{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:55:31Z","timestamp":1789646131796,"version":"4.0.0"},"reference-count":106,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100020828","name":"Research Institute, University of Bucharest","doi-asserted-by":"publisher","award":["17\/02.03.2026"],"award-info":[{"award-number":["17\/02.03.2026"]}],"id":[{"id":"10.13039\/501100020828","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020828","name":"Research Institute, University of Bucharest","doi-asserted-by":"publisher","award":["27N\/03.01.2023"],"award-info":[{"award-number":["27N\/03.01.2023"]}],"id":[{"id":"10.13039\/501100020828","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020828","name":"Research Institute, University of Bucharest","doi-asserted-by":"publisher","award":["760230"],"award-info":[{"award-number":["760230"]}],"id":[{"id":"10.13039\/501100020828","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007336","name":"University of Bucharest","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018987","name":"Romanian Government Ministry of Research and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018987","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015622","name":"Ministerul Cercet\u0103rii \u015fi Inov\u0103rii","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015622","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.ejmech.2026.119003","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T23:41:40Z","timestamp":1779925300000},"page":"119003","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Redox-active copper(II) complexes with mixed heterocyclic N-donor ligands as dual antimicrobial and anti-tumor agents"],"prefix":"10.1016","volume":"316","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9340-2581","authenticated-orcid":false,"given":"Dragos Tudor","family":"Jula","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4018-7610","authenticated-orcid":false,"given":"Mihaela","family":"Badea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6033-3710","authenticated-orcid":false,"given":"Catalin","family":"Maxim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7342-5398","authenticated-orcid":false,"given":"Ioana-Cristina","family":"Marinas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4196-8160","authenticated-orcid":false,"given":"Madalina-Diana","family":"Gaboreanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8190-9512","authenticated-orcid":false,"given":"Arpad Mihai","family":"Rostas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5449-9108","authenticated-orcid":false,"given":"Maria","family":"Suciu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9287-5485","authenticated-orcid":false,"given":"Lavinia","family":"Ruta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4901-7896","authenticated-orcid":false,"given":"Ileana","family":"Farcasanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9801-2055","authenticated-orcid":false,"given":"Alina","family":"Tirsoaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4002-3579","authenticated-orcid":false,"given":"Emilia-Elena","family":"Iorgulescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6098-1857","authenticated-orcid":false,"given":"Mariana Carmen","family":"Chifiriuc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9175-4531","authenticated-orcid":false,"given":"Victoras","family":"Iordanescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4208-0972","authenticated-orcid":false,"given":"Rodica","family":"Olar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ejmech.2026.119003_b1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s11671-024-04170-x","article-title":"The modification of conventional liposomes for targeted antimicrobial delivery to treat infectious diseases","volume":"20","author":"Okafor","year":"2025","journal-title":"Discov. Nano"},{"issue":"1","key":"10.1016\/j.ejmech.2026.119003_b2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s43556-024-00239-2","article-title":"Molecular mechanisms and therapeutic strategies in overcoming chemotherapy resistance in cancer","volume":"6","author":"Gu","year":"2025","journal-title":"Mol. Biomed."},{"issue":"3","key":"10.1016\/j.ejmech.2026.119003_b3","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.3390\/ijms26031376","article-title":"Modification in structures of active compounds in anticancer mitochondria-targeted therapy","volume":"26","author":"Pyrczak-Felczykowska","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2026.119003_b4","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.622064","article-title":"New insights into the cancer\u2013microbiome\u2013immune axis: decrypting a decade of discoveries","volume":"12","author":"Jain","year":"2021","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.ejmech.2026.119003_b5","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s00345-024-05403-5","article-title":"Research progress on intratumoral microorganisms in renal cancer","volume":"43","author":"Zhang","year":"2025","journal-title":"World J. Urol."