{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:36:31Z","timestamp":1785890191796,"version":"3.56.0"},"reference-count":140,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific &amp; Industrial Research","doi-asserted-by":"publisher","award":["MMP075202"],"award-info":[{"award-number":["MMP075202"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.ejmech.2025.118224","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T06:39:53Z","timestamp":1760078393000},"page":"118224","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Benzoxaboroles in medicinal chemistry: A structure-guided perspective on next-generation therapeutics"],"prefix":"10.1016","volume":"301","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9266-8790","authenticated-orcid":false,"given":"Akhil","family":"Nagar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4819-7602","authenticated-orcid":false,"given":"Dipayan","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8108-5875","authenticated-orcid":false,"given":"Ruchita","family":"Bardiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6508-4183","authenticated-orcid":false,"given":"Atul","family":"Shirkhedkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3767-3351","authenticated-orcid":false,"given":"Viren","family":"Soni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3918-0462","authenticated-orcid":false,"given":"Sahil","family":"Sonawane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7208-2103","authenticated-orcid":false,"given":"Pritam","family":"Chaudhari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7831-1795","authenticated-orcid":false,"given":"Arindam","family":"Talukdar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2025.118224_bib1","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.4155\/fmc.09.71","article-title":"Therapeutic potential of boron-containing compounds","volume":"1","author":"Baker","year":"2009","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib2","doi-asserted-by":"crossref","first-page":"611","DOI":"10.4155\/fmc.13.60","article-title":"Focusing on boron in medicinal chemistry","volume":"5","author":"Ramachandran","year":"2013","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib3","doi-asserted-by":"crossref","first-page":"653","DOI":"10.4155\/fmc.13.38","article-title":"Boron chemicals in diagnosis and therapeutics","volume":"5","author":"Das","year":"2013","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib4","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nchem.2814","article-title":"The versatility of boron in biological target engagement","volume":"9","author":"Diaz","year":"2017","journal-title":"Nat. Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib5","doi-asserted-by":"crossref","first-page":"7820","DOI":"10.1021\/acs.jmedchem.7b00952","article-title":"Stilbene boronic acids form a covalent bond with human transthyretin and inhibit its aggregation","volume":"60","author":"Smith","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib6","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.str.2005.11.019","article-title":"Crystal structure of the boronic acid-based proteasome inhibitor Bortezomib in complex with the yeast 20S proteasome","volume":"14","author":"Groll","year":"2006","journal-title":"Structure"},{"key":"10.1016\/j.ejmech.2025.118224_bib7","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1126\/science.1142189","article-title":"An antifungal agent inhibits an Aminoacyl-tRNA synthetase by trapping tRNA in the editing site","volume":"316","author":"Rock","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2025.118224_bib8","doi-asserted-by":"crossref","first-page":"6561","DOI":"10.1038\/ncomms7561","article-title":"Targeting bacteria via iminoboronate chemistry of amine-presenting lipids","volume":"6","author":"Bandyopadhyay","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2025.118224_bib9","doi-asserted-by":"crossref","first-page":"14015","DOI":"10.1021\/jacs.8b07366","article-title":"Sub-picomolar inhibition of HIV-1 protease with a boronic acid","volume":"140","author":"Windsor","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2025.118224_bib10","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1021\/acs.jmedchem.9b01518","article-title":"Discovery of Taniborbactam (VNRX-5133): a broad-spectrum Serine- and Metallo-\u03b2-lactamase inhibitor for carbapenem-resistant bacterial infections","volume":"63","author":"Liu","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib11","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.1016\/j.febslet.2012.07.058","article-title":"Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center","volume":"586","author":"Freund","year":"2012","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ejmech.2025.118224_bib12","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1016\/j.bmcl.2009.03.007","article-title":"Discovery and structure\u2013activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis","volume":"19","author":"Akama","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"5","key":"10.1016\/j.ejmech.2025.118224_bib13","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1177\/107327480301000502","article-title":"Bortezomib (PS-341): a novel, first-in-class proteasome inhibitor for the treatment of multiple myeloma and other cancers","volume":"10","author":"Richardson","year":"2003","journal-title":"Cancer Control"},{"key":"10.1016\/j.ejmech.2025.118224_bib14","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1021\/acs.jmedchem.8b01719","article-title":"Design of N-Benzoxaborole