{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T04:12:53Z","timestamp":1793938373351,"version":"4.8.0"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100017957","name":"Health Commission of Guizhou Province","doi-asserted-by":"publisher","award":["gzwkj2025-252"],"award-info":[{"award-number":["gzwkj2025-252"]}],"id":[{"id":"10.13039\/100017957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017957","name":"Health Commission of Guizhou Province","doi-asserted-by":"publisher","award":["gzwkj2025-347"],"award-info":[{"award-number":["gzwkj2025-347"]}],"id":[{"id":"10.13039\/100017957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010828","name":"Department of Education of Guizhou Province","doi-asserted-by":"publisher","award":["Qianjiaoji[2024] 120"],"award-info":[{"award-number":["Qianjiaoji[2024] 120"]}],"id":[{"id":"10.13039\/501100010828","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004001","name":"Guizhou Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["[2026] 708"],"award-info":[{"award-number":["[2026] 708"]}],"id":[{"id":"10.13039\/501100004001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004001","name":"Guizhou Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["[2025] 162"],"award-info":[{"award-number":["[2025] 162"]}],"id":[{"id":"10.13039\/501100004001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003459","name":"Guizhou University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003459","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.ejmech.2026.118730","type":"journal-article","created":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T16:02:02Z","timestamp":1772294522000},"page":"118730","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Current landscape and therapeutic prospects of indole-azole hybrids for colorectal cancer treatment: A mini-review"],"prefix":"10.1016","volume":"309","author":[{"given":"Xiping","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8877-1392","authenticated-orcid":false,"given":"Zhi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ejmech.2026.118730_bib2","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"issue":"1","key":"10.1016\/j.ejmech.2026.118730_bib3","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.mpmed.2022.10.014","article-title":"Colorectal cancer","volume":"51","author":"Greef","year":"2023","journal-title":"Medicine"},{"issue":"7","key":"10.1016\/j.ejmech.2026.118730_bib4","doi-asserted-by":"crossref","DOI":"10.1002\/ardp.70066","article-title":"Current landscape of hydroxamic acid hybrids with anti-colorectal cancer potential","volume":"358","author":"Cheng","year":"2025","journal-title":"Arch. Pharm."},{"issue":"10449","key":"10.1016\/j.ejmech.2026.118730_bib5","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S0140-6736(24)00360-X","article-title":"Colorectal cancer","volume":"404","author":"Eng","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.ejmech.2026.118730_bib6","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1007\/s44197-025-00348-3","article-title":"Assessing the colorectal cancer landscape: a comprehensive exploration of future trends in 216 countries and territories from 2021 to 2040","volume":"15","author":"Olfatifar","year":"2025","journal-title":"J. Epidemiol. Glob. Hea."},{"key":"10.1016\/j.ejmech.2026.118730_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102666","article-title":"Evolving landscape of colorectal cancer: global and regional burden, risk factor dynamics, and future scenarios (the global burden of disease 1990-2050)","volume":"104","author":"Zhou","year":"2025","journal-title":"Ageing Res. Rev."},{"issue":"2","key":"10.1016\/j.ejmech.2026.118730_bib8","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/s41575-024-01025-9","article-title":"Moving towards more personalized approaches in locally advanced and metastatic colorectal cancer: colorectal cancer in 2024","volume":"22","author":"Sievers","year":"2025","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"11","key":"10.1016\/j.ejmech.2026.118730_bib9","doi-asserted-by":"crossref","DOI":"10.1002\/ardp.202300402","article-title":"The anti-breast cancer potential of indole\/isatin hybrids","volume":"356","author":"Wang","year":"2023","journal-title":"Arch. Pharm."