{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T14:04:11Z","timestamp":1781273051546,"version":"3.54.1"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["113-2320-B-002-033-MY3"],"award-info":[{"award-number":["113-2320-B-002-033-MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["112-2628-M-A49-004-MY3"],"award-info":[{"award-number":["112-2628-M-A49-004-MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.ejmech.2026.118805","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T06:47:15Z","timestamp":1774939635000},"page":"118805","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Discovery of an N,N\u2032-diarylurea with potent activity against multidrug-resistant Staphylococcus aureus via perturbation of membrane homeostasis"],"prefix":"10.1016","volume":"311","author":[{"given":"Hui-Hui","family":"Yeo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Hsun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Xuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Hsuan","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Wen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hsuan","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-Chieh","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9269-7444","authenticated-orcid":false,"given":"Yen-Ku","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2026.118805_bib1","first-page":"135","article-title":"Penicillin's discovery and antibiotic resistance: lessons for the future?","volume":"90","author":"Lobanovska","year":"2017","journal-title":"Yale J. Biol. Med."},{"key":"10.1016\/j.ejmech.2026.118805_bib2","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.GPP3-0057-2018","article-title":"Antibiotic resistance and the MRSA problem","volume":"7","author":"Vestergaard","year":"2019","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.ejmech.2026.118805_bib3","doi-asserted-by":"crossref","first-page":"107","DOI":"10.2174\/1874070702014010107","article-title":"Antimicrobials Misuse\/Overuse: adverse effect, mechanism, challenges and strategies to combat resistance","volume":"14","author":"Mittal","year":"2020","journal-title":"Open Biotechnol. J."},{"key":"10.1016\/j.ejmech.2026.118805_bib4","first-page":"1199","article-title":"GBD 2021 antimicrobial resistance collaborators, global burden of bacterial antimicrobial resistance 1990-2021: a systematic analysis with forecasts to 2050","volume":"404","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.ejmech.2026.118805_bib5","series-title":"Forecasting the Fallout from AMR: Economic Impacts of Antimicrobial Resistance in Humans. A Report from the Ecoamr Series. Woah;World Bank","author":"McDonnell","year":"2024"},{"key":"10.1016\/j.ejmech.2026.118805_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002184","article-title":"Will 10 Million People Die a Year due to Antimicrobial Resistance by 2050?","volume":"13","author":"de Kraker","year":"2016","journal-title":"PLoS Med."},{"key":"10.1016\/j.ejmech.2026.118805_bib7","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","article-title":"Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis","volume":"399","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.ejmech.2026.118805_bib8","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jmii.2024.11.008","article-title":"Clinical characteristics and genomic changes of recurrent methicillin-resistant Staphylococcus aureus bacteremia","volume":"58","author":"Chang","year":"2025","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"10.1016\/j.ejmech.2026.118805_bib9","series-title":"Antimicrobial Resistance - an Open Challenge","article-title":"Antimicrobial resistance in staphylococci at the Human\u2013 animal interface","author":"Schmidt","year":"2015"},{"key":"10.1016\/j.ejmech.2026.118805_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.microb.2025.100281","article-title":"Current strategies against multidrug-resistant Staphylococcus aureus and advances toward future therapy","volume":"6","author":"Kumar","year":"2025","journal-title":"Microbe"},{"key":"10.1016\/j.ejmech.2026.118805_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/ardp.70131","article-title":"Structural modification of heterocyclic scaffolds: a strategy for antibacterial drug discovery","volume":"358","author":"Gupta","year":"2025","journal-title":"Arch. Pharm. (Weinheim, Ger.)"},{"key":"10.1016\/j.ejmech.2026.118805_bib12","doi-asserted-by":"crossref","first-page":"11459","DOI":"10.1021\/acs.jmedchem.4c01347","article-title":"Rational molecular editing: a new paradigm in drug discovery","volume":"67","author":"Ma","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118805_bib13","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1021\/acsmedchemlett.5c00061","article-title":"From natural products to small molecules: recent advancements in Anti-MRSA therapeutics","volume":"16","author":"Smith","year":"2025","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2026.118805_bib14","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1093\/jac\/dkv367","article-title":"In vitro and in vivo activity of a novel sorafenib derivative SC5005 against MRSA","volume":"71","author":"Chang","year":"2016","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.ejmech.2026.118805_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2022.128975","article-title":"Synthesis and biological evaluation of novel N,N\u2019-diarylurea derivatives as potent antibacterial agents against MRSA","volume":"75","author":"Du","year":"2022","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2026.118805_bib16","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01140-20","article-title":"The neutrally charged Diarylurea Compound PQ401 kills antibiotic-resistant and antibiotic-tolerant Staphylococcus aureus","volume":"11","author":"Kim","year":"2020","journal-title":"mBio"},{"key":"10.1016\/j.ejmech.2026.118805_bib17","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41557-019-0378-7","article-title":"Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms","volume":"12","author":"Le","year":"2020","journal-title":"Nat. Chem."