{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T01:16:29Z","timestamp":1793063789506,"version":"4.5.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100022894","name":"All India Institute of Medical Sciences, Jodhpur","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100022894","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["CRG\/2019\/000670"],"award-info":[{"award-number":["CRG\/2019\/000670"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004541","name":"Ministry of Education, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004541","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019497","name":"Indian Institute of Technology Jodhpur","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.ejmech.2025.118522","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T07:40:48Z","timestamp":1766475648000},"page":"118522","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Discovery of a glycosylated colchicine derivative as a neuroprotective agent for ischemic stroke"],"prefix":"10.1016","volume":"304","author":[{"given":"Moumita","family":"Jash","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanju","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubham","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juhee","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surojit","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nehal","family":"Purohit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajsekhar","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Umar","family":"Arshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aniket","family":"Jana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8203-8613","authenticated-orcid":false,"given":"Surajit","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2025.118522_bib1","doi-asserted-by":"crossref","first-page":"S85","DOI":"10.1016\/j.wneu.2011.07.023","article-title":"Epidemiology and the global burden of stroke","volume":"76","author":"Mukherjee","year":"2011","journal-title":"World Neurosurg."},{"key":"10.1016\/j.ejmech.2025.118522_bib2","first-page":"239","article-title":"Brain natriuretic peptide in patients with acute ischemic stroke: role of statins, biomed","volume":"4","author":"Al-Kuraishy","year":"2020","journal-title":"Biotechnol. Res. J."},{"key":"10.1016\/j.ejmech.2025.118522_bib3","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1007\/s11010-023-04793-1","article-title":"The potential therapeutic effect of phosphodiesterase 5 inhibitors in the acute ischemic stroke (AIS)","volume":"479","author":"AlRuwaili","year":"2024","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.ejmech.2025.118522_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/biom14030305","article-title":"Understanding the pathophysiology of ischemic stroke: the basis of current therapies and opportunity for new ones","volume":"14","author":"Salaudeen","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.ejmech.2025.118522_bib5","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1089\/jmf.2015.3644","article-title":"Therapeutic potential of natural product-based oral nanomedicines for stroke prevention","volume":"19","author":"Mutoh","year":"2016","journal-title":"J. Med. Food"},{"key":"10.1016\/j.ejmech.2025.118522_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107695","article-title":"Natural medicine in neuroprotection for ischemic stroke: challenges and prospective","volume":"216","author":"Tao","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejmech.2025.118522_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.pupt.2021.102008","article-title":"Sequential doxycycline and colchicine combination therapy in Covid-19: the salutary effects","volume":"67","author":"Al-Kuraishy","year":"2021","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.ejmech.2025.118522_bib8","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s11883-025-01291-1","article-title":"Insight into the mechanistic role of Colchicine in atherosclerosis","volume":"27","author":"Al-Kuraishy","year":"2025","journal-title":"Curr. Atheroscler. Rep."},{"key":"10.1016\/j.ejmech.2025.118522_bib9","doi-asserted-by":"crossref","first-page":"9195","DOI":"10.1038\/s41598-022-13133-0","article-title":"Effects of colchicine use on ischemic and hemorrhagic stroke risk in diabetic patients with and without gout","volume":"12","author":"Yeh","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2025.118522_bib10","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1161\/ATVBAHA.124.319851","article-title":"Colchicine's role in cardiovascular disease management","volume":"44","author":"Buckley","year":"2024","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ejmech.2025.118522_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2024.102835","article-title":"Colchicine for secondary prevention of ischaemic