{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:28:02Z","timestamp":1777865282503,"version":"3.51.4"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014440","name":"Gobierno de Espa\u00f1a Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["CNS2022-135304"],"award-info":[{"award-number":["CNS2022-135304"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006302","name":"Universidad de Alcal\u00e1","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006302","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012818","name":"Community of Madrid","doi-asserted-by":"publisher","award":["2018-T1\/IND-10054"],"award-info":[{"award-number":["2018-T1\/IND-10054"]}],"id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012818","name":"Community of Madrid","doi-asserted-by":"publisher","award":["2022-5A\/IND-24227"],"award-info":[{"award-number":["2022-5A\/IND-24227"]}],"id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.ejmech.2026.118648","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T16:45:21Z","timestamp":1770828321000},"page":"118648","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Aliphatic azo compounds as programmable nitrogen donors in alkyne-mediated heterocycle synthesis: Implications for medicinal chemistry"],"prefix":"10.1016","volume":"307","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7265-4113","authenticated-orcid":false,"given":"Clara","family":"Ma\u00f1as","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2960-5404","authenticated-orcid":false,"given":"Est\u00edbaliz","family":"Merino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2026.118648_bib1","unstructured":"https:\/\/www.drugdiscoverytrends.com\/2024s-blockbusters-top-50-pharmaceuticals-by-sales\/."},{"issue":"24","key":"10.1016\/j.ejmech.2026.118648_bib2","doi-asserted-by":"crossref","first-page":"9283","DOI":"10.1039\/c3cs60228a","article-title":"C\u2013N bond forming cross-coupling reactions: an overview","volume":"42","author":"Bariwal","year":"2013","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.ejmech.2026.118648_bib3","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1139\/a11-018","article-title":"Azo dyes: past, present and the future","volume":"19","author":"Bafana","year":"2011","journal-title":"Environ. Rev."},{"key":"10.1016\/j.ejmech.2026.118648_bib4","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41570-021-00334-w","article-title":"Advances and opportunities in the exciting world of azobenzenes","volume":"6","author":"Jerca","year":"2022","journal-title":"Nat. Rev. Chem"},{"key":"10.1016\/j.ejmech.2026.118648_bib5","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1007\/s43630-022-00262-8","article-title":"New tricks and emerging applications from contemporary azobenzene research","volume":"21","author":"Fedele","year":"2022","journal-title":"Photochem. Photobiol. Sci."},{"key":"10.1016\/j.ejmech.2026.118648_bib6","series-title":"The Chemistry and Application of Dyes","first-page":"72","article-title":"Azo dyes and pigments","year":"1990"},{"key":"10.1016\/j.ejmech.2026.118648_bib7","series-title":"The Chemistry of the Hydrazo, Azo and Azoxy Groups, Patai's Chemistry of Functional Groups","year":"1997"},{"key":"10.1016\/j.ejmech.2026.118648_bib8","series-title":"Industrial Dyes: Chemistry, Properties, Applications","year":"2003"},{"key":"10.1016\/j.ejmech.2026.118648_bib9","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/B978-0-08-096701-1.00070-7","article-title":"8-Azo- and peroxy initiators","volume":"3","author":"Moad","year":"1989","journal-title":"Comprehensive Polymer Science and Supplements"},{"issue":"16","key":"10.1016\/j.ejmech.2026.118648_bib10","doi-asserted-by":"crossref","first-page":"5336","DOI":"10.1021\/acs.joc.5c00315","article-title":"Electrochemistry of azobenzenes and its potential for energy storage","volume":"90","author":"Schatz","year":"2025","journal-title":"J. Org. Chem."