{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:26:11Z","timestamp":1791429971463,"version":"4.3.3"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["G83-28"],"award-info":[{"award-number":["G83-28"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["PLG\/2026\/019113"],"award-info":[{"award-number":["PLG\/2026\/019113"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["GB80-24"],"award-info":[{"award-number":["GB80-24"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82151308"],"award-info":[{"award-number":["82151308"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82430045"],"award-info":[{"award-number":["82430045"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007835","name":"Wenzhou Medical University","doi-asserted-by":"publisher","award":["KYQD20221102"],"award-info":[{"award-number":["KYQD20221102"]}],"id":[{"id":"10.13039\/100007835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007835","name":"Wenzhou Medical University","doi-asserted-by":"publisher","award":["KYYW202430"],"award-info":[{"award-number":["KYYW202430"]}],"id":[{"id":"10.13039\/100007835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015097","name":"Interdisciplinary Centre for Mathematical and Computational Modelling","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012652","name":"Wenzhou Medical University Eye Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012652","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015292","name":"Key Research Project of Liaoning","doi-asserted-by":"publisher","award":["2023C03079"],"award-info":[{"award-number":["2023C03079"]}],"id":[{"id":"10.13039\/501100015292","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2021ZD0203400"],"award-info":[{"award-number":["2021ZD0203400"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017599","name":"Science and Technology Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2024KY1300"],"award-info":[{"award-number":["2024KY1300"]}],"id":[{"id":"10.13039\/501100017599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["LQN25H120006"],"award-info":[{"award-number":["LQN25H120006"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008990","name":"Science and Technology Department of Zhejiang Province","doi-asserted-by":"publisher","award":["2023ZY1011"],"award-info":[{"award-number":["2023ZY1011"]}],"id":[{"id":"10.13039\/501100008990","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ejmech.2026.118880","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T06:53:15Z","timestamp":1776840795000},"page":"118880","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Discovery of Trolox amide derivatives as potent membrane-targeted ferroptosis inhibitors for corneal injury therapy"],"prefix":"10.1016","volume":"313","author":[{"given":"Jingyi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio","family":"Osella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhuan","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiasheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang-fan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7998-9055","authenticated-orcid":false,"given":"Feng","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.ejmech.2026.118880_bib1","article-title":"Emerging strategies in treating corneal alkali burns: a narrative review","volume":"15","author":"Mittal","year":"2023","journal-title":"Cureus"},{"issue":"2","key":"10.1016\/j.ejmech.2026.118880_bib2","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.survophthal.2017.09.005","article-title":"Treatment of acute ocular chemical burns","volume":"63","author":"Sharma","year":"2018","journal-title":"Surv. Ophthalmol."},{"issue":"2","key":"10.1016\/j.ejmech.2026.118880_bib3","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s40265-021-01660-5","article-title":"Treatment of non-infectious corneal injury: review of diagnostic agents, therapeutic medications, and future targets","volume":"82","author":"Dang","year":"2022","journal-title":"Drugs"},{"key":"10.1016\/j.ejmech.2026.118880_bib4","article-title":"Ferroptosis: a novel mechanism of cell death in ophthalmic conditions","volume":"15","author":"Yang","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejmech.2026.118880_bib5","article-title":"Ferroptosis in ocular diseases: mechanisms, crosstalk with other cell death pathways, and therapeutic prospects","volume":"12","author":"Huang","year":"2025","journal-title":"Front. Med. (Lausanne)"},{"issue":"1","key":"10.1016\/j.ejmech.2026.118880_bib6","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1167\/iovs.10-6167","article-title":"Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model","volume":"52","author":"Kubota","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"12","key":"10.1016\/j.ejmech.2026.118880_bib7","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1002\/2211-5463.12141","article-title":"Glutathione peroxidase 4 plays an important role in oxidative homeostasis and wound repair in corneal epithelial cells","volume":"6","author":"Sakai","year":"2016","journal-title":"FEBS Open Bio"},{"issue":"2","key":"10.1016\/j.ejmech.2026.118880_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/btm2.10276","article-title":"Ferrostatin-1-loaded liposome for treatment of corneal alkali burn via targeting ferroptosis","volume":"7","author":"Wang","year":"2022","journal-title":"Bioeng. Transl. Med."