","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/s41556-021-00672-3","article-title":"LIMIT is an immunogenic lncRNA in cancer immunity and immunotherapy","volume":"23","author":"Li","year":"2021","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ejmech.2025.118195_bib209","doi-asserted-by":"crossref","first-page":"3671","DOI":"10.1158\/1078-0432.CCR-12-3404","article-title":"First-in-human phase I dose-escalation study of the HSP90 inhibitor AUY922 in patients with advanced solid tumors","volume":"19","author":"Sessa","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ejmech.2025.118195_bib210","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/s41392-025-02166-2","article-title":"Advances in the structures, mechanisms and targeting of molecular chaperones","volume":"10","author":"Gu","year":"2025","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.ejmech.2025.118195_bib211","first-page":"2139","article-title":"Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to Taxol","volume":"63","author":"Solit","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejmech.2025.118195_bib212","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0003-4975(01)02787-4","article-title":"Enhancement of paclitaxel-mediated cytotoxicity in lung cancer cells by 17-allylamino geldanamycin: in vitro and in vivo analysis","volume":"72","author":"Nguyen","year":"2001","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.ejmech.2025.118195_bib213","doi-asserted-by":"crossref","DOI":"10.1177\/17588359231217976","article-title":"Phase Ib study of HSP90 inhibitor, onalespib (AT13387), in combination with paclitaxel in patients with advanced triple-negative breast cancer","volume":"15","author":"Williams","year":"2023","journal-title":"Ther. Adv. Med. Oncol."},{"key":"10.1016\/j.ejmech.2025.118195_bib214","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.lungcan.2021.10.001","article-title":"Phase 1 multicenter study of the HSP90 inhibitor SNX-5422 plus carboplatin and paclitaxel in patients with lung cancers","volume":"162","author":"Gutierrez","year":"2021","journal-title":"Lung Cancer"},{"key":"10.1016\/j.ejmech.2025.118195_bib215","doi-asserted-by":"crossref","first-page":"5355","DOI":"10.1158\/0008-5472.CAN-19-4036","article-title":"Nanoengineered disruption of heat shock protein 90 targets drug-induced resistance and relieves natural killer cell suppression in breast cancer","volume":"80","author":"Smalley","year":"2020","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejmech.2025.118195_bib216","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.1016\/j.apsb.2022.11.024","article-title":"A redox-responsive self-assembling COA-4-arm PEG prodrug nanosystem for dual drug delivery suppresses cancer metastasis and drug resistance by downregulating hsp90 expression","volume":"13","author":"Zhou","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.ejmech.2025.118195_bib217","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/ijc.20611","article-title":"Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin","volume":"113","author":"Bagatell","year":"2005","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ejmech.2025.118195_bib218","doi-asserted-by":"crossref","first-page":"6163","DOI":"10.3390\/cancers13246163","article-title":"HSP90 inhibition synergizes with cisplatin to eliminate basal-like pancreatic ductal adenocarcinoma cells","volume":"13","author":"Ewers","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.ejmech.2025.118195_bib219","doi-asserted-by":"crossref","first-page":"4748","DOI":"10.1158\/1078-0432.CCR-20-1306","article-title":"Ganetespib in combination with Pemetrexed-Platinum chemotherapy in patients with Pleural Mesothelioma (MESO-02): a phase Ib trial","volume":"26","author":"Fennell","year":"2020","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ejmech.2025.118195_bib220","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3390\/ph16020230","article-title":"Ganetespib with methotrexate acts synergistically to impede NF-\u03baB\/p65 signaling in human lung cancer A549 cells","volume":"16","author":"Subaiea","year":"2023","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.ejmech.2025.118195_bib221","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1007\/s00210-023-02807-9","article-title":"Enhancing therapeutic efficacy in breast cancer: a study on the combined cytotoxic effects of doxorubicin and MPC-3100, Naunyn","volume":"397","author":"G\u00f6k\u015fen Tosun","year":"2024","journal-title":"Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.ejmech.2025.118195_bib222","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/s12032-023-02181-9","article-title":"Synergistic induction of apoptosis in liver cancer cells: exploring the combined potential of doxorubicin and XL-888","volume":"40","author":"Kaplan","year":"2023","journal-title":"Med. Oncol."