benzofuran GSK8175\u2014Optimization of human pharmacokinetics inspired by metabolites of a failed clinical HCV inhibitor","volume":"62","author":"Chong","year":"2019","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001151","article-title":"SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis","volume":"5","author":"Jacobs","year":"2011","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.ejmech.2025.118224_bib16","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1080\/13543776.2018.1473379","article-title":"Benzoxaborole compounds for therapeutic uses: a patent review (2010- 2018)","volume":"28","author":"Nocentini","year":"2018","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.ejmech.2025.118224_bib17","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.jorganchem.2006.10.013","article-title":"Stability of boronic esters \u2013 structural effects on the relative rates of transesterification of 2-(phenyl)-1,3,2-dioxaborolane","volume":"692","author":"Roy","year":"2007","journal-title":"J. Organomet. Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib18","doi-asserted-by":"crossref","first-page":"5224","DOI":"10.1021\/cr500642d","article-title":"Recent developments in the chemistry and biological applications of benzoxaboroles","volume":"115","author":"Adamczyk-Wo\u017aniak","year":"2015","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejmech.2025.118224_bib19","doi-asserted-by":"crossref","first-page":"7317","DOI":"10.1016\/j.bmcl.2010.10.071","article-title":"Synthesis and biological evaluations of P4-benzoxaborole-substituted macrocyclic inhibitors of HCV NS3 protease","volume":"20","author":"Ding","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2025.118224_bib20","doi-asserted-by":"crossref","first-page":"4462","DOI":"10.1016\/j.bmc.2014.04.065","article-title":"The unique chemistry of benzoxaboroles: current and emerging applications in biotechnology and therapeutic treatments","volume":"22","author":"Liu","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib21","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1007\/s11426-013-4981-y","article-title":"The synthesis of benzoxaboroles and their applications in medicinal chemistry","volume":"56","author":"Zhang","year":"2013","journal-title":"Sci. China Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib22","series-title":"Bortezomib Formulations","author":"Usayapant A","year":"2015"},{"key":"10.1016\/j.ejmech.2025.118224_bib23","first-page":"135","article-title":"Velcade (Bortezomib) receives 2 new FDA indications: for retreatment of patients with multiple myeloma and for first-line treatment of patients with mantle-cell lymphoma","volume":"8","author":"Raedler","year":"2015","journal-title":"Am. Heal. Drug Benefits"},{"key":"10.1016\/j.ejmech.2025.118224_bib25","series-title":"Boron Containing Small Compound","author":"Baker SJ","year":"2010"},{"key":"10.1016\/j.ejmech.2025.118224_bib26","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1358\/dot.2017.53.4.2604174","article-title":"Crisaborole: phosphodiesterase inhibitor for treatment of atopic dermatitis","volume":"53","author":"Paton","year":"2017","journal-title":"Drugs Today"},{"key":"10.1016\/j.ejmech.2025.118224_bib27","unstructured":"Safety and efficacy study of Cefepime\/VNRX-5133 in patients with complicated urinary tract infections (CERTAIN-1), NCT03840148 (n.d.). https:\/\/clinicaltrials.gov\/study\/NCT03840148#xd_co_f=MDYwMjkzZDktYzdlMS00Mjk2LTkwNGEtZDU2ZTNmYTg2OTgw\u223c."},{"key":"10.1016\/j.ejmech.2025.118224_bib28","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1159\/000073086","article-title":"Treatment failures and relapses in onychomycosis: a stubborn clinical problem","volume":"207","author":"Arrese","year":"2003","journal-title":"Dermatology"},{"key":"10.1016\/j.ejmech.2025.118224_bib29","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/j.1365-2710.2009.01107.x","article-title":"Toenail onychomycosis: an important global disease burden","volume":"35","author":"Thomas","year":"2010","journal-title":"J. Clin. Pharm. Ther."},{"key":"10.1016\/j.ejmech.2025.118224_bib30","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1111\/jdv.16394","article-title":"Onychomycosis: a review","volume":"34","author":"Gupta","year":"2020","journal-title":"J. Eur. Acad. Dermatology Venereol"},{"key":"10.1016\/j.ejmech.2025.118224_bib31","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1468-3083.2004.00988.x","article-title":"Topical antifungal drugs for the treatment of onychomycosis: an overview of current strategies for monotherapy and combination therapy","volume":"19","author":"Baran","year":"2005","journal-title":"J. Eur. Acad. Dermatology Venereol."},{"key":"10.1016\/j.ejmech.2025.118224_bib32","doi-asserted-by":"crossref","first-page":"7468","DOI":"10.1021\/jm050676a","article-title":"Identification of borinic esters as inhibitors of bacterial cell growth and bacterial methyltransferases, CcrM and MenH","volume":"48","author":"Benkovic","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib33","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.1021\/jm0603724","article-title":"Discovery of a new boron-containing antifungal agent, 5-Fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the potential treatment of onychomycosis","volume":"49","author":"Baker","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib34","doi-asserted-by":"crossref","first-page":"4674","DOI":"10.1021\/jo400617j","article-title":"Substituent effects and pH profiles for stability constants of arylboronic acid diol