},{"issue":"1","key":"10.1016\/j.ejmech.2026.118880_bib9","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1167\/iovs.66.1.23","article-title":"Mustard gas induced corneal injury involves ferroptosis and p38 MAPK signaling","volume":"66","author":"Sinha","year":"2025","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"1","key":"10.1016\/j.ejmech.2026.118880_bib10","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3390\/pharmaceutics15010118","article-title":"A novel ferroptosis inhibitor UAMC-3203, a potential treatment for corneal epithelial wound","volume":"15","author":"Balla","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejmech.2026.118880_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.117015","article-title":"A prospective therapeutic strategy: GPX4-targeted ferroptosis mediators","volume":"281","author":"Qian","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118880_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116290","article-title":"Recent research progress based on ferroptosis-related signaling pathways and the tumor microenvironment on it effects","volume":"269","author":"Yu","year":"2024","journal-title":"Eur. J. Med. Chem."},{"issue":"1","key":"10.1016\/j.ejmech.2026.118880_bib13","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41420-022-01297-7","article-title":"Recent progress in ferroptosis: inducers and inhibitors","volume":"8","author":"Du","year":"2022","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.ejmech.2026.118880_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.117042","article-title":"Discovery of phenazine derivatives as a new class of non-classical ferroptosis inhibitors and efficacy evaluation on a mouse model of liver injury","volume":"282","author":"Wu","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118880_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.117192","article-title":"Discovery and optimization of 1,2,4-triazole derivatives as novel ferroptosis inhibitors","volume":"284","author":"Zhang","year":"2025","journal-title":"Eur. J. Med. Chem."},{"issue":"12","key":"10.1016\/j.ejmech.2026.118880_bib16","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.3390\/antiox13121571","article-title":"Mechanisms of vitamins inhibiting ferroptosis","volume":"13","author":"Zhang","year":"2024","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.ejmech.2026.118880_bib17","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.freeradbiomed.2021.08.234","article-title":"Diverse cytoprotective actions of vitamin E isoforms- role as peroxyl radical scavengers and complementary functions with selenoproteins","volume":"175","author":"Saito","year":"2021","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.ejmech.2026.118880_bib18","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1084\/jem.20140857","article-title":"T cell lipid peroxidation induces ferroptosis and prevents immunity to infection","volume":"212","author":"Matsushita","year":"2015","journal-title":"J. Exp. Med."},{"issue":"6","key":"10.1016\/j.ejmech.2026.118880_bib19","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/BF02672164","article-title":"Antioxidant activity and stability of 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid","volume":"52","author":"Cort","year":"1975","journal-title":"J. Am. Oil Chem. Soc."},{"issue":"11\u201312","key":"10.1016\/j.ejmech.2026.118880_bib20","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1080\/10715762.2021.2017912","article-title":"Prevention of ferroptosis in acute scenarios: an in vitro study with classic and novel anti-ferroptotic compounds","volume":"55","author":"Naime","year":"2021","journal-title":"Free Radic. Res."},{"issue":"4","key":"10.1016\/j.ejmech.2026.118880_bib21","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s10600-020-03113-z","article-title":"Synthesis and antioxidant activity evaluation of Trolox derivatives","volume":"56","author":"Xu","year":"2020","journal-title":"Chem. Nat. Compd."},{"key":"10.1016\/j.ejmech.2026.118880_bib22","doi-asserted-by":"crossref","DOI":"10.1590\/s2175-97902022e18887","article-title":"Synthesis and biological activity of Trolox amide derivatives","volume":"58","author":"Xu","year":"2022","journal-title":"Braz. J. Pharm. Sci."