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Chem."},{"issue":"1","key":"10.1016\/j.ejmech.2025.118300_bib86","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1085\/jgp.201311102","article-title":"Nicotine exploits a COPI-mediated process for chaperone-mediated up-regulation of its receptors","volume":"143","author":"Henderson","year":"2014","journal-title":"J. Gen. Physiol."},{"issue":"4","key":"10.1016\/j.ejmech.2025.118300_bib87","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.bcp.2015.07.028","article-title":"Allosteric modulation of nicotinic acetylcholine receptors","volume":"97","author":"Chatzidaki","year":"2015","journal-title":"Biochem. 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Chem."},{"key":"10.1016\/j.ejmech.2025.118300_bib96","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.drugalcdep.2015.06.005","article-title":"Effects of nicotine and minor tobacco alkaloids on intracranial-self-stimulation in rats","volume":"153","author":"Harris","year":"2015","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.ejmech.2025.118300_bib97","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2019.112187","article-title":"An electrophysiological characterization of naturally occurring tobacco alkaloids and their action on human \u03b14\u03b22 and \u03b17 nicotinic acetylcholine receptors","volume":"170","author":"Alijevic","year":"2020","journal-title":"Phytochemistry"},{"issue":"5","key":"10.1016\/j.ejmech.2025.118300_bib98","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1080\/14786410600604583","article-title":"Epibatidine and its analogues as nicotinic acetylcholine receptor agonist: an update","volume":"20","author":"Yogeeswari","year":"2006","journal-title":"Nat. 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