{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T08:28:07Z","timestamp":1787041687174,"version":"build-2736575974"},"reference-count":133,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.ejmech.2026.119070","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T15:44:23Z","timestamp":1782229463000},"page":"119070","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["GPR120\/free fatty acid receptor 4 (FFAR-4) agonists, antagonists, allosteric modulators: Computational drug design and discovery review"],"prefix":"10.1016","volume":"317","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7657-4452","authenticated-orcid":false,"given":"Syed Jawad Ali","family":"Shah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Hayat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Inam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilal","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hizar","family":"Subthain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2026.119070_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26062501","article-title":"Potential therapeutic exploitation of G protein-coupled receptor 120 (GPR120\/FFAR4) signaling in obesity-related metabolic disorders","volume":"26","author":"Szukiewicz","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2026.119070_bib2","doi-asserted-by":"crossref","first-page":"4312","DOI":"10.1021\/acs.jmedchem.0c01002","article-title":"GPR120\/FFAR4 pharmacology: focus on agonists in type 2 diabetes mellitus drug discovery","volume":"64","author":"Carullo","year":"2021","journal-title":"J. Med. Chem."},{"issue":"3","key":"10.1016\/j.ejmech.2026.119070_bib3","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/aps.2011.173","article-title":"Tools for GPCR drug discovery","volume":"33","author":"Zhang","year":"2012","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ejmech.2026.119070_bib4","series-title":"Membr. Protein Struct. Determ.","first-page":"141","article-title":"Recent progress in the structure determination of GPCRs, a membrane protein family with high potential as pharmaceutical targets","author":"Cherezov","year":"2010"},{"key":"10.1016\/j.ejmech.2026.119070_bib5","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1124\/mol.111.077388","article-title":"Differential signaling by splice variants of the human free fatty acid receptor GPR120","volume":"81","author":"Watson","year":"2012","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejmech.2026.119070_bib6","doi-asserted-by":"crossref","first-page":"6050","DOI":"10.1016\/j.csbj.2021.11.005","article-title":"Structure based prediction of a novel GPR120 antagonist based on pharmacophore screening and molecular dynamics simulations","volume":"19","author":"Pal","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.ejmech.2026.119070_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.715877","article-title":"Metabolic functions of G protein-coupled receptors and \u03b2-Arrestin-Mediated signaling pathways in the pathophysiology of type 2 diabetes and obesity","volume":"12","author":"Oliveira De Souza","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.ejmech.2026.119070_bib8","article-title":"Exploring GPR120\/FFAR4 pharmacology: unveiling novel therapeutic avenues through molecular signaling pathways for Alzheimer's disease intervention","volume":"48","author":"Gogu","year":"2025","journal-title":"Brain Behav. Immun. - Health"},{"key":"10.1016\/j.ejmech.2026.119070_bib9","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3390\/biom15020291","article-title":"G-Protein-Coupled receptor (GPCR) signaling and pharmacology in metabolism: physiology, mechanisms, and therapeutic potential","volume":"15","author":"Cho","year":"2025","journal-title":"Biomolecules"},{"key":"10.1016\/j.ejmech.2026.119070_bib10","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.cell.2010.07.041","article-title":"GPR120 is an Omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects","volume":"142","author":"Oh","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.ejmech.2026.119070_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2024.108784","article-title":"Biased agonism at free-fatty acid receptor-4 (FFA4\/GPR120)","volume":"266","author":"Teyani","year":"2025","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejmech.2026.119070_bib12","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s43587-025-01028-4","article-title":"Allosteric activation of a cell-type-specific GPR120 inhibits amyloid pathology of Alzheimer's disease","volume":"6","author":"He","year":"2025","journal-title":"Nat. Aging"},{"key":"10.1016\/j.ejmech.2026.119070_bib13","doi-asserted-by":"crossref","DOI":"10.1126\/science.add6220","article-title":"Unsaturated bond recognition leads to biased signal in a fatty acid receptor","volume":"380","author":"Mao","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2026.119070_bib14","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1021\/acsptsci.0c00008","article-title":"Differential role of serines and threonines in intracellular loop 3 and C-Terminal tail of the histamine H4 receptor