{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T11:09:40Z","timestamp":1774004980820,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22271318"],"award-info":[{"award-number":["22271318"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["2025A03J2927"],"award-info":[{"award-number":["2025A03J2927"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010618","name":"Guangzhou University of Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010618","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.ejmech.2026.118625","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T17:47:56Z","timestamp":1769708876000},"page":"118625","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Synthesis, biological evaluation and mechanism study of 2-benzoyl-quinazolinone derivative as ferroptosis inhibitor for the treatment of Parkinson's disease"],"prefix":"10.1016","volume":"306","author":[{"given":"Fengxian","family":"Luo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanqing","family":"Pang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingjie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.ejmech.2026.118625_bib1","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron dependent form of nonapoptotic cell death","volume":"149","author":"Scott","year":"2012","journal-title":"Cell"},{"issue":"14","key":"10.1016\/j.ejmech.2026.118625_bib2","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","article-title":"Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications","volume":"185","author":"Brent","year":"2022","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.ejmech.2026.118625_bib3","doi-asserted-by":"crossref","first-page":"3785","DOI":"10.1016\/j.apsb.2024.05.025","article-title":"Unveiling ferroptosis as a promising therapeutic avenue for colorectal cancer and colitis treatment","volume":"14","author":"Kao","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"issue":"3","key":"10.1016\/j.ejmech.2026.118625_bib4","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/med.21934","article-title":"Targeting ferroptosis in cardio-metabolic-diseases: mechanisms and therapeutic prospects","volume":"43","author":"Zhang","year":"2023","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.ejmech.2026.118625_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116777","article-title":"Targeting ferroptosis in neuroimmune and neurodegenerative disorders for the development of novel therapeutics","volume":"176","author":"Li","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.ejmech.2026.118625_bib6","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.canlet.2014.11.014","article-title":"The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells","volume":"356","author":"Louandre","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ejmech.2026.118625_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2021.126798","article-title":"Role of ferroptosis in cisplatin-induced acute nephrotoxicity in mice","volume":"67","author":"Ikeda","year":"2021","journal-title":"J. Trace Elem. Med. Biol."},{"issue":"4","key":"10.1016\/j.ejmech.2026.118625_bib8","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1111\/cbdd.14281","article-title":"Sulfasalazine inhibits esophageal cancer cell proliferation by mediating ferroptosis","volume":"102","author":"Yin","year":"2023","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.ejmech.2026.118625_bib9","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.canlet.2020.02.015","article-title":"Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs","volume":"483","author":"Su","year":"2020","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ejmech.2026.118625_bib10","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.1007\/s12035-020-01956-9","article-title":"New probucol analogues inhibit ferroptosis, improve mitochondrial parameters, and induce glutathione peroxidase in HT-22 cells","volume":"57","author":"Caeran Bueno","year":"2020","journal-title":"Mol. Neurobiol."},{"issue":"16","key":"10.1016\/j.ejmech.2026.118625_bib11","doi-asserted-by":"crossref","first-page":"6161","DOI":"10.7150\/thno.98172","article-title":"A novel ferroptosis inhibitor, Thonningianin A, improves alzheimer's disease by activating GPX4","volume":"14","author":"Yong","year":"2024","journal-title":"Theranostics"},{"issue":"33","key":"10.1016\/j.ejmech.2026.118625_bib12","doi-asserted-by":"crossref","first-page":"14331","DOI":"10.1021\/jacs.0c06379","article-title":"Potent ferroptosis inhibitors can catalyze the cross-dismutation of phospholipid-derived Peroxyl radicals and hydroperoxyl radicals","volume":"142","author":"JiaFei","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2026.118625_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115945","article-title":"Novel 3-hydroxypyridin-4(1H)-One derivatives as ferroptosis inhibitors with iron-chelating and reactive oxygen species scavenging activities and therapeutic effect in cisplatin-induced cytotoxicity","volume":"263","author":"Zhang","year":"2024","journal-title":"Eur. J. Med. Chem."