esters","volume":"78","author":"Mart\u00ednez-Aguirre","year":"2013","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib35","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1021\/ml200215j","article-title":"Ring structure and aromatic substituent effects on the pKa of the benzoxaborole pharmacophore","volume":"3","author":"Tomsho","year":"2012","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2025.118224_bib36","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jmb.2009.04.073","article-title":"Crystal structures of the human and fungal cytosolic Leucyl-tRNA synthetase editing domains: a structural basis for the rational design of antifungal benzoxaboroles","volume":"390","author":"Seiradake","year":"2009","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.ejmech.2025.118224_bib37","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.molstruc.2019.01.018","article-title":"Synthesis and structural elucidation of novel antifungal N-(fluorophenyl)piperazinyl benzoxaboroles and their analogues","volume":"1181","author":"Borys","year":"2019","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.ejmech.2025.118224_bib38","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/aoc.2880","article-title":"Biological activity of selected boronic acids and their derivatives","volume":"26","author":"Adamczyk-Wo\u017aniak","year":"2012","journal-title":"Appl. Organomet. Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib39","doi-asserted-by":"crossref","first-page":"37187","DOI":"10.1039\/D0RA07767D","article-title":"Mechanochemical synthesis of antifungal bis(benzoxaboroles)","volume":"10","author":"Borys","year":"2020","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejmech.2025.118224_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.105560","article-title":"Synthesis, structure, properties and antimicrobial activity of para trifluoromethyl phenylboronic derivatives","volume":"119","author":"Adamczyk-Wo\u017aniak","year":"2022","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib41","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/aoc.3132","article-title":"Investigation of fungicidal activity of 3-piperazine-bis(benzoxaborole) and its boronic acid analogue","volume":"28","author":"Wieczorek","year":"2014","journal-title":"Appl. Organomet. Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25245999","article-title":"Synthesis and influence of 3-Amino benzoxaboroles structure on their activity against Candida albicans","volume":"25","author":"Wieczorek","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2025.118224_bib43","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1039\/C2NJ40687J","article-title":"Lewis acidity and sugar receptor activity of 3-amino-substituted benzoxaboroles and their ortho-aminomethylphenylboronic acid analogues","volume":"37","author":"Adamczyk-Wo\u017aniak","year":"2013","journal-title":"New J. Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib44","first-page":"914","article-title":"50 years of chemistry and biochemistry","volume":"2006","author":"Cereghetti Erick M","year":"2006","journal-title":"Synthesis (Stuttg)"},{"key":"10.1016\/j.ejmech.2025.118224_bib45","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/ja.2016.34","article-title":"New conjugates of polyene macrolide amphotericin B with benzoxaboroles: synthesis and properties","volume":"69","author":"Tevyashova","year":"2016","journal-title":"J. Antibiot. (Tokyo)."},{"key":"10.1016\/j.ejmech.2025.118224_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0188573","article-title":"Pore-forming activity of new conjugate antibiotics based on amphotericin B","volume":"12","author":"Efimova","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.ejmech.2025.118224_bib47","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","article-title":"Carbonic anhydrases: novel therapeutic applications for inhibitors and activators","volume":"7","author":"Supuran","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejmech.2025.118224_bib48","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1016\/j.cub.2005.10.040","article-title":"Fungal adenylyl cyclase integrates CO2 sensing with cAMP signaling and virulence","volume":"15","author":"Klengel","year":"2005","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ejmech.2025.118224_bib49","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1128\/EC.5.1.103-111.2006","article-title":"Cryptococcus neoformans senses CO2 through the carbonic anhydrase Can2 and the adenylyl cyclase Cac1","volume":"5","author":"Gewiss","year":"2006","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.ejmech.2025.118224_bib50","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/j.cub.2005.09.047","article-title":"Carbonic anhydrase and CO2 sensing during Cryptococcus neoformans growth, differentiation, and virulence","volume":"15","author":"Bahn","year":"2005","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ejmech.2025.118224_bib51","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1016\/j.bmcl.2009.03.147","article-title":"Carbonic anhydrase inhibitors. Inhibition of the fungal \u03b2-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids","volume":"19","author":"Innocenti","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2025.118224_bib52","doi-asserted-by":"crossref","first-page":"4406","DOI":"10.1016\/j.bmc.2016.07.035","article-title":"Bortezomib inhibits bacterial and fungal \u03b2-carbonic anhydrases","volume":"24","author":"Supuran","year":"2016","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib53","doi-asserted-by":"crossref","first-page":"11983","DOI":"10.1039\/C6CC06399C","article-title":"Benzoxaborole as a new chemotype for carbonic anhydrase inhibition","volume":"52","author":"Alterio","year":"2016","journal-title":"Chem. Commun."