},{"issue":"29","key":"10.1016\/j.ejmech.2026.118648_bib11","doi-asserted-by":"crossref","first-page":"9192","DOI":"10.1021\/ja8018093","article-title":"Azobenzenes as light-controlled molecular electronic switches in nanoscale metal-molecule-metal junctions","volume":"130","author":"Mativetsky","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2026.118648_bib12","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ejmech.2015.12.017","article-title":"Pyrrole: an emerging scaffold for construction of valuable therapeutic agents","volume":"110","author":"Gholap","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118648_bib13","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.ejmech.2014.11.059","article-title":"Recent advances in bioactive pyrazoles","volume":"97","author":"K\u00fc\u00e7\u00fckg\u00fczel","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118648_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2024.117656","article-title":"Synthesis and biological evaluation of triazolones\/oxadiazolones as novel urease inhibitors","volume":"102","author":"Wang","year":"2024","journal-title":"Bioorg. Med. Chem."},{"issue":"6","key":"10.1016\/j.ejmech.2026.118648_bib15","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1021\/cr800278z","article-title":"Mitsunobu and related reactions: advances and applications","volume":"109","author":"Kumara Swamy","year":"2009","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejmech.2026.118648_bib16","article-title":"Base-mediated [3 + 2] cyclization\/rearrangement of N-2,2,2-trifluoroethylisatin ketimines with diethyl azodicarboxylate for construction of spirooxindoles containing trifluoromethyl-1,2,4-triazoles","volume":"285\u2013286","author":"Zhang","year":"2025","journal-title":"J. Fluor. Chem."},{"issue":"4","key":"10.1016\/j.ejmech.2026.118648_bib17","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1021\/acs.joc.3c02377","article-title":"K2CO3 catalyzed (3+2) cycloaddition reaction of N-2,2,2-trifluoroethylisatin ketimines with azodicarboxylates: access to spirooxindoles containing trifluoromethyl-1,2,4-triazolines","volume":"89","author":"Gu","year":"2024","journal-title":"J. Org. Chem."},{"issue":"18","key":"10.1016\/j.ejmech.2026.118648_bib18","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.2165\/11208240-000000000-00000","article-title":"Celecoxib. A review of its use for symptomatic relief in the treatment of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis","volume":"71","author":"McCormack","year":"2011","journal-title":"Drugs"},{"issue":"5","key":"10.1016\/j.ejmech.2026.118648_bib19","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1080\/17512433.2023.2196401","article-title":"Parametric population pharmacokinetics of isoniazid: a systematic review","volume":"16","author":"Li","year":"2023","journal-title":"Expet Rev. Clin. Pharmacol."},{"issue":"9","key":"10.1016\/j.ejmech.2026.118648_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.cclet.2025.110912","article-title":"Pyrazole derivatives: recent advances in discovery and development of pesticides","volume":"36","author":"Du","year":"2024","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.ejmech.2026.118648_bib21","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1021\/acs.accounts.6b00043","article-title":"The breaking and mending of meso-Tetraarylporphyrins: transmuting the pyrrolic building blocks","volume":"49","author":"Bruckner","year":"2016","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.ejmech.2026.118648_bib22","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1039\/D2MD00206J","article-title":"Pyrazole-containing pharmaceuticals: target, pharmacological activity, and their SAR studies","volume":"13","author":"Li","year":"2022","journal-title":"RSC Med. Chem."},{"issue":"1","key":"10.1016\/j.ejmech.2026.118648_bib23","doi-asserted-by":"crossref","DOI":"10.1002\/cmdc.202300447","article-title":"Pyrrole: a decisive scaffold for the development of therapeutic agents and structure-activity relationship","volume":"19","author":"Ganesh","year":"2024","journal-title":"ChemMedChem"},{"issue":"10","key":"10.1016\/j.ejmech.2026.118648_bib24","doi-asserted-by":"crossref","first-page":"7788","DOI":"10.1021\/acs.jmedchem.4c00652","article-title":"Triazoles in medicinal chemistry: physicochemical properties, bioisosterism, and application","volume":"67","author":"Guan","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118648_bib25","doi-asserted-by":"crossref","DOI":"10.1021\/acs.orglett.5c04366","article-title":"Diazacyclobutene ring cleavage provides 1,2-diazetidin-3-ones via intramolecular nucleophilic cyclization","author":"Noori","year":"2025","journal-title":"Org. Lett."