},{"issue":"3","key":"10.1016\/j.ejmech.2026.118730_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/ardp.202500001","article-title":"The current landscape of 1,2,3-triazole hybrids with anticancer therapeutic potential: part I","volume":"358","author":"Huang","year":"2025","journal-title":"Arch. Pharm."},{"issue":"5","key":"10.1016\/j.ejmech.2026.118730_bib11","doi-asserted-by":"crossref","first-page":"377","DOI":"10.2174\/1568026620666200908162311","article-title":"Indole alkaloids, synthetic dimers and hybrids with potential In vivo anticancer activity","volume":"21","author":"Song","year":"2021","journal-title":"Curr. Top. Med. Chem."},{"issue":"16","key":"10.1016\/j.ejmech.2026.118730_bib12","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.2174\/0115701808288928240226104445","article-title":"Anti-tumor activity of indole: a review","volume":"21","author":"Mohamed","year":"2024","journal-title":"Lett. Drug Des. Discov."},{"key":"10.1016\/j.ejmech.2026.118730_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115495","article-title":"Current scenario of pyrazole hybrids with in vivo therapeutic potential against cancers","volume":"257","author":"Xu","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118730_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.111073","article-title":"A comprehensive review on phosphatidylinositol-3-kinase (PI3K) and its inhibitors bearing pyrazole or indazole core for cancer therapy","volume":"398","author":"Bastos","year":"2024","journal-title":"Chem. Biol. Interact."},{"issue":"12","key":"10.1016\/j.ejmech.2026.118730_bib15","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1080\/17568919.2025.2521250","article-title":"The current landscape of indole hybrids with in vivo antitumor potential","volume":"17","author":"Ling","year":"2025","journal-title":"Future Med. Chem."},{"issue":"4","key":"10.1016\/j.ejmech.2026.118730_bib16","doi-asserted-by":"crossref","DOI":"10.1002\/ardp.202500031","article-title":"The current landscape of 1,2,3-triazole hybrids with anticancer therapeutic potential: part I","volume":"358","author":"Xu","year":"2025","journal-title":"Arch. Pharm."},{"issue":"10","key":"10.1016\/j.ejmech.2026.118730_bib17","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1080\/17568919.2025.2504336","article-title":"An insight into the in vivo antitumor therapeutic potential of indole-(fused) pyri(mi)dine hybrids","volume":"17","author":"Xu","year":"2025","journal-title":"Future Med. Chem."},{"issue":"16","key":"10.1016\/j.ejmech.2026.118730_bib18","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1080\/17568919.2025.2550929","article-title":"Thiazole derivatives in cancer therapy: mechanistic insights, bioactivity, and future perspective","volume":"17","author":"Saini","year":"2025","journal-title":"Future Med. Chem."},{"issue":"3","key":"10.1016\/j.ejmech.2026.118730_bib19","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1039\/D3MD00677H","article-title":"Indole-containing pharmaceuticals: targets, pharmacological activities, and SAR studies","volume":"15","author":"Zeng","year":"2024","journal-title":"RSC Med. Chem."},{"issue":"1","key":"10.1016\/j.ejmech.2026.118730_bib20","doi-asserted-by":"crossref","DOI":"10.1002\/ardp.202100158","article-title":"1,2,3-Triazole hybrids as anticancer agents: a review","volume":"355","author":"Alam","year":"2022","journal-title":"Arch. Pharm."},{"key":"10.1016\/j.ejmech.2026.118730_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112359","article-title":"Current scenario of indole derivatives with potential anti-drug-resistant cancer activity","volume":"200","author":"Jia","year":"2020","journal-title":"Eur. J. Med. Chem."},{"issue":"1","key":"10.1016\/j.ejmech.2026.118730_bib22","doi-asserted-by":"crossref","DOI":"10.1002\/ardp.202400873","article-title":"The current landscape of 1,2,3-triazole-(fused) six-membered nitrogen-containing heteroaromatic ring hybrids with anticancer therapeutic potential","volume":"358","author":"Xu","year":"2025","journal-title":"Arch. Pharm."