},{"key":"10.1016\/j.ejmech.2025.118224_bib54","doi-asserted-by":"crossref","first-page":"175","DOI":"10.2174\/157489112803521922","article-title":"Novel antimicrobial agents against multi-drug-resistant gram-negative bacteria: an overview","volume":"7","author":"Karras","year":"2012","journal-title":"Recent Pat. Anti-Infect. Drug Discov."},{"key":"10.1016\/j.ejmech.2025.118224_bib55","doi-asserted-by":"crossref","first-page":"182","DOI":"10.2174\/157489112803521959","article-title":"Novel antimicrobial agents against multi-drug-resistant gram-positive bacteria: an overview","volume":"7","author":"Giannakaki","year":"2012","journal-title":"Recent Pat. Anti-Infect. Drug Discov."},{"key":"10.1016\/j.ejmech.2025.118224_bib56","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2475067","article-title":"Mechanisms of antimicrobial resistance in ESKAPE pathogens","volume":"2016","author":"Santajit","year":"2016","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.ejmech.2025.118224_bib57","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4167\/jbv.2015.45.2.67","article-title":"Glycopeptide antibiotics: structure and mechanisms of action","volume":"45","author":"Kang","year":"2015","journal-title":"Jbv"},{"key":"10.1016\/j.ejmech.2025.118224_bib58","doi-asserted-by":"crossref","first-page":"641","DOI":"10.4155\/fmc.13.16","article-title":"Synthesis and study of antibacterial activities of antibacterial glycopeptide antibiotics conjugated with benzoxaboroles","volume":"5","author":"Printsevskaya","year":"2013","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib59","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1070\/RCR4448","article-title":"Design of dual action antibiotics as an approach to search for new promising drugs","volume":"84","author":"Tevyashova","year":"2015","journal-title":"Russ. Chem. Rev."},{"key":"10.1016\/j.ejmech.2025.118224_bib60","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41429-018-0107-2","article-title":"Synthesis and evaluation of biological activity of benzoxaborole derivatives of azithromycin","volume":"72","author":"Tevyashova","year":"2019","journal-title":"J. Antibiot. (Tokyo)."},{"key":"10.1016\/j.ejmech.2025.118224_bib61","doi-asserted-by":"crossref","first-page":"5800","DOI":"10.1002\/ejoc.201700989","article-title":"Design, synthesis and X-ray crystal structure of iodinated benzoboroxole derivatives by consecutive metal\u2013iodine exchange of 3,4,5-Triiodoanisole","volume":"2017","author":"Al-Zoubi","year":"2017","journal-title":"European J. Org. Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib62","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ab.2012.08.024","article-title":"Time-dependent, reversible, oxaborole inhibition of Escherichia coli leucyl-tRNA synthetase measured with a continuous fluorescence assay","volume":"431","author":"Shapiro","year":"2012","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ejmech.2025.118224_bib63","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1128\/AAC.02058-12","article-title":"Discovery of a novel class of boron-based antibacterials with activity against gram-negative bacteria","volume":"57","author":"Vincent","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2025.118224_bib64","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1128\/AAC.00160-13","article-title":"Potency and spectrum of activity of AN3365, a novel boron-containing protein synthesis inhibitor, tested against clinical isolates of enterobacteriaceae and nonfermentative gram-negative Bacilli","volume":"57","author":"E","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2025.118224_bib65","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1128\/AAC.02580-12","article-title":"Comparative in vitro activities of GSK2251052, a novel boron-containing Leucyl-tRNA synthetase inhibitor, against 916 anaerobic organisms","volume":"57","author":"C","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2025.118224_bib66","doi-asserted-by":"crossref","DOI":"10.1124\/dmd.112.050153","article-title":"Disposition and metabolism of GSK2251052 in humans: a novel boron-containing antibiotic","volume":"41","author":"Bowers","year":"2013","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejmech.2025.118224_bib67","doi-asserted-by":"crossref","first-page":"3334","DOI":"10.1128\/AAC.02483-12","article-title":"Intrapulmonary pharmacokinetics of GSK2251052 in healthy volunteers","volume":"57","author":"David","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2025.118224_bib69","article-title":"Epetraborole is active against Mycobacterium abscessus","volume":"65","author":"S","year":"2021","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2025.118224_bib70","article-title":"A Leucyl-tRNA synthetase inhibitor with broad-spectrum antimycobacterial activity","volume":"65","author":"S","year":"2021","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2025.118224_bib71","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1016\/j.tet.2016.03.038","article-title":"Synthesis and evaluation of functionalized benzoboroxoles as potential anti-tuberculosis agents","volume":"72","author":"Alam","year":"2016","journal-title":"Tetrahedron"},{"key":"10.1016\/j.ejmech.2025.118224_bib72","article-title":"A novel benzoxaborole is active against Escherichia coli and binds to FabI","volume":"65","author":"Soma","year":"2021","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2025.118224_bib73","doi-asserted-by":"crossref","first-page":"5935","DOI":"10.1039\/C9SC00415G","article-title":"Targeting extracellular glycans: tuning multimeric boronic acids for pathogen-selective killing of Mycobacterium tuberculosis","volume":"10","author":"Guy","year":"2019","journal-title":"Chem. Sci."