},{"key":"10.1016\/j.ejmech.2026.119003_b6","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.117702","article-title":"Recent advances in the discovery of copper (II) complexes as potential anticancer drugs","volume":"292","author":"Rogalewicz","year":"2025","journal-title":"Eur. J. Med. Chem."},{"issue":"24","key":"10.1016\/j.ejmech.2026.119003_b7","doi-asserted-by":"crossref","first-page":"5830","DOI":"10.3390\/molecules25245830","article-title":"Improvement in the pharmacological profile of copper biological active complexes by their incorporation into organic or inorganic matrix","volume":"25","author":"Badea","year":"2020","journal-title":"Molecules"},{"issue":"12","key":"10.1016\/j.ejmech.2026.119003_b8","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3390\/inorganics12120307","article-title":"Interaction of phenanthroline-containing copper complexes with model phospholipid membranes","volume":"12","author":"Freddi","year":"2024","journal-title":"Inorganics"},{"issue":"11","key":"10.1016\/j.ejmech.2026.119003_b9","doi-asserted-by":"crossref","DOI":"10.1002\/cmdc.202400060","article-title":"Copper and copper complexes in tumor therapy","volume":"19","author":"Wang","year":"2024","journal-title":"ChemMedChem"},{"issue":"13","key":"10.1016\/j.ejmech.2026.119003_b10","doi-asserted-by":"crossref","first-page":"9116","DOI":"10.1021\/acs.inorgchem.0c00925","article-title":"Copper complexes with 1, 10-phenanthroline derivatives: Underlying factors affecting their cytotoxicity","volume":"59","author":"Nunes","year":"2020","journal-title":"Inorg. Chem."},{"issue":"4","key":"10.1016\/j.ejmech.2026.119003_b11","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.bbrc.2020.09.104","article-title":"In vitro and in vivo antitumoral activity of a ternary copper (II) complex","volume":"533","author":"Lopes","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejmech.2026.119003_b12","doi-asserted-by":"crossref","DOI":"10.1016\/j.poly.2023.116431","article-title":"Copper (II)\/diiminic complexes based on 2-hydroxybenzophenones: DNA-and BSA-binding studies and antitumor activity against HCT116 and HepG2 tumor cells","volume":"239","author":"Rodrigues","year":"2023","journal-title":"Polyhedron"},{"issue":"21","key":"10.1016\/j.ejmech.2026.119003_b13","doi-asserted-by":"crossref","first-page":"9502","DOI":"10.1007\/s10853-024-09795-y","article-title":"Synthesis, electronic and vibrational properties, solvation effects, ADME and cytotoxic assay of aqua-(1, 10-phenanthroline)-tyrosinato-copper (II) nitrate dihydrate complex: experimental and theoretical studies","volume":"59","author":"Pereira","year":"2024","journal-title":"J. Mater. Sci."},{"issue":"11","key":"10.1016\/j.ejmech.2026.119003_b14","doi-asserted-by":"crossref","first-page":"3504","DOI":"10.3390\/molecules27113504","article-title":"Casiopeinas of third generations: synthesis, characterization, cytotoxic activity and structure\u2013activity relationships of mixed chelate compounds with bioactive secondary ligands","volume":"27","author":"Figueroa-DePaz","year":"2022","journal-title":"Molecules"},{"issue":"10","key":"10.1016\/j.ejmech.2026.119003_b15","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3390\/inorganics11100394","article-title":"The importance of being casiopeina as polypharmacologycal profile (mixed chelate\u2013copper (II) complexes and their in vitro and in vivo activities)","volume":"11","author":"Aguilar-Jim\u00e9nez","year":"2023","journal-title":"Inorganics"},{"issue":"6","key":"10.1016\/j.ejmech.2026.119003_b16","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1039\/D3DT03862A","article-title":"Cu (ii) complexes with a salicylaldehyde derivative and \u03b1-diimines as co-ligands: synthesis, characterization, biological activity. Experimental and theoretical approach","volume":"53","author":"Selakovi\u0107","year":"2024","journal-title":"Dalton Trans."