stroke and atherosclerotic events: a meta-analysis of randomised trials","volume":"76","author":"Fiolet","year":"2024","journal-title":"eClinicalMedicine"},{"key":"10.1016\/j.ejmech.2025.118522_bib12","doi-asserted-by":"crossref","first-page":"187","DOI":"10.4103\/bc.bc_24_21","article-title":"Colchicine for the prevention of ischemic stroke: an updated meta-analysis of randomized clinical trials","volume":"7","author":"Al-Atta","year":"2021","journal-title":"Brain Circ"},{"key":"10.1016\/j.ejmech.2025.118522_bib13","article-title":"Magnitude of effect of low dose colchicine, a newly food and drug administration approved treatment for stroke prevention","volume":"34","author":"Escalera","year":"2025","journal-title":"J. Stroke Cerebrovasc. Dis. Off. J. Natl. Stroke Assoc."},{"key":"10.1016\/j.ejmech.2025.118522_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2025.1529458","article-title":"Colchicine in stroke prevention: potential benefits and limitations of an anti-inflammatory therapy","volume":"16","author":"Corbali","year":"2025","journal-title":"Front. Neurol."},{"key":"10.1016\/j.ejmech.2025.118522_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26157591","article-title":"Revitalizing colchicine: novel delivery platforms and derivatives to expand its therapeutic potential","volume":"26","author":"V Dubashynskaya","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2025.118522_bib16","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13075-020-2120-7","article-title":"Adverse events during oral colchicine use: a systematic review and meta-analysis of randomised controlled trials","volume":"22","author":"Stewart","year":"2020","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.ejmech.2025.118522_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111788","article-title":"Recent developments on (-)-colchicine derivatives: synthesis and structure-activity relationship","volume":"185","author":"Ghawanmeh","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118522_bib18","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1021\/np070588o","article-title":"Neuroprotective limonoids of root bark of Dictamnus dasycarpus","volume":"71","author":"Yoon","year":"2008","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.ejmech.2025.118522_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28155826","article-title":"Protective effects and mechanisms of pectolinarin against H(2)O(2)-Induced oxidative stress in SH-SY5Y neuronal cells","volume":"28","author":"Pang","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2025.118522_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2023.134662","article-title":"Quantification and visualization of hydrogen peroxide in an ischemic model and serum samples from stroke patients using a reaction-based fluorescence sensor","volume":"397","author":"Lu","year":"2023","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.ejmech.2025.118522_bib21","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1089\/ars.2010.3549","article-title":"Pathophysiologically relevant levels of hydrogen peroxide induce glutamate-independent neurodegeneration that involves activation of transient receptor potential melastatin 7 channels","volume":"14","author":"Coombes","year":"2011","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.ejmech.2025.118522_bib22","doi-asserted-by":"crossref","first-page":"153","DOI":"10.4103\/2394-8108.195279","article-title":"Targeting oxidative stress for the treatment of ischemic stroke: upstream and downstream therapeutic strategies","volume":"2","author":"Li","year":"2016","journal-title":"Brain Circ."},{"key":"10.1016\/j.ejmech.2025.118522_bib23","doi-asserted-by":"crossref","first-page":"4844","DOI":"10.1016\/j.apsb.2025.04.024","article-title":"Discovery of powerful multifaceted antioxidant for combating oxidative stress associated with neurodegenerative disorders","volume":"15","author":"Khan","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.ejmech.2025.118522_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/biot.70064","article-title":"Neuroprotective potential of human platelet lysate in parkinson's disease: insights into oxidative stress, mitochondrial dysfunction, cell death, and reactive gliosis in experimental models","volume":"20","author":"Beura","year":"2025","journal-title":"Biotechnol. J."