{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T19:00:53Z","timestamp":1780513253410,"version":"3.54.1"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 113-2321-B-A49-004"],"award-info":[{"award-number":["NSTC 113-2321-B-A49-004"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 113-2313-B-A49-002"],"award-info":[{"award-number":["NSTC 113-2313-B-A49-002"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 114-2321-B-A49-001"],"award-info":[{"award-number":["NSTC 114-2321-B-A49-001"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024990","name":"National Yang Ming Chiao Tung University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024990","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010002","name":"Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.ejmech.2026.118568","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T16:12:54Z","timestamp":1767888774000},"page":"118568","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Novel dual-functional peptides designed via NanoBiT spike pseudovirus system for real-time monitoring and inhibition of SARS-CoV-2 infection"],"prefix":"10.1016","volume":"305","author":[{"given":"Cheng-Han","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Hsin","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Rui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu-Ching","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-Hung","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1140-7933","authenticated-orcid":false,"given":"Chih-Sheng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2026.118568_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2020.105924","article-title":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): the epidemic and the challenges","volume":"55","author":"Lai","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.ejmech.2026.118568_bib2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.4103\/jfmpc.jfmpc_839_21","article-title":"SARS, MERS and CoVID-19: an overview and comparison of clinical, laboratory and radiological features","volume":"11","author":"Pustake","year":"2022","journal-title":"J. Fam. Med. Prim. Care"},{"key":"10.1016\/j.ejmech.2026.118568_bib4","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1007\/s11427-021-1964-4","article-title":"Overview of SARS-CoV-2 genome-encoded proteins","volume":"65","author":"Bai","year":"2022","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.ejmech.2026.118568_bib5","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41392-022-00884-5","article-title":"Structural biology of SARS-CoV-2: open the door for novel therapies","volume":"7","author":"Yan","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.ejmech.2026.118568_bib6","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.16234","article-title":"The development and application of pseudoviruses: assessment of SARS-CoV-2 pseudoviruses","volume":"11","author":"Tan","year":"2023","journal-title":"PeerJ"},{"key":"10.1016\/j.ejmech.2026.118568_bib7","doi-asserted-by":"crossref","first-page":"820","DOI":"10.3390\/v15040820","article-title":"DRAVP: a comprehensive database of antiviral peptides and proteins","volume":"15","author":"Liu","year":"2023","journal-title":"Viruses"},{"key":"10.1016\/j.ejmech.2026.118568_bib8","article-title":"Navigating novel uncertainties of COVID-19: the rise of the JN.1 variant","volume":"16","author":"Altamimi","year":"2024","journal-title":"Cureus"},{"key":"10.1016\/j.ejmech.2026.118568_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-68678-z","article-title":"Emergence of SARS-CoV-2 omicron variant JN.1 in Tamil Nadu, India \u2013 clinical characteristics and novel mutations","volume":"14","author":"Selvavinayagam","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2026.118568_bib10","article-title":"1 variant of COVID-19: immune evasion, transmissibility, and implications for global health","volume":"12","author":"Siddiqui","year":"2025","journal-title":"Ther. Adv. Infect. Dis."},{"key":"10.1016\/j.ejmech.2026.118568_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2021.153443","article-title":"Recent advances and challenges of RT-PCR tests for the diagnosis of COVID-19","volume":"221","author":"Teymouri","year":"2021","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.ejmech.2026.118568_bib12","article-title":"Review of COVID-19 testing and diagnostic methods","volume":"44","author":"Filchakova","year":"2022","journal-title":"Talanta"},{"key":"10.1016\/j.ejmech.2026.118568_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2022.106070","article-title":"A comprehensive review of COVID-19 detection techniques: from laboratory systems to wearable devices","volume":"149","author":"Alyafei","year":"2022","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.ejmech.2026.118568_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2024.117629","article-title":"Phage display based biosensing: recent advances and challenges","volume":"173","author":"Wang","year":"2024","journal-title":"TrAC, Trends Anal. Chem."