{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T12:07:27Z","timestamp":1793362047745,"version":"4.5.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.ejmech.2026.119024","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T15:47:47Z","timestamp":1780415267000},"page":"119024","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Discovery of novel chalcone-benzenesulfonamide conjugates as PPAR\u03b3 agonists: Design, synthesis, and biological evaluation"],"prefix":"10.1016","volume":"316","author":[{"given":"Islam H.","family":"Ali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha M.","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed M.","family":"El Kerdawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud T.","family":"Abo-elfadl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba M.I.","family":"Abdallah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3176-0187","authenticated-orcid":false,"given":"Iman A.Y.","family":"Ghannam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2026.119024_bib1","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/347645a0","article-title":"Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators","volume":"347","author":"Issemann","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2026.119024_bib2","doi-asserted-by":"crossref","first-page":"4811","DOI":"10.1021\/acs.jmedchem.0c00048","article-title":"Insights into PPAR\u03b3 phosphorylation and its inhibition mechanism","volume":"63","author":"Montanari","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119024_bib3","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1146\/annurev.med.53.082901.104018","article-title":"The mechanisms of action of PPARs","volume":"53","author":"Berger","year":"2002","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.ejmech.2026.119024_bib4","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1021\/jm990554g","article-title":"The PPARs: from orphan receptors to drug discovery","volume":"43","author":"Willson","year":"2000","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119024_bib5","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/47254","article-title":"Dominant negative mutations in human PPAR\u03b3 associated with severe insulin resistance, diabetes mellitus and hypertension","volume":"402","author":"Barroso","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2026.119024_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2019.115263","article-title":"Anti-diabetic drugs recent approaches and advancements","volume":"28","author":"Dowarah","year":"2020","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119024_bib7","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.cmet.2014.08.005","article-title":"Thiazolidinediones and the promise of insulin sensitization in type 2 diabetes","volume":"20","author":"Soccio","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.ejmech.2026.119024_bib8","series-title":"Peroxisome Proliferator-Activated Receptors: Discovery and Recent Advances","first-page":"87","article-title":"Safety of PPAR agonists","author":"Youssef","year":"2013"},{"key":"10.1016\/j.ejmech.2026.119024_bib9","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1248\/bpb.34.1094","article-title":"Pharmacology and in vitro profiling of a novel peroxisome proliferator-activated receptor \u03b3 ligand, Cerco-A","volume":"34","author":"Wakabayashi","year":"2011","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ejmech.2026.119024_bib10","doi-asserted-by":"crossref","first-page":"10335","DOI":"10.1021\/acs.jmedchem.6b01340","article-title":"Probing the complex binding modes of the PPAR\u03b3 partial agonist 2-Chloro-N-(3-chloro-4-((5-chlorobenzo[d]thiazol-2-yl)thio)phenyl)-4-(trifluoromethyl)benzenesulfonamide (T2384) to orthosteric and allosteric sites with NMR spectroscopy","volume":"59","author":"Hughes","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119024_bib11","doi-asserted-by":"crossref","DOI":"10.1155\/2008\/936906","article-title":"The development of INT131 as a selective PPARgamma modulator: approach to a safer insulin sensitizer","volume":"2008","author":"Higgins","year":"2008","journal-title":"PPAR Res."},{"key":"10.1016\/j.ejmech.2026.119024_bib12","doi-asserted-by":"crossref","first-page":"4584","DOI":"10.1021\/acs.jmedchem.6b01727","article-title":"Structure\u2013activity relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) analogs for PPAR\u03b3-Targeted antidiabetics","volume":"60","author":"Frkic","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119024_bib13","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.3390\/pharmaceutics14102139","article-title":"Development of heterocyclic PPAR ligands for potential therapeutic applications","volume":"14","author":"Virendra","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejmech.2026.119024_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2019.103115","article-title":"Design, synthesis, molecular modeling and anti-hyperglycemic evaluation of phthalimide-sulfonylurea hybrids as PPAR\u03b3 and SUR