in \u03b2-Arrestin and G protein-coupled receptor kinase interaction, internalization, and signaling","volume":"3","author":"Verweij","year":"2020","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"10.1016\/j.ejmech.2026.119070_bib15","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.bbrc.2010.05.057","article-title":"Agonism with the omega-3 fatty acids \u03b1-linolenic acid and docosahexaenoic acid mediates phosphorylation of both the short and long isoforms of the human GPR120 receptor","volume":"396","author":"Burns","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejmech.2026.119070_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1184014","article-title":"Development of tolerance to chemokine receptor antagonists: current paradigms and the need for further investigation","volume":"14","author":"Grudzien","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejmech.2026.119070_bib17","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1177\/2042018815618177","article-title":"Stimulation of incretin secreting cells","volume":"7","author":"Pais","year":"2016","journal-title":"Ther. Adv. Endocrinol. Metab."},{"key":"10.1016\/j.ejmech.2026.119070_bib18","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1152\/physiol.00029.2018","article-title":"The difference \u03b4-Cells make in glucose control","volume":"33","author":"Huising","year":"2018","journal-title":"Physiology"},{"key":"10.1016\/j.ejmech.2026.119070_bib19","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1007\/s00018-017-2492-2","article-title":"GPR120: a critical role in adipogenesis, inflammation, and energy metabolism in adipose tissue, cell","volume":"74","author":"Song","year":"2017","journal-title":"Mol. Life Sci. CMLS"},{"key":"10.1016\/j.ejmech.2026.119070_bib20","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ejphar.2015.03.094","article-title":"Functions of omega-3 fatty acids and FFA4 (GPR120) in macrophages","volume":"785","author":"Im","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejmech.2026.119070_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1694892","article-title":"Macrophages: their role in immunity and their relationship with fatty acids in health and disease","volume":"16","author":"Rueda-Mungu\u00eda","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejmech.2026.119070_bib22","doi-asserted-by":"crossref","first-page":"6173","DOI":"10.1523\/JNEUROSCI.2595-20.2021","article-title":"GPR120 signaling controls Amyloid-\u03b2 degrading activity of matrix metalloproteinases","volume":"41","author":"Kikuchi","year":"2021","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.ejmech.2026.119070_bib23","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.pneurobio.2017.01.004","article-title":"Potential of GPCRs to modulate MAPK and mTOR pathways in Alzheimer's disease","volume":"149\u2013150","author":"Franco","year":"2017","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.ejmech.2026.119070_bib24","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201708047","article-title":"The GPR120 agonist TUG\u2010891 promotes metabolic health by stimulating mitochondrial respiration in brown fat","author":"Schilperoort","year":"2018","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.ejmech.2026.119070_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2026.117685","article-title":"Agonism of FFA4\/GPR120 activates tyrosine hydroxylase and confers neuroprotection from 6-OHDA-induced cytotoxicity in PC12 cells and in a rat 6-OHDA model of Parkinson's disease","volume":"245","author":"Moghaddam","year":"2026","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejmech.2026.119070_bib26","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.3390\/ijms22041763","article-title":"Pharmacology of free Fatty acid receptors and their allosteric modulators","volume":"22","author":"Grundmann","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2026.119070_bib27","article-title":"Activation of GPR120 by TUG891 ameliorated cisplatin-induced acute kidney injury via repressing ER stress and apoptosis","volume":"126","author":"Huang","year":"2020","journal-title":"Biomed. Pharmacother. Biomedecine Pharmacother."},{"key":"10.1016\/j.ejmech.2026.119070_bib28","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s00018-024-05207-1","article-title":"A novel fatty acid analogue triggers CD36\u2013GPR120 interaction and exerts anti-inflammatory action in endotoxemia","volume":"81","author":"Boutanquoi","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ejmech.2026.119070_bib29","doi-asserted-by":"crossref","first-page":"20345","DOI":"10.1074\/jbc.M114.561449","article-title":"The molecular basis of ligand interaction at free Fatty acid receptor 4 (FFA4\/GPR120)","volume":"289","author":"Hudson","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejmech.2026.119070_bib30","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1021\/acscentsci.3c01155","article-title":"From functional fatty acids to potent and selective natural-product-inspired mimetics via conformational