},{"key":"10.1016\/j.ejmech.2026.118805_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/ardp.202400047","article-title":"Discovery of N,N'-diarylurea molecules with activity against multidrug-resistant Staphylococcus aureus","volume":"357","author":"Yeo","year":"2024","journal-title":"Arch Pharm (Weinheim, Ger.)"},{"key":"10.1016\/j.ejmech.2026.118805_bib19","doi-asserted-by":"crossref","first-page":"5962","DOI":"10.1016\/j.cell.2025.07.033","article-title":"A generative deep learning approach to de novo antibiotic design","volume":"188","author":"Krishnan","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.ejmech.2026.118805_bib20","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3390\/antibiotics12010112","article-title":"Diarylureas: new promising small molecules against Streptococcus mutans for the treatment of dental caries","volume":"12","author":"Iacopetta","year":"2023","journal-title":"Antibiotics"},{"key":"10.1016\/j.ejmech.2026.118805_bib21","article-title":"A convenient synthesis of some diarylurea and thiourea derivatives as antimicrobial compounds","volume":"25","author":"Hassan","year":"2014","journal-title":"Chem. Process Eng. Res."},{"key":"10.1016\/j.ejmech.2026.118805_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/femsre\/fuad011","article-title":"Galleria mellonella-intracellular bacteria pathogen infection models: the ins and outs","volume":"47","author":"Asai","year":"2023","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.ejmech.2026.118805_bib23","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s42826-020-00078-6","article-title":"The 'R' principles in laboratory animal experiments","volume":"36","author":"Lee","year":"2020","journal-title":"Lab Anim Res"},{"key":"10.1016\/j.ejmech.2026.118805_bib24","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1080\/21505594.2015.1135289","article-title":"Galleria mellonella infection models for the study of bacterial diseases and for antimicrobial drug testing","volume":"7","author":"Tsai","year":"2016","journal-title":"Virulence"},{"key":"10.1016\/j.ejmech.2026.118805_bib25","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1177\/0023677219883319","article-title":"Defining body-weight reduction as a humane endpoint: a critical appraisal","volume":"54","author":"Talbot","year":"2020","journal-title":"Lab Anim-Uk"},{"key":"10.1016\/j.ejmech.2026.118805_bib26","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jpha.2015.11.005","article-title":"Methods for in vitro evaluating antimicrobial activity: a review","volume":"6","author":"Balouiri","year":"2016","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.ejmech.2026.118805_bib27","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nrmicro.2017.42","article-title":"Persistent bacterial infections and persister cells","volume":"15","author":"Fisher","year":"2017","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ejmech.2026.118805_bib28","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41392-024-01866-5","article-title":"Bacterial persisters: molecular mechanisms and therapeutic development","volume":"9","author":"Niu","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.ejmech.2026.118805_bib29","article-title":"Isolation and characterization of persisters of the pathogenic microorganism Staphylococcus aureus","volume":"27","author":"Li","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.ejmech.2026.118805_bib30","doi-asserted-by":"crossref","DOI":"10.1155\/cjid\/1542576","article-title":"The bacterial biofilms: formation, impacts, and possible management targets in the healthcare System","volume":"2024","author":"Omwenga","year":"2024","journal-title":"Can. J. Infect. Dis. Med. Microbiol."},{"key":"10.1016\/j.ejmech.2026.118805_bib31","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s44259-025-00096-1","article-title":"Antibiotics re-booted-time to kick back against drug resistance","volume":"3","author":"Blaskovich","year":"2025","journal-title":"NPJ Antimicrob. Resist."},{"key":"10.1016\/j.ejmech.2026.118805_bib32","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202051034","article-title":"Antibiotic resistance and persistence-Implications for human health and treatment perspectives","volume":"21","author":"Huemer","year":"2020","journal-title":"EMBO Rep."},{"key":"10.1016\/j.ejmech.2026.118805_bib33","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1093\/jac\/47.5.647","article-title":"Mutation frequencies for resistance to fusidic acid and rifampicin in Staphylococcus aureus","volume":"47","author":"O'Neill","year":"2001","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.ejmech.2026.118805_bib34","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1128\/AAC.50.4.1228-1237.2006","article-title":"In vitro characterization of the antibacterial spectrum of novel bacterial type II topoisomerase inhibitors of the aminobenzimidazole class","volume":"50","author":"Mani","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2026.118805_bib35","doi-asserted-by":"crossref","first-page":"7459","DOI":"10.1021\/acs.jmedchem.4c03167","article-title":"Development of membrane-targeting osthole derivatives containing pyridinium Quaternary ammonium moieties with potent anti-methicillin-resistant Staphylococcus aureus properties","volume":"68","author":"Xu","year":"2025","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118805_bib36","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3389\/fcell.2016.00029","article-title":"Analysis of antimicrobial-triggered membrane depolarization using voltage sensitive dyes","volume":"4","author":"te Winkel","year":"2016","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ejmech.2026.118805_bib37","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/s41564-021-01013-8","article-title":"Identification of structurally diverse menaquinone-binding antibiotics with in vivo activity against