},{"key":"10.1016\/j.ejmech.2025.118195_bib223","article-title":"Hypoxia-responsive covalent organic framework nanoplatform for breast-cancer-targeted Cocktail immunotherapy via triple therapeutic switch mechanisms","volume":"21","author":"Huang","year":"2025","journal-title":"Small"},{"key":"10.1016\/j.ejmech.2025.118195_bib224","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2024.102423","article-title":"A targeted and core-shell structured gambogic acid nanomedicine for ameliorating breast cancer-associated osteolysis","volume":"58","author":"Zhang","year":"2024","journal-title":"Nano Today"},{"key":"10.1016\/j.ejmech.2025.118195_bib225","article-title":"\"Cicada out of the shell\" deep penetration and blockage of the HSP90 pathway by ROS-responsive supramolecular gels to augment trimodal synergistic therapy","volume":"11","author":"Li","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.ejmech.2025.118195_bib226","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.actbio.2024.11.035","article-title":"Thermo-responsive gold nanorod vesicles for combined NIR-II photothermal therapy and chemotherapy of solid tumors","volume":"192","author":"Xing","year":"2025","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ejmech.2025.118195_bib227","article-title":"Curcumin-enhanced NIR-II-responsive gold nanobipyramids for targeted HSP 90 inhibition","volume":"31","author":"Diao","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.ejmech.2025.118195_bib228","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1111\/cas.15269","article-title":"HSP90 promotes radioresistance of cervical cancer cells via reducing FBXO6-mediated CD147 polyubiquitination","volume":"113","author":"Song","year":"2022","journal-title":"Cancer Sci."},{"key":"10.1016\/j.ejmech.2025.118195_bib229","article-title":"HSP90 inhibition suppresses tumor glycolytic flux to potentiate the therapeutic efficacy of radiotherapy for head and neck cancer","volume":"10","author":"Chen","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ejmech.2025.118195_bib230","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.3389\/fonc.2020.01668","article-title":"Priming of anti-tumor immune mechanisms by radiotherapy is augmented by inhibition of heat shock protein 90","volume":"10","author":"Ernst","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ejmech.2025.118195_bib231","doi-asserted-by":"crossref","first-page":"5246","DOI":"10.1158\/1078-0432.CCR-19-3102","article-title":"Low-dose Hsp90 inhibitor selectively Radiosensitizes HNSCC and pancreatic xenografts","volume":"26","author":"Mehta","year":"2020","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ejmech.2025.118195_bib232","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2025.1451156","article-title":"Enhancing glioblastoma therapy: unveiling synergistic anticancer effects of Onalespib - radiotherapy combination therapy","volume":"15","author":"Uffenorde","year":"2025","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ejmech.2025.118195_bib233","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/j.ijrobp.2021.03.048","article-title":"Pharmacological inhibition of HSP90 radiosensitizes head and neck squamous cell carcinoma xenograft by inhibition of DNA damage repair, nucleotide metabolism, and radiation-induced tumor vasculogenesis","volume":"110","author":"Naz","year":"2021","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.ejmech.2025.118195_bib234","doi-asserted-by":"crossref","first-page":"viii132","DOI":"10.1093\/neuonc\/noae165.0515","article-title":"Dddr-30. Enhanced chemo and radio-sensitization of gliomas by HSP90 inhibition with JIN-001, a novel blood-brain barrier penetrant HSP90 inhibitor","volume":"26","author":"Xu","year":"2024","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.ejmech.2025.118195_bib235","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.canlet.2017.01.015","article-title":"The Hsp70 inhibiting peptide aptamer A17 potentiates radiosensitization of tumor cells by Hsp90 inhibition","volume":"390","author":"Schilling","year":"2017","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ejmech.2025.118195_bib236","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/13543776.2024.2327295","article-title":"Recent developments of HSP90 inhibitors: an updated patent review (2020-present)","volume":"34","author":"Liu","year":"2024","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.ejmech.2025.118195_bib237","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1158\/1535-7163.MCT-19-0911","article-title":"Heat shock protein-90 inhibition alters activation of pancreatic stellate cells and enhances the efficacy of PD-1 blockade in pancreatic cancer","volume":"20","author":"Zhang","year":"2021","journal-title":"Mol. Cancer Therapeut."},{"key":"10.1016\/j.ejmech.2025.118195_bib238","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2025.2475620","article-title":"XL888 and pembrolizumab modulate the immune landscape of colorectal tumors in a phase Ib\/II clinical trial","volume":"14","author":"Phillips","year":"2025","journal-title":"OncoImmunology"},{"key":"10.1016\/j.ejmech.2025.118195_bib239","first-page":"A434","article-title":"403 Correlative analysis of blood and biopsy samples from a clinical trial of Hsp90 inhibition in combination with pembrolizumab reveals increased intratumoral myeloid cell accumulation after treatment","volume":"9","author":"Herting","year":"2021","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ejmech.2025.118195_bib240","first-page":"A202","article-title":"330 Investigating the clinical safety, efficacy, and immune modulation of combined XL888 and pembrolizumab in metastatic gastrointestinal malignancies","volume":"8","author":"Herting","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.ejmech.2025.118195_bib241","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.3390\/biomedicines10112747","article-title":"Impaired heat shock protein expression in activated T cells in B-cell lymphoma","volume":"10","author":"Albakova","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.ejmech.2025.118195_bib242","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0191264","article-title":"17-AAG inhibits vemurafenib-associated MAP kinase activation and is synergistic with cellular immunotherapy in a murine melanoma