},{"issue":"9","key":"10.1016\/j.ejmech.2026.118730_bib23","doi-asserted-by":"crossref","first-page":"5519","DOI":"10.1021\/acs.jmedchem.0c01958","article-title":"Discovery of 4-Arylindolines containing a thiazole moiety as potential antitumor agents inhibiting the programmed cell Death-1\/Programmed cell death-ligand 1 interaction","volume":"64","author":"Qin","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118730_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.rechem.2023.101209","article-title":"Synthesis, in-silico studies, and biological evaluation of some novel 3-thiazolyl-indoles as CDK2-inhibitors","volume":"6","author":"Gomha","year":"2023","journal-title":"Results Chem."},{"issue":"37","key":"10.1016\/j.ejmech.2026.118730_bib25","doi-asserted-by":"crossref","first-page":"34044","DOI":"10.1021\/acsomega.3c05038","article-title":"Synthesis, biological evaluation, and molecular docking of novel azolylhydrazonothiazoles as potential anticancer agents","volume":"8","author":"Al-Humaidi","year":"2023","journal-title":"ACS Omega"},{"issue":"40","key":"10.1016\/j.ejmech.2026.118730_bib26","doi-asserted-by":"crossref","first-page":"41944","DOI":"10.1021\/acsomega.4c06889","article-title":"Synthesis and evaluation of Thiazolyl-indole-2-carboxamide derivatives as potent multitarget anticancer agents","volume":"9","author":"Saadan","year":"2024","journal-title":"ACS Omega"},{"issue":"5","key":"10.1016\/j.ejmech.2026.118730_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/cmdc.202400817","article-title":"New indole-based Phenylthiazolyl-2,4-dihydropyrazolones as tubulin polymerization inhibitors: multicomponent synthesis, cytotoxicity evaluation, and in silico studies","volume":"20","author":"Bakchi","year":"2025","journal-title":"ChemMedChem"},{"issue":"1","key":"10.1016\/j.ejmech.2026.118730_bib28","doi-asserted-by":"crossref","DOI":"10.1186\/s13065-024-01277-1","article-title":"Oxindole-benzothiazole hybrids as CDK2 inhibitors and anticancer agents: design, synthesis and biological evaluation","volume":"18","author":"Abdel-Mohsen","year":"2024","journal-title":"BMC Chem."},{"issue":"9","key":"10.1016\/j.ejmech.2026.118730_bib29","doi-asserted-by":"crossref","first-page":"7620","DOI":"10.1021\/acs.jmedchem.4c00454","article-title":"Discovery of a Meisoindigo-Derived PROTAC as the ATM degrader: revolutionizing colorectal cancer therapy via synthetic lethality with ATR inhibitors","volume":"67","author":"Liu","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118730_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2021.116453","article-title":"Synthesis of novel indole-thiazolidinone hybrid structures as promising scaffold with anticancer potential","volume":"50","author":"Kryshchyshyn-Dylevych","year":"2021","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118730_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114422","article-title":"Novel hybrid pyrrolidinedione-thiazolidinones as potential anticancer agents: synthesis and biological evaluation","volume":"238","author":"Finiuk","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118730_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114465","article-title":"Design, synthesis of DNA-interactive 4-thiazolidinone-based indolo-\/pyrroloazepinone conjugates as potential cytotoxic and topoisomerase I inhibitors","volume":"238","author":"Kadagathur","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118730_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.jfluchem.2021.109879","article-title":"Synthesis and cytotoxicity evaluation of novel 5-fluorinated indoles","volume":"250","author":"Budovsk\u00e1","year":"2021","journal-title":"J. Fluor. Chem."},{"key":"10.1016\/j.ejmech.2026.118730_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.tet.2023.133573","article-title":"Indole phytoalexins-derived bis-indoles: design, synthesis and in vitro antiproliferative evaluation","volume":"143","author":"Budovsk\u00e1","year":"2023","journal-title":"Tetrahedron"},{"key":"10.1016\/j.ejmech.2026.118730_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.104481","article-title":"Development of \u03b2-carboline-benzothiazole hybrids via carboxamide formation as cytotoxic agents: DNA intercalative topoisomerase II\u03b1 inhibition and apoptosis induction","volume":"106","author":"Tokala","year":"2021","journal-title":"Bioorg. Chem."