{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T10:31:35Z","timestamp":1779100295042,"version":"3.51.4"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2025A1515012144"],"award-info":[{"award-number":["2025A1515012144"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304274"],"award-info":[{"award-number":["82304274"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473788"],"award-info":[{"award-number":["82473788"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.ejmech.2025.118294","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T07:58:19Z","timestamp":1761379099000},"page":"118294","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"P1","title":["Design, synthesis and biological evaluation of novel coumarin derivatives as Pseudomonas aeruginosa biofilm inhibitors"],"prefix":"10.1016","volume":"302","author":[{"given":"Wenqian","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiantian","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenmeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyang","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pinghua","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8741-4219","authenticated-orcid":false,"given":"Feng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2025.118294_bib1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0140-6736(24)02081-6","article-title":"Multidrug-resistant gram-negative bacterial infections","volume":"405","author":"Macesic","year":"2025","journal-title":"Lancet"},{"key":"10.1016\/j.ejmech.2025.118294_bib2","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","article-title":"Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis","volume":"399","author":"Collaborators","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.ejmech.2025.118294_bib3","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1021\/acs.jmedchem.1c01781","article-title":"New Pqs quorum sensing system inhibitor as an antibacterial synergist against multidrug-resistant Pseudomonas aeruginosa","volume":"65","author":"Liu","year":"2022","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118294_bib4","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/s41579-020-00477-5","article-title":"Pseudomonas aeruginosa adaptation and evolution in patients with cystic fibrosis","volume":"19","author":"Rossi","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ejmech.2025.118294_bib5","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1056\/NEJMra0800353","article-title":"Infection in the pathogenesis and course of chronic obstructive pulmonary disease","volume":"359","author":"Sethi","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejmech.2025.118294_bib6","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2209383119","article-title":"Catheter-associated urinary tract infection by Pseudomonas aeruginosa progresses through acute and chronic phases of infection","volume":"119","author":"Mekonnen","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejmech.2025.118294_bib7","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.tim.2011.04.005","article-title":"Pseudomonas aeruginosa: all roads lead to resistance","volume":"19","author":"Breidenstein","year":"2011","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.ejmech.2025.118294_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232415779","article-title":"Role of efflux pumps on antimicrobial resistance in Pseudomonas aeruginosa","volume":"23","author":"Lorusso","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2025.118294_bib9","article-title":"\u03b2-Lactamase diversity in Pseudomonas aeruginosa","volume":"69","author":"Mack Andrew","year":"2025","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2025.118294_bib10","doi-asserted-by":"crossref","first-page":"10921","DOI":"10.1021\/acs.jmedchem.0c00763","article-title":"Novel 2-substituted 3-hydroxy-1,6-dimethylpyridin-4(1H)-ones as dual-acting biofilm inhibitors of Pseudomonas aeruginosa","volume":"63","author":"Liu","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118294_bib11","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/s41579-022-00682-4","article-title":"Tolerance and resistance of microbial biofilms","volume":"20","author":"Ciofu","year":"2022","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ejmech.2025.118294_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115665","article-title":"Design, synthesis and biological evaluation of novel 3-hydroxypyridin-4(1H)-ones based hybrids as Pseudomonas aeruginosa biofilm inhibitors","volume":"259","author":"Liu","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118294_bib13","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/s41579-022-00767-0","article-title":"The biofilm life cycle: expanding the conceptual model of biofilm formation","volume":"20","author":"Sauer","year":"2022","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ejmech.2025.118294_bib14","doi-asserted-by":"crossref","first-page":"4934","DOI":"10.1016\/j.apsb.2024.08.002","article-title":"Novel benzothiazole derivatives target the Gac\/Rsm two-component system as antibacterial synergists against Pseudomonas aeruginosa infections","volume":"14","author":"Liu","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.ejmech.2025.118294_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0304491","article-title":"The interplay of Pseudomonas aeruginosa and Staphylococcus aureus in dual-species biofilms impacts development, antibiotic resistance and virulence of biofilms in in vitro wound infection models","volume":"19","author":"Vestweber","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.ejmech.2025.118294_bib16","doi-asserted-by":"crossref","first-page":"6210","DOI":"10.1021\/acs.jmedchem.4c02517","article-title":"Hybrid molecules of benzothiazole and hydroxamic acid as dual-acting biofilm inhibitors with antibacterial synergistic effect against Pseudomonas aeruginosa infections","volume":"68","author":"Zhang","year":"2025","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118294_bib17","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/nrmicro.2016.89","article-title":"Quorum sensing signal-response systems in gram-negative