},{"key":"10.1016\/j.ejmech.2025.118522_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.117471","article-title":"Discovery of potential Leonurine-based therapeutic lead MJ210 attenuates Parkinson's disease pathogenesis via NF-\u03baB and MAPK pathways: mechanistic insights from in vitro and in vivo rotenone models","volume":"289","author":"Gupta","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118522_bib26","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3389\/fphar.2020.00281","article-title":"\u03b1-Cyperone attenuates H(2)O(2)-Induced oxidative stress and apoptosis in SH-SY5Y cells via activation of Nrf2","volume":"11","author":"Huang","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejmech.2025.118522_bib27","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-34455-y","article-title":"Deep analysis of mitochondria and cell health using machine learning","volume":"8","author":"Zahedi","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2025.118522_bib28","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.921","article-title":"Curcumin protects neural cells against ischemic injury in N2a cells and mouse brain with ischemic stroke","volume":"8","author":"Xie","year":"2018","journal-title":"Brain Behav"},{"key":"10.1016\/j.ejmech.2025.118522_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1207748","article-title":"ROS-Responsive exogenous functional mitochondria can rescue neural cells post-ischemic stroke","volume":"11","author":"Li","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ejmech.2025.118522_bib30","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s12031-016-0807-7","article-title":"Neuroserpin Attenuates H(2)O(2)-Induced oxidative stress in hippocampal neurons via AKT and BCL-2 signaling pathways","volume":"61","author":"Cheng","year":"2017","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.ejmech.2025.118522_bib31","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1016\/j.bbamcr.2016.09.012","article-title":"Activation of apoptosis signalling pathways by reactive oxygen species","volume":"1863","author":"Redza-Dutordoir","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejmech.2025.118522_bib32","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/j.biocel.2008.10.029","article-title":"Hydrogen peroxide-induced neuronal apoptosis is associated with inhibition of protein phosphatase 2A and 5, leading to activation of MAPK pathway","volume":"41","author":"Chen","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.ejmech.2025.118522_bib33","doi-asserted-by":"crossref","first-page":"4578","DOI":"10.7150\/ijbs.69892","article-title":"Artemisinin attenuated ischemic stroke induced cell apoptosis through activation of ERK1\/2\/CREB\/BCL-2 signaling pathway in vitro and in vivo","volume":"18","author":"Peng","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.ejmech.2025.118522_bib34","article-title":"MiRNA: involvement of the MAPK pathway in ischemic stroke. A promising therapeutic target","volume":"57","author":"Gugliandolo","year":"2021","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.ejmech.2025.118522_bib35","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.mad.2017.04.001","article-title":"The anti-inflammatory effect of melatonin in SH-SY5Y neuroblastoma cells exposed to sublethal dose of hydrogen peroxide","volume":"164","author":"Nopparat","year":"2017","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.ejmech.2025.118522_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.freeradbiomed.2024.10.216","article-title":"Discovery of gallic acid-based mitochondriotropic antioxidant attenuates LPS-Induced neuroinflammation","author":"Garg","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejmech.2025.118522_bib37","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1021\/acschemneuro.8b00497","article-title":"Power of tyrosine assembly in microtubule stabilization and neuroprotection fueled by phenol appendages","volume":"10","author":"Barman","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.ejmech.2025.118522_bib38","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1021\/acschemneuro.2c00771","article-title":"Vanillin Benzothiazole derivative reduces cellular reactive oxygen species and detects amyloid fibrillar aggregates in alzheimer's disease brain","volume":"14","author":"Gharai","year":"2023","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.ejmech.2025.118522_bib39","doi-asserted-by":"crossref","first-page":"6215","DOI":"10.1007\/s11033-019-05060-7","article-title":"Temporal changes in physiological and molecular markers in various brain regions following transient global ischemia in rats","volume":"46","author":"Kapoor","year":"2019","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.ejmech.2025.118522_bib40","doi-asserted-by":"crossref","DOI":"10.3791\/61865","article-title":"A Murine model of ischemic retinal injury induced by transient bilateral common carotid artery occlusion","author":"Lee","year":"2020","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.ejmech.2025.118522_bib41","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.brainresprot.2003.12.001","article-title":"An optimized triphenyltetrazolium chloride method for identification of cerebral infarcts","volume":"13","author":"Joshi","year":"2004","journal-title":"Brain Res. Brain Res. Protoc."