},{"issue":"12","key":"10.1016\/j.ejmech.2026.118625_bib14","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.tips.2023.08.012","article-title":"Beyond ferrostatin-1: a comprehensive review of ferroptosis inhibitors","volume":"44","author":"Scarpellini","year":"2023","journal-title":"Trends Pharmacol. Sci."},{"issue":"2","key":"10.1016\/j.ejmech.2026.118625_bib15","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1124\/jpet.121.000534","article-title":"C culmsee characterization of novel diphenylamine compounds as ferroptosis inhibitors","volume":"378","author":"Hinder","year":"2021","journal-title":"J. Pharmacol. Exp. Therapeut."},{"issue":"14","key":"10.1016\/j.ejmech.2026.118625_bib16","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1038\/s41467-023-38753-6","article-title":"Lysyl oxidase-like 3 restrains mitochondrial ferroptosis to promote liver cancer chemoresistance by stabilizing dihydroorotate dehydrogenase","author":"Zhan","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2026.118625_bib17","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/s41420-021-00698-4","article-title":"Cell death inhibitors protect against brain damage caused by cardiac ischemia\/reperfusion injury","volume":"7","author":"Liao","year":"2021","journal-title":"Cell Death Discov."},{"issue":"11","key":"10.1016\/j.ejmech.2026.118625_bib18","doi-asserted-by":"crossref","first-page":"11340","DOI":"10.1021\/acs.jmedchem.5c00280","article-title":"Discovery of THB derivates as ferroptosis inhibitors for the treatment of acute kidney injury by targeting VDAC","volume":"68","author":"Peng","year":"2025","journal-title":"J. Med. Chem."},{"issue":"19","key":"10.1016\/j.ejmech.2026.118625_bib19","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13024-024-00728-6","article-title":"Abulseoud. Melatonin: a ferroptosis inhibitor with potential therapeutic efficacy for the post-COVID-19 trajectory of accelerated brain aging and neurodegeneration","author":"Yehia","year":"2024","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.ejmech.2026.118625_bib20","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/s41531-025-01022-y","article-title":"Lactobacillus reuteri-derived \u03b3-amino butyric acid alleviates MPTP-induced Parkinson's disease through inhibiting ferroptosis via the AKT-GSK3\u03b2-GPX4 axis","volume":"11","author":"Dong","year":"2025","journal-title":"npj Parkinson's Dis."},{"key":"10.1016\/j.ejmech.2026.118625_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-025-08319-z","article-title":"Ferroptosis inhibition protects against \u03b1-synuclein-related neuronal cell death","author":"Majern\u00edkov\u00e1","year":"2025","journal-title":"Cell Death Dis."},{"issue":"20","key":"10.1016\/j.ejmech.2026.118625_bib22","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202502195","article-title":"A druglike Ferrostatin-1 analogue as a ferroptosis inhibitor and photoluminescent indicator","volume":"64","author":"Yan","year":"2025","journal-title":"Angew. Chem. Int. Ed."},{"issue":"6","key":"10.1016\/j.ejmech.2026.118625_bib23","doi-asserted-by":"crossref","first-page":"4687","DOI":"10.1021\/acs.jmedchem.1c01775","article-title":"Discovery of a novel stilbene derivative as a microtubule targeting agent capable of inducing cell ferroptosis","volume":"65","author":"Zhou","year":"2022","journal-title":"J. Med. Chem."},{"issue":"3","key":"10.1016\/j.ejmech.2026.118625_bib24","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/s41419-021-03516-y","article-title":"Induction of ferroptosis in human nasopharyngeal cancer cells by cucurbitacin B: molecular mechanism and therapeutic potential","volume":"12","author":"Huang","year":"2021","journal-title":"Cell Death Dis."},{"issue":"78","key":"10.1016\/j.ejmech.2026.118625_bib25","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ejmech.2014.03.036","article-title":"Synthesis and anticancer activities of 4-(4-substituted piperazin)-5,6,7-trialkoxy quinazoline derivatives","volume":"6","author":"Zhang","year":"2014","journal-title":"Eur. J. Med. Chem."