},{"issue":"1","key":"10.1016\/j.ejmech.2026.118648_bib26","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1021\/ol062675y","article-title":"Highly enantioselective and diastereoselective 1,3-dipolar cycloaddition reactions between azomethine imines and 3-acryloyl-2-oxazolidinone catalyzed by binaphthyldiimine\u2212Ni(II) complexes","volume":"9","author":"Suga","year":"2007","journal-title":"Org. Lett."},{"key":"10.1016\/j.ejmech.2026.118648_bib27","series-title":"Drug Approval Package: Celebrex (Celecoxib) Capsules","year":"1998"},{"issue":"3","key":"10.1016\/j.ejmech.2026.118648_bib29","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1021\/acs.chemrev.0c01015","article-title":"Fluorinated pyrazoles: from synthesis to applications","volume":"121","author":"Mykhailiuk","year":"2021","journal-title":"Chem. Rev."},{"issue":"3","key":"10.1016\/j.ejmech.2026.118648_bib30","doi-asserted-by":"crossref","DOI":"10.1002\/ardp.202400470","article-title":"A review of recent advances in anticancer activity and SAR of pyrazole derivatives","volume":"358","author":"Hofny","year":"2025","journal-title":"Arch. Pharm."},{"key":"10.1016\/j.ejmech.2026.118648_bib31","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s42452-025-06528-x","article-title":"Synthetic aspects, structural insights and pharmacological potential of pyrazole derivatives: an overview","volume":"7","author":"Menezes","year":"2025","journal-title":"Discov. Appl. Sci."},{"key":"10.1016\/j.ejmech.2026.118648_bib32","doi-asserted-by":"crossref","first-page":"12889","DOI":"10.1039\/D3RA01931D","volume":"13","author":"Alamshany","year":"2023","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejmech.2026.118648_bib33","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.ejmech.2013.10.004","article-title":"Pyrazole scaffold: a remarkable tool in the development of anticancer, Agents","volume":"70","author":"Kumar","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118648_bib34","first-page":"6062","article-title":"Synthesis of pyrazole by removal of oxygen froman ester-carbonyl group with triphenylphosphine","author":"Cookson","year":"1963","journal-title":"J. Chem. Soc."},{"issue":"21","key":"10.1016\/j.ejmech.2026.118648_bib35","doi-asserted-by":"crossref","first-page":"8095","DOI":"10.1039\/c2ra21249h","article-title":"Triphenylphosphine-mediated reaction of dialkyl azodicarboxylate with activated alkenes leading to pyrazolines","volume":"2","author":"Yamazaki","year":"2012","journal-title":"RSC Adv."},{"issue":"13","key":"10.1016\/j.ejmech.2026.118648_bib36","doi-asserted-by":"crossref","first-page":"9010","DOI":"10.1021\/acs.jmedchem.1c00099","volume":"64","author":"Cioffi","year":"2021","journal-title":"J. Med. Chem."},{"issue":"D1","key":"10.1016\/j.ejmech.2026.118648_bib37","doi-asserted-by":"crossref","first-page":"D1465","DOI":"10.1093\/nar\/gkad751","article-title":"TTD: therapeutic target database describing target druggability information","volume":"52","author":"Zhou","year":"2024","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.ejmech.2026.118648_bib38","doi-asserted-by":"crossref","first-page":"D1633","DOI":"10.1093\/nar\/gkae1075","article-title":"BindingDB in 2024: a FAIR knowledgebase of protein-small molecule binding data","volume":"53","author":"Liu","year":"2025","journal-title":"Nucleic Acids Res."},{"issue":"11","key":"10.1016\/j.ejmech.2026.118648_bib39","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1158\/1535-7163.MCT-21-0361","article-title":"Vimseltinib: a precision CSF1R therapy for tenosynovial giant cell tumors and diseases promoted by macrophages","volume":"20","author":"Smith","year":"2021","journal-title":"Mol. Cancer Therapeut."