},{"issue":"17","key":"10.1016\/j.ejmech.2026.119003_b17","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.3390\/molecules25173777","article-title":"Copper (II) complexes with mixed heterocycle ligands as promising antibacterial and antitumor species","volume":"25","author":"Rostas","year":"2020","journal-title":"Molecules"},{"issue":"22","key":"10.1016\/j.ejmech.2026.119003_b18","doi-asserted-by":"crossref","first-page":"6772","DOI":"10.3390\/molecules26226772","article-title":"Biological activity of triazolopyrimidine copper (II) complexes modulated by an auxiliary NN-chelating heterocycle ligands","volume":"26","author":"Ruta","year":"2021","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.ejmech.2026.119003_b19","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.3390\/ijms24032688","article-title":"Copper (II) species with improved anti-melanoma and antibacterial activity by inclusion in \u03b2-cyclodextrin","volume":"24","author":"Tirsoaga","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2026.119003_b20","article-title":"Crystal structure refinement","author":"Sheldrick","year":"1993","journal-title":"A Comput. Program. Cryst. Struct. Refinement"},{"key":"10.1016\/j.ejmech.2026.119003_b21","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.tiv.2016.08.007","article-title":"Oxidative stress generation of silver nanoparticles in three bacterial genera and its relationship with the antimicrobial activity","volume":"36","author":"Quinteros","year":"2016","journal-title":"Toxicol. Vitr."},{"key":"10.1016\/j.ejmech.2026.119003_b22","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cryobiol.2019.04.003","article-title":"Myocardial protection by propolis during prolonged hypothermic preservation","volume":"88","author":"Braik","year":"2019","journal-title":"Cryobiology"},{"issue":"22","key":"10.1016\/j.ejmech.2026.119003_b23","doi-asserted-by":"crossref","DOI":"10.1063\/5.0004608","article-title":"The ORCA quantum chemistry program package","volume":"152","author":"Neese","year":"2020","journal-title":"J. Chem. Phys."},{"issue":"5","key":"10.1016\/j.ejmech.2026.119003_b24","article-title":"Software update: The ORCA program system-version 5.0","volume":"12","author":"Neese","year":"2022","journal-title":"Wiley Interdiscip. Rev.: Comput. Mol. Sci."},{"issue":"18","key":"10.1016\/j.ejmech.2026.119003_b25","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1039\/b508541a","article-title":"Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: Design and assessment of accuracy","volume":"7","author":"Weigend","year":"2005","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.ejmech.2026.119003_b26","series-title":"A generally applicable atomic-charge dependent London dispersion correction scheme","author":"Caldeweyher","year":"2019"},{"issue":"9","key":"10.1016\/j.ejmech.2026.119003_b27","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1002\/jcc.26139","article-title":"Effect of the solute cavity on the solvation energy and its derivatives within the framework of the Gaussian charge scheme","volume":"41","author":"Garcia-Rat\u00e9s","year":"2020","journal-title":"J. Comput. Chem."},{"issue":"2","key":"10.1016\/j.ejmech.2026.119003_b28","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"issue":"8","key":"10.1016\/j.ejmech.2026.119003_b29","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","article-title":"AutoDock Vina 1.2. 0: new docking methods, expanded force field, and python bindings","volume":"61","author":"Eberhardt","year":"2021","journal-title":"J. Chem. Inf. Model."},{"issue":"1","key":"10.1016\/j.ejmech.2026.119003_b30","first-page":"57","article-title":"Python: a programming language for software integration and development","volume":"17","author":"Sanner","year":"1999","journal-title":"J. Mol. Graph Model."},{"key":"10.1016\/j.ejmech.2026.119003_b31","series-title":"Infrared and Raman Spectra of Inorganic and Coordination Compounds, Part B: Applications in Coordination, Organometallic, and Bioinorganic Chemistry","author":"Nakamoto","year":"2009"},{"key":"10.1016\/j.ejmech.2026.119003_b32","series-title":"Inorganic electronic spectroscopy","author":"Lever","year":"1969"},{"key":"10.1016\/j.ejmech.2026.119003_b33","series-title":"Complex Chemistry","first-page":"55","article-title":"A new look at the stereochemistry and electronic properties of complexes of the copper (II) ion","author":"Emsley","year":"1984"},{"issue":"8","key":"10.1016\/j.ejmech.2026.119003_b34","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1021\/ed083p1229","article-title":"The determination of the geometry of Cu (II) complexes: an EPR spectroscopy experiment","volume":"83","author":"Garribba","year":"2006","journal-title":"J. Chem. Educ."