},{"key":"10.1016\/j.ejmech.2026.118568_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2025.117880","article-title":"Recent advances in M13 phage display: novel strategies of construction and biopanning recognition elements for food safety detection","volume":"289","author":"Liu","year":"2025","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.ejmech.2026.118568_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2024.116951","article-title":"A biosensor-based phage display selection method for automated, high-throughput nanobody discovery","volume":"271","author":"De Keyser","year":"2025","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.ejmech.2026.118568_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12929-019-0592-z","article-title":"Development of therapeutic antibodies for the treatment of diseases","volume":"27","author":"Lu","year":"2020","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.ejmech.2026.118568_bib18","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1021\/acsomega.1c04873","article-title":"Phage display-derived peptide for the specific binding of SARS-CoV-2","volume":"7","author":"Yang","year":"2021","journal-title":"ACS Omega"},{"key":"10.1016\/j.ejmech.2026.118568_bib19","doi-asserted-by":"crossref","first-page":"7461","DOI":"10.1021\/jacs.4c15843","article-title":"Identification of covalent cyclic peptide inhibitors targeting protein\u2013protein interactions using phage display","volume":"47","author":"Wang","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2026.118568_bib20","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.3390\/v13061120","article-title":"Discovery of antivirals using phage display","volume":"13","author":"Sokullu","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.ejmech.2026.118568_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.128455","article-title":"Review of phage display: a jack-of-all-trades and master of most biomolecule display","volume":"256","author":"Song","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejmech.2026.118568_bib22","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.3390\/ijms25052935","article-title":"Inhibitory efficacy of main components of Scutellaria baicalensis on the interaction between spike protein of SARS-CoV-2 and human angiotensin-converting enzyme II","volume":"25","author":"Lin","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2026.118568_bib23","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1186\/s12985-025-02839-y","article-title":"Development and characterization of a pseudovirus system for human Aichi virus: in vitro and in vivo analysis","volume":"22","author":"Wu","year":"2025","journal-title":"Virol. J."},{"key":"10.1016\/j.ejmech.2026.118568_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2024.116630","article-title":"Engineering a NanoBiT biosensor for detecting angiotensin-converting enzyme-2 (hACE2) interaction with SARS-CoV-2 spike protein and screening the inhibitors to block hACE2 and spike interaction","volume":"263","author":"Lin","year":"2024","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.ejmech.2026.118568_bib25","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3390\/v17030337","article-title":"Neutralizing antibody screening using NanoBiT-based virus-like particles of foot-and-mouth disease type Asia1 enhances biosafety and sensitivity","volume":"17","author":"Kim","year":"2025","journal-title":"Viruses"},{"key":"10.1016\/j.ejmech.2026.118568_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2025.344623","article-title":"An in vivo NanoBiT-based pseudoviral biosensor for real-time monitoring of SARS-CoV-2 spike\/hACE2 interactions and therapeutic screening","volume":"1376","author":"Lin","year":"2025","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.ejmech.2026.118568_bib27","first-page":"20","article-title":"Using Nano-luciferase binary (NanoBiT) technology to assess the interaction between viral spike protein and angiotensin-converting enzyme II by aptamers","volume":"14","author":"Lin","year":"2025","journal-title":"Biotechnologia"},{"key":"10.1016\/j.ejmech.2026.118568_bib28","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.addr.2020.08.008","article-title":"Recent trends in protein and peptide-based biomaterials for advanced drug delivery","volume":"156","author":"Varanko","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejmech.2026.118568_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115908","article-title":"Highly potent dual-targeting angiotensin-converting enzyme 2 (ACE2) and neuropilin-1 (NRP1) peptides: a promising broad-spectrum therapeutic strategy against SARS-CoV-2 infection","volume":"263","author":"Mei","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118568_bib30","doi-asserted-by":"crossref","first-page":"90","DOI":"10.2144\/btn-2019-0054","article-title":"Hybridoma technology: the preferred method for monoclonal antibody generation for in vivo applications","volume":"67","author":"Zaroff","year":"2019","journal-title":"Biotechniques"},{"key":"10.1016\/j.ejmech.2026.118568_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106639","article-title":"Hybridoma technology: a versatile method for isolation of monoclonal antibodies, its applicability across species, limitations, advancement and future perspectives","volume":"85","author":"Parray","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejmech.2026.118568_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.111258","article-title":"Mice carrying the full-length human immunoglobulin loci produce antigen-specific human antibodies with the lambda light chain","volume":"27","author":"Shimoya","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.ejmech.2026.118568_bib33","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.it.2021.10.008","article-title":"Single B cell technologies for monoclonal antibody discovery","volume":"42","author":"Pedrioli","year":"2021","journal-title":"Trends Immunol."