agonists","volume":"91","author":"El-Zahabi","year":"2019","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2026.119024_bib15","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ejmech.2017.06.033","article-title":"A novel structural class of coumarin-chalcone fibrates as PPAR\u03b1\/\u03b3 agonists with potent antioxidant activities: design, synthesis, biological evaluation and molecular docking studies","volume":"138","author":"Niu","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119024_bib16","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1111\/cbdd.13319","article-title":"Design, synthesis chalcone derivatives as AdipoR agonist for type 2 diabetes","volume":"92","author":"Zhu","year":"2018","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.ejmech.2026.119024_bib17","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.bioorg.2017.11.010","article-title":"Design, synthesis and molecular docking of thiazolidinedione based benzene sulphonamide derivatives containing pyrazole core as potential anti-diabetic agents","volume":"76","author":"Naim","year":"2018","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2026.119024_bib18","doi-asserted-by":"crossref","first-page":"15691","DOI":"10.1039\/D4RA02143F","article-title":"Innovation of 6-sulfonamide-2H-chromene derivatives as antidiabetic agents targeting \u03b1-amylase, \u03b1-glycosidase, and PPAR-\u03b3 inhibitors with in silico molecular docking simulation","volume":"14","author":"Thabet","year":"2024","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejmech.2026.119024_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116279","article-title":"Novel thiazolidin-4-one benzenesulfonamide hybrids as PPAR\u03b3 agonists: design, synthesis and in vivo anti-diabetic evaluation","volume":"269","author":"Ali","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119024_bib20","doi-asserted-by":"crossref","first-page":"5463","DOI":"10.1021\/acsomega.3c07149","article-title":"Novel thiazolidinedione and rhodanine derivatives regulate glucose metabolism, improve insulin sensitivity, and activate the peroxisome proliferator-activated \u03b3 receptor","volume":"9","author":"Al Neyadi","year":"2024","journal-title":"ACS Omega"},{"key":"10.1016\/j.ejmech.2026.119024_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2025.142578","article-title":"Design, synthesis and biological evaluation of phenoxyacetic acid derivatives linked to pyrazole scaffold as PPAR-\u03b1\/\u03b3 agonists and COX-2 inhibitors with dual Antidiabetic\/anti-inflammatory activities","volume":"1340","author":"Fadaly","year":"2025","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.ejmech.2026.119024_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.826811","article-title":"The role of peroxisome proliferator-activated receptor gamma and atherosclerosis: post-translational modification and selective modulators","volume":"13","author":"Yin","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ejmech.2026.119024_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.109353","article-title":"Design and synthesis of new 1,3,4-oxadiazole-1,2,3,4-tetrahydroisoquinoline hybrids as selective COX-2 inhibitors","volume":"168","author":"Abo-Elmagd","year":"2026","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2026.119024_bib24","doi-asserted-by":"crossref","DOI":"10.1007\/s11030-025-11431-z","article-title":"Design, synthesis, biological evaluation and computational studies of novel phthalimides as dual COX-2\/5-LOX inhibitors","author":"Hassan","year":"2026","journal-title":"Mol. Divers."},{"key":"10.1016\/j.ejmech.2026.119024_bib25","doi-asserted-by":"crossref","DOI":"10.1002\/ddr.22249","article-title":"Diphenyl urea-benzylidene acetohydrazide hybrids as fibroblast growth factor receptor 1 inhibitors and anticancer agents","volume":"85","author":"Abdel-Mohsen","year":"2024","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.ejmech.2026.119024_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107848","article-title":"Discovery of novel diaryl urea-oxindole hybrids as BRAF kinase inhibitors targeting BRAF and KRAS mutant cancers","volume":"153","author":"Ghannam","year":"2024","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2026.119024_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/ardp.202200341","article-title":"Novel 2-oxo-2-phenylethoxy and benzyloxy diaryl urea hybrids as VEGFR-2 inhibitors: design, synthesis, and anticancer evaluation","volume":"356","author":"Ghannam","year":"2023","journal-title":"Arch. Pharm. (Weinheim, Ger.)"},{"key":"10.1016\/j.ejmech.2026.119024_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.105883","article-title":"Design, synthesis and anticancer activity of novel 2-arylbenzimidazole\/2-thiopyrimidines and 2-thioquinazolin-4(3H)-ones conjugates as targeted RAF and VEGFR-2 kinases inhibitors","volume":"126","author":"Ali","year":"2022","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2026.119024_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/ardp.201700299","article-title":"Design, synthesis, and molecular docking of novel indole scaffold-based VEGFR-2 inhibitors as targeted anticancer agents","volume":"351","author":"Roaiah","year":"2018","journal-title":"Arch. Pharm. (Weinheim, Ger.)"