{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T04:00:28Z","timestamp":1794024028239,"version":"4.8.0"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.ejmech.2026.118789","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T07:34:24Z","timestamp":1773992064000},"page":"118789","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Multi-target pyrazolopyrimidine-coumarin derivatives as potent CA IX\/XII and tubulin polymerization inhibitors: Design, synthesis, and biological evaluation"],"prefix":"10.1016","volume":"310","author":[{"given":"Mahmoud S.","family":"Elkotamy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Abdelrahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Giovannuzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud Abdelrahman","family":"Alkabbani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Nocentini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wagdy M.","family":"Eldehna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatem A.","family":"Abdel-Aziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar M.","family":"Abou-Seri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2026.118789_bib1","first-page":"309","volume":"vol. 35","author":"Nikolaou","year":"2018"},{"key":"10.1016\/j.ejmech.2026.118789_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1222575","volume":"13","author":"Zaarour","year":"2023","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ejmech.2026.118789_bib3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3390\/metabo8010019","volume":"8","author":"Mboge","year":"2018","journal-title":"Metabolites"},{"key":"10.1016\/j.ejmech.2026.118789_bib4","author":"Elkotamy","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118789_bib5","author":"Eldehna","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejmech.2026.118789_bib6","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s10534-013-9613-7","volume":"26","author":"Maret","year":"2013","journal-title":"Biometals"},{"key":"10.1016\/j.ejmech.2026.118789_bib7","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1016\/j.bmc.2017.03.027","volume":"25","author":"Carta","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118789_bib8","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1080\/14756366.2018.1428572","volume":"33","author":"Supuran","year":"2018","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118789_bib9","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1021\/acs.jmedchem.5b01720","volume":"59","author":"Ferraroni","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118789_bib10","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3109\/14756366.2015.1122001","volume":"31","author":"Supuran","year":"2016","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118789_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1091\/mbc.E25-05-0247","volume":"37","author":"Wethekam","year":"2026","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.ejmech.2026.118789_bib12","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3390\/ph13010008","volume":"13","author":"McLoughlin","year":"2020","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.ejmech.2026.118789_bib13","series-title":"Targeting the Colchicine Binding Site on Tubulin to Overcome Multidrug Resistance and Anticancer Efficacy of Selective Survivin Inhibitors","author":"Arnst","year":"2018"},{"key":"10.1016\/j.ejmech.2026.118789_bib14","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/cbdd.12629","volume":"87","author":"Jameel","year":"2016","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.ejmech.2026.118789_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.104163","volume":"103","author":"Al-Warhi","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2026.118789_bib16","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1080\/14756366.2022.2056734","volume":"37","author":"Tawfik","year":"2022","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118789_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112897","volume":"209","author":"Abdelrahman","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118789_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2019.103143","volume":"91","author":"Govindaiah","year":"2019","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2026.118789_bib19","volume":"137","author":"Song","year":"2023","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2026.118789_bib20","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.1016\/j.bmc.2018.05.022","volume":"26","author":"Batran","year":"2018","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118789_bib21","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.ejmech.2016.11.019","volume":"126","author":"Cherukupalli","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118789_bib22","doi-asserted-by":"crossref","first-page":"3756","DOI":"10.1039\/D4RA07556K","volume":"15","author":"Iorkula","year":"2025","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejmech.2026.118789_bib23","author":"Elgiushy","year":"2025","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2026.118789_bib24","volume":"202","author":"Li","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118789_bib25","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1080\/13543776.2023.2291390","volume":"33","author":"Peerzada","year":"2023","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.ejmech.2026.118789_bib26","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1016\/j.bmc.2017.02.037","volume":"25","author":"Fares","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118789_bib27","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1080\/14756366.2022.2070744","volume":"37","author":"Yousef","year":"2022","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118789_bib28","volume":"38","author":"Al-Sanea","year":"2023","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118789_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.140462","volume":"303","author":"Elkotamy","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejmech.2026.118789_bib30","doi-asserted-by":"crossref","first-page":"17335","DOI":"10.1039\/c3ra41604f","volume":"3","author":"Singh","year":"2013","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejmech.2026.118789_bib31","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1039\/p29830000175","volume":"2","author":"Bellamy","year":"1983","journal-title":"Journal of the Chemical Society, Perkin Transactions"},{"key":"10.1016\/j.ejmech.2026.118789_bib32","doi-asserted-by":"crossref","first-page":"3538","DOI":"10.1002\/jhet.2977","volume":"54","author":"\u015eener","year":"2017","journal-title":"J. Heterocycl. Chem."