bacteria","volume":"14","author":"Papenfort","year":"2016","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ejmech.2025.118294_bib18","doi-asserted-by":"crossref","first-page":"10385","DOI":"10.1021\/acs.jmedchem.8b00540","article-title":"Pseudomonas aeruginosa quorum sensing systems as drug discovery targets: current position and future perspectives","volume":"61","author":"Soukarieh","year":"2018","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118294_bib19","doi-asserted-by":"crossref","first-page":"5929","DOI":"10.1021\/acs.jmedchem.5b01698","article-title":"Novel strategies for the treatment of Pseudomonas aeruginosa infections","volume":"59","author":"Wagner","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118294_bib20","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/jobm.201600175","article-title":"Crataeva nurvala nanoparticles inhibit virulence factors and biofilm formation in clinical isolates of Pseudomonas aeruginosa","volume":"57","author":"Ali","year":"2017","journal-title":"J. Basic Microbiol."},{"key":"10.1016\/j.ejmech.2025.118294_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115972","article-title":"Novel igustilide derivatives target quorum sensing system LasR\/LasB and relieve inflammatory response against Pseudomonas aeruginosa infection","volume":"263","author":"Liu","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118294_bib22","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1021\/acschembio.8b00577","article-title":"Structure\u2013function analyses of the N-butanoyl L-homoserine lactone quorum-sensing signal define features critical to activity in RhlR","volume":"13","author":"Boursier","year":"2018","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.ejmech.2025.118294_bib23","doi-asserted-by":"crossref","first-page":"6271","DOI":"10.1007\/s00253-019-09878-w","article-title":"Metabolomic analysis of quorum sensing inhibitor hordenine on Pseudomonas aeruginosa","volume":"103","author":"Zhou","year":"2019","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.ejmech.2025.118294_bib24","doi-asserted-by":"crossref","first-page":"14735","DOI":"10.1021\/acs.jmedchem.3c01268","article-title":"Novel coumarin derivatives inhibit the quorum sensing system and iron homeostasis as antibacterial synergists against Pseudomonas aeruginosa","volume":"66","author":"Liu","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118294_bib25","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1073\/pnas.0307694100","article-title":"Analysis of Pseudomonas aeruginosa 4-hydroxy-2-alkylquinolines (HAQs) reveals a role for 4-hydroxy-2-heptylquinoline in cell-to-cell communication","volume":"101","author":"D\u00e9ziel","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejmech.2025.118294_bib26","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.3390\/biom8020029","article-title":"Critical assessment of methods to quantify biofilm growth and evaluate antibiofilm activity of host defence peptides","volume":"8","author":"Haney","year":"2018","journal-title":"Biomolecules"},{"key":"10.1016\/j.ejmech.2025.118294_bib27","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/35023079","article-title":"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen","volume":"406","author":"Stover","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2025.118294_bib28","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s13238-014-0100-x","article-title":"The hierarchy quorum sensing network in Pseudomonas aeruginosa","volume":"6","author":"Lee","year":"2015","journal-title":"Protein Cell"},{"key":"10.1016\/j.ejmech.2025.118294_bib29","doi-asserted-by":"crossref","first-page":"680","DOI":"10.3390\/pathogens3030680","article-title":"Pseudomonas aeruginosa diversification during infection development in cystic fibrosis lungs-a review","volume":"3","author":"Sousa","year":"2014","journal-title":"Pathogens"},{"key":"10.1016\/j.ejmech.2025.118294_bib30","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/nrmicro2695","article-title":"Should we stay or should we go: mechanisms and ecological consequences for biofilm dispersal","volume":"10","author":"McDougald","year":"2012","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ejmech.2025.118294_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241511895","article-title":"Transcriptional regulators controlling virulence in Pseudomonas aeruginosa","volume":"24","author":"S\u00e1nchez-Jim\u00e9nez","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2025.118294_bib32","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.3390\/microorganisms10051026","article-title":"Lactiplantibacillus plantarum-derived biosurfactant attenuates quorum sensing-mediated virulence and biofilm formation in Pseudomonas aeruginosa and chromobacterium violaceum","volume":"10","author":"Patel","year":"2022","journal-title":"Microorganisms"},{"key":"10.1016\/j.ejmech.2025.118294_bib33","doi-asserted-by":"crossref","first-page":"3128","DOI":"10.3390\/ijms22063128","article-title":"Pseudomonas aeruginosa: an audacious pathogen with an adaptable arsenal of virulence factors","volume":"22","author":"Jurado-Mart\u00edn","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2025.118294_bib34","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1128\/JB.01140-07","article-title":"Pseudomonas aeruginosa PqsA is an anthranilate-coenzyme a ligase","volume":"190","author":"Coleman","year":"2008","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ejmech.2025.118294_bib35","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1021\/acs.jmedchem.6b01025","article-title":"Disulfide bond-containing ajoene analogues as novel quorum sensing inhibitors of Pseudomonas aeruginosa","volume":"60","author":"Fong","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118294_bib36","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1099\/00221287-148-1-87","article-title":"Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound","volume":"148","author":"Hentzer","year":"2002","journal-title":"Microbiology (Read.)"