profiling","volume":"10","author":"Markham","year":"2024","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.ejmech.2026.119070_bib31","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s00210-009-0425-9","article-title":"Novel selective ligands for free fatty acid receptors GPR120 and GPR40","volume":"380","author":"Hara","year":"2009","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.ejmech.2026.119070_bib32","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1124\/mol.110.066324","article-title":"Structure-activity relationships of GPR120 agonists based on a docking simulation","volume":"78","author":"Sun","year":"2010","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejmech.2026.119070_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0087848","article-title":"KDT501, a derivative from hops, normalizes glucose metabolism and body weight in rodent models of diabetes","volume":"9","author":"Konda","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ejmech.2026.119070_bib34","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1210\/js.2017-00202","article-title":"Effects of KDT501 on metabolic parameters in insulin-resistant prediabetic humans","volume":"1","author":"Kern","year":"2017","journal-title":"J. Endocr. Soc."},{"key":"10.1016\/j.ejmech.2026.119070_bib35","doi-asserted-by":"crossref","first-page":"10534","DOI":"10.1039\/D0FO02442B","article-title":"Teadenol A in microbial fermented tea acts as a novel ligand on GPR120 to increase GLP-1 secretion","volume":"11","author":"Nagasawa","year":"2020","journal-title":"Food Funct."},{"key":"10.1016\/j.ejmech.2026.119070_bib36","article-title":"The GPR120 agonist TUG-891 mitigates ischemic brain injury by attenuating endoplasmic reticulum stress and apoptosis via the PI3K\/AKT signaling pathway","volume":"22","author":"Sun","year":"2025","journal-title":"Neurother. J. Am. Soc. Exp. Neurother."},{"key":"10.1016\/j.ejmech.2026.119070_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232012237","article-title":"How arrestins and GRKs regulate the function of long chain fatty acid receptors","volume":"23","author":"Alharbi","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2026.119070_bib38","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/sj.bjp.0706770","article-title":"Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules","volume":"148","author":"Briscoe","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejmech.2026.119070_bib39","article-title":"Novel phenoxyalkanoic acid derivatives as free Fatty acid receptor 4 agonists for treating type 2 diabetes mellitus","volume":"25","author":"Li","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"24","key":"10.1016\/j.ejmech.2026.119070_bib40","doi-asserted-by":"crossref","first-page":"9018","DOI":"10.3390\/molecules27249018","article-title":"Discovery of novel and selective G-protein coupled receptor 120 (GPR120) agonists for the treatment of type 2 diabetes mellitus","volume":"27","author":"Wang","year":"2022","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.ejmech.2026.119070_bib41","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1021\/acsmedchemlett.6b00360","article-title":"Design, synthesis, and evaluation of novel and selective G-protein coupled receptor 120 (GPR120) spirocyclic agonists","volume":"8","author":"Cox","year":"2016","journal-title":"ACS Med. Chem. Lett."},{"issue":"15","key":"10.1016\/j.ejmech.2026.119070_bib42","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1016\/j.bmcl.2018.06.047","article-title":"Discovery of novel selective GPR120 agonists with potent anti-diabetic activity by hybrid design","volume":"28","author":"Sheng","year":"2018","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2026.119070_bib43","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1080\/13543776.2020.1811852","article-title":"GPR120 agonists for the treatment of diabetes: a patent review (2014 present)","volume":"30","author":"Zhang","year":"2020","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.ejmech.2026.119070_bib44","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1016\/j.bmcl.2014.05.012","article-title":"Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4\/GPR120)","volume":"24","author":"Sparks","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2026.119070_bib45","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.cell.2013.03.034","article-title":"Allostery in disease and in drug discovery","volume":"153","author":"Nussinov","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.ejmech.2026.119070_bib46","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.str.2019.01.003","article-title":"Allostery in its many disguises: from theory to applications","volume":"27","author":"Wodak","year":"2019","journal-title":"Structure"},{"key":"10.1016\/j.ejmech.2026.119070_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2022.167751","article-title":"Multiscale allostery: basic mechanisms and versatility in diagnostics and drug design","volume":"434","author":"Berezovsky","year":"2022","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.ejmech.2026.119070_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2025.169050","article-title":"Allostery