model","volume":"13","author":"Joshi","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.ejmech.2025.118195_bib243","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22126309","article-title":"Effects of a unique combination of the whole-body low dose radiotherapy with Inactivation of two immune checkpoints and\/or a heat shock protein on the transplantable lung cancer in mice","volume":"22","author":"Nowosielska","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2025.118195_bib244","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1005045","article-title":"Hsp90\u03b2 inhibition upregulates interferon response and enhances immune checkpoint blockade therapy in murine tumors","volume":"13","author":"Rahmy","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejmech.2025.118195_bib245","doi-asserted-by":"crossref","first-page":"4265","DOI":"10.1021\/acsami.9b19148","article-title":"Ultrafast low-temperature photothermal therapy activates autophagy and recovers immunity for efficient antitumor treatment","volume":"12","author":"Deng","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ejmech.2025.118195_bib246","article-title":"Icaritin represses autophagy to promote colorectal cancer cell apoptosis and sensitized low-temperature photothermal therapy via targeting HSP90-TXNDC9 interactions","author":"He","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.ejmech.2025.118195_bib247","article-title":"Expanded ROS generation and hypoxia reversal: excipient-free self-assembled Nanotheranostics for enhanced cancer photodynamic immunotherapy","volume":"36","author":"Yang","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ejmech.2025.118195_bib248","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.7150\/thno.14882","article-title":"HSP90 inhibitor Encapsulated Photo-Theranostic nanoparticles for synergistic combination cancer therapy","volume":"6","author":"Lin","year":"2016","journal-title":"Theranostics"},{"key":"10.1016\/j.ejmech.2025.118195_bib249","doi-asserted-by":"crossref","first-page":"20458","DOI":"10.1021\/acsanm.3c04655","article-title":"Hyaluronic acid-Functionalized polydopamine nanoparticles augment photothermal therapy via Synergetic tumor-targeting and heat shock protein inhibition","volume":"6","author":"Ruan","year":"2023","journal-title":"ACS Appl. Nano Mater."},{"key":"10.1016\/j.ejmech.2025.118195_bib250","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1080\/02656736.2021.1983036","article-title":"HSP90 inhibition acts synergistically with heat to induce a pro-immunogenic form of cell death in colon cancer cells","volume":"38","author":"Mouratidis","year":"2021","journal-title":"Int. J. Hyperther."},{"key":"10.1016\/j.ejmech.2025.118195_bib251","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1186\/s12951-021-01037-6","article-title":"Molecularly engineered carrier-free co-delivery nanoassembly for self-sensitized photothermal cancer therapy","volume":"19","author":"Shan","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.ejmech.2025.118195_bib252","doi-asserted-by":"crossref","first-page":"17688","DOI":"10.1021\/acsanm.4c02918","article-title":"Nanoscale gambogic acid Liposomes for NIR-II Photoacoustic Imaging and photothermal-chemo tumor therapy","volume":"7","author":"Yang","year":"2024","journal-title":"ACS Appl. Nano Mater."},{"key":"10.1016\/j.ejmech.2025.118195_bib253","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12951-020-00749-5","article-title":"Synergy of hypoxia relief and heat shock protein inhibition for phototherapy enhancement","volume":"19","author":"Zhang","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.ejmech.2025.118195_bib254","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202300945","article-title":"Stimulus-detonated Biomimetic \"Nanobomb\" with controlled release of HSP90 inhibitor to disrupt mitochondrial function for synergistic gas and photothermal therapy","volume":"12","author":"Yang","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.ejmech.2025.118195_bib255","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s12943-023-01790-2","article-title":"Metal-enriched HSP90 nanoinhibitor overcomes heat resistance in hyperthermic intraperitoneal chemotherapy used for peritoneal metastases","volume":"22","author":"Wang","year":"2023","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.ejmech.2025.118195_bib256","doi-asserted-by":"crossref","first-page":"17145","DOI":"10.1021\/acsnano.4c03887","article-title":"Enhancing magnetic hyperthermia efficacy through targeted heat shock protein 90 inhibition: unveiling immune-mediated therapeutic synergy in glioma treatment","volume":"18","author":"Gupta","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.ejmech.2025.118195_bib257","article-title":"H2S-Mediated gas therapy and HSP90 downregulation Synergically enhance tumor microwave thermal therapy","volume":"34","author":"Li","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.ejmech.2025.118195_bib258","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.canlet.2017.07.028","article-title":"The HSP90 inhibitor, NVP-AUY922, attenuates intrinsic PI3K inhibitor resistance in KRAS-mutant non-small cell lung cancer","volume":"406","author":"Park","year":"2017","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ejmech.2025.118195_bib259","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.canlet.2015.12.015","article-title":"The HSP90 inhibitor, NVP-AUY922, sensitizes KRAS-mutant non-small cell lung cancer with intrinsic resistance to MEK