},{"key":"10.1016\/j.ejmech.2025.118294_bib37","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00253-019-10201-w","article-title":"Regulation and controlling the motility properties of Pseudomonas aeruginosa","volume":"104","author":"Khan","year":"2020","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.ejmech.2025.118294_bib38","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1146\/annurev-micro-092611-150055","article-title":"Pseudomonas aeruginosa twitching motility: type IV pili in action","volume":"66","author":"Burrows","year":"2012","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.ejmech.2025.118294_bib39","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/cbdd.12478","article-title":"Antibiotic adjuvants: diverse strategies for controlling drug-resistant pathogens","volume":"85","author":"Gill","year":"2015","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.ejmech.2025.118294_bib40","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.drup.2011.02.001","article-title":"Fighting bacterial infections-future treatment options","volume":"14","author":"Fernebro","year":"2011","journal-title":"Drug Resist Updat"},{"key":"10.1016\/j.ejmech.2025.118294_bib41","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1093\/cid\/cit223","article-title":"Effect of adequate single-drug vs combination antimicrobial therapy on mortality in Pseudomonas aeruginosa bloodstream infections: a post Hoc analysis of a prospective cohort","volume":"57","author":"Pe\u00f1a","year":"2013","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ejmech.2025.118294_bib42","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s11096-015-0067-6","article-title":"Risk factors associated with unfavorable short-term treatment outcome in patients with documented Pseudomonas aeruginosa infection","volume":"37","author":"DiMondi","year":"2015","journal-title":"Int. J. Clin. Pharm."},{"key":"10.1016\/j.ejmech.2025.118294_bib43","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1086\/313677","article-title":"New uses for new and old quinolones and the challenge of resistance","volume":"30","author":"Hooper","year":"2000","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ejmech.2025.118294_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.782733","article-title":"Galleria mellonella as a suitable model of bacterial infection: past, present and future","volume":"11","author":"M\u00e9nard","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.ejmech.2025.118294_bib45","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1146\/annurev.cellbio.21.012704.131001","article-title":"Quorum sensing: cell-to-cell communication in bacteria","volume":"21","author":"Waters","year":"2005","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.ejmech.2025.118294_bib46","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.3390\/molecules25102283","article-title":"Calpurnia aurea (Aiton) benth extracts reduce quorum sensing controlled virulence factors in Pseudomonas aeruginosa","volume":"25","author":"Cosa","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2025.118294_bib47","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1574-6968.2008.01415.x","article-title":"Biofilm-detached cells, a transition from a sessile to a planktonic phenotype: a comparative study of adhesion and physiological characteristics in Pseudomonas aeruginosa","volume":"290","author":"Rollet","year":"2009","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.ejmech.2025.118294_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.108815","article-title":"Design, synthesis, antibacterial evaluation, and molecular modelling studies of 1,2,3-triazole-linked coumarin-vanillin hybrids as potential DNA gyrase and topoisomerase IV inhibitors","volume":"164","author":"Khanna","year":"2025","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2025.118294_bib49","doi-asserted-by":"crossref","first-page":"18823","DOI":"10.1021\/acsomega.1c02046","article-title":"Coumarin exhibits broad-spectrum antibiofilm and antiquorum sensing activity against gram-negative bacteria: in vitro and in silico investigation","volume":"6","author":"Qais","year":"2021","journal-title":"ACS Omega"},{"key":"10.1016\/j.ejmech.2025.118294_bib50","doi-asserted-by":"crossref","DOI":"10.1080\/20002297.2022.2055523","article-title":"Anti-biofilm activities of coumarin as quorum sensing inhibitor for Porphyromonas gingivalis","volume":"14","author":"He","year":"2022","journal-title":"J. Oral Microbiol."},{"key":"10.1016\/j.ejmech.2025.118294_bib51","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.biotechadv.2018.11.013","article-title":"Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies","volume":"37","author":"Pang","year":"2019","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.ejmech.2025.118294_bib52","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0966-842X(00)01913-2","article-title":"Mechanisms of biofilm resistance to antimicrobial agents","volume":"9","author":"Mah","year":"2001","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.ejmech.2025.118294_bib53","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nrmicro1557","article-title":"Persister cells, dormancy and infectious disease","volume":"5","author":"Lewis","year":"2007","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ejmech.2025.118294_bib54","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1046\/j.1365-2958.2003.03525.x","article-title":"Biofilm formation by Pseudomonas aeruginosa wild type, flagella and type IV pili mutants","volume":"48","author":"Klausen","year":"2003","journal-title":"Mol. Microbiol."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523425010591?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523425010591?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T21:31:30Z","timestamp":1764624690000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523425010591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":54,"alternative-id":["S0223523425010591"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2025.118294","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis and biological evaluation of novel coumarin derivatives as Pseudomonas aeruginosa biofilm inhibitors","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2025.118294","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118294"}}