},{"key":"10.1016\/j.ejmech.2026.118648_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2022.128928","article-title":"Discovery of vimseltinib (DCC-3014), a highly selective CSF1R switch-control kinase inhibitor, in clinical development for the treatment of tenosynovial giant cell tumor (TGCT)","volume":"74","author":"Caldwell","year":"2022","journal-title":"Bioorg. Med. Chem. Lett"},{"issue":"8","key":"10.1016\/j.ejmech.2026.118648_bib41","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202400534","article-title":"Insights into the biological activities and substituent effects of pyrrole derivatives: the chemistry-biology connection","volume":"21","author":"Manya","year":"2024","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.ejmech.2026.118648_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112783","article-title":"Bioactive pyrrole-based compounds with target selectivity","volume":"208","author":"Petri","year":"2020","journal-title":"Eur. J. Med. Chem."},{"issue":"1","key":"10.1016\/j.ejmech.2026.118648_bib43","doi-asserted-by":"crossref","DOI":"10.1002\/cmdc.202300447","article-title":"Pyrrole: a decisive scaffold for the development of therapeutic agents and structure-activity relationship","volume":"19","author":"Ganesh","year":"2024","journal-title":"ChemMedChem"},{"key":"10.1016\/j.ejmech.2026.118648_bib44","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ejmech.2015.12.017","article-title":"Pyrrole: an emerging scaffold for construction of valuable therapeutic agents","volume":"110","author":"Gholap","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118648_bib45","doi-asserted-by":"crossref","first-page":"4540","DOI":"10.1039\/D5MD00403A","article-title":"Analysis of the structural diversity of heterocycles amongst European medicines agency approved pharmaceuticals (2014\u20132023","volume":"16","author":"Ward","year":"2025","journal-title":"RSC Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118648_bib46","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1186\/s13065-024-01340-x","article-title":"Novel pyrrole based triazole moiety as therapeutic hybrid: synthesis, characterization and anti-alzheimer potential with molecular mechanism of protein ligand profile","volume":"18","author":"Khan","year":"2024","journal-title":"BMC Chem."},{"issue":"43","key":"10.1016\/j.ejmech.2026.118648_bib47","doi-asserted-by":"crossref","first-page":"37039","DOI":"10.1039\/C6RA03411J","article-title":"Active methylenes in the synthesis of a pyrrole motif: an imperative structural unit of pharmaceuticals, natural products and optoelectronic materials","volume":"6","author":"Khajuria","year":"2016","journal-title":"RSC Adv."},{"issue":"4","key":"10.1016\/j.ejmech.2026.118648_bib48","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/adsc.201000796","article-title":"Zinc(II) triflate-catalyzed divergent synthesis of polyfunctionalized pyrroles","volume":"353","author":"Attanasi","year":"2011","journal-title":"Adv. Synth. Catal."},{"issue":"1","key":"10.1016\/j.ejmech.2026.118648_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.cclet.2022.05.002","article-title":"Au-catalyzed neighboring hydroxymethyl group directed cycloaddition of alkyne with diazadienes: synthesis of polysubstituted pyrroles","volume":"34","author":"Shi","year":"2023","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.ejmech.2026.118648_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115434","article-title":"Clinically approved small-molecule drugs for the treatment of rheumatoid arthritis","volume":"256","author":"Zhao","year":"2023","journal-title":"Eur. J. Med. Chem."},{"issue":"3","key":"10.1016\/j.ejmech.2026.118648_bib51","first-page":"242","article-title":"Atorvastatin: in the management of hyperlipidaemia","volume":"46","author":"Ray","year":"2000","journal-title":"J. Postgrad. Med."},{"key":"10.1016\/j.ejmech.2026.118648_bib52","doi-asserted-by":"crossref","first-page":"363","DOI":"10.2147\/DDDT.S334727","article-title":"Evaluating the therapeutic potential of ritlecitinib for the treatment of alopecia areata","volume":"16","author":"Ramirez-Marin","year":"2022","journal-title":"Drug Des. Dev. Ther."