},{"key":"10.1016\/j.ejmech.2025.118522_bib42","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s00210-020-02007-9","article-title":"Pretreatment with bisoprolol and vitamin E alone or in combination provides neuroprotection against cerebral ischemia\/reperfusion injury in rats","volume":"394","author":"Salehi","year":"2021","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.ejmech.2025.118522_bib43","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/3119649","article-title":"Docosahexaenoic acid alleviates brain damage by promoting mitophagy in mice with ischaemic stroke","volume":"2022","author":"Sun","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ejmech.2025.118522_bib44","doi-asserted-by":"crossref","first-page":"9062","DOI":"10.1021\/acs.jmedchem.6b00976","article-title":"A novel parkinson's disease drug candidate with potent anti-neuroinflammatory effects through the src signaling pathway","volume":"59","author":"Wang","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2025.118522_bib45","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci12101287","article-title":"Sucrose preference Test as a measure of anhedonic behavior in a chronic unpredictable mild stress model of depression: outstanding issues","volume":"12","author":"Markov","year":"2022","journal-title":"Brain Sci."},{"key":"10.1016\/j.ejmech.2025.118522_bib46","first-page":"1167","article-title":"Pathogenic mechanisms following ischemic stroke","volume":"38","author":"Khoshnam","year":"2017","journal-title":"Neurol. Sci. Off. J. Ital. Neurol. Soc. Ital. Soc. Clin. Neurophysiol."},{"key":"10.1016\/j.ejmech.2025.118522_bib47","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/s41598-022-27034-9","article-title":"Early evolution of glial morphology and inflammatory cytokines following hypoxic-ischemic injury in the newborn piglet brain","volume":"13","author":"Teo","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2025.118522_bib48","doi-asserted-by":"crossref","DOI":"10.3389\/fmmed.2023.1240862","article-title":"Astrocytes in stroke-induced neurodegeneration: a timeline","volume":"3","author":"Collyer","year":"2023","journal-title":"Front. Mol. Med."},{"key":"10.1016\/j.ejmech.2025.118522_bib49","doi-asserted-by":"crossref","first-page":"246","DOI":"10.4103\/IJCIIS.IJCIIS_7_20","article-title":"Statin therapy associated with decreased neuronal injury measured by serum S100\u03b2 levels in patients with acute ischemic stroke","volume":"11","author":"Al-Kuraishy","year":"2021","journal-title":"Int. J. Crit. Illn. Inj. Sci."},{"key":"10.1016\/j.ejmech.2025.118522_bib50","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3389\/fncel.2018.00106","article-title":"Automated morphological analysis of Microglia after stroke","volume":"12","author":"Heindl","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.ejmech.2025.118522_bib51","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.997786","article-title":"Microglia morphophysiological diversity and its implications for the CNS","volume":"13","author":"Vidal-Itriago","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejmech.2025.118522_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/bc.bc_46_19","article-title":"Role of vinpocetine in ischemic stroke and poststroke outcomes: a critical review","volume":"6","author":"Al-Kuraishy","year":"2020","journal-title":"Brain Circ."},{"key":"10.1016\/j.ejmech.2025.118522_bib53","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1007\/s11064-012-0822-1","article-title":"Protective effect of luteolin in experimental ischemic stroke: upregulated SOD1, CAT, Bcl-2 and claudin-5, down-regulated MDA and Bax expression","volume":"37","author":"Qiao","year":"2012","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ejmech.2025.118522_bib54","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1134\/S1607672924600313","article-title":"Neuroprotective effect of ganoderic acid against focal ischemic stroke induced by Middle cerebral artery occlusion in the rats via suppression of oxidative stress and inflammation","volume":"518","author":"Liu","year":"2024","journal-title":"Dokl. Biochem. Biophys."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523425012875?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523425012875?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T15:28:22Z","timestamp":1773934102000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523425012875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":54,"alternative-id":["S0223523425012875"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2025.118522","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of a glycosylated colchicine derivative as a neuroprotective agent for ischemic stroke","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2025.118522","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"118522"}}