},{"key":"10.1016\/j.ejmech.2026.119003_b35","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1007\/s10534-021-00334-9","article-title":"Antiproliferative and antibacterial properties of biocompatible copper (II) complexes bearing chelating N, N-heterocycle ligands and potential mechanisms of action","volume":"34","author":"Olar","year":"2021","journal-title":"Biometals"},{"issue":"3","key":"10.1016\/j.ejmech.2026.119003_b36","article-title":"Vanadium dioxide nanocoating induces tumor cell death through mitochondrial electron transport chain interruption","volume":"3","author":"Li","year":"2019","journal-title":"Glob. Challenges"},{"issue":"8","key":"10.1016\/j.ejmech.2026.119003_b37","doi-asserted-by":"crossref","first-page":"563","DOI":"10.3390\/jof10080563","article-title":"Phenotypic and genotypic characterization of resistance and virulence markers in candida spp. Isolated from community-acquired infections in bucharest, and the impact of AgNPs on the highly resistant isolates","volume":"10","author":"Corbu","year":"2024","journal-title":"J. Fungi"},{"issue":"2","key":"10.1016\/j.ejmech.2026.119003_b38","first-page":"215","article-title":"Snapshot of resistance and virulence features in ESCAPE strains frequently isolated from surgical wound infections in a Romanian hospital","volume":"30","author":"Rayyif","year":"2022","journal-title":"Rev. Romana Med. Lab."},{"issue":"3","key":"10.1016\/j.ejmech.2026.119003_b39","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1128\/microbiolspec.GPP3-0044-2018","article-title":"The Gram-positive bacterial cell wall","volume":"7","author":"Rohde","year":"2019","journal-title":"Microbiol. Spectr."},{"issue":"3","key":"10.1016\/j.ejmech.2026.119003_b40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nmicrobiol.2017.1","article-title":"Mechanisms of envelope permeability and antibiotic influx and efflux in Gram-negative bacteria","volume":"2","author":"Masi","year":"2017","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.ejmech.2026.119003_b41","doi-asserted-by":"crossref","DOI":"10.1016\/j.cis.2022.102603","article-title":"Lipopolysaccharides at solid and liquid interfaces: models for biophysical studies of the gram-negative bacterial outer membrane","volume":"301","author":"Paracini","year":"2022","journal-title":"Adv. Colloid Interface Sci."},{"issue":"7","key":"10.1016\/j.ejmech.2026.119003_b42","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/nrmicro2163","article-title":"The versatility and adaptation of bacteria from the genus Stenotrophomonas","volume":"7","author":"Ryan","year":"2009","journal-title":"Nat. Rev. Microbiol."},{"issue":"8","key":"10.1016\/j.ejmech.2026.119003_b43","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.3390\/antibiotics12081304","article-title":"The art of war with Pseudomonas aeruginosa: targeting mex efflux pumps directly to strategically enhance antipseudomonal drug efficacy","volume":"12","author":"Avakh","year":"2023","journal-title":"Antibiotics"},{"issue":"9","key":"10.1016\/j.ejmech.2026.119003_b44","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.3390\/pathogens10091187","article-title":"Oxidative stress response in pseudomonas aeruginosa","volume":"10","author":"da Cruz Nizer","year":"2021","journal-title":"Pathogens"},{"issue":"6","key":"10.1016\/j.ejmech.2026.119003_b45","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1111\/jam.13301","article-title":"Fungal cell membrane-promising drug target for antifungal therapy","volume":"121","author":"Sant","year":"2016","journal-title":"J. Appl. Microbiol."},{"issue":"11","key":"10.1016\/j.ejmech.2026.119003_b46","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1515\/hsz-2017-0152","article-title":"Reactive nitrogen species (RNS)-resistant microbes: adaptation and medical implications","volume":"398","author":"Tharmalingam","year":"2017","journal-title":"Biol. Chem."},{"issue":"6","key":"10.1016\/j.ejmech.2026.119003_b47","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1111\/1574-6976.12026","article-title":"Antimicrobial strategies centered around reactive oxygen species\u2013bactericidal antibiotics, photodynamic therapy, and beyond","volume":"37","author":"Vatansever","year":"2013","journal-title":"FEMS Microbiol. Rev."},{"issue":"5","key":"10.1016\/j.ejmech.2026.119003_b48","doi-asserted-by":"crossref","first-page":"924","DOI":"10.3390\/microorganisms10050924","article-title":"Gram-negative bacterial envelope homeostasis under oxidative and nitrosative stress","volume":"10","author":"Chautrand","year":"2022","journal-title":"Microorganisms"},{"issue":"3","key":"10.1016\/j.ejmech.2026.119003_b49","doi-asserted-by":"crossref","first-page":"674","DOI":"10.3390\/molecules27030674","article-title":"Recent developments in nitric oxide donors and delivery for antimicrobial and anti-biofilm applications","volume":"27","author":"Poh","year":"2022","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.ejmech.2026.119003_b50","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1007\/s10311-024-01715-5","article-title":"Biofilm formation, occurrence, microbial communication, impact and characterization methods in natural and anthropic systems: A review","volume":"22","author":"Elumalai","year":"2024","journal-title":"Environ. Chem. Lett."