},{"key":"10.1016\/j.ejmech.2026.119024_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.118264","article-title":"Structural and functional insights into PPAR-\u03b3: review of its potential and drug design innovations for the development of antidiabetic agents","volume":"302","author":"Gupta","year":"2026","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119024_bib31","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1080\/17568919.2025.2571022","article-title":"Recent advances in the design, development and therapeutic applications of PPAR\u03b3 agonists","volume":"17","author":"Ghannam","year":"2025","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119024_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.108226","article-title":"Peroxisome proliferator-activated receptors (PPARs) agonists as promising neurotherapeutics","volume":"156","author":"Ghannam","year":"2025","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2026.119024_bib33","first-page":"95","article-title":"Benzenesulfonamide-based PPAR\u03b3 agonists as anticancer agents targeting JNK and MAPK cascades","volume":"69","author":"Abo-elfadl","year":"2026","journal-title":"Egypt. J. Chem."},{"key":"10.1016\/j.ejmech.2026.119024_bib34","doi-asserted-by":"crossref","DOI":"10.1002\/ardp.202100399","article-title":"Design and synthesis of novel quinazolinone-based fibrates as PPARalpha agonists with antihyperlipidemic activity","volume":"355","author":"Hassan","year":"2022","journal-title":"Arch. Pharm. (Weinheim, Ger.)"},{"key":"10.1016\/j.ejmech.2026.119024_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.105170","article-title":"Discovery of 4-benzyloxy and 4-(2-phenylethoxy) chalcone fibrate hybrids as novel PPARalpha agonists with anti-hyperlipidemic and antioxidant activities: design, synthesis and in Vitro\/in vivo biological evaluation","volume":"115","author":"Hassan","year":"2021","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2026.119024_bib36","doi-asserted-by":"crossref","first-page":"6299","DOI":"10.1039\/D5MD00787A","article-title":"Novel chalcone 2-thiopyrimidine conjugates as dual VEGFR-2\/BRAF inhibitors: design, synthesis, in vitro cytotoxicity, and molecular docking study","volume":"16","author":"Abdelaziz","year":"2025","journal-title":"RSC Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119024_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107728","article-title":"Novel benzenesulfonamides as dual VEGFR2\/FGFR1 inhibitors targeting breast cancer: design, synthesis, anticancer activity and in silico studies","volume":"152","author":"Hassan","year":"2024","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2026.119024_bib38","article-title":"Model of streptozotocin-nicotinamide induced type 2 diabetes: a comparative review","volume":"18","author":"Rais","year":"2022","journal-title":"Curr. Diabetes Rev."},{"key":"10.1016\/j.ejmech.2026.119024_bib39","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1365-2265.2010.03811.x","article-title":"Pioglitazone improvement of fasting and postprandial hyperglycaemia in Mexican-American patients with type 2 diabetes: a double tracer OGTT study","volume":"73","author":"Glass","year":"2010","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.ejmech.2026.119024_bib40","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1111\/dom.14811","article-title":"The glucose tolerance test in mice: sex, drugs and protocol","volume":"24","author":"Kennard","year":"2022","journal-title":"Diabetes Obes. Metabol."},{"key":"10.1016\/j.ejmech.2026.119024_bib42","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","article-title":"GROMACS: high performance molecular simulations through multi-level parallelism from laptops to supercomputers","volume":"1\u20132","author":"Abraham","year":"2015","journal-title":"SoftwareX"},{"key":"10.1016\/j.ejmech.2026.119024_bib43","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera--a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.ejmech.2026.119024_bib44","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.1073\/pnas.051632198","article-title":"Potency of michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups","volume":"98","author":"Dinkova-Kostova","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejmech.2026.119024_bib45","doi-asserted-by":"crossref","first-page":"7228","DOI":"10.1021\/jm901278z","article-title":"Structure-activity relationship studies of chalcone leading to 3-hydroxy-4,3',4',5'-tetramethoxychalcone and its analogues as potent nuclear factor kappaB inhibitors and their anticancer activities","volume":"52","author":"Srinivasan","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119024_bib46","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1089\/ars.2012.4909","article-title":"Identification of michael acceptor-centric pharmacophores with substituents that yield strong thioredoxin reductase inhibitory character correlated to antiproliferative activity","volume":"19","author":"Gan","year":"2013","journal-title":"Antioxid. Redox