{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:07:15Z","timestamp":1787756835495,"version":"build-2784847793"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005693","name":"Hainan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204193"],"award-info":[{"award-number":["82204193"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.ejmech.2025.118270","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:22:48Z","timestamp":1761697368000},"page":"118270","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"P1","title":["Design, synthesis, and induction of tumor ferroptosis activity of a novel FSP1 protein degrading agent"],"prefix":"10.1016","volume":"302","author":[{"given":"Yanhong","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinzhuo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunkai","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1603-7142","authenticated-orcid":false,"given":"Congjun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2025.118270_bib1","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41580-024-00703-5","article-title":"The cell biology of ferroptosis","volume":"25","author":"Dixon","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejmech.2025.118270_bib2","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.ejmech.2025.118270_bib3","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s41392-024-01969-z","article-title":"Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects","volume":"9","author":"Ru","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.ejmech.2025.118270_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.pscia.2025.100088","article-title":"Enhancing ferroptosis and inhibiting ABCB1 make the novel aldose reductase inhibitor 5F-E a promising sensitizer in liver cancer","author":"Zheng","year":"2025","journal-title":"Pharmaceutical Science Advances"},{"key":"10.1016\/j.ejmech.2025.118270_bib5","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.jconrel.2024.07.063","article-title":"\u201cAll-in-one\u201d metal polyphenol network nanocapsules integrated microneedle patches for lipophagy fueled ferroptosis-mediated multimodal therapy","volume":"373","author":"Wang","year":"2024","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejmech.2025.118270_bib6","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1021\/acs.jnatprod.2c01022","article-title":"Structure revisions of phenolic bisabolane sesquiterpenes and a ferroptosis inhibitor from the marine-derived fungus Aspergillus versicolor YPH93","volume":"86","author":"Li","year":"2023","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.ejmech.2025.118270_bib7","doi-asserted-by":"crossref","first-page":"277","DOI":"10.7150\/thno.101001","article-title":"A STING agonist prodrug reprograms tumor-associated macrophage to boost colorectal cancer immunotherapy","volume":"15","author":"Deng","year":"2025","journal-title":"Theranostics"},{"key":"10.1016\/j.ejmech.2025.118270_bib8","article-title":"New-onset age of metabolic-associated fatty liver disease and incident cardiovascular diseases: findings from prospective cohort","volume":"2","author":"Zheng","year":"2024","journal-title":"Innovat. Med."},{"key":"10.1016\/j.ejmech.2025.118270_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107115","article-title":"A novel mitochondria-targeting DHODH inhibitor induces robust ferroptosis and alleviates immune suppression","volume":"202","author":"Hai","year":"2024","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejmech.2025.118270_bib10","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41586-019-1707-0","article-title":"FSP1 is a glutathione-independent ferroptosis suppressor","volume":"575","author":"Doll","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2025.118270_bib11","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/s41586-019-1705-2","article-title":"The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis","volume":"575","author":"Bersuker","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2025.118270_bib12","doi-asserted-by":"crossref","first-page":"3309","DOI":"10.1021\/acs.jmedchem.4c02530","article-title":"Development of a highly selective ferroptosis inducer targeting GPX4 with 2-Ethynylthiazole-4-carboxamide as Electrophilic warhead","volume":"68","author":"Gu","year":"2025","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118270_bib13","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/s41418-022-01096-8","article-title":"Elevated FSP1 protects KRAS-mutated cells from ferroptosis during tumor initiation","volume":"30","author":"M\u00fcller","year":"2023","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ejmech.2025.118270_bib14","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.molmed.2023.05.013","article-title":"FSP1: a key regulator of ferroptosis","volume":"29","author":"Li","year":"2023","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.ejmech.2025.118270_bib15","doi-asserted-by":"crossref","first-page":"13312","DOI":"10.1021\/acs.jmedchem.1c00569","article-title":"Discovery of a potent glutathione peroxidase 4 inhibitor as a selective ferroptosis inducer","volume":"64","author":"Xu","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118270_bib16","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jcmgh.2023.03.001","article-title":"Ferroptosis suppressor protein 1 inhibition promotes tumor ferroptosis and anti-tumor immune responses in liver cancer","volume":"16","author":"Cheu","year":"2023","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ejmech.2025.118270_bib17","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/s41586-023-06255-6","article-title":"Phase separation of FSP1 