},{"issue":"22","key":"10.1016\/j.ejmech.2026.119003_b51","doi-asserted-by":"crossref","first-page":"4189","DOI":"10.1039\/D2TB00555G","article-title":"Nitric oxide-propelled nanomotors for bacterial biofilm elimination and endotoxin removal to treat infected burn wounds","volume":"10","author":"Peng","year":"2022","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.ejmech.2026.119003_b52","article-title":"Metallic and metal oxide nanoparticles in treating Pseudomonas aeruginosa infections","volume":"91","author":"Kapoor","year":"2024","journal-title":"J. Drug Deliv. Sci. Technol."},{"issue":"1","key":"10.1016\/j.ejmech.2026.119003_b53","doi-asserted-by":"crossref","first-page":"e01751","DOI":"10.1128\/mbio.01751-23","article-title":"The respiratory enzyme complex Rnf is vital for metabolic adaptation and virulence in Fusobacterium nucleatum","volume":"15","author":"Britton","year":"2024","journal-title":"MBio"},{"issue":"2","key":"10.1016\/j.ejmech.2026.119003_b54","doi-asserted-by":"crossref","first-page":"174","DOI":"10.15407\/exp-oncology.2024.02.174","article-title":"Considering dimethyl sulfoxide solvent toxicity to mammalian cells and its biological effects","volume":"46","author":"Hassan","year":"2024","journal-title":"Exp. Oncol."},{"issue":"3","key":"10.1016\/j.ejmech.2026.119003_b55","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.2217\/rme-2019-0145","article-title":"Dimethyl sulfoxide: a central player since the dawn of cryobiology, is efficacy balanced by toxicity?","volume":"15","author":"Awan","year":"2020","journal-title":"Regen. Med."},{"key":"10.1016\/j.ejmech.2026.119003_b56","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.saa.2019.01.042","article-title":"New mixed amino acids complexes of iron (III) and zinc (II) with isonitrosoacetophenone: Synthesis, spectral characterization, DFT study and anticancer activity","volume":"213","author":"Rahmouni","year":"2019","journal-title":"Spectrochim. Acta Part A: Mol. Biomol. Spectrosc."},{"issue":"3","key":"10.1016\/j.ejmech.2026.119003_b57","doi-asserted-by":"crossref","first-page":"653","DOI":"10.3390\/molecules25030653","article-title":"SiO2-PVA-Fe (acac) 3 hybrid based superparamagnetic nanocomposites for nanomedicine: morpho-textural evaluation and in vitro cytotoxicity assay","volume":"25","author":"Putz","year":"2020","journal-title":"Molecules"},{"issue":"23","key":"10.1016\/j.ejmech.2026.119003_b58","doi-asserted-by":"crossref","first-page":"7305","DOI":"10.3390\/molecules26237305","article-title":"The implication of low dose dimethyl sulfoxide on mitochondrial function and oxidative damage in cultured cardiac and cancer cells","volume":"26","author":"Sangweni","year":"2021","journal-title":"Molecules"},{"issue":"12","key":"10.1016\/j.ejmech.2026.119003_b59","doi-asserted-by":"crossref","first-page":"3094","DOI":"10.1007\/s13346-023-01375-y","article-title":"Quality by design\u2013based development and optimization of fourth-generation ternary solid dispersion of standardized Piper longum extract for melanoma therapy","volume":"13","author":"Mohapatra","year":"2023","journal-title":"Drug Deliv. Transl. Res."},{"issue":"1","key":"10.1016\/j.ejmech.2026.119003_b60","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s10856-026-07022-5","article-title":"A pH-responsive mesoporous Zn-MOF nanocarrier for efficient cisplatin delivery and inhibition of A549 cancer cells","volume":"37","author":"Ye","year":"2026","journal-title":"J. Mater. Sci., Mater. Med."},{"key":"10.1016\/j.ejmech.2026.119003_b61","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2023.101018","article-title":"Cuproptosis: A novel therapeutic target for overcoming cancer drug resistance","volume":"72","author":"Wang","year":"2024","journal-title":"Drug Resist. Updat."},{"issue":"5","key":"10.1016\/j.ejmech.2026.119003_b62","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/s41571-024-00876-0","article-title":"Targeting cuproplasia and cuproptosis in cancer","volume":"21","author":"Tang","year":"2024","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"4","key":"10.1016\/j.ejmech.2026.119003_b63","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/s41556-020-0481-4","article-title":"Copper is an essential regulator of the autophagic kinases ULK1\/2 to drive lung adenocarcinoma","volume":"22","author":"Tsang","year":"2020","journal-title":"Nature Cell Biol."},{"issue":"7","key":"10.1016\/j.ejmech.2026.119003_b64","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1158\/1541-7786.MCR-21-0250","article-title":"BRAFV600E-driven lung adenocarcinoma requires copper to sustain autophagic signaling and processing","volume":"20","author":"Tsang","year":"2022","journal-title":"Mol. Cancer Res."