},{"key":"10.1016\/j.ejmech.2025.118224_bib74","doi-asserted-by":"crossref","first-page":"9524","DOI":"10.1039\/C9OB02222H","article-title":"Dimeric benzoboroxoles for targeted activity against Mycobacterium tuberculosis","volume":"17","author":"Guy","year":"2019","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib75","doi-asserted-by":"crossref","first-page":"8032","DOI":"10.1039\/c3cs60148j","article-title":"Selective sensing of saccharides using simple boronic acids and their aggregates","volume":"42","author":"Wu","year":"2013","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.ejmech.2025.118224_bib76","doi-asserted-by":"crossref","unstructured":"P. Kerff F., Fonze, E., Sauvage, E., Frere, J.M., Charlier, STRUCTURE OF THE CLASS D BETA-LACTAMASE OXA-10 IN COMPLEX WITH A PHENYLBORONIC ACID, n.d. https:\/\/doi.org\/https:\/\/doi.org\/10.2210\/pdb1K6S\/pdb.","DOI":"10.2210\/pdb1k6s\/pdb"},{"key":"10.1016\/j.ejmech.2025.118224_bib77","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1021\/acsinfecdis.5b00031","article-title":"4,5-Disubstituted 6-Aryloxy-1,3-dihydrobenzo[c][1,2]oxaboroles are broad-spectrum serine \u03b2-Lactamase inhibitors","volume":"1","author":"McKinney","year":"2015","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.ejmech.2025.118224_bib78","doi-asserted-by":"crossref","DOI":"10.1080\/14756366.2024.2435365","article-title":"Structural comparison of substrate-binding pockets of serine \u03b2-lactamases in classes A, C, and D","volume":"40","author":"Lee","year":"2025","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib79","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1021\/acsmedchemlett.0c00403","article-title":"Benzoxaboroles: new potent inhibitors of the carbonic anhydrases of the pathogenic bacterium Vibrio cholerae","volume":"11","author":"Bonardi","year":"2020","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2025.118224_bib80","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1021\/acsinfecdis.9b00071","article-title":"Antibacterial activity and mode of action of a sulfonamide-based class of oxaborole Leucyl-tRNA-Synthetase inhibitors","volume":"5","author":"Si","year":"2019","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.ejmech.2025.118224_bib81","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1038\/srep02475","article-title":"Discovery of a potent benzoxaborole-based anti-pneumococcal agent targeting leucyl-tRNA synthetase","volume":"3","author":"Hu","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2025.118224_bib82","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/nsmb986","article-title":"The crystal structure of leucyl-tRNA synthetase complexed with tRNALeu in the post-transfer\u2013editing conformation","volume":"12","author":"Tukalo","year":"2005","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.ejmech.2025.118224_bib83","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jmb.2004.11.060","article-title":"Crystal structure of Leucyl-tRNA synthetase from the archaeon Pyrococcus horikoshii reveals a novel editing domain orientation","volume":"346","author":"Fukunaga","year":"2005","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.ejmech.2025.118224_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2020.115871","article-title":"Discovery of benzhydrol-oxaborole derivatives as Streptococcus pneumoniae leucyl-tRNA synthetase inhibitors","volume":"29","author":"Hao","year":"2021","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib85","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/jhet.1997","article-title":"Arylspiroborates derived from 4-tert-Butylcatechol and 3,5-Di-tert-butylcatechol and their antimicrobial activities","volume":"51","author":"Webb","year":"2014","journal-title":"J. Heterocycl. Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib86","article-title":"Synthesis and biological activity of arylspiroborate salts derived from Caffeic acid Phenethyl ester","volume":"2015","author":"H\u00e9bert","year":"2015","journal-title":"Int. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib87","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.1021\/acs.jmedchem.8b01938","article-title":"Discovery and mechanistic study of tailor-made quinoline derivatives as topoisomerase 1 poison with potent anticancer activity","volume":"62","author":"Kundu","year":"2019","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112551","article-title":"Development of a metabolically stable topoisomerase I poison as anticancer agent","volume":"202","author":"Kundu","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib89","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.canlet.2004.06.001","article-title":"Boric acid inhibits human prostate cancer cell proliferation","volume":"216","author":"Barranco","year":"2004","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ejmech.2025.118224_bib90","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1038\/sj.bjc.6603009","article-title":"Cellular changes in boric acid-treated DU-145 prostate cancer cells","volume":"94","author":"Barranco","year":"2006","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ejmech.2025.118224_bib91","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/01926230490260899","article-title":"Boron