in disease: anticancer drugs, pockets, and the tumor heterogeneity challenge","volume":"437","author":"Nussinov","year":"2025","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.ejmech.2026.119070_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2025.169407","article-title":"Allostery in disease: from mutations, mechanisms, and signalling partners to diagnostic and drug therapies","volume":"437","author":"Berezovsky","year":"2025","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.ejmech.2026.119070_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.sbi.2023.102758","article-title":"Allosteric drugs: new principles and design approaches","volume":"84","author":"Tee","year":"2024","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.ejmech.2026.119070_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.sbi.2025.103172","article-title":"Allosteric solution to the problems of undruggable targets, drug toxicity, and emerging resistance","volume":"95","author":"Tee","year":"2025","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.ejmech.2026.119070_bib52","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1124\/jpet.123.001838","article-title":"Allostery: the good, the bad, and the ugly","volume":"388","author":"Kenakin","year":"2024","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejmech.2026.119070_bib53","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.sbi.2020.01.010","article-title":"Allosteric drugs and mutations: chances, challenges, and necessity","volume":"62","author":"Guarnera","year":"2020","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.ejmech.2026.119070_bib54","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev-pharmtox-010611-134525","article-title":"Drugs for allosteric sites on receptors","volume":"54","author":"Wenthur","year":"2014","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.ejmech.2026.119070_bib55","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrd2760","article-title":"Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders","volume":"8","author":"Conn","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejmech.2026.119070_bib56","doi-asserted-by":"crossref","first-page":"e269","DOI":"10.1016\/j.ddtec.2012.10.007","article-title":"Allosteric modulation of class C GPCRs: a novel approach for the treatment of CNS disorders","volume":"10","author":"Engers","year":"2013","journal-title":"Drug Discov. Today Technol."},{"key":"10.1016\/j.ejmech.2026.119070_bib57","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s12032-017-0969-3","article-title":"Linoleic acid induces migration and invasion through FFAR4- and PI3K-\/Akt-dependent pathway in MDA-MB-231 breast cancer cells","volume":"34","author":"Serna-Marquez","year":"2017","journal-title":"Med. Oncol."},{"key":"10.1016\/j.ejmech.2026.119070_bib58","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1124\/mol.116.107821","article-title":"Probe-Dependent negative allosteric modulators of the long-chain free Fatty acid receptor FFA4","volume":"91","author":"Watterson","year":"2017","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejmech.2026.119070_bib59","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41392-024-01803-6","article-title":"G protein-coupled receptors (GPCRs): advances in structures, mechanisms and drug discovery","volume":"9","author":"Zhang","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.ejmech.2026.119070_bib60","doi-asserted-by":"crossref","first-page":"eadp7040","DOI":"10.1126\/sciadv.adp7040","article-title":"Positive allosteric modulation of a GPCR ternary complex","volume":"10","author":"Burger","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ejmech.2026.119070_bib61","doi-asserted-by":"crossref","first-page":"3324","DOI":"10.3390\/ph3103324","article-title":"Allosteric modulation of G protein coupled receptors by Cytoplasmic, transmembrane and extracellular ligands","volume":"3","author":"Yanamala","year":"2010","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.ejmech.2026.119070_bib62","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1124\/mol.118.115113","article-title":"Does the lipid bilayer orchestrate access and binding of ligands to transmembrane Orthosteric\/Allosteric sites of G protein-coupled receptors?","volume":"96","author":"Szlenk","year":"2019","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejmech.2026.119070_bib63","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1021\/acsmedchemlett.6b00360","article-title":"Design, synthesis, and evaluation of novel and selective G-protein coupled receptor 120 (GPR120) Spirocyclic agonists","volume":"8","author":"Cox","year":"2017","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2026.119070_bib64","doi-asserted-by":"crossref","first-page":"6907","DOI":"10.3390\/molecules26226907","article-title":"Novel GPR120 agonists with improved pharmacokinetic profiles for the treatment of type 2 diabetes","volume":"26","author":"Ji","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2026.119070_bib65","doi-asserted-by":"crossref","first-page":"9018","DOI":"10.3390\/molecules27249018","article-title":"Discovery