},{"key":"10.1016\/j.ejmech.2026.118568_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109433","article-title":"A SARS-CoV-2 neutralizing antibody selected from COVID-19 patients binds to the ACE2\u2013RBD interface and is tolerant to most known RBD mutations","volume":"36","author":"Bertoglio","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.ejmech.2026.118568_bib35","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/s41589-020-00679-1","article-title":"Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2","volume":"17","author":"Bracken","year":"2021","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.ejmech.2026.118568_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2023.125093","article-title":"Bioscreening specific peptide-expressing phage and its application in sensitive dual-mode immunoassay of SARS-CoV-2 spike antigen","volume":"266","author":"Pang","year":"2024","journal-title":"Talanta"},{"key":"10.1016\/j.ejmech.2026.118568_bib37","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.3390\/v14112402","article-title":"Analysis of compositional bias in a commercial phage display peptide library by next-generation sequencing","volume":"14","author":"Sloth","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.ejmech.2026.118568_bib38","doi-asserted-by":"crossref","first-page":"519","DOI":"10.3390\/diagnostics14050519","article-title":"Advances and challenges in SARS-CoV-2 detection: a review of molecular and serological technologies","volume":"14","author":"El-Daly","year":"2024","journal-title":"Diagnostics"},{"key":"10.1016\/j.ejmech.2026.118568_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.jviromet.2021.114221","article-title":"An optimized and robust SARS-CoV-2 pseudovirus system for viral entry research","volume":"295","author":"Yang","year":"2021","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.ejmech.2026.118568_bib40","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.3390\/ijms22052268","article-title":"Characterization of critical determinants of ACE2\u2013SARS-CoV-2 RBD interaction","volume":"22","author":"Brown","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2026.118568_bib41","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.3390\/v13061055","article-title":"A bioluminescent biosensor for quantifying the interaction of SARS-CoV-2 and its receptor ACE2 in cells and in vitro","volume":"13","author":"Yang","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.ejmech.2026.118568_bib42","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.7150\/thno.68636","article-title":"Phage display derived peptides for Alzheimer's disease therapy and diagnosis","volume":"12","author":"Zhang","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.ejmech.2026.118568_bib43","doi-asserted-by":"crossref","first-page":"811","DOI":"10.3390\/v11090811","article-title":"Long-acting HIV-1 fusion inhibitory peptides and their mechanisms of action","volume":"11","author":"Wang","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.ejmech.2026.118568_bib44","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/s41422-020-0305-x","article-title":"Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion","volume":"30","author":"Xia","year":"2020","journal-title":"Cell Res."},{"key":"10.1016\/j.ejmech.2026.118568_bib45","first-page":"13","article-title":"Tumor-targeting peptides from combinatorial libraries","volume":"110\u2013111","author":"Liu","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejmech.2026.118568_bib46","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.7150\/ijbs.59184","article-title":"Construction and applications of SARS-CoV-2 pseudoviruses: a mini review","volume":"17","author":"Chen","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.ejmech.2026.118568_bib47","doi-asserted-by":"crossref","first-page":"e82","DOI":"10.1016\/S1473-3099(23)00813-7","article-title":"Genotype to phenotype Japan (G2P-Japan) Consortium, J. Zahradnik, J. Ito, K. Sato, Virological characteristics of the SARS-CoV-2 JN.1 variant","volume":"24","author":"Kaku","year":"2024","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.ejmech.2026.118568_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2025.106092","article-title":"Immune evasion of Omicron variants JN.1, KP.2, and KP.3 to the polyclonal and monoclonal antibodies from COVID-19 convalescents and vaccine recipients","volume":"235","author":"Wu","year":"2025","journal-title":"Antivir. Res."},{"key":"10.1016\/j.ejmech.2026.118568_bib49","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.cell.2020.03.045","article-title":"Structural and functional basis of SARS-CoV-2 entry by using human ACE2","volume":"181","author":"Wang","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.ejmech.2026.118568_bib50","doi-asserted-by":"crossref","first-page":"6855","DOI":"10.1038\/s41467-021-27180-0","article-title":"Spike residue 403 affects binding of coronavirus spikes to human ACE2","volume":"12","author":"Zech","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2026.118568_bib51","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.cell.2022.01.001","article-title":"Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2","volume":"185","author":"Han","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.ejmech.2026.118568_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.virol.2024.110383","article-title":"Architects of infection: a structural overview of SARS-related coronavirus spike glycoproteins","volume":"604","author":"Hills","year":"2025","journal-title":"Virology"},{"key":"10.1016\/j.ejmech.2026.118568_bib53","article-title":"ACE2 coding variants in different populations and their potential impact on SARS-CoV-2 binding affinity","author":"Ali","year":"2020","journal-title":"Biochem. Biophys. Rep."