promotes ferroptosis","volume":"619","author":"Nakamura","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2025.118270_bib18","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1021\/acschembio.2c00028","article-title":"Identification of a small molecule that enhances ferroptosis via inhibition of ferroptosis suppressor protein 1 (FSP1)","volume":"17","author":"Yoshioka","year":"2022","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.ejmech.2025.118270_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.117737","article-title":"Design, synthesis and biological evaluation of triazolothiadiazole derivatives as FSP1 inhibitors for sensitizing cancer cells to ferroptosis","volume":"293","author":"Liu","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118270_bib20","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/s41586-023-06255-6","article-title":"Phase separation of FSP1 promotes ferroptosis","volume":"619","author":"Nakamura","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2025.118270_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.115015","article-title":"Targeting ferroptosis: paving new roads for drug design and discovery","volume":"247","author":"Gu","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118270_bib22","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.chembiol.2023.04.007","article-title":"Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis","volume":"30","author":"Hendricks","year":"2023","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.ejmech.2025.118270_bib23","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1016\/j.apsb.2024.03.015","article-title":"Idebenone alleviates doxorubicin-induced cardiotoxicity by stabilizing FSP1 to inhibit ferroptosis","volume":"14","author":"Qiu","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.ejmech.2025.118270_bib24","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1038\/s41594-023-01145-x","article-title":"FSP1 inhibition: pick your pocket","volume":"30","author":"Bebber","year":"2023","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.ejmech.2025.118270_bib25","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1038\/s41594-023-01136-y","article-title":"Integrated chemical and genetic screens unveil FSP1 mechanisms of ferroptosis regulation","volume":"30","author":"Nakamura","year":"2023","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.ejmech.2025.118270_bib26","article-title":"PROTAC degraders of FSP1 act as potent GPX4 sensitizers to induce ferroptosis for hepatoma treatment","author":"Zhu","year":"2025","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.ejmech.2025.118270_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.117539","article-title":"Discovery of novel rigid STING PROTAC degraders as potential therapeutics for acute kidney injury","volume":"290","author":"Ma","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118270_bib28","article-title":"Proteolysis-targeting chimera (PROTAC) for targeted protein degradation and cancer therapy","volume":"13","author":"Xin","year":"2020","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.ejmech.2025.118270_bib29","article-title":"PROTAC targeted protein degraders: the past is prologue","volume":"21","author":"Mikl\u00f3s","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejmech.2025.118270_bib30","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/s41556-022-00850-x","article-title":"EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis","volume":"24","author":"Wang","year":"2022","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ejmech.2025.118270_bib31","article-title":"Chemically induced degradation of epigenetic targets","volume":"52","author":"Md","year":"2023","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.ejmech.2025.118270_bib32","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1016\/j.bmc.2011.05.013","article-title":"Inhibition of the cellular function of perforin by 1-amino-2,4-dicyanopyrido[1,2-a]benzimidazoles","volume":"19","author":"Lyons","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118270_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111867","article-title":"Design, synthesis and biological evaluation of new Axl kinase inhibitors containing 1,3,4-oxadiazole acetamide moiety as novel linker","volume":"186","author":"Xu","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118270_bib34","doi-asserted-by":"crossref","first-page":"6092","DOI":"10.1021\/ja311795d","article-title":"A comprehensive mathematical model for three-body binding equilibria","volume":"135","author":"Douglass","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2025.118270_bib35","doi-asserted-by":"crossref","first-page":"13516","DOI":"10.1021\/acs.jmedchem.5c00229","article-title":"Azoacetylene electrophiles for proteome-wide ligand and target discovery: supporting targeted protein degradation","volume":"68","author":"Du","year":"2025","journal-title":"J. Med. Chem."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523425010359?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523425010359?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T21:31:34Z","timestamp":1764624694000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523425010359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":35,"alternative-id":["S0223523425010359"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2025.118270","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis, and induction of tumor ferroptosis activity of a novel FSP1 protein degrading agent","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2025.118270","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118270"}}