{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T02:18:48Z","timestamp":1791685128155,"version":"4.3.4"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["GZB20250222"],"award-info":[{"award-number":["GZB20250222"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22376016"],"award-info":[{"award-number":["22376016"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22022601"],"award-info":[{"award-number":["22022601"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.ejmech.2026.118577","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:20:52Z","timestamp":1768004452000},"page":"118577","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Preclinical evaluation of 68Ga-labeled acetazolamide derivatives as radiotracers targeting carbonic anhydrase IX in clear cell renal cell carcinoma"],"prefix":"10.1016","volume":"305","author":[{"given":"Wanjia","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3488-7864","authenticated-orcid":false,"given":"Mengchao","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2026.118577_bib1","unstructured":"Global Cancer Observatory: Cancer Today. Lyon, France: International Agency for Research on Cancer. https:\/\/gco.iarc.who.int\/today. Accessed July 5, 2025."},{"issue":"5","key":"10.1016\/j.ejmech.2026.118577_bib2","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.eururo.2005.11.035","article-title":"2004 WHO classification of the renal tumors of the adults","volume":"49","author":"Lopez-Beltran","year":"2006","journal-title":"Eur. Urol."},{"issue":"1","key":"10.1016\/j.ejmech.2026.118577_bib4","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.euo.2023.07.004","volume":"7","author":"Nguyen","year":"2024","journal-title":"Eur. Urol. Oncol."},{"issue":"1","key":"10.1016\/j.ejmech.2026.118577_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15586\/jkcvhl.2015.20","article-title":"Clinicians' Real world perceptions of pre-nephrectomy diagnostic biopsy performance as a driver of reduction in unnecessary surgeries in renal tumors","volume":"2","author":"Fahy","year":"2015","journal-title":"J Kidney Cancer VHL"},{"issue":"3","key":"10.1016\/j.ejmech.2026.118577_bib6","doi-asserted-by":"crossref","first-page":"4","DOI":"10.7812\/TPP\/12-110","article-title":"Accuracy and implications of percutaneous renal biopsy in the management of renal masses","volume":"17","author":"Londono","year":"2013","journal-title":"Perm. J."},{"issue":"21","key":"10.1016\/j.ejmech.2026.118577_bib7","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.1200\/JCO.2004.08.120","article-title":"Accuracy of whole-body dual-modality Fluorine-18\u20132-Fluoro-2-Deoxy-D-Glucose positron emission tomography and computed tomography (FDG-PET\/CT) for tumor staging in solid tumors: Comparison with CT and PET","volume":"22","author":"Antoch","year":"2004","journal-title":"J. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.ejmech.2026.118577_bib8","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1046\/j.1442-2042.2002.00416.x","article-title":"Significance of 18F-Fluorodeoxyglucose Positron Epission Temographyt(FDG-PET) for Detection df Renal CellrCarcicoma cnd Immunohistichemical Glucose Trgnsportet 1 (GLUT-1) Expressionein the Cancer","volume":"9","author":"Miyakita","year":"2002","journal-title":"Int. J. Urol."},{"issue":"9","key":"10.1016\/j.ejmech.2026.118577_bib9","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1007\/s00259-003-1211-4","article-title":"Efficiency of [18F]FDG PET in Charactericing Renal Cancrr andcDetecting distant Medastasesm A Comparisancwith CT","volume":"30","author":"Aide","year":"2003","journal-title":"Eur J Nucl Med Mol I"},{"issue":"4","key":"10.1016\/j.ejmech.2026.118577_bib10","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/MNM.0b013e3283442e3b","article-title":"A prospective diagnostic accuracy study of 18F-Fluorodeoxyglucose-Positron Emission Temography\/Computed Tomographytin the Evaluationeof Indeterminite Renal Massrs","volume":"32","author":"\u00d6z\u00fcLKER","year":"2011","journal-title":"Nucl. Med. Commun."},{"issue":"12","key":"10.1016\/j.ejmech.2026.118577_bib11","doi-asserted-by":"crossref","DOI":"10.1007\/s12032-014-0304-1","article-title":"Expression of HIF-1\u03b1 and CAIX in nasopharyngeal carcinoma and their correlation with patients' prognosis","volume":"31","author":"Chen","year":"2014","journal-title":"Med. Oncol."},{"issue":"4","key":"10.1016\/j.ejmech.2026.118577_bib12","article-title":"Carbonic anhydrase IX: an atypical target for innovative Therapies in cancer","volume":"1879","author":"Ronca","year":"2024","journal-title":"Bba-Rev Cancer"},{"key":"10.1016\/j.ejmech.2026.118577_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2016.00069","article-title":"Prognostic significance of carbonic anhydrase IX expression in cancer patients: a meta-analysis","volume":"6","author":"Van Kuijk","year":"2016","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ejmech.2026.118577_bib14","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2023.41.16_suppl.4554","article-title":"Results from phase 3 study of 89Zr-DFO-girentuximab for PET\/CT Imaging ofiClear CellcRenalcCellrCarcicoma cZIRCON)","volume":"41","author":"Shuch","year":"2023","journal-title":"J. Clin. Oncol."},{"issue":"6","key":"10.1016\/j.ejmech.2026.118577_bib15","doi-asserted-by":"crossref","first-page":"943","DOI":"10.2967\/jnumed.115.170514","article-title":"A 99mTc-Labeled Ligand of Carbolic Anhydrcse IX Seaectively Tarsets Renal Ctll Carcrnoma cn Vico","volume":"57","author":"Krall","year":"2016","journal-title":"J. Nucl. Med."