},{"issue":"17","key":"10.1016\/j.ejmech.2026.118730_bib36","doi-asserted-by":"crossref","DOI":"10.1002\/slct.202405930","article-title":"Design and synthesis of some new Indole-piperazine-1,2,3-triazole conjugates; In vitro anticancer, molecular docking, and ADMET studies","volume":"10","author":"Lingaswamy","year":"2025","journal-title":"ChemistrySelect"},{"key":"10.1016\/j.ejmech.2026.118730_bib37","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1039\/D2MD00044J","article-title":"N-1,2,3-Triazole-isatin derivatives: antiproliferation effects and target identification in solid tumour cell lines","volume":"13","author":"Busto","year":"2022","journal-title":"RSC Med. Chem."},{"issue":"13","key":"10.1016\/j.ejmech.2026.118730_bib38","doi-asserted-by":"crossref","DOI":"10.1002\/cmdc.202200164","article-title":"Development of isatin-based schiff bases targeting VEGFR-2 inhibition: synthesis, characterization, antiproliferative properties, and QSAR studies","volume":"17","author":"Seliem","year":"2022","journal-title":"ChemMedChem"},{"key":"10.1016\/j.ejmech.2026.118730_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.rechem.2024.101536","article-title":"An efficient synthesis and anticancer evaluation of 1,2,3-triazolo-indole-2-carboxylate derivatives","volume":"7","author":"Anantoju","year":"2024","journal-title":"Results Chem."},{"issue":"47","key":"10.1016\/j.ejmech.2026.118730_bib40","doi-asserted-by":"crossref","DOI":"10.1002\/slct.202203778","article-title":"Synthesis, anticancer activity and molecular docking studies of hybrid molecules containing indole-thiazolidinedione-triazole moieties","volume":"7","author":"Perike","year":"2022","journal-title":"ChemistrySelect"},{"key":"10.1016\/j.ejmech.2026.118730_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2022.134415","article-title":"Design of new hybrids indole\/phthalimide\/oxadiazole-1,2,3 triazole agents and their anticancer properties","volume":"1274","author":"Mohamed","year":"2023","journal-title":"J. Mol. Struct."},{"issue":"46","key":"10.1016\/j.ejmech.2026.118730_bib42","doi-asserted-by":"crossref","first-page":"21869","DOI":"10.1039\/D1NJ03892C","article-title":"Discovery of new indole-based 1,2,4-triazole derivatives as potent tubulin polymerization inhibitors with anticancer activity","volume":"45","author":"Yang","year":"2021","journal-title":"New J. Chem."},{"issue":"7","key":"10.1016\/j.ejmech.2026.118730_bib43","doi-asserted-by":"crossref","DOI":"10.1002\/ddr.70008","article-title":"Design, synthesis, and evaluation of novel indole-based small molecules as sirtuin inhibitors with anticancer activities","volume":"85","author":"Binarci","year":"2024","journal-title":"Drug Dev. Res."},{"issue":"13","key":"10.1016\/j.ejmech.2026.118730_bib44","doi-asserted-by":"crossref","first-page":"13907","DOI":"10.1021\/acs.jmedchem.5c00927","article-title":"Discovery of 1H-Pyrrolo[2,3-b]pyridine derivatives as highly selective, and orally available ATM inhibitors with potent in vivo antitumor activity","volume":"68","author":"Guo","year":"2025","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118730_bib45","doi-asserted-by":"crossref","first-page":"e66","DOI":"10.1186\/s13065-021-00793-8","article-title":"Synthesis of novel indole-isoxazole hybrids and evaluation of their cytotoxic activities on hepatocellular carcinoma cell lines","volume":"15","author":"Hawash","year":"2021","journal-title":"BMC Chem."},{"key":"10.1016\/j.ejmech.2026.118730_bib46","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1021\/acsptsci.5c00103","article-title":"Discovery of anticancer indole-based 4,5-Dihydroisoxazole derivative with selectivity toward leukemia cells","volume":"8","author":"Majirsk\u00e1","year":"2025","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"10.1016\/j.ejmech.2026.118730_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2022.128745","article-title":"Discovery of benzo[d]oxazol-2(3H)-one derivatives as a new class of TNIK inhibitors for the treatment of colorectal cancer","volume":"67","author":"Luo","year":"2022","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"13","key":"10.1016\/j.ejmech.2026.118730_bib48","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1080\/17568919.2024.2347084","article-title":"Anti-proliferation evaluation of new derivatives of indole-6-carboxylate ester as receptor tyrosine kinase inhibitors","volume":"16","author":"Allawi","year":"2024","journal-title":"Future Med. Chem."