supplementation inhibits the growth and local expression of IGF-1 in human prostate adenocarcinoma (LNCaP) tumors in nude mice","volume":"32","author":"Gallardo-Williams","year":"2004","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.ejmech.2025.118224_bib92","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/pros.10166","article-title":"Inhibition of the enzymatic activity of prostate-specific antigen by boric acid and 3-nitrophenyl boronic acid","volume":"54","author":"Gallardo-Williams","year":"2003","journal-title":"Prostate"},{"key":"10.1016\/j.ejmech.2025.118224_bib93","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s12011-007-8081-8","article-title":"Comparative effects of boric acid and calcium fructoborate on breast cancer cells","volume":"122","author":"Scorei","year":"2008","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.ejmech.2025.118224_bib94","doi-asserted-by":"crossref","first-page":"153","DOI":"10.4161\/cam.2.3.6484","article-title":"Phenylboronic acid selectively inhibits human prostate and breast cancer cell migration and decreases viability","volume":"2","author":"Bradke","year":"2008","journal-title":"Cell Adh. Migr."},{"key":"10.1016\/j.ejmech.2025.118224_bib95","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jorganchem.2015.06.021","article-title":"Synthesis and evaluation of functionalized aminobenzoboroxoles as potential anti-cancer agents","volume":"798","author":"Suman","year":"2015","journal-title":"J. Organomet. Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib96","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2020.127259","article-title":"Synthesis and biological evaluation of arylphosphonium-benzoxaborole conjugates as novel anticancer agents","volume":"30","author":"Jonnalagadda","year":"2020","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2025.118224_bib97","doi-asserted-by":"crossref","first-page":"6765","DOI":"10.1021\/acs.jmedchem.9b00736","article-title":"Design, synthesis, and structure\u2013activity relationship of 7-Propanamide benzoxaboroles as potent anticancer agents","volume":"62","author":"Zhang","year":"2019","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib98","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s10637-018-0611-z","article-title":"Discovering simple phenylboronic acid and benzoxaborole derivatives for experimental oncology \u2013 phase cycle-specific inducers of apoptosis in A2780 ovarian cancer cells","volume":"37","author":"Psurski","year":"2019","journal-title":"Invest. New Drugs"},{"key":"10.1016\/j.ejmech.2025.118224_bib99","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.1016\/j.bmc.2009.03.058","article-title":"Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isoforms I and II and transmembrane, tumor-associated isoforms IX and XII with boronic acids","volume":"17","author":"Winum","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib100","doi-asserted-by":"crossref","first-page":"5064","DOI":"10.1016\/j.bmc.2016.10.023","article-title":"Bortezomib inhibits mammalian carbonic anhydrases","volume":"25","author":"Supuran","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib101","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1021\/acsmedchemlett.7b00369","article-title":"Benzoxaboroles as efficient inhibitors of the \u03b2-Carbonic anhydrases from pathogenic fungi: activity and modeling Study","volume":"8","author":"Nocentini","year":"2017","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2025.118224_bib102","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1021\/acsmedchemlett.9b00252","article-title":"Bis-benzoxaboroles: design, synthesis, and biological evaluation as carbonic anhydrase inhibitors","volume":"10","author":"Larcher","year":"2019","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2025.118224_bib103","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001541","article-title":"Human African trypanosomiasis in South Sudan: how can we prevent a new epidemic?","volume":"6","author":"Ruiz-Postigo","year":"2012","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.ejmech.2025.118224_bib104","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1179\/2047773213Y.0000000105","article-title":"A current analysis of chemotherapy strategies for the treatment of human African trypanosomiasis","volume":"107","author":"Babokhov","year":"2013","journal-title":"Pathog. Glob. Health"},{"key":"10.1016\/j.ejmech.2025.118224_bib105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002230","article-title":"Safety, pharmacokinetic, and efficacy studies of oral DB868 in a first stage vervet monkey model of human African trypanosomiasis","volume":"7","author":"Thuita","year":"2013","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.ejmech.2025.118224_bib106","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.pt.2012.12.005","article-title":"Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story","volume":"29","author":"Baker","year":"2013","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.ejmech.2025.118224_bib107","doi-asserted-by":"crossref","first-page":"e371","DOI":"10.1016\/S2214-109X(13)70078-0","article-title":"The drug and vaccine landscape for neglected diseases (2000\u201311): a systematic assessment","volume":"1","author":"Pedrique","year":"2013","journal-title":"Lancet Glob. Heal"},{"key":"10.1016\/j.ejmech.2025.118224_bib109","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ejmech.2014.04.079","article-title":"Novel pyrrolobenzoxaboroles: design, synthesis, and biological