},{"issue":"12","key":"10.1016\/j.ejmech.2026.118577_bib16","first-page":"1884","article-title":"Value of [68Ga]Ga-NYM046 PET\/CT, in Comparisoncwith 18F-FDG PET\/CT, for Diagnosis of Clear Cdll Renal Celc Carccnoma","volume":"65","author":"Lou","year":"2024","journal-title":"c Nucc Med"},{"issue":"10","key":"10.1016\/j.ejmech.2026.118577_bib17","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1007\/s00259-023-06248-7","article-title":"Preclinical and pilot clinical evaluation of a small-molecule carbonic anhydrase IX targeting PET tracer in clear cell renal cell carcinoma","volume":"50","author":"Zhu","year":"2023","journal-title":"Eur J Nucl Med Mol I"},{"issue":"4","key":"10.1016\/j.ejmech.2026.118577_bib18","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1007\/s00259-024-07007-y","article-title":"Evaluation of the safety, Biodistribution, Dosimetry of [18F]AlF-NYM005 and initial experience in clear cell renal cell carcinoma: an interim analysis of A prospective trial","volume":"52","author":"Yang","year":"2025","journal-title":"Eur J Nucl Med Mol I"},{"issue":"21","key":"10.1016\/j.ejmech.2026.118577_bib19","doi-asserted-by":"crossref","first-page":"18230","DOI":"10.1021\/jacs.5c05198","article-title":"Small organic carbonic anhydrase IX ligands from DNA-Encoded chemical libraries for tumor-targeted delivery of radionuclides","volume":"147","author":"M\u00fcLLER","year":"2025","journal-title":"J. Am. Chem. Soc."},{"issue":"5","key":"10.1016\/j.ejmech.2026.118577_bib20","doi-asserted-by":"crossref","first-page":"740","DOI":"10.2967\/jnumed.123.267175","article-title":"First-in-Human safety, imaging, and dosimetry of a carbonic anhydrase IX-Targeting peptide, [68Ga]Ga-DPI-4452, in Patients wpth Clear CellcRenalcCellrCarcicoma","volume":"65","author":"Hofman","year":"2024","journal-title":"J. Nucl. Med."},{"issue":"5","key":"10.1016\/j.ejmech.2026.118577_bib21","doi-asserted-by":"crossref","first-page":"761","DOI":"10.2967\/jnumed.123.266309","article-title":"Preclinical characterization of DPI-4452: a 68Ga\/177Lu Theranostic Ligand for Catbonic Anhydlase IX","volume":"65","author":"Massi\u00e8RE","year":"2024","journal-title":"J. Nucl. Med."},{"issue":"9","key":"10.1016\/j.ejmech.2026.118577_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2020.115424","article-title":"Design, synthesis & biological evaluation of ferulic acid-based small molecule inhibitors against tumor-associated carbonic anhydrase IX","volume":"28","author":"Aneja","year":"2020","journal-title":"Bioorgan Med Chem"},{"key":"10.1016\/j.ejmech.2026.118577_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.110947","article-title":"Design, synthesis and mechanism study of coumarin-sulfonamide derivatives as carbonic anhydrase IX inhibitors with anticancer activity","volume":"393","author":"Lv","year":"2024","journal-title":"Chem. Biol. Interact."},{"issue":"1","key":"10.1016\/j.ejmech.2026.118577_bib25","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13550-016-0221-8","article-title":"The effect of purification of 68Ga-labeled Exendin oneIn Vivo Diitrvbutidn","volume":"6","author":"Brom","year":"2016","journal-title":"EJNMMI Res."},{"issue":"3","key":"10.1016\/j.ejmech.2026.118577_bib26","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1021\/acs.molpharmaceut.5b00934","article-title":"PET imaging of carbonic anhydrase IX expression of HT-29 tumor xenograft mice with 68Ga-Labeled Benzenesulfonamides","volume":"13","author":"Lau","year":"2016","journal-title":"Mol Pharmaceutics"},{"issue":"10","key":"10.1016\/j.ejmech.2026.118577_bib27","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1007\/s00259-023-06248-7","article-title":"Preclinical and pilot clinical evaluation of a small-molecule carbonic anhydrase IX targeting PET tracer in clear cell renal cell carcinoma","volume":"50","author":"Zhu","year":"2023","journal-title":"Eur J Nucl Med Mol I"},{"issue":"1","key":"10.1016\/j.ejmech.2026.118577_bib28","doi-asserted-by":"crossref","first-page":"37","DOI":"10.62347\/VHYY2134","article-title":"CAIX-targeted PET imaging agents based on acetazolamide small molecule for clear cell renal cell carcinoma","volume":"15","author":"Li","year":"2025","journal-title":"Am J Nucl Med Mol Imaging"},{"issue":"18","key":"10.1016\/j.ejmech.2026.118577_bib29","doi-asserted-by":"crossref","first-page":"13332","DOI":"10.1021\/acs.jmedchem.3c01475","article-title":"Synthesis, preclinical evaluation, and first-in-human PET study of [68Ga]-Labeled Biphenyl-Cbiphenyl-cPSMA Tracers","volume":"66","author":"Chen","year":"2023","journal-title":"J. Med. Chem."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S022352342600022X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S022352342600022X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:09:10Z","timestamp":1777529350000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S022352342600022X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":27,"alternative-id":["S022352342600022X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2026.118577","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preclinical evaluation of 68Ga-labeled acetazolamide derivatives as radiotracers targeting carbonic anhydrase IX in clear cell renal cell carcinoma","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2026.118577","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118577"}}