{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T02:02:10Z","timestamp":1774663330074,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82460497"],"award-info":[{"award-number":["82460497"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.ejmech.2026.118581","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T07:57:10Z","timestamp":1768291030000},"page":"118581","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Design and synthesis of dual-activity biphenyl inhibitors against SARS-CoV-2 and bladder cancer"],"prefix":"10.1016","volume":"306","author":[{"given":"Lin Lin","family":"Shang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teng Long","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Situ","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songhui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9288-0652","authenticated-orcid":false,"given":"Li Ping","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2026.118581_bib1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.ejmech.2026.118581_bib2","doi-asserted-by":"crossref","first-page":"7863","DOI":"10.1128\/JVI.78.15.7863-7866.2004","article-title":"Severe acute respiratory syndrome coronavirus phylogeny: toward consensus","volume":"78","author":"Gorbalenya","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.ejmech.2026.118581_bib3","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41579-020-00459-7","article-title":"Characteristics of SARS-CoV-2 and COVID-19","volume":"19","author":"Hu","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ejmech.2026.118581_bib4","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.rce.2020.08.005","article-title":"Incubation period of COVID-19: a systematic review and meta-analysis","volume":"221","author":"Quesada","year":"2021","journal-title":"Rev. Clin. Esp."},{"key":"10.1016\/j.ejmech.2026.118581_bib6","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.3390\/vaccines11121737","article-title":"mRNA and adenoviral vector vaccine platforms utilized in COVID-19 vaccines: technologies, ecosystem, and future directions","volume":"11","author":"Okuyama","year":"2023","journal-title":"Vaccines"},{"key":"10.1016\/j.ejmech.2026.118581_bib7","series-title":"Evaluating the Interplay Between Viral Proteases and Host Ubiquitin-like Immunoregulatory Proteins","author":"Freitas","year":"2021"},{"key":"10.1016\/j.ejmech.2026.118581_bib8","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-79357-0","article-title":"Biochemical and biophysical characterization of the main protease, 3-chymotrypsin-like protease (3CLpro) from the novel coronavirus SARS-CoV 2","volume":"10","author":"Ferreira","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2026.118581_bib9","first-page":"283","article-title":"CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells, Signal Transduct Target","volume":"5","author":"Wang","year":"2020","journal-title":"Ther"},{"key":"10.1016\/j.ejmech.2026.118581_bib10","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1038\/s41467-020-15562-9","article-title":"Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV","volume":"11","author":"Ou","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2026.118581_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2021.692168","article-title":"Catalytic dyad residues His41 and Cys145 impact the catalytic activity and overall conformational fold of the main SARS-CoV-2 protease 3-chymotrypsin-like protease","volume":"9","author":"Ferreira","year":"2021","journal-title":"Front. Chem."},{"key":"10.1016\/j.ejmech.2026.118581_bib12","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.thromres.2020.04.031","article-title":"The role of neutrophil extracellular traps in Covid-19: only an hypothesis or a potential new field of research?","volume":"191","author":"Mozzini","year":"2020","journal-title":"Thromb. Res."},{"key":"10.1016\/j.ejmech.2026.118581_bib13","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1126\/science.abl4784","article-title":"An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19","volume":"374","author":"Owen","year":"2021","journal-title":"Science."},{"key":"10.1016\/j.ejmech.2026.118581_bib14","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41392-023-01482-9","article-title":"Discovery of novel non-peptidic and non-covalent small-molecule 3CLpro inhibitors as potential candidate for COVID-19 treatment","volume":"8","author":"Jiang","year":"2023","journal-title":"Signal Transduction Targeted Ther."},{"key":"10.1016\/j.ejmech.2026.118581_bib15","doi-asserted-by":"crossref","first-page":"25428","DOI":"10.1002\/anie.202109965","article-title":"NMR spectroscopy of the main protease of SARS-CoV-2 and fragment-based screening identify three protein hotspots and an antiviral fragment","volume":"60","author":"Cantrelle","year":"2021","journal-title":"Angew Chem. Int. Ed."