},{"key":"10.1016\/j.ejmech.2026.118568_bib54","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.1016\/j.csbj.2025.07.034","article-title":"Stoichiometric insights into SARS-CoV-2 spike\u2013ACE2 binding across variants","volume":"27","author":"Akinwumi","year":"2025","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.ejmech.2026.118568_bib55","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.chom.2024.01.003","article-title":"Evolution of human H3N2 influenza virus receptor specificity has substantially expanded the receptor-binding domain site","volume":"32","author":"Thompson","year":"2024","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.ejmech.2026.118568_bib56","doi-asserted-by":"crossref","DOI":"10.1099\/jgv.0.001951","article-title":"Mapping respiratory syncytial virus fusion protein interactions with the receptor IGF1R and the impact of alanine-scanning mutagenesis on viral infection","volume":"105","author":"Hayes","year":"2024","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.ejmech.2026.118568_bib57","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1038\/s41586-020-2312-y","article-title":"The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice","volume":"583","author":"Bao","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2026.118568_bib58","doi-asserted-by":"crossref","first-page":"5165","DOI":"10.1038\/s41467-020-18880-0","article-title":"ACE2 mouse models: a toolbox for cardiovascular and pulmonary research","volume":"11","author":"Jia","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2026.118568_bib59","doi-asserted-by":"crossref","first-page":"9710","DOI":"10.1038\/s41598-024-60613-6","article-title":"In vivo bioluminescence imaging of the intracerebral fibroin-controlled AAV-\u03b1-synuclein diffusion for monitoring the central nervous system and peripheral expression","volume":"14","author":"Mazzocco","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2026.118568_bib60","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/s41586-025-09332-0","article-title":"Respiratory viral infections awaken metastatic breast cancer cells in lungs","volume":"645","author":"Chia","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2026.118568_bib61","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1013093","article-title":"In vivo Dicer-2 interactome during viral infection reveals novel pro and antiviral factors in Drosophila melanogaster","volume":"21","author":"Rousseau","year":"2025","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ejmech.2026.118568_bib62","doi-asserted-by":"crossref","first-page":"28527","DOI":"10.1021\/acsami.2c03707","article-title":"Peptide binder with high-affinity for the SARS-CoV-2 spike receptor-binding domain","volume":"14","author":"Yu","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ejmech.2026.118568_bib63","article-title":"Virus tracking technologies and their applications in viral life cycle: research advances and future perspectives","volume":"14","author":"Liu","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejmech.2026.118568_bib64","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.3390\/medicina59091554","article-title":"ACE2 and a traditional Chinese medicine formula NRICM101 could alleviate the inflammation and pathogenic process of acute lung injury","volume":"59","author":"Lin","year":"2023","journal-title":"Medicina"},{"key":"10.1016\/j.ejmech.2026.118568_bib65","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3390\/ijms25010329","article-title":"Studying the roles of renin angiotensin system in the accelerating disease of high-fat diet induced diabetic nephropathy by a db\/db and ACE2 double gene knockout mouse model","volume":"25","author":"Chen","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2026.118568_bib66","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1016\/j.fertnstert.2008.09.007","article-title":"Identification of novel peptides specifically binding to endometriosis by screening phage-displaying peptide libraries","volume":"92","author":"Chang","year":"2009","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.ejmech.2026.118568_bib67","doi-asserted-by":"crossref","first-page":"6051","DOI":"10.1021\/acs.chemrev.4c00004","article-title":"Diversification of phage-displayed peptide libraries with noncanonical amino acid mutagenesis and chemical modification","volume":"124","author":"Hampton","year":"2024","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejmech.2026.118568_bib68","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.1054782","article-title":"Advances, applications, and limitations of portable and rapid detection technologies for routinely encountered foodborne pathogens","volume":"13","author":"Quintela","year":"2022","journal-title":"Front. Microbiol."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523426000139?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523426000139?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T01:11:36Z","timestamp":1773537096000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523426000139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":67,"alternative-id":["S0223523426000139"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2026.118568","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel dual-functional peptides designed via NanoBiT spike pseudovirus system for real-time monitoring and inhibition of SARS-CoV-2 infection","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2026.118568","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118568"}}