},{"issue":"12","key":"10.1016\/j.ejmech.2026.118648_bib53","doi-asserted-by":"crossref","first-page":"3442","DOI":"10.1021\/acschembio.6b00677","article-title":"Discovery of a JAK3-Selective inhibitor: functional differentiation of JAK3-Selective inhibition over pan-JAK or JAK1-Selective inhibition","volume":"11","author":"Telliez","year":"2016","journal-title":"ACS Chem. Biol."},{"issue":"6","key":"10.1016\/j.ejmech.2026.118648_bib54","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.1021\/acs.chemrev.5b00599","article-title":"Triazolinediones as highly enabling synthetic tools","volume":"116","author":"De Bruycker","year":"2016","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejmech.2026.118648_bib55","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/nchem.2023","article-title":"Triazolinediones enable ultrafast and reversible click chemistry for the design of dynamic polymer systems","volume":"6","author":"Billiet","year":"2014","journal-title":"Nat. Chem."},{"key":"10.1016\/j.ejmech.2026.118648_bib56","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202400637","article-title":"Significance of triazole in medicinal chemistry: advancement in drug design, reward and biological activity","volume":"21","author":"Ajmal","year":"2024","journal-title":"Chem. Biodiversity"},{"key":"10.1016\/j.ejmech.2026.118648_bib57","doi-asserted-by":"crossref","DOI":"10.1007\/s10895-025-04412-w","article-title":"Design, synthesis, antimicrobial evaluation, molecular docking, and computational studies of new 1,2,4-Triazolo[4,3-a]pyrimidin-5(1 H)-one derivatives","author":"El-Etrawy","year":"2025","journal-title":"J. Fluoresc."},{"key":"10.1016\/j.ejmech.2026.118648_bib58","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1021\/acs.jnatprod.6b00057","article-title":"The natural product Essramycin and three of its isomers are devoid of antibacterial activity","volume":"79","author":"Wang","year":"2016","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.ejmech.2026.118648_bib59","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1016\/j.bmc.2009.03.018","article-title":"Design and synthesis of N-2, 6-difluorophenyl-5-methoxyl-1, 2, 4-triazolo [1, 5-a]-pyrimidine-2-sulfonamide as acetohydroxyacid synthase inhibitor","volume":"17","author":"Chen","year":"2009","journal-title":"Bioorg. Med. Chem."},{"issue":"24","key":"10.1016\/j.ejmech.2026.118648_bib60","doi-asserted-by":"crossref","first-page":"8009","DOI":"10.1021\/acs.orglett.8b03590","article-title":"Accessing the rare diazacyclobutene motif","volume":"20","author":"Narangoda","year":"2018","journal-title":"Org. Lett."},{"issue":"13","key":"10.1016\/j.ejmech.2026.118648_bib61","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1039\/D3CC05088B","article-title":"Synthesis of mesoionic triazolones via a formal [3+2] cycloaddition between 4-phenyl-1,2,4-triazoline-3,5-dione and alkynes","volume":"60","author":"Kuroda","year":"2024","journal-title":"Chem. Commun."},{"issue":"8","key":"10.1016\/j.ejmech.2026.118648_bib62","doi-asserted-by":"crossref","first-page":"6570","DOI":"10.1021\/acs.jmedchem.4c00026","article-title":"Discovery of novel aryl triazolone dihydropyridines (ATDPs) targeting highly conserved residue W229 as promising HIV-1 NNRTIs","volume":"67","author":"Sun","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118648_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2024.117656","article-title":"Synthesis and biological evaluation of triazolones\/oxadiazolones as novel urease inhibitors","volume":"102","author":"Wang","year":"2024","journal-title":"Bioorg. Med. Chem."},{"issue":"16","key":"10.1016\/j.ejmech.2026.118648_bib64","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1021\/jo00190a015","article-title":"Reaction of triazolinediones with acetylenes. Electrophilic addition","volume":"49","author":"Cheng","year":"1984","journal-title":"J. Org. Chem."