},{"key":"10.1016\/j.ejmech.2026.118581_bib16","doi-asserted-by":"crossref","first-page":"3623","DOI":"10.1038\/s41467-021-23751-3","article-title":"Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease","volume":"12","author":"Su","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2026.118581_bib17","doi-asserted-by":"crossref","first-page":"3132","DOI":"10.3390\/molecules23123132","article-title":"Design, synthesis, and biological activity of novel myricetin derivatives containing amide, thioether, and 1,3,4-thiadiazole moieties","volume":"23","author":"Ruan","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2026.118581_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2022.115118","article-title":"Systematic identification of chemical components in Fufang shuanghua oral liquid and screening of potential active components against SARS-CoV-2 protease","volume":"223","author":"Jiang","year":"2023","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.ejmech.2026.118581_bib19","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1142\/S0192415X17500823","article-title":"Differences in chemical component and anticancer activity of green and ripe Forsythiae Fructus","volume":"45","author":"Bao","year":"2017","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.ejmech.2026.118581_bib20","doi-asserted-by":"crossref","first-page":"108560","DOI":"10.1016\/j.bioorg.2025.108560","article-title":"Discovery of baicalein derivatives as novel covalent inhibitors of SARS CoV-2 Mpro: Structure-activity relationships and inhibitory mechanisms","volume":"161","author":"Zhang","year":"2025","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2026.118581_bib21","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.3390\/ijms17101681","article-title":"The fascinating effects of baicalein on cancer: a review","volume":"17","author":"Liu","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2026.118581_bib22","series-title":"Sybyl-X Molecular Modeling Software Packages","year":"2012"},{"key":"10.1016\/j.ejmech.2026.118581_bib23","first-page":"22","article-title":"AMBER user's manual, interim","volume":"3","author":"Vay","year":"2000","journal-title":"Rep"},{"key":"10.1016\/j.ejmech.2026.118581_bib24","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1021\/ci100275a","article-title":"Assessing the performance of the MM\/PBSA and MM\/GBSA methods. 1. The accuracy of binding free energy calculations based on molecular dynamics simulations","volume":"51","author":"Hou","year":"2011","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.ejmech.2026.118581_bib25","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1023\/A:1008763014207","article-title":"Combined molecular mechanical and continuum solvent approach (MM-PBSA\/GBSA) to predict ligand binding","volume":"18","author":"Massova","year":"2000","journal-title":"Perspect. Drug Discov."},{"key":"10.1016\/j.ejmech.2026.118581_bib26","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1002\/jcc.21666","article-title":"Assessing the performance of the molecular mechanics\/poisson boltzmann surface area and molecular mechanics\/generalized born surface area methods. II. The accuracy of ranking poses generated from docking","volume":"32","author":"Hou","year":"2011","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.ejmech.2026.118581_bib27","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1021\/ar000033j","article-title":"Calculating structures and free energies of complex molecules: combining molecular mechanics and continuum models","volume":"33","author":"Kollman","year":"2000","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.ejmech.2026.118581_bib28","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/minf.201100135","article-title":"Free energy calculations by the molecular mechanics poisson-boltzmann surface area method","volume":"31","author":"Homeyer","year":"2012","journal-title":"Mol. Inf."},{"key":"10.1016\/j.ejmech.2026.118581_bib29","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1126\/science.abb4489","article-title":"Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease","volume":"368","author":"Dai","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2026.118581_bib30","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/ejoc.201301128","article-title":"Synthesis of (+)-O-methylthalibrine by employing a stereocontrolled bischler-napieralski reaction and an electrochemically generated diaryl ether","volume":"2014","author":"Kawabata","year":"2014","journal-title":"Eur. J. Org. Chem."},{"key":"10.1016\/j.ejmech.2026.118581_bib31","doi-asserted-by":"crossref","first-page":"12107","DOI":"10.1021\/acssuschemeng.2c01606","article-title":"Toward the photocatalytic valorization of lignin: conversion of a model lignin hexamer with multiple functionalities","volume":"10","author":"Murnaghan","year":"2022","journal-title":"ACS Sustainable Chem. Eng."},{"key":"10.1016\/j.ejmech.2026.118581_bib32","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1039\/c2gc36098e","article-title":"A simple and efficient approach for the palladium-catalyzed ligand-free Suzuki reaction in water","volume":"14","author":"Liu","year":"2012","journal-title":"Green Chem."},{"key":"10.1016\/j.ejmech.2026.118581_bib33","doi-asserted-by":"crossref","first-page":"15894","DOI":"10.1021\/jacs.2c07529","article-title":"Simple and practical conversion of benzoic acids to phenols at room temperature","volume":"144","author":"Xiong","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2026.118581_bib34","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41422-020-0282-0","article-title":"Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro","volume":"30","author":"Wang","year":"2020","journal-title":"Cell Res."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523426000267?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523426000267?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T01:47:00Z","timestamp":1773971220000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523426000267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":33,"alternative-id":["S0223523426000267"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2026.118581","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design and synthesis of dual-activity biphenyl inhibitors against SARS-CoV-2 and bladder cancer","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2026.118581","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118581"}}