inhibitor, trametinib","volume":"372","author":"Park","year":"2016","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ejmech.2025.118195_bib260","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114918","article-title":"Ganetespib (STA-9090) augments sorafenib efficacy via necroptosis induction in hepatocellular carcinoma: implications from preclinical data for a novel therapeutic approach","volume":"164","author":"Saber","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejmech.2025.118195_bib261","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-43486-z","article-title":"Combination therapy of tyrosine kinase inhibitor sorafenib with the HSP90 inhibitor onalespib as a novel treatment regimen for thyroid cancer","volume":"13","author":"Mortensen","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2025.118195_bib262","doi-asserted-by":"crossref","first-page":"7338","DOI":"10.1007\/s12010-023-04424-x","article-title":"Targeted inhibition of Hsp90 in combination with Metformin modulates programmed cell death pathways in A549 lung cancer cells","volume":"195","author":"Hasan","year":"2023","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.1016\/j.ejmech.2025.118195_bib263","doi-asserted-by":"crossref","DOI":"10.1111\/cas.70058","article-title":"Pimitespib, an HSP90 inhibitor, enhances the efficacy of PARP inhibitors in PARP inhibitor-Insensitive breast cancer cells","author":"Muraoka","year":"2025","journal-title":"Cancer Sci."},{"key":"10.1016\/j.ejmech.2025.118195_bib264","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1002\/ijc.34461","article-title":"Combination of pimitespib (TAS-116) with sunitinib is an effective therapy for imatinib-resistant gastrointestinal stromal tumors","volume":"152","author":"Teranishi","year":"2023","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ejmech.2025.118195_bib265","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1002\/cncr.34730","article-title":"Dose-escalation trial of combination dabrafenib, trametinib, and AT13387 in patients with BRAF-mutant solid tumors","volume":"129","author":"Mooradian","year":"2023","journal-title":"Cancer"},{"key":"10.1016\/j.ejmech.2025.118195_bib266","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.3390\/molecules28031210","article-title":"Alvespimycin inhibits heat shock protein 90 and overcomes imatinib resistance in chronic myeloid leukemia cell lines","volume":"28","author":"Alves","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2025.118195_bib267","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.7150\/thno.93236","article-title":"The HSP90 inhibitor HVH-2930 exhibits potent efficacy against trastuzumab-resistant HER2-positive breast cancer","volume":"14","author":"Park","year":"2024","journal-title":"Theranostics"},{"key":"10.1016\/j.ejmech.2025.118195_bib268","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110434","article-title":"Low dose HSP90 inhibition with AUY922 blunts rapid evolution of metastatic and drug resistant phenotypes induced by TGF-\u03b2 and paclitaxel in A549 cells","volume":"129","author":"Bacon","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejmech.2025.118195_bib269","article-title":"AUY922 improves sensitivity to sunitinib in clear cell renal cell carcinoma based on network pharmacology and in vitro experiments","volume":"10","author":"Chen","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.ejmech.2025.118195_bib270","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2023.110639","article-title":"Gastric cancer derived mesenchymal stem cells promoted DNA repair and cisplatin resistance through up-regulating PD-L1\/Rad51 in gastric cancer","volume":"106","author":"Wang","year":"2023","journal-title":"Cell. Signal."},{"key":"10.1016\/j.ejmech.2025.118195_bib271","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00280-022-04407-5","article-title":"Hsp90 inhibition sensitizes DLBCL cells to cisplatin","volume":"89","author":"Schmidt","year":"2022","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.ejmech.2025.118195_bib272","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2024.1430833","article-title":"Type II mode of JAK2 inhibition and destabilization are potential therapeutic approaches against the ruxolitinib resistance driven myeloproliferative neoplasms","volume":"14","author":"Gorantla","year":"2024","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ejmech.2025.118195_bib273","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1038\/s41375-024-02253-3","article-title":"Dynamics of clonal hematopoiesis under DNA-damaging treatment in patients with ovarian cancer","volume":"38","author":"Arends","year":"2024","journal-title":"Leukemia"},{"key":"10.1016\/j.ejmech.2025.118195_bib274","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.62347\/XFJH3424","article-title":"The small-molecule drug homoharringtonine targets HSF1 to suppress pancreatic cancer progression","volume":"14","author":"Li","year":"2024","journal-title":"Am. J. Cancer Res."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523425009602?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523425009602?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T09:25:49Z","timestamp":1773134749000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523425009602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":274,"alternative-id":["S0223523425009602"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2025.118195","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HSP90 inhibitors in cancer immunotherapy: Therapeutic opportunities and challenges","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2025.118195","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"118195"}}