},{"issue":"2","key":"10.1016\/j.ejmech.2026.118730_bib49","article-title":"New Indole-6-Carboxylic acid derivatives as multi-target antiproliferative agents: synthesis, in silico studies, and cytotoxicity evaluation","volume":"21","author":"Allawi","year":"2024","journal-title":"Chem. Biodiversity"},{"issue":"10","key":"10.1016\/j.ejmech.2026.118730_bib50","doi-asserted-by":"crossref","DOI":"10.1002\/ardp.202300721","article-title":"Benzimidazole-oxindole hybrids: a novel class of selective dual CDK2 and GSK-3\u03b2 inhibitors of potent anticancer activity","volume":"357","author":"Abdel-Mohsen","year":"2024","journal-title":"Arch. Pharm."},{"key":"10.1016\/j.ejmech.2026.118730_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107243","article-title":"Benzimidazole-oxindole hybrids as multi-kinase inhibitors targeting melanoma","volume":"146","author":"Allam","year":"2024","journal-title":"Bioorg. Chem."},{"issue":"1","key":"10.1016\/j.ejmech.2026.118730_bib52","doi-asserted-by":"crossref","first-page":"e90","DOI":"10.3390\/molecules27010090","article-title":"Co-inhibition of P-gp and HSP90 by an isatin-derived compound contributes to the increase of the chemosensitivity of MCF7\/ADR-resistant cells to doxorubicin","volume":"27","author":"Abdalla","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2026.118730_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.113003","article-title":"N-Substituted benzimidazole acrylonitriles as in vitro tubulin polymerization inhibitors: synthesis, biological activity and computational analysis","volume":"211","author":"Perin","year":"2021","journal-title":"Eur. J. Med. Chem."},{"issue":"12","key":"10.1016\/j.ejmech.2026.118730_bib54","doi-asserted-by":"crossref","DOI":"10.1002\/cmdc.202400052","article-title":"Development of benzimidazole-substituted spirocyclopropyl oxindole derivatives as cytotoxic agents: Tubulin polymerization inhibition and apoptosis inducing studies","volume":"19","author":"Sakla","year":"2024","journal-title":"ChemMedChem"},{"key":"10.1016\/j.ejmech.2026.118730_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.106124","article-title":"Novel spirooxindole based benzimidazole scaffold: in vitro, nanoformulation and in vivo studies on anticancer and antimetastatic activity of breast adenocarcinoma","volume":"129","author":"Barakat","year":"2022","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2026.118730_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2023.117297","article-title":"Regioselective synthesis and in vitro cytotoxicity evaluation of 3-thiooxindole derivatives: tubulin polymerization inhibition and apoptosis inducing studies","volume":"90","author":"Sakla","year":"2023","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118730_bib57","article-title":"Design, synthesis, and biological evaluation of Benzo[cd]indol-2(1H)-ones derivatives as a lysosome-targeted anti-metastatic agent","volume":"11","author":"Li","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ejmech.2026.118730_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2023.129370","article-title":"Design, synthesis and anti-tumor evaluation of plinabulin derivatives as potential agents targeting \u03b2-tubulin","volume":"91","author":"Fang","year":"2023","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2026.118730_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2024.117946","article-title":"Synthesis, pharmacological evaluation, and modeling of novel quaternary ammonium salts derived from \u03b2-carboline containing an imidazole moiety as angiogenesis inhibitors","volume":"114","author":"Chen","year":"2024","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118730_bib60","doi-asserted-by":"crossref","first-page":"4427","DOI":"10.1039\/D1NJ05471F","article-title":"Multicomponent synthesis of novel \u03b2-carbolinefused imidazolium derivatives via the Mannich reaction: cytotoxicity, molecular docking, and mechanistic studies as angiogenesis inhibitors","volume":"46","author":"Zhu","year":"2022","journal-title":"New J. Chem."