},{"issue":"32","key":"10.1016\/j.ejmech.2026.118648_bib65","doi-asserted-by":"crossref","first-page":"8596","DOI":"10.1039\/C5OB01086A","article-title":"1,3-Dipolar cycloadditions of azomethine imines","volume":"13","author":"N\u00e1jera","year":"2015","journal-title":"Org. Biomol. Chem."},{"issue":"3","key":"10.1016\/j.ejmech.2026.118648_bib66","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/ja.2008.124","article-title":"Essramycin: a first triazolopyrimidine antibiotic isolated from nature","volume":"61","author":"El-Gendy","year":"2008","journal-title":"J. Antibiot."},{"issue":"5","key":"10.1016\/j.ejmech.2026.118648_bib67","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1021\/acsinfecdis.4c01028","article-title":"Florasulam is a potent inhibitor of Mycobacterium tuberculosis acetohydroxyacid synthase and possesses in vivo antituberculosis activity","volume":"11","author":"Wun","year":"2025","journal-title":"ACS Infect. Dis."},{"issue":"5","key":"10.1016\/j.ejmech.2026.118648_bib68","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1021\/ja909062q","article-title":"Tyrosine bioconjugation through aqueous ene-type reactions: a click-like reaction for tyrosine","volume":"132","author":"Ban","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2026.118648_bib69","article-title":"Tyrosine bioconjugation through aqueous ene-like reactions","author":"Barbas","year":"2011","journal-title":"Patent WO2011079315"},{"issue":"4","key":"10.1016\/j.ejmech.2026.118648_bib70","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1021\/bc300665t","article-title":"Facile and stabile linkages through tyrosine: bioconjugation strategies with the tyrosine-click reaction","volume":"24","author":"Ban","year":"2013","journal-title":"Bioconjug. Chem."},{"issue":"4","key":"10.1016\/j.ejmech.2026.118648_bib71","doi-asserted-by":"crossref","first-page":"569","DOI":"10.2174\/092986712798918789","article-title":"A review on biological activities and chemical synthesis of hydrazide derivatives","volume":"19","author":"Narang","year":"2012","journal-title":"Curr. Med. Chem."},{"issue":"2","key":"10.1016\/j.ejmech.2026.118648_bib72","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s00044-016-1756-y","article-title":"Hydrazide-hydrazones as potential antimicrobial agents: overview of the literature since 2010","volume":"26","author":"Popio\u0142ek","year":"2017","journal-title":"Med. Chem. Res."},{"issue":"4","key":"10.1016\/j.ejmech.2026.118648_bib73","doi-asserted-by":"crossref","first-page":"348","DOI":"10.4065\/mcp.2010.0820","article-title":"Current concepts in the management of tuberculosis","volume":"86","author":"Sia","year":"2011","journal-title":"Mayo Clin. Proc."},{"issue":"7","key":"10.1016\/j.ejmech.2026.118648_bib74","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.1016\/j.ejmech.2010.03.002","article-title":"Benzylidene\/2-chlorobenzylidene hydrazides: synthesis, antimicrobial activity, QSAR studies and antiviral evaluation","volume":"45","author":"Kumar","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118648_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2024.138012","article-title":"Hydrazide-hydrazone\/hydrazone as enabling linkers in anti-cancer drug discovery: a comprehensive review","volume":"1307","author":"Murugappan","year":"2024","journal-title":"J. Mol. Struct."},{"issue":"19","key":"10.1016\/j.ejmech.2026.118648_bib76","doi-asserted-by":"crossref","first-page":"3737","DOI":"10.1016\/S0040-4039(99)00584-5","article-title":"Electrophilic amination of racemic and non-racemic allenyltitaniums. One-pot synthesis of \u03b1-hydrazinoalkynes from propargylic alcohol derivatives","volume":"40","author":"An","year":"1999","journal-title":"Tetrahedron Lett."},{"issue":"25","key":"10.1016\/j.ejmech.2026.118648_bib77","doi-asserted-by":"crossref","first-page":"7828","DOI":"10.1021\/ja803480b","article-title":"Preparation of substituted enol derivatives from terminal alkynes and their synthetic utility","volume":"130","author":"DeBergh","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2026.118648_bib78","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1055\/s-0029-1219944","article-title":"Selective propargylation of azo compounds with barium reagents","volume":"10","author":"Yanagisawa","year":"2010","journal-title":"Synlett"},{"issue":"22","key":"10.1016\/j.ejmech.2026.118648_bib79","doi-asserted-by":"crossref","first-page":"9959","DOI":"10.1021\/jo301840e","article-title":"Radical amination of C(sp3)\u2212H bonds using N-hydroxyphthalimide and dialkyl azodicarboxylate","volume":"77","author":"Amaoka","year":"2012","journal-title":"J. Org. Chem."