evaluation against Trypanosoma brucei","volume":"81","author":"Wu","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007315","article-title":"The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing","volume":"14","author":"Begolo","year":"2018","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ejmech.2025.118224_bib111","doi-asserted-by":"crossref","first-page":"9616","DOI":"10.1073\/pnas.1807915115","article-title":"Clinical and veterinary trypanocidal benzoxaboroles target CPSF3","volume":"115","author":"Wall","year":"2018","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ejmech.2025.118224_bib112","doi-asserted-by":"crossref","first-page":"385","DOI":"10.15252\/emmm.201607370","article-title":"Targeting Toxoplasma gondii CPSF3 as a new approach to control toxoplasmosis","volume":"9","author":"Palencia","year":"2017","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.ejmech.2025.118224_bib113","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14574","article-title":"A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue","volume":"8","author":"Sonoiki","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2025.118224_bib114","doi-asserted-by":"crossref","DOI":"10.1007\/s12038-020-00031-8","article-title":"Deciphering the interaction of benzoxaborole inhibitor AN2690 with connective polypeptide 1 (CP1) editing domain of Leishmania donovani leucyl-tRNA synthetase","volume":"45","author":"Tandon","year":"2020","journal-title":"J. Biosci."},{"key":"10.1016\/j.ejmech.2025.118224_bib115","doi-asserted-by":"crossref","first-page":"16159","DOI":"10.1021\/acs.jmedchem.1c01437","article-title":"DNDI-6148: a novel benzoxaborole preclinical candidate for the treatment of visceral leishmaniasis","volume":"64","author":"Mowbray","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib116","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27134026","article-title":"Integration of ligand-based and structure-based methods for the design of small-molecule TLR7 antagonists","volume":"27","author":"Pal","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2025.118224_bib117","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112978","article-title":"Synthesis and characterization of new potent TLR7 antagonists based on analysis of the binding mode using biomolecular simulations","volume":"210","author":"Pal","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib118","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.csbj.2019.02.006","article-title":"Ligand-based pharmacophore modeling, virtual screening and molecular docking studies for discovery of potential topoisomerase I inhibitors","volume":"17","author":"Pal","year":"2019","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.ejmech.2025.118224_bib119","doi-asserted-by":"crossref","first-page":"4776","DOI":"10.1021\/acs.jmedchem.0c00011","article-title":"A chemical switch for transforming a purine agonist for toll-like receptor 7 to a clinically relevant antagonist","volume":"63","author":"Mukherjee","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006850","article-title":"Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles","volume":"14","author":"Zhang","year":"2018","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ejmech.2025.118224_bib121","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1038\/s41564-022-01211-y","article-title":"Discovery of an orally active benzoxaborole prodrug effective in the treatment of chagas disease in non-human primates","volume":"7","author":"Padilla","year":"2022","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.ejmech.2025.118224_bib122","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1186\/s13071-016-1654-7","article-title":"Evaluation of fluralaner and afoxolaner treatments to control flea populations, reduce pruritus and minimize dermatologic lesions in naturally infested dogs in private residences in west central Florida USA","volume":"9","author":"Dryden","year":"2016","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.ejmech.2025.118224_bib123","doi-asserted-by":"crossref","first-page":"5589","DOI":"10.1016\/j.bmcl.2015.10.044","article-title":"Discovery of an orally bioavailable isoxazoline benzoxaborole (AN8030) as a long acting animal ectoparasiticide","volume":"25","author":"Zhang","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2025.118224_bib124","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1016\/j.bmcl.2016.04.093","article-title":"Optimization of isoxazoline amide benzoxaboroles for identification of a development candidate as an oral long acting animal ectoparasiticide","volume":"26","author":"Zhang","year":"2016","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2025.118224_bib125","unstructured":"World Malaria Report 2020. World Health Organization, n.d. https:\/\/www.who.int\/publications\/i\/item\/9789240015791."},{"key":"10.1016\/j.ejmech.2025.118224_bib126","unstructured":"Malaria: Artemisinin Resistance. World Health Organization, n.d. https:\/\/www.who.int\/news-room\/questions-and-answers\/item\/artemisinin-resistance."