},{"key":"10.1016\/j.ejmech.2026.118730_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2024.130070","article-title":"Development of 3-indolyl substituted phenyl pyrazolo-carboxamide hybrids as potential type II VEGFR-2 inhibitors and in vitro cytotoxicity studies","volume":"117","author":"Valapil","year":"2025","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2026.118730_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2023.135477","article-title":"Novel indole-pyrazole hybrids as potential tubulin-targeting agents; synthesis, antiproliferative evaluation, and molecular modeling studies","volume":"1285","author":"Hawash","year":"2023","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.ejmech.2026.118730_bib63","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1039\/D2MD00340F","article-title":"Synthesis and bioactive evaluation of N-((1-methyl-1H-indol-3-yl)methyl)-N-(3,4,5-trimethoxyphenyl)acetamide derivatives as agents for inhibiting tubulin polymerization","volume":"14","author":"Ren","year":"2023","journal-title":"RSC Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118730_bib64","doi-asserted-by":"crossref","first-page":"12361","DOI":"10.1021\/acsomega.1c01604","article-title":"Design, synthesis, anticancer evaluation, enzymatic assays, and a molecular modeling study of novel pyrazole-indole hybrids","volume":"6","author":"Hassan","year":"2021","journal-title":"ACS Omega"},{"key":"10.1016\/j.ejmech.2026.118730_bib65","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-48494-7","article-title":"Novel 3-(pyrazol-4-yl)-2-(1H-indole-3-carbonyl)acrylonitrile derivatives induce intrinsic and extrinsic apoptotic death mediated P53 in HCT116 colon carcinoma","volume":"13","author":"Mohamed","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2026.118730_bib66","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1039\/D2MD00442A","article-title":"Design, synthesis and in vitro cytotoxicity evaluation of indolo-pyrazoles grafted with thiazolidinone as tubulin polymerization inhibitors","volume":"14","author":"Soni","year":"2023","journal-title":"RSC Med. Chem."},{"issue":"22","key":"10.1016\/j.ejmech.2026.118730_bib67","doi-asserted-by":"crossref","DOI":"10.1002\/cmdc.202400422","article-title":"Design, development of pyrazole-linked spirocyclopropyl oxindole-carboxamides as potential cytotoxic agents and type III allosteric VEGFR-2 inhibitors","volume":"19","author":"Valapil","year":"2024","journal-title":"ChemMedChem"},{"key":"10.1016\/j.ejmech.2026.118730_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2021.130159","article-title":"Isatin-Schiff's base and chalcone hybrids as chemically apoptotic inducers and EGFR inhibitors; design, synthesis, anti-proliferative activities and in silico evaluation","volume":"1234","author":"Fayed","year":"2021","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.ejmech.2026.118730_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.105114","article-title":"Synthesis of 1,4-dihydropyrazolo[4,3-b]indoles via intramolecular C(sp2)-N bond formation involving nitrene insertion, DFT study and their anticancer assessment","volume":"114","author":"Kaur","year":"2021","journal-title":"Bioorg. Chem."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523426001753?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523426001753?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T21:18:40Z","timestamp":1784668720000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523426001753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":68,"alternative-id":["S0223523426001753"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2026.118730","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Current landscape and therapeutic prospects of indole-azole hybrids for colorectal cancer treatment: A mini-review","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2026.118730","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118730"}}