of novel and selective G-Protein coupled receptor 120 (GPR120) agonists for the treatment of type 2 diabetes mellitus","volume":"27","author":"Wang","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2026.119070_bib66","doi-asserted-by":"crossref","first-page":"4774","DOI":"10.3390\/nu15224774","article-title":"Identification of crocetin as a dual agonist of GPR40 and GPR120 responsible for the antidiabetic effect of saffron","volume":"15","author":"Zhao","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.ejmech.2026.119070_bib67","doi-asserted-by":"crossref","DOI":"10.1530\/endoabs.104.P111","article-title":"GPR120\/GPR40 agonism activates downstream signalling molecules that improve beta cell function and insulin resistance in type 2 diabetes","author":"McGinn","year":"2024","journal-title":"Endocr. Abstr."},{"key":"10.1016\/j.ejmech.2026.119070_bib68","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1021\/acsmedchemlett.2c00160","article-title":"Optimization of first-in-class dual-acting FFAR1\/FFAR4 allosteric modulators with novel mode of action","volume":"13","author":"L\u00fcckmann","year":"2022","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2026.119070_bib69","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0189060","article-title":"The acute glucose lowering effect of specific GPR120 activation in mice is mainly driven by glucagon-like peptide 1","volume":"12","author":"Sundstr\u00f6m","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.ejmech.2026.119070_bib70","first-page":"260","article-title":"Activation of GPR120 promotes the metastasis of breast cancer through the PI3K\/Akt\/NF-\u03baB signaling pathway, Anticancer","volume":"30","author":"Zhang","year":"2019","journal-title":"Drugs"},{"key":"10.1016\/j.ejmech.2026.119070_bib71","doi-asserted-by":"crossref","first-page":"6050","DOI":"10.1016\/j.csbj.2021.11.005","article-title":"Structure based prediction of a novel GPR120 antagonist based on pharmacophore screening and molecular dynamics simulations","volume":"19","author":"Pal","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.ejmech.2026.119070_bib72","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1004678","article-title":"Structure-Based statistical mechanical model accounts for the causality and energetics of allosteric communication","volume":"12","author":"Guarnera","year":"2016","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.ejmech.2026.119070_bib73","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1006228","article-title":"Reversing allosteric communication: from detecting allosteric sites to inducing and tuning targeted allosteric response","volume":"14","author":"Tee","year":"2018","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.ejmech.2026.119070_bib74","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.str.2019.01.014","article-title":"Toward comprehensive allosteric control over protein activity","volume":"27","author":"Guarnera","year":"2019","journal-title":"Structure"},{"key":"10.1016\/j.ejmech.2026.119070_bib75","doi-asserted-by":"crossref","DOI":"10.1063\/5.0139848","article-title":"Sequence-dependent model of allosteric communication","volume":"158","author":"Guarnera","year":"2023","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.ejmech.2026.119070_bib76","doi-asserted-by":"crossref","first-page":"D265","DOI":"10.1093\/nar\/gky1028","article-title":"AlloMAPS: allosteric mutation analysis and polymorphism of signaling database","volume":"47","author":"Tan","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejmech.2026.119070_bib77","doi-asserted-by":"crossref","first-page":"D345","DOI":"10.1093\/nar\/gkac828","article-title":"AlloMAPS 2: allosteric fingerprints of the AlphaFold and Pfam-trRosetta predicted structures for engineering and design","volume":"51","author":"Tan","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejmech.2026.119070_bib78","doi-asserted-by":"crossref","first-page":"W116","DOI":"10.1093\/nar\/gkaa338","article-title":"AlloSigMA 2: paving the way to designing allosteric effectors and to exploring allosteric effects of mutations","volume":"48","author":"Tan","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejmech.2026.119070_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2025.169293","article-title":"Designing structure-specific and switchable allosteric effectors for GPCRs based on the causality and energetics of inherent signaling","volume":"437","author":"Dong","year":"2025","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.ejmech.2026.119070_bib80","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s12974-017-0869-7","article-title":"Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation","volume":"14","author":"Dragano","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.ejmech.2026.119070_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121475","article-title":"Incretins play an important role in FFA4\/GPR120 regulation of glucose metabolism by