},{"issue":"1","key":"10.1016\/j.ejmech.2026.119003_b65","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.canlet.2008.03.001","article-title":"The release of fibroblast growth factor-1 from melanoma cells requires copper ions and is mediated by phosphatidylinositol 3-kinase\/Akt intracellular signaling pathway","volume":"267","author":"Di Serio","year":"2008","journal-title":"Cancer Lett."},{"issue":"4","key":"10.1016\/j.ejmech.2026.119003_b66","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s00432-024-05641-5","article-title":"Unveiling the promising anticancer effect of copper-based compounds: A comprehensive review","volume":"150","author":"Abdolmaleki","year":"2024","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.ejmech.2026.119003_b67","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103552","article-title":"Copper in melanoma: at the crossroad of protumorigenic and anticancer roles","author":"Chrzan","year":"2025","journal-title":"Redox Biol."},{"issue":"6","key":"10.1016\/j.ejmech.2026.119003_b68","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1002\/ijc.23664","article-title":"Inhibition of melanogenesis as a radiation sensitizer for melanoma therapy","volume":"123","author":"Bro\u017cyna","year":"2008","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ejmech.2026.119003_b69","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114454","article-title":"The anti-melanogenic effects of ellagic acid through induction of autophagy in melanocytes and suppression of UVA-activated \u03b1-MSH pathways via Nrf2 activation in keratinocytes","volume":"185","author":"Yang","year":"2021","journal-title":"Biochem. Pharmacol."},{"issue":"10","key":"10.1016\/j.ejmech.2026.119003_b70","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.3390\/cancers12102863","article-title":"Copper complexes as anticancer agents targeting topoisomerases I and II","volume":"12","author":"Molinaro","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.ejmech.2026.119003_b71","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107994","article-title":"Hydrazone copper (II) complexes suppressed lung adenocarcinoma by activating multiple anticancer pathway","volume":"154","author":"Li","year":"2025","journal-title":"Bioorg. Chem."},{"issue":"3","key":"10.1016\/j.ejmech.2026.119003_b72","doi-asserted-by":"crossref","first-page":"645","DOI":"10.3390\/molecules27030645","article-title":"Mapping the DNA damaging effects of polypyridyl copper complexes with DNA electrochemical biosensors","volume":"27","author":"Banasiak","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2026.119003_b73","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2023.134986","article-title":"Mixed-ligand copper (II) hydrazone complexes: Synthesis, structure, and anti-lung cancer properties","volume":"1279","author":"Wu","year":"2023","journal-title":"J. Mol. Struct."},{"issue":"2","key":"10.1016\/j.ejmech.2026.119003_b74","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3390\/inorganics9020012","article-title":"Copper (II) complexes with tetradentate piperazine-based ligands: DNA cleavage and cytotoxicity","volume":"9","author":"Doniz Kettenmann","year":"2021","journal-title":"Inorganics"},{"key":"10.1016\/j.ejmech.2026.119003_b75","series-title":"Antiproliferative effects of novel copper (II) complexes on lung Cancer cell line","author":"Abdullah","year":"2022"},{"key":"10.1016\/j.ejmech.2026.119003_b76","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2024.112550","article-title":"Development of Cu (II) 4-hydroxybenzoylhydrazone complexes that induce mitochondrial DNA damage and mitochondria-mediated apoptosis in liver cancer","volume":"256","author":"Jiang","year":"2024","journal-title":"J. Inorg. Biochem."},{"issue":"1","key":"10.1016\/j.ejmech.2026.119003_b77","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3390\/futurepharmacol5010010","article-title":"Water-soluble Cu (II) complexes with polypyridyl ligands: Anticancer activity and DNA interaction","volume":"5","author":"dos Santos","year":"2025","journal-title":"Futur. Pharmacol."},{"issue":"5","key":"10.1016\/j.ejmech.2026.119003_b78","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1007\/s00709-021-01613-5","article-title":"Melanization as unfavorable factor in amelanotic melanoma cell biology","volume":"258","author":"Skoniecka","year":"2021","journal-title":"Protoplasma"},{"issue":"1","key":"10.1016\/j.ejmech.2026.119003_b79","article-title":"Evaluation of melanogenesis in A-375 cells in the presence of DMSO and analysis of pyrolytic profile of isolated melanin","volume":"2012","author":"Chodurek","year":"2012","journal-title":"Sci. World J."