},{"key":"10.1016\/j.ejmech.2026.118880_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.108045","article-title":"Trolox derivatives: synthesis, structure-activity relationship and promote wound healing by regulating oxidative stress and inflammation","volume":"154","author":"Zhao","year":"2025","journal-title":"Bioorg. Chem."},{"issue":"4","key":"10.1016\/j.ejmech.2026.118880_bib24","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0223-5234(98)80065-2","article-title":"Synthesis and anti-inflammatory activity of N-(aza)arylcarboxamides derived from Trolox\u00ae","volume":"33","author":"Moulin","year":"1998","journal-title":"Eur. J. Med. Chem."},{"issue":"20","key":"10.1016\/j.ejmech.2026.118880_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242015295","article-title":"Phenylacetyl-\/Trolox- amides: synthesis, sigma-1, HDAC-6, and antioxidant activities","volume":"24","author":"Flores","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"22","key":"10.1016\/j.ejmech.2026.118880_bib26","doi-asserted-by":"crossref","first-page":"8985","DOI":"10.1021\/acs.jmedchem.5b01325","article-title":"Tacrine-Trolox hybrids: a novel class of centrally active, nonhepatotoxic multi-target-directed ligands exerting anticholinesterase and antioxidant activities with low in vivo toxicity","volume":"58","author":"Nepovimova","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.118880_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.118068","article-title":"Vitamin K-Trolox synergism realized in hybrid neuroprotectant with potent anti-ferroptosi\/oxytosis activity, reduced toxicity, and in vivo efficacy in Alzheimer's disease mouse model","volume":"299","author":"He","year":"2025","journal-title":"Eur. J. Med. Chem."},{"issue":"5","key":"10.1016\/j.ejmech.2026.118880_bib28","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.ejmech.2026.118880_bib29","doi-asserted-by":"crossref","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.ejmech.2026.118880_bib30","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1016\/j.chembiol.2020.10.010","article-title":"Using the oxytosis\/ferroptosis pathway to understand and treat age-associated neurodegenerative diseases","volume":"27","author":"Maher","year":"2020","journal-title":"Cell Chem. Biol."},{"issue":"6","key":"10.1016\/j.ejmech.2026.118880_bib31","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.apsb.2018.05.006","article-title":"Mitochondria-targeting drug conjugates for cytotoxic, anti-oxidizing and sensing purposes: current strategies and future perspectives","volume":"8","author":"Battogtokh","year":"2018","journal-title":"Acta Pharm. Sin. B"},{"issue":"10","key":"10.1016\/j.ejmech.2026.118880_bib32","doi-asserted-by":"crossref","first-page":"5944","DOI":"10.1021\/cr200084z","article-title":"Free radical lipid peroxidation: mechanisms and analysis","volume":"111","author":"Yin","year":"2011","journal-title":"Chem. Rev."},{"issue":"4","key":"10.1016\/j.ejmech.2026.118880_bib33","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.foodchem.2008.08.008","article-title":"DPPH antioxidant assay revisited","volume":"113","author":"Sharma","year":"2009","journal-title":"Food Chem."},{"issue":"10","key":"10.1016\/j.ejmech.2026.118880_bib34","doi-asserted-by":"crossref","first-page":"4619","DOI":"10.1021\/jf010586o","article-title":"Development and validation of an improved oxygen radical absorbance capacity assay using fluorescein as the fluorescent probe","volume":"49","author":"Ou","year":"2001","journal-title":"J. Agric. Food Chem."},{"issue":"1","key":"10.1016\/j.ejmech.2026.118880_bib35","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1021\/jf0305231","article-title":"Extending applicability of the oxygen radical absorbance capacity (ORAC\u2212fluorescein) assay","volume":"52","author":"D\u00e1valos","year":"2004","journal-title":"J. Agric. Food Chem."},{"issue":"4","key":"10.1016\/j.ejmech.2026.118880_bib36","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/jcc.21367","article-title":"CHARMM general force field: a force field for drug-like molecules compatible with the CHARMM all-atom additive biological force fields","volume":"31","author":"Vanommeslaeghe","year":"2010","journal-title":"J. Comput. Chem."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523426003259?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523426003259?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T13:26:00Z","timestamp":1783171560000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523426003259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":36,"alternative-id":["S0223523426003259"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2026.118880","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of Trolox amide derivatives as potent membrane-targeted ferroptosis inhibitors for corneal injury therapy","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2026.118880","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118880"}}