multidrug-resistant pathogens","volume":"7","author":"Li","year":"2022","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.ejmech.2026.118805_bib38","doi-asserted-by":"crossref","first-page":"6233","DOI":"10.1021\/acs.jpcb.5c02384","article-title":"Laurdan adopts distinct, phase-specific orientations in lipid membranes","volume":"129","author":"Lester","year":"2025","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.ejmech.2026.118805_bib39","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nprot.2011.419","article-title":"Quantitative imaging of membrane lipid order in cells and organisms","volume":"7","author":"Owen","year":"2011","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ejmech.2026.118805_bib40","doi-asserted-by":"crossref","first-page":"E7077","DOI":"10.1073\/pnas.1611173113","article-title":"Daptomycin inhibits cell envelope synthesis by interfering with fluid membrane microdomains","volume":"113","author":"M\u00fcller","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.ejmech.2026.118805_bib41","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.3390\/pharmaceutics14101992","article-title":"Bactericidal activity of carvacrol against involves alteration of membrane fluidity and integrity through interaction with membrane phospholipids","volume":"14","author":"Wijesundara","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejmech.2026.118805_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.glmedi.2024.100081","article-title":"Antimicrobial resistance: impacts, challenges, and future prospects","volume":"2","author":"Ahmed","year":"2024","journal-title":"J. Med. Surg. Public Health"},{"key":"10.1016\/j.ejmech.2026.118805_bib43","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.ijantimicag.2013.05.015","article-title":"Evaluation of the effect of serum proteins on the antibacterial activity and pharmacodynamics of ceftaroline against Staphylococcus aureus","volume":"42","author":"Dalhof","year":"2013","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.ejmech.2026.118805_bib44","doi-asserted-by":"crossref","first-page":"364","DOI":"10.3389\/fphar.2017.00364","article-title":"Antimicrobial activity and resistance: influencing factors","volume":"8","author":"Li","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejmech.2026.118805_bib45","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1186\/s12866-025-04475-6","article-title":"YZ462 exhibits potent antibacterial activity against methicillin-resistant Staphylococcus aureus through bacterial membrane disruption","volume":"25","author":"Guo","year":"2025","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.ejmech.2026.118805_bib46","doi-asserted-by":"crossref","first-page":"16055","DOI":"10.1021\/ja5086244","article-title":"Quantification of electrophilic activation by hydrogen-bonding organocatalysts","volume":"136","author":"Walvoord","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2026.118805_bib47","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.3390\/molecules18032904","article-title":"Discovery of hybrid dual N-Acylhydrazone and diaryl urea derivatives as potent antitumor agents: design, synthesis and cytotoxicity evaluation","volume":"18","author":"Zhai","year":"2012","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2026.118805_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2023.117298","article-title":"Design, synthesis, and anticancer evaluation of arylurea derivatives as potent and selective type II irreversible covalent FGFR4 inhibitors","volume":"87","author":"Wang","year":"2023","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118805_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.117715","article-title":"Design and synthesis of benzothiazole aryl urea derivatives as potent anti-staphylococcal agents targeting autolysin-mediated peptidoglycan hydrolases","volume":"292","author":"Zhou","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118805_bib50","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1016\/j.bmcl.2016.01.075","article-title":"Antischistosomal activity of N,N\u2019-arylurea analogs against Schistosoma japonicum","volume":"26","author":"Yao","year":"2016","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2026.118805_bib51","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1021\/jm00335a025","article-title":"The synthesis of N-Hydroxycarbanilides and their evaluation as germicides","volume":"7","author":"Hoffman","year":"1964","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118805_bib52","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.bmcl.2011.10.126","article-title":"In vitro inhibition of translation initiation by N,N\u2019-diarylureas\u2014potential anti-cancer agents","volume":"22","author":"Denoyelle","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2026.118805_bib53","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1248\/cpb.c12-00234","article-title":"Design, synthesis and anticancer activities of Diaryl urea derivatives bearing N-Acylhydrazone moiety","volume":"60","author":"Zhang","year":"2012","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.ejmech.2026.118805_bib54","series-title":"Performance Standards for Antimicrobial Susceptibility Testing","year":"2022"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523426002503?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523426002503?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T13:46:48Z","timestamp":1781272008000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523426002503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":54,"alternative-id":["S0223523426002503"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2026.118805","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of an N,N\u2032-diarylurea with potent activity against multidrug-resistant Staphylococcus aureus via perturbation of membrane homeostasis","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2026.118805","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118805"}}