},{"key":"10.1016\/j.ejmech.2026.119003_b80","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.842496","article-title":"Melanoma, melanin, and melanogenesis: The Yin and Yang relationship","volume":"12","author":"Slominski","year":"2022","journal-title":"Front. Oncol."},{"issue":"11","key":"10.1016\/j.ejmech.2026.119003_b81","doi-asserted-by":"crossref","first-page":"5632","DOI":"10.1021\/acs.molpharmaceut.4c00618","article-title":"Nitric oxide-releasing topical treatments for cutaneous melanoma","volume":"21","author":"Grayton","year":"2024","journal-title":"Mol. Pharm."},{"issue":"1","key":"10.1016\/j.ejmech.2026.119003_b82","article-title":"A metabolic perspective on nitric oxide function in melanoma","volume":"1879","author":"Jimenez","year":"2024","journal-title":"Biochim. Biophys. Acta (BBA)-Reviews Cancer"},{"issue":"2","key":"10.1016\/j.ejmech.2026.119003_b83","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.bbcan.2017.09.005","article-title":"The role of nitric oxide in melanoma","volume":"1868","author":"Yarlagadda","year":"2017","journal-title":"Biochim. Biophys. Acta (BBA)-Reviews Cancer"},{"issue":"2","key":"10.1016\/j.ejmech.2026.119003_b84","doi-asserted-by":"crossref","first-page":"362","DOI":"10.21037\/tlcr-23-621","article-title":"Survivin in lung cancer: a potential target for therapy and prevention\u2014a narrative review","volume":"13","author":"Pachimatla","year":"2024","journal-title":"Transl. Lung Cancer Res."},{"issue":"19","key":"10.1016\/j.ejmech.2026.119003_b85","doi-asserted-by":"crossref","first-page":"6801","DOI":"10.3390\/jcm14196801","article-title":"From prognostic marker to therapeutic agent: The role of nitric oxide in lung cancer","volume":"14","author":"Pianigiani","year":"2025","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.ejmech.2026.119003_b86","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2024.05.033","article-title":"Nitric oxide water-driven immunogenic cell death: Unfolding mitochondrial dysfunction\u2019s role in sensitizing lung adenocarcinoma to ferroptosis and autophagic cell death","volume":"222","author":"Negi","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejmech.2026.119003_b87","doi-asserted-by":"crossref","DOI":"10.1016\/j.niox.2026.02.005","article-title":"The role of nitric oxide in inflammation, tumor microenvironment, and cancer therapy","author":"Nair","year":"2026","journal-title":"Nitric Oxide"},{"issue":"13","key":"10.1016\/j.ejmech.2026.119003_b88","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.3390\/molecules30132802","article-title":"The role of nitric oxide in cancer treatment: ally or foe?","volume":"30","author":"My\u015bliwiec","year":"2025","journal-title":"Molecules"},{"issue":"18","key":"10.1016\/j.ejmech.2026.119003_b89","doi-asserted-by":"crossref","first-page":"4361","DOI":"10.3390\/molecules29184361","article-title":"Metal-based drug\u2013DNA interactions and analytical determination methods","volume":"29","author":"Hangan","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2026.119003_b90","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2023.135751","article-title":"Non-covalent binding studies of transition metal complexes with DNA: A review","volume":"1288","author":"Kumar","year":"2023","journal-title":"J. Mol. Struct."},{"issue":"5","key":"10.1016\/j.ejmech.2026.119003_b91","doi-asserted-by":"crossref","first-page":"764","DOI":"10.3390\/pharmaceutics13050764","article-title":"DNA-Binding and cytotoxicity of copper (I) complexes containing functionalized dipyridylphenazine ligands","volume":"13","author":"Alsaedi","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejmech.2026.119003_b92","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jphotobiol.2013.03.002","article-title":"DNA interaction studies of a novel Cu (II) complex as an intercalator containing curcumin and bathophenanthroline ligands","volume":"122","author":"Shahabadi","year":"2013","journal-title":"J. Photochem. Photobiol. B: Biol."},{"key":"10.1016\/j.ejmech.2026.119003_b93","first-page":"1","article-title":"Role of free radicals and catalytic metal ions in human disease: an overview","volume":"186","author":"Gutteridge","year":"1990","journal-title":"Methods Enzymol."},{"issue":"1","key":"10.1016\/j.ejmech.2026.119003_b94","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/0014-5793(92)80911-Y","article-title":"Biologically relevant metal ion-dependent hydroxyl radical generation An update","volume":"307","author":"Halliwell","year":"1992","journal-title":"FEBS Lett."