{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T10:57:00Z","timestamp":1794481020739,"version":"4.9.1"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373843"],"award-info":[{"award-number":["82373843"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82404584"],"award-info":[{"award-number":["82404584"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016067","name":"Shaanxi Administration of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["2022-SLRH-YQ-009"],"award-info":[{"award-number":["2022-SLRH-YQ-009"]}],"id":[{"id":"10.13039\/100016067","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016067","name":"Shaanxi Administration of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["2025-ZY-004"],"award-info":[{"award-number":["2025-ZY-004"]}],"id":[{"id":"10.13039\/100016067","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016067","name":"Shaanxi Administration of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["2025-CXTD-07"],"award-info":[{"award-number":["2025-CXTD-07"]}],"id":[{"id":"10.13039\/100016067","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011710","name":"Shaanxi Province Department of Science and Technology","doi-asserted-by":"publisher","award":["2024CY-JJQ-73"],"award-info":[{"award-number":["2024CY-JJQ-73"]}],"id":[{"id":"10.13039\/501100011710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011710","name":"Shaanxi Province Department of Science and Technology","doi-asserted-by":"publisher","award":["2024NC-YBXM-100"],"award-info":[{"award-number":["2024NC-YBXM-100"]}],"id":[{"id":"10.13039\/501100011710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011710","name":"Shaanxi Province Department of Science and Technology","doi-asserted-by":"publisher","award":["2024SF-GJHX-12"],"award-info":[{"award-number":["2024SF-GJHX-12"]}],"id":[{"id":"10.13039\/501100011710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011710","name":"Shaanxi Province Department of Science and Technology","doi-asserted-by":"publisher","award":["S2024-YF-ZDCXL-ZDLSF-0008"],"award-info":[{"award-number":["S2024-YF-ZDCXL-ZDLSF-0008"]}],"id":[{"id":"10.13039\/501100011710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011710","name":"Shaanxi Province Department of Science and Technology","doi-asserted-by":"publisher","award":["2025QCY-KXJ-107"],"award-info":[{"award-number":["2025QCY-KXJ-107"]}],"id":[{"id":"10.13039\/501100011710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011710","name":"Shaanxi Province Department of Science and Technology","doi-asserted-by":"publisher","award":["2024CY-JJQ-52"],"award-info":[{"award-number":["2024CY-JJQ-52"]}],"id":[{"id":"10.13039\/501100011710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011710","name":"Shaanxi Province Department of Science and Technology","doi-asserted-by":"publisher","award":["2023-ZDLNY-17"],"award-info":[{"award-number":["2023-ZDLNY-17"]}],"id":[{"id":"10.13039\/501100011710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011710","name":"Shaanxi Province Department of Science and Technology","doi-asserted-by":"publisher","award":["2 025QCY-KXJ-102"],"award-info":[{"award-number":["2 025QCY-KXJ-102"]}],"id":[{"id":"10.13039\/501100011710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011710","name":"Shaanxi Province Department of Science and Technology","doi-asserted-by":"publisher","award":["2024 PT-ZCK-20"],"award-info":[{"award-number":["2024 PT-ZCK-20"]}],"id":[{"id":"10.13039\/501100011710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.ejmech.2025.118316","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:05:50Z","timestamp":1761869150000},"page":"118316","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"P2","title":["Conformationally restricted pleuromutilins via a pyridinyl-amide tether bias peptidyl transferase center engagement enabling broad-spectrum potency against multidrug-resistant bacteria"],"prefix":"10.1016","volume":"302","author":[{"given":"Lansheng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingxing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengzhou","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7360-8998","authenticated-orcid":false,"given":"Chengyuan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2025.118316_bib1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","article-title":"Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis","volume":"399","author":"Murray","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.ejmech.2025.118316_bib2","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/S0140-6736(24)01867-1","article-title":"Global burden of bacterial antimicrobial resistance 1990 \u2013 2021: a systematic analysis with forecasts to 2050","volume":"404","author":"Naghavi","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.ejmech.2025.118316_bib3","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/S1473-3099(24)00176-2","article-title":"Global, regional, and national incidence and mortality burden of non-COVID-19 lower respiratory infections and aetiologies, 1990 \u2013 2021: a systematic analysis from the global burden of disease study 2021","volume":"24","author":"Bender","year":"2024","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.ejmech.2025.118316_bib4","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/S1473-3099(24)00158-0","article-title":"Global burden associated with 85 pathogens in 2019: a systematic