Signaling"},{"key":"10.1016\/j.ejmech.2026.119024_bib47","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1021\/jm058056x","article-title":"Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents","volume":"50","author":"Sierra","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119024_bib48","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S1097-2765(00)80448-7","article-title":"Asymmetry in the PPARgamma\/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors","volume":"5","author":"Gampe","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ejmech.2026.119024_bib49","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1021\/jm960628d","article-title":"Synthesis and structure-activity relationships of carboxylated chalcones: a novel series of CysLT1 (LTD4) receptor antagonists","volume":"40","author":"Zwaagstra","year":"1997","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119024_bib50","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1021\/jm00111a038","article-title":"(Methoxyalkyl)thiazoles: a new series of potent, selective, and orally active 5-lipoxygenase inhibitors displaying high enantioselectivity","volume":"34","author":"Bird","year":"1991","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119024_bib51","doi-asserted-by":"crossref","first-page":"3218","DOI":"10.1016\/j.bmc.2016.05.047","article-title":"Development of hydroxy-based sphingosine kinase inhibitors and anti-inflammation in dextran sodium sulfate induced colitis in mice","volume":"24","author":"Xi","year":"2016","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119024_bib52","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1002\/cmdc.202100252","article-title":"Computer-aided search for 5-Arylideneimidazolone anticancer agents able to overcome ABCB1-Based multidrug resistance","volume":"16","author":"Kaczor","year":"2021","journal-title":"ChemMedChem"},{"key":"10.1016\/j.ejmech.2026.119024_bib53","doi-asserted-by":"crossref","first-page":"4921","DOI":"10.1016\/j.bmc.2012.06.045","article-title":"Small molecules that protect against \u03b2-amyloid-induced cytotoxicity by inhibiting aggregation of \u03b2-amyloid","volume":"20","author":"Lee","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119024_bib54","article-title":"Alteration of PPAR-GAMMA (PPARG; PPAR\u03b3) and PTEN gene expression in acute myeloid leukemia patients and the promising anticancer effects of PPAR\u03b3 stimulation using pioglitazone on AML cells","volume":"9","author":"Esmaeili","year":"2021","journal-title":"Mol. Genet. Genom. Med."},{"key":"10.1016\/j.ejmech.2026.119024_bib55","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s40360-023-00730-6","article-title":"Fenofibrate alleviates NAFLD by enhancing the PPAR\u03b1\/PGC-1\u03b1 signaling pathway coupling mitochondrial function","volume":"25","author":"Wang","year":"2024","journal-title":"BMC Pharmacol Toxicol"},{"key":"10.1016\/j.ejmech.2026.119024_bib56","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ejphar.2011.01.015","article-title":"Effects of antidiabetic drugs in high-fat diet and streptozotocin-nicotinamide-induced type 2 diabetic mice","volume":"655","author":"Tahara","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejmech.2026.119024_bib57","doi-asserted-by":"crossref","first-page":"799","DOI":"10.3390\/molecules26040799","article-title":"Design, synthesis, and in silico multitarget pharmacological simulations of acid bioisosteres with a validated in vivo antihyperglycemic effect","volume":"26","author":"Dom\u00ednguez-Mendoza","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2026.119024_bib58","doi-asserted-by":"crossref","first-page":"340","DOI":"10.3390\/molecules23020340","article-title":"Design, synthesis and in combo antidiabetic bioevaluation of multitarget phenylpropanoic acids","volume":"23","author":"Col\u00edn-Lozano","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2026.119024_bib59","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/2494067","article-title":"Metabolic syndrome and hypertension resulting from fructose enriched diet in wistar rats","volume":"2017","author":"Dupas","year":"2017","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.ejmech.2026.119024_bib60","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1021\/ci500020m","article-title":"g_mmpbsa--a GROMACS tool for high-throughput MM-PBSA calculations","volume":"54","author":"Kumari","year":"2014","journal-title":"J. Chem. Inf. Model."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523426004691?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523426004691?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T06:13:02Z","timestamp":1783923182000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523426004691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":59,"alternative-id":["S0223523426004691"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2026.119024","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of novel chalcone-benzenesulfonamide conjugates as PPAR\u03b3 agonists: Design, synthesis, and biological evaluation","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2026.119024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119024"}}