},{"issue":"2","key":"10.1016\/j.ejmech.2026.118648_bib80","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1021\/acsomega.7b01512","article-title":"Impairing powerhouse in colon cancer cells by hydrazide\u2013hydrazone-based small molecule","volume":"3","author":"Patil","year":"2018","journal-title":"ACS Omega"},{"key":"10.1016\/j.ejmech.2026.118648_bib81","doi-asserted-by":"crossref","DOI":"10.1039\/D4RA06500J","article-title":"Discovery of pyrazole-based analogs as CDK2 inhibitors with apoptotic-inducing activity: design, synthesis and molecular dynamics study","volume":"14","author":"Ali","year":"2024","journal-title":"RSC Adv."},{"issue":"15","key":"10.1016\/j.ejmech.2026.118648_bib82","article-title":"Novel triazole-carbohydrazide hydrazones with dual antioxidant and antibacterial potential","author":"Badawy","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2026.118648_bib83","article-title":"Antimicrobial activity of novel substituted 1,2,4-triazole and 1,3-thiazole derivatives","volume":"1295","author":"Saffour","year":"2025","journal-title":"J. Mol. Struct."},{"issue":"4","key":"10.1016\/j.ejmech.2026.118648_bib84","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s00223-015-0051-0","article-title":"Cathepsin K inhibition: a new mechanism for the treatment of osteoporosis","volume":"98","author":"Duong","year":"2016","journal-title":"Calcif. Tissue Int."},{"issue":"41","key":"10.1016\/j.ejmech.2026.118648_bib85","doi-asserted-by":"crossref","first-page":"5451","DOI":"10.1039\/C4CC01397B","article-title":"Asymmetric synthesis of heteroaryl atropisomers via a gold-catalyzed cycloisomerization\u2013amination cascade reaction","volume":"50","author":"Guo","year":"2014","journal-title":"Chem. Commun."},{"issue":"15","key":"10.1016\/j.ejmech.2026.118648_bib86","doi-asserted-by":"crossref","first-page":"9734","DOI":"10.1021\/acs.joc.9b01515","article-title":"Cycloaddition\/electrocyclic ring opening sequence between alkynyl sulfides and azodicarboxylates to provide N,N-dicarbamoyl 2-iminothioimidates","volume":"84","author":"Narangoda","year":"2019","journal-title":"J. Org. Chem."},{"issue":"22","key":"10.1016\/j.ejmech.2026.118648_bib87","doi-asserted-by":"crossref","first-page":"7417","DOI":"10.1021\/acs.joc.5c00705","article-title":"Diazacyclobutenes as reactive intermediates: the cascade cyclization of thiolated ene-ynes and azodicarboxylates to provide tetrahydroindoles","volume":"90","author":"Kwain","year":"2025","journal-title":"J. Org. Chem."},{"issue":"1","key":"10.1016\/j.ejmech.2026.118648_bib88","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.ica.2010.11.037","article-title":"Effects of a derivative thiazoline\/thiazolidine azine ligand and its cadmium complexes on phagocytic activity by human neutrophils","volume":"366","author":"Vi\u00f1uelas-Zah\u00ednos","year":"2011","journal-title":"Inorg. Chim. Acta."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523426000930?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523426000930?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:10:43Z","timestamp":1777529443000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523426000930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":87,"alternative-id":["S0223523426000930"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2026.118648","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aliphatic azo compounds as programmable nitrogen donors in alkyne-mediated heterocycle synthesis: Implications for medicinal chemistry","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2026.118648","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"118648"}}