},{"issue":"2","key":"10.1016\/j.ejmech.2026.118625_bib26","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1021\/acsinfecdis.9b00397","article-title":"Macrofilaricidal benzimidazole-benzoxaborole hybrids as an approach to the treatment of river blindness: part 2. Ketone linked analogs","volume":"6","author":"Carter","year":"2020","journal-title":"ACS Infect. Dis."},{"issue":"27","key":"10.1016\/j.ejmech.2026.118625_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202203539","article-title":"Iridium-catalyzed ligand-controlled remote para-Selective C-H activation and borylation of twisted aromatic amides","volume":"61","author":"Hoque","year":"2022","journal-title":"Angew Chem Int Ed Engl."},{"issue":"6","key":"10.1016\/j.ejmech.2026.118625_bib28","doi-asserted-by":"crossref","first-page":"4687","DOI":"10.1021\/acs.jmedchem.1c01775","article-title":"Discovery of a novel stilbene derivative as a microtubule targeting agent capable of inducing cell ferroptosis","volume":"65","author":"Zhou","year":"2022","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118625_bib29","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/j.ejmech.2018.08.053","article-title":"Structure-based drug design: synthesis and biological evaluation of quinazolin-4-amine derivatives as selective Aurora A kinase inhibitors","volume":"157","author":"Long","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118625_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115913","article-title":"Discovery of 4-hydroxyl pyrazole derivatives as potent ferroptosis inhibitors","volume":"263","author":"Ying","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118625_bib31","article-title":"Exogenous 1,25(OH)2D3\/VD3 counteracts RSL3-Induced ferroptosis by enhancing antioxidant capacity and regulating iron ion transport: using zebrafish as a model","volume":"387","author":"Cheng","year":"2023","journal-title":"Chem-Bio Interact"},{"key":"10.1016\/j.ejmech.2026.118625_bib32","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.freeradbiomed.2022.08.011","article-title":"Hinokitiol functions as a ferroptosis inhibitor to confer neuroprotection","volume":"190","author":"Xi","year":"2022","journal-title":"Free Radical Bio Med"},{"key":"10.1016\/j.ejmech.2026.118625_bib33","article-title":"Neuroprotective effects of Tongtian oral liquid, a traditional Chinese medicine in the Parkinson's disease-induced zebrafish model","volume":"148","author":"Shan","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.ejmech.2026.118625_bib34","doi-asserted-by":"crossref","first-page":"180","DOI":"10.7150\/ijbs.64654","article-title":"Integrative analysis of the molecular mechanisms, immunological features and immunotherapy response of ferroptosis regulators across 33 cancer types","volume":"18","author":"Tang","year":"2022","journal-title":"Int. J. Biol. Sci."},{"issue":"Database issue","key":"10.1016\/j.ejmech.2026.118625_bib35","doi-asserted-by":"crossref","first-page":"D571","DOI":"10.1093\/nar\/gkac935","article-title":"FerrDb V2: update of the manually curated database of ferroptosis regulators and ferroptosis-disease associations","volume":"51","author":"Zhou","year":"2023","journal-title":"Nucleic Acids Res."},{"issue":"28","key":"10.1016\/j.ejmech.2026.118625_bib36","doi-asserted-by":"crossref","first-page":"20668","DOI":"10.1074\/jbc.M113.479154","article-title":"The crystal structure of six-transmembrane epithelial antigen of the prostate 4 (Steap4), a ferri\/cuprireductase, suggests a novel interdomain flavin-binding site","volume":"288","author":"Gauss","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"62","key":"10.1016\/j.ejmech.2026.118625_bib37","article-title":"The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1","author":"Cheff","year":"2023","journal-title":"Redox Biol."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S022352342600070X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S022352342600070X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T09:01:39Z","timestamp":1773997299000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S022352342600070X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":37,"alternative-id":["S022352342600070X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2026.118625","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis, biological evaluation and mechanism study of 2-benzoyl-quinazolinone derivative as ferroptosis inhibitor for the treatment of Parkinson's disease","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2026.118625","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118625"}}