},{"key":"10.1016\/j.ejmech.2026.118789_bib33","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1246\/cl.2001.110","volume":"30","author":"Sugino","year":"2001","journal-title":"Chem. Lett."},{"key":"10.1016\/j.ejmech.2026.118789_bib34","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1002\/jhet.5570380428","volume":"38","author":"El\u2010Taweel","year":"2001","journal-title":"J. Heterocycl. Chem."},{"key":"10.1016\/j.ejmech.2026.118789_bib35","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/nrc1951","volume":"6","author":"Shoemaker","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ejmech.2026.118789_bib36","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/jnci\/82.13.1107","volume":"82","author":"Skehan","year":"1990","journal-title":"JNCI: Journal of the National Cancer Institute"},{"key":"10.1016\/j.ejmech.2026.118789_bib37","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ejmech.2014.09.051","volume":"87","author":"Kaur","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118789_bib38","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1021\/bi901760d","volume":"49","author":"Mukherjee","year":"2010","journal-title":"Biochemistry"},{"key":"10.1016\/j.ejmech.2026.118789_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107759","volume":"152","author":"Abdelaal","year":"2024","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2026.118789_bib40","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.4155\/fmc-2018-0288","volume":"10","author":"Ibrahim","year":"2018","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118789_bib41","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/ardp.201400337","volume":"348","author":"Fares","year":"2015","journal-title":"Arch. Pharmazie"},{"key":"10.1016\/j.ejmech.2026.118789_bib42","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.3390\/ph18111770","volume":"18","author":"Eldehna","year":"2025","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.ejmech.2026.118789_bib43","doi-asserted-by":"crossref","DOI":"10.1002\/ddr.70211","volume":"87","author":"Elgohary","year":"2026","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.ejmech.2026.118789_bib44","first-page":"1","author":"Elkotamy","year":"2025","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.ejmech.2026.118789_bib45","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12906-015-0543-5","volume":"15","author":"Tiwary","year":"2015","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.ejmech.2026.118789_bib46","doi-asserted-by":"crossref","DOI":"10.1002\/ddr.70214","volume":"87","author":"Fakhry","year":"2026","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.ejmech.2026.118789_bib47","doi-asserted-by":"crossref","first-page":"9004","DOI":"10.1021\/acs.jmedchem.5b01343","volume":"58","author":"Leitans","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118789_bib48","doi-asserted-by":"crossref","first-page":"9545","DOI":"10.1073\/pnas.161301298","volume":"98","author":"Whittington","year":"2001","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ejmech.2026.118789_bib49","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/nature02393","volume":"428","author":"Ravelli","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2026.118789_bib50","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232012235","volume":"23","author":"Abo Elmaaty","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2026.118789_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.108247","volume":"157","author":"Elkotamy","year":"2025","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2026.118789_bib52","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1021\/ja01535a045","volume":"80","author":"Taylor","year":"1958","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2026.118789_bib53","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s13318-024-00903-6","volume":"49","author":"Elbarbry","year":"2024","journal-title":"Eur. J. Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.ejmech.2026.118789_bib54","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1038\/nprot.2006.179","volume":"1","author":"Vichai","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ejmech.2026.118789_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107766","volume":"153","author":"Elgohary","year":"2024","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2026.118789_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107644","volume":"151","author":"Elkotamy","year":"2024","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2026.118789_bib57","volume":"103","author":"Wang","year":"2020","journal-title":"Bioorg. Chem."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523426002345?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523426002345?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T02:42:39Z","timestamp":1775616159000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523426002345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":57,"alternative-id":["S0223523426002345"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2026.118789","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multi-target pyrazolopyrimidine-coumarin derivatives as potent CA IX\/XII and tubulin polymerization inhibitors: Design, synthesis, and biological evaluation","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2026.118789","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118789"}}