analysis for the global burden of disease study 2019","volume":"24","author":"Naghavi","year":"2024","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.ejmech.2025.118316_bib5","doi-asserted-by":"crossref","first-page":"10557","DOI":"10.1021\/acs.jmedchem.1c00480","article-title":"Current landscape and future perspective of oxazolidinone scaffolds containing antibacterial drugs","volume":"64","author":"Zhao","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118316_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156038","article-title":"Antibacterial effect and mechanisms of action of forsythoside B, alone and in combination with antibiotics, against Acinetobacter baumannii and Pseudomonas aeruginosa","volume":"135","author":"Shi","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ejmech.2025.118316_bib7","doi-asserted-by":"crossref","DOI":"10.1128\/cmr.00148-22","article-title":"Virulence attributes of successful methicillin-resistant Staphylococcus aureus lineages","volume":"36","author":"Jiang","year":"2023","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.ejmech.2025.118316_bib8","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41586-021-04265-w","article-title":"Emergence of methicillin resistance predates the clinical use of antibiotics","volume":"602","author":"Larsen","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2025.118316_bib9","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/s41579-021-00649-x","article-title":"Antibiotic resistance in the environment","volume":"20","author":"Larsson","year":"2022","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ejmech.2025.118316_bib10","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1126\/science.adk8013","article-title":"An antibiotic preorganized for ribosomal binding overcomes antimicrobial resistance","volume":"383","author":"Wu","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2025.118316_bib11","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1021\/acsinfecdis.4c00218","article-title":"A review of antibacterial candidates with new modes of action","volume":"10","author":"Butler","year":"2024","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.ejmech.2025.118316_bib12","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/s00203-023-03699-2","article-title":"A review of current antibiotic resistance and promising antibiotics with novel modes of action to combat antibiotic resistance","volume":"205","author":"Chen","year":"2023","journal-title":"Arch. Microbiol."},{"key":"10.1016\/j.ejmech.2025.118316_bib13","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/s41570-021-00313-1","article-title":"Towards the sustainable discovery and development of new antibiotics","volume":"5","author":"Miethke","year":"2021","journal-title":"Nat. Rev. Chem"},{"key":"10.1016\/j.ejmech.2025.118316_bib14","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1073\/pnas.37.9.570","article-title":"Antibiotic substances from basidiomycetes: VIII. Pleurotus multilus (Fr.) Sacc. and Pleurotus Passeckerianus Pilat","volume":"37","author":"Kavanagh","year":"1951","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.ejmech.2025.118316_bib15","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1073\/pnas.38.7.555","article-title":"Antibiotic substances from basidiomycetes: IX. Drosophila Subtarata. (Batsch Ex Fr.) Quel","volume":"38","author":"Kavanagh","year":"1952","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.ejmech.2025.118316_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116313","article-title":"Recent advances in developing modified C14 side chain pleuromutilins as novel antibacterial agents","volume":"269","author":"Liu","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118316_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115653","article-title":"Design, synthesis, and evaluation of novel pleuromutilin aryl acrylate derivatives as promising broad-spectrum antibiotics especially for combatting multi-drug resistant gram-negative bacteria","volume":"259","author":"Li","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118316_bib18","doi-asserted-by":"crossref","first-page":"4772","DOI":"10.1021\/jm500312x","article-title":"Design, synthesis, and structure-activity relationship studies of novel thioether pleuromutilin derivatives as potent antibacterial agents","volume":"57","author":"Ling","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118316_bib19","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.3382\/ps\/pex105","article-title":"Efficacy of tiamulin alone or in combination with chlortetracycline against experimental Mycoplasma gallisepticum infection in chickens","volume":"96","author":"Garmyn","year":"2017","journal-title":"Poult. Sci."},{"key":"10.1016\/j.ejmech.2025.118316_bib20","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1128\/AAC.7.5.517","article-title":"In vivo efficacy of 81.723 hfu, a new pleuromutilin derivative against experimentally induced airsacculitis in chicks and Turkey poults","volume":"7","author":"Laber","year":"1975","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2025.118316_bib21","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1177\/1060028020932521","article-title":"Lefamulin: the first systemic pleuromutilin antibiotic","volume":"54","author":"Chahine","year":"2020","journal-title":"Ann. Pharmacother."