},{"key":"10.1016\/j.ejmech.2025.118224_bib127","doi-asserted-by":"crossref","first-page":"4886","DOI":"10.1128\/AAC.00820-16","article-title":"Antimalarial benzoxaboroles target Plasmodium falciparum Leucyl-tRNA synthetase","volume":"60","author":"Sonoiki","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2025.118224_bib128","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.bmcl.2010.12.034","article-title":"Synthesis and structure\u2013activity relationships of novel benzoxaboroles as a new class of antimalarial agents","volume":"21","author":"Zhang","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2025.118224_bib129","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.bmcl.2011.12.096","article-title":"Benzoxaborole antimalarial agents. Part 2: discovery of fluoro-substituted 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles","volume":"22","author":"Zhang","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2025.118224_bib130","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/jlcr.2926","article-title":"Benzoxaborole antimalarial agents. Part 3: design and syntheses of (carboxy-13C-3,3-2H2)-labeled and (3-14C)-labeled 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles","volume":"55","author":"Zhang","year":"2012","journal-title":"J. Label. Compd. Radiopharm."},{"key":"10.1016\/j.ejmech.2025.118224_bib131","doi-asserted-by":"crossref","first-page":"5344","DOI":"10.1021\/acs.jmedchem.5b00678","article-title":"Benzoxaborole antimalarial agents. Part 4. Discovery of potent 6-(2-(Alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles","volume":"58","author":"Zhang","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib132","doi-asserted-by":"crossref","first-page":"5889","DOI":"10.1021\/acs.jmedchem.7b00621","article-title":"Benzoxaborole antimalarial agents. Part 5. Lead optimization of novel amide pyrazinyloxy benzoxaboroles and identification of a preclinical candidate","volume":"60","author":"Zhang","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib133","article-title":"Plasmodium falciparum resistance to a lead benzoxaborole due to blocked compound activation and altered ubiquitination or sumoylation","volume":"11","author":"V","year":"2020","journal-title":"mBio"},{"key":"10.1016\/j.ejmech.2025.118224_bib134","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.101871","article-title":"Target identification of an antimalarial oxaborole identifies AN13762 as an alternative chemotype for targeting CPSF3 in apicomplexan parasites","volume":"23","author":"Bellini","year":"2020","journal-title":"iScience"},{"key":"10.1016\/j.ejmech.2025.118224_bib135","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.104733","article-title":"Synthesis and antiplasmodial evaluation of 1H-1,2,3-triazole grafted 4-aminoquinoline-benzoxaborole hybrids and benzoxaborole analogues","volume":"109","author":"Saini","year":"2021","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib136","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1021\/acs.jmedchem.4c02805","article-title":"Discovery of an orally efficacious Pyrazolo[3,4-d]pyrimidine benzoxaborole as a potent inhibitor of cryptosporidium","volume":"68","author":"Gasonoo","year":"2025","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118224_bib137","article-title":"DS86760016, a Leucyl-tRNA synthetase inhibitor, is active against Mycobacterium abscessus, antimicrob","volume":"67","author":"Quang","year":"2023","journal-title":"Agents Chemother."},{"key":"10.1016\/j.ejmech.2025.118224_bib138","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009965","article-title":"Efficacy of epetraborole against Mycobacterium abscessus is increased with norvaline","volume":"17","author":"Sullivan","year":"2021","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ejmech.2025.118224_bib139","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms9071408","article-title":"Identification of resistance determinants for a promising antileishmanial oxaborole series","volume":"9","author":"Van den Kerkhof","year":"2021","journal-title":"Microorganisms"},{"key":"10.1016\/j.ejmech.2025.118224_bib140","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26113309","article-title":"Organoboron compounds: effective antibacterial and antiparasitic agents","volume":"26","author":"Coghi","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2025.118224_bib141","doi-asserted-by":"crossref","first-page":"5510","DOI":"10.1038\/s41598-022-09392-6","article-title":"Structural basis to repurpose boron-based proteasome inhibitors Bortezomib and Ixazomib as \u03b2-lactamase inhibitors","volume":"12","author":"Perbandt","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2025.118224_bib142","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/0002-9343(60)90082-6","article-title":"A study of the inverse relationship between pKa and rate of renal excretion of phenylbutazone analogs in man and dog","volume":"29","author":"Gutman","year":"1960","journal-title":"Am. J. Med."},{"key":"10.1016\/j.ejmech.2025.118224_bib143","doi-asserted-by":"crossref","first-page":"9371","DOI":"10.1021\/acs.jmedchem.4c03093","article-title":"Strategic design and optimization of umifenovir analogues: balancing antiviral efficacy and hERG toxicity against SARS-CoV-2","volume":"68","author":"Hoque","year":"2025","journal-title":"J. Med. Chem."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523425009894?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523425009894?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T23:19:19Z","timestamp":1773184759000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523425009894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":140,"alternative-id":["S0223523425009894"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2025.118224","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Benzoxaboroles in medicinal chemistry: A structure-guided perspective on next-generation therapeutics","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2025.118224","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118224"}}