},{"issue":"1","key":"10.1016\/j.ejmech.2026.119003_b95","doi-asserted-by":"crossref","first-page":"7417","DOI":"10.1038\/s41598-021-86477-8","article-title":"Ascorbate oxidation by iron, copper and reactive oxygen species: Review, model development, and derivation of key rate constants","volume":"11","author":"Shen","year":"2021","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.ejmech.2026.119003_b96","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.2174\/0929867053764635","article-title":"Metals, toxicity and oxidative stress","volume":"12","author":"Valko","year":"2005","journal-title":"Curr. Med. Chem."},{"issue":"9","key":"10.1016\/j.ejmech.2026.119003_b97","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0107289","article-title":"Structure of the N-terminal Gyrase B fragment in complex with ADP-Pi reveals rigid-body motion induced by ATP hydrolysis","volume":"9","author":"Stanger","year":"2014","journal-title":"PloS One"},{"issue":"11","key":"10.1016\/j.ejmech.2026.119003_b98","doi-asserted-by":"crossref","first-page":"4584","DOI":"10.1021\/jm500463c","article-title":"Antibacterial inhibitors of gram-positive thymidylate kinase: structure\u2013activity relationships and chiral preference of a new hydrophobic binding region","volume":"57","author":"Kawatkar","year":"2014","journal-title":"J. Med. Chem."},{"issue":"38","key":"10.1016\/j.ejmech.2026.119003_b99","doi-asserted-by":"crossref","first-page":"15775","DOI":"10.1073\/pnas.1103496108","article-title":"Structural basis for the broad specificity to host-cell ligands by the pathogenic fungus Candida albicans","volume":"108","author":"Salgado","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"5","key":"10.1016\/j.ejmech.2026.119003_b100","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.chembiol.2009.04.001","article-title":"Mycolic acid cyclopropanation is essential for viability, drug resistance, and cell wall integrity of Mycobacterium tuberculosis","volume":"16","author":"Barkan","year":"2009","journal-title":"Chem. Biol."},{"key":"10.1016\/j.ejmech.2026.119003_b101","article-title":"Unraveling the versatility of human serum albumin\u2013A comprehensive review of its biological significance and therapeutic potential","volume":"6","author":"Ashraf","year":"2023","journal-title":"Curr. Res. Struct. Biol."},{"issue":"4","key":"10.1016\/j.ejmech.2026.119003_b102","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1073\/pnas.78.4.2179","article-title":"Structure of a B-DNA dodecamer: conformation and dynamics","volume":"78","author":"Drew","year":"1981","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"16","key":"10.1016\/j.ejmech.2026.119003_b103","doi-asserted-by":"crossref","first-page":"6059","DOI":"10.1021\/bi050021b","article-title":"Solution structural study of a DNA duplex containing the Guanine-N7 adduct formed by a cytotoxic platinum- acridine hybrid agent","volume":"44","author":"Baruah","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.ejmech.2026.119003_b104","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2022.111861","article-title":"Complexes of copper (II) with tetradentate s, O-ligands: Synthesis, characterization, DNA\/albumin interactions, molecular docking simulations and antitumor activity","volume":"233","author":"\u017divanovi\u0107","year":"2022","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.ejmech.2026.119003_b105","doi-asserted-by":"crossref","DOI":"10.1016\/j.poly.2023.116448","article-title":"A computational insight on the noncovalent interactions of aminothiazole-based palladium (II) complexes with DNA as a potent anticancer agent","volume":"239","author":"Singh","year":"2023","journal-title":"Polyhedron"},{"issue":"2","key":"10.1016\/j.ejmech.2026.119003_b106","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1093\/nar\/gkw1147","article-title":"DNA structure directs positioning of the mitochondrial genome packaging protein Abf2p","volume":"45","author":"Chakraborty","year":"2017","journal-title":"Nucleic Acids Res."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523426004484?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523426004484?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T06:09:35Z","timestamp":1783922975000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523426004484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":106,"alternative-id":["S0223523426004484"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2026.119003","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Redox-active copper(II) complexes with mixed heterocyclic N-donor ligands as dual antimicrobial and anti-tumor agents","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2026.119003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119003"}}