},{"key":"10.1016\/j.ejmech.2025.118316_bib22","doi-asserted-by":"crossref","first-page":"5061","DOI":"10.1021\/acs.jmedchem.2c02135","article-title":"Discovery of quaternized pyridine-thiazole-pleuromutilin derivatives with broad-spectrum antibacterial and potent Anti-MRSA activity","volume":"66","author":"Xia","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118316_bib23","doi-asserted-by":"crossref","first-page":"9479","DOI":"10.1021\/acs.jmedchem.5c00152","article-title":"Linker and head-group exploration of Anti-MRSA triaromatic pleuromutilins","volume":"68","author":"Heidtmann","year":"2025","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118316_bib24","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a027110","article-title":"Pleuromutilins: potent drugs for resistant bugs-mode of action and resistance","volume":"7","author":"Paukner","year":"2017","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.ejmech.2025.118316_bib25","doi-asserted-by":"crossref","first-page":"3335","DOI":"10.1021\/acs.jmedchem.4c02557","article-title":"Kidney targeting smart antibiotic discovery: multimechanism pleuromutilins for pyelonephritis therapy","volume":"68","author":"Tian","year":"2025","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118316_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.117731","article-title":"Discovery of novel triphenylphosphonium conjugated pleuromutilin with enhanced anti-MRSA effect and broaden antibacterial spectrum","volume":"294","author":"Feng","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118316_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.118037","article-title":"Design, synthesis, and bioactivity of newly potent pleuromutilin derivatives","volume":"298","author":"Li","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118316_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116745","article-title":"Novel pleuromutilin derivatives conjugated with phenyl-sulfide and boron-containing moieties as potent antibacterial agents against antibiotic-resistant bacteria","volume":"277","author":"Luo","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118316_bib29","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1128\/AAC.7.5.507","article-title":"Antimicrobial activities of 81.723 hfu, a new pleuromutilin derivative","volume":"7","author":"Drews","year":"1975","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2025.118316_bib30","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1128\/AAC.50.1.379-381.2006","article-title":"Comparative in vitro activities of retapamulin (SB-275833) against 141 clinical isolates of Propionibacterium spp., including 117 P. acnes isolates","volume":"50","author":"Goldstein","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2025.118316_bib31","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1128\/AAC.01432-05","article-title":"Activity of retapamulin (SB-275833), a novel pleuromutilin, against selected resistant gram-positive cocci","volume":"50","author":"Jones","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2025.118316_bib32","article-title":"A comprehensive overview of the antibiotics approved in the last two decades: retrospects and prospects","volume":"28","author":"Shi","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2025.118316_bib33","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1749-6632.2011.06219.x","article-title":"Are pleuromutilin antibiotics finally fit for human use?","volume":"1241","author":"Novak","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ejmech.2025.118316_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.117697","article-title":"Conformational restriction enables discovering a series of chroman derivatives as potent and selective NaV1.8 inhibitors with improved pharmacokinetic properties","volume":"293","author":"Li","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118316_bib35","doi-asserted-by":"crossref","first-page":"18828","DOI":"10.1021\/acs.jmedchem.4c01221","article-title":"Structure-guided conformational restriction leading to high-affinity, selective, and cell-active tetrahydroisoquinoline-based noncovalent Keap1-Nrf2 inhibitors","volume":"67","author":"Qin","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118316_bib36","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1016\/j.bmcl.2017.04.079","article-title":"Conformational control in structure-based drug design","volume":"27","author":"Zheng","year":"2017","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.ejmech.2025.118316_bib37","doi-asserted-by":"crossref","first-page":"6840","DOI":"10.1021\/acs.jmedchem.2c00168","article-title":"Conformational constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine derivatives as new fourth-generation epidermal growth factor receptor inhibitors targeting T790M\/C797S mutations","volume":"65","author":"Chen","year":"2022","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118316_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114195","article-title":"Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy","volume":"233","author":"Yin","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118316_bib39","doi-asserted-by":"crossref","first-page":"12681","DOI":"10.1002\/chem.201201211","article-title":"Elucidation of the active conformation of vancomycin dimers with antibacterial activity against vancomycin-resistant bacteria","volume":"18","author":"Nakamura","year":"2012","journal-title":"Chemistry"},{"issue":"4","key":"10.1016\/j.ejmech.2025.118316_bib40","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.02388-17","article-title":"Unraveling the metabolic routes of retapamulin: insights into drug development of pleuromutilins","volume":"62","author":"Sun","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2025.118316_bib41","doi-asserted-by":"crossref","first-page":"11928","DOI":"10.1074\/jbc.RA118.002486","article-title":"Probing the correlation between insulin activity and structural stability through introduction of the rigid A6-A11 bond","volume":"293","author":"Ong","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejmech.2025.118316_bib42","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/s41392-022-00904-4","article-title":"Therapeutic peptides: current applications and future directions","volume":"7","author":"Wang","year":"2022","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.ejmech.2025.118316_bib43","doi-asserted-by":"crossref","first-page":"3587","DOI":"10.1039\/D1TB02757C","article-title":"Recent advances in the design of antimicrobial peptide conjugates","volume":"10","author":"Silva","year":"2022","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.ejmech.2025.118316_bib44","doi-asserted-by":"crossref","first-page":"5699","DOI":"10.1021\/acs.jmedchem.4c03020","article-title":"Discovery of cationic lugdunin derivatives with membrane-disrupting activity against resistant bacteria via radical reactions and amino acid mutations","volume":"68","author":"He","year":"2025","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118316_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.118014","article-title":"Arginine vs tryptophan-based \u03b2-turn in the \u03b2-hairpin antimicrobial peptides: superior antibacterial properties of the arginine-containing \u03b2-turn sequences","volume":"298","author":"Li","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118316_bib46","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.2174\/1389201017666160808160513","article-title":"Cell proliferation and cytotoxicity assays","volume":"17","author":"Adan","year":"2016","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.ejmech.2025.118316_bib47","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1093\/jac\/32.4.519","article-title":"The post-antibiotic effect","volume":"32","author":"MacKenzie","year":"1993","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.ejmech.2025.118316_bib48","doi-asserted-by":"crossref","DOI":"10.1038\/srep39004","article-title":"A novel pleuromutilin antibacterial compound, its binding mode and selectivity mechanism","volume":"6","author":"Eyal","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2025.118316_bib49","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s44259-024-00046-3","article-title":"Mechanisms of antimicrobial resistance in biofilms","volume":"2","author":"Liu","year":"2024","journal-title":"NPJ Antimicrob Resist."},{"key":"10.1016\/j.ejmech.2025.118316_bib50","doi-asserted-by":"crossref","first-page":"801","DOI":"10.3389\/fmicb.2019.00801","article-title":"Optimisation of the protocol for the LIVE\/DEAD(\u00ae) BacLight(TM) bacterial viability kit for rapid determination of bacterial load","volume":"10","author":"Robertson","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ejmech.2025.118316_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113389","article-title":"Hepatic palmitoyl-proteomes and acyl-protein thioesterase protein proximity networks link lipid modification and mitochondria","volume":"42","author":"Speck","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.ejmech.2025.118316_bib52","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/s42003-023-05216-z","article-title":"Induction of open-form bile canaliculus formation by hepatocytes for evaluation of biliary drug excretion","volume":"6","author":"Arakawa","year":"2023","journal-title":"Commun. Biol."},{"key":"10.1016\/j.ejmech.2025.118316_bib53","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1038\/s41467-024-45421-w","article-title":"Detection of senescence using machine learning algorithms based on nuclear features","volume":"15","author":"Duran","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2025.118316_bib54","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0009-3084(94)90035-3","article-title":"Characterization of the steady-state and dynamic fluorescence properties of the potential-sensitive dye bis-(1,3-dibutylbarbituric acid)trimethine oxonol (Dibac4(3)) in model systems and cells","volume":"69","author":"Epps","year":"1994","journal-title":"Chem. Phys. Lipids"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523425010815?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523425010815?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T08:58:08Z","timestamp":1780909088000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523425010815"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":54,"alternative-id":["S0223523425010815"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2025.118316","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Conformationally restricted pleuromutilins via a pyridinyl-amide tether bias peptidyl transferase center engagement enabling broad-spectrum potency against multidrug-resistant bacteria","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2025.118316","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118316"}}