GW-9508","volume":"318","author":"McKillop","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.ejmech.2026.119070_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.108875","article-title":"Flavonoid-based dual modulation of GPR120 and PPAR\u03b3: a potential therapeutic strategy for metabolic disease intervention","volume":"164","author":"Gone","year":"2025","journal-title":"Bioorganic Chem"},{"key":"10.1016\/j.ejmech.2026.119070_bib83","doi-asserted-by":"crossref","first-page":"4283","DOI":"10.1021\/jm200371q","article-title":"Progress in structure based drug design for G protein-coupled receptors","volume":"54","author":"Congreve","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119070_bib84","series-title":"Free Fatty Acid Receptor 4 in Cardiac Myocytes Ameliorates Ischemic Cardiomyopathy","author":"Zhang","year":"2024"},{"key":"10.1016\/j.ejmech.2026.119070_bib85","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1007\/s10620-020-06280-9","article-title":"G-Protein-Coupled receptors 120 agonist III improves hepatic inflammation and ER stress in steatohepatitis","volume":"66","author":"Chen","year":"2021","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.ejmech.2026.119070_bib86","first-page":"353","article-title":"Docosahexanoic acid attenuates palmitate-induced apoptosis by autophagy upregulation via GPR120\/mTOR axis in insulin-secreting cells, endocrinol","volume":"39","author":"Hong","year":"2024","journal-title":"Metab"},{"key":"10.1016\/j.ejmech.2026.119070_bib87","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41422-023-00814-2","article-title":"Sensing unsaturated fatty acids: insights from GPR120 signaling","volume":"33","author":"Zhang","year":"2023","journal-title":"Cell Res."},{"key":"10.1016\/j.ejmech.2026.119070_bib88","series-title":"Free Fat. Acid Recept","first-page":"57","article-title":"Application of GPCR structures for modelling of free Fatty acid receptors","author":"Tikhonova","year":"2016"},{"key":"10.1016\/j.ejmech.2026.119070_bib89","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s10544-025-00736-3","article-title":"Deciphering the allosteric dynamics of GPR120-fatty acid interactions within a bilayer nanogold electrochemical receptor biosensor: the impact of replacing tryptophan 198 with proline","volume":"27","author":"Xu","year":"2025","journal-title":"Biomed. Microdevices"},{"key":"10.1016\/j.ejmech.2026.119070_bib90","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.1038\/onc.2015.467","article-title":"Molecular mechanisms of target recognition by lipid GPCRs: relevance for cancer","volume":"35","author":"Van Jaarsveld","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.ejmech.2026.119070_bib91","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s43556-023-00156-w","article-title":"Structure, function and drug discovery of GPCR signaling","volume":"4","author":"Cheng","year":"2023","journal-title":"Mol. Biomed."},{"key":"10.1016\/j.ejmech.2026.119070_bib92","doi-asserted-by":"crossref","DOI":"10.1002\/minf.202400046","article-title":"Distinct binding hotspots for natural and synthetic agonists of FFA4 from in silico approaches","volume":"43","author":"Patient","year":"2024","journal-title":"Mol. Inf."},{"key":"10.1016\/j.ejmech.2026.119070_bib93","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/s41422-023-00835-x","article-title":"Structural basis of omega-3 fatty acid receptor FFAR4 activation and G protein coupling selectivity","volume":"33","author":"Yin","year":"2023","journal-title":"Cell Res."},{"key":"10.1016\/j.ejmech.2026.119070_bib94","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/s41586-020-2419-1","article-title":"Molecular basis of \u03b2-arrestin coupling to formoterol-bound \u03b21-adrenoceptor","volume":"583","author":"Lee","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2026.119070_bib95","doi-asserted-by":"crossref","first-page":"7895","DOI":"10.1038\/ncomms8895","article-title":"Structural prerequisites for G-protein activation by the neurotensin receptor","volume":"6","author":"Krumm","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2026.119070_bib96","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nature09648","article-title":"Structure of a nanobody-stabilized active state of the \u03b22 adrenoceptor","volume":"469","author":"Rasmussen","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2026.119070_bib97","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nature12944","article-title":"Molecular control of \u03b4-opioid receptor signalling","volume":"506","author":"Fenalti","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2026.119070_bib98","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2020.597809","article-title":"Disrupted lipid raft shuttling of Fc\u03b5RI by n-3 polyunsaturated Fatty acid is associated with ligation of G protein-coupled receptor 120 (GPR120) in human mast cell line LAD2","volume":"7","author":"Wang","year":"2020","journal-title":"Front. Nutr."},{"key":"10.1016\/j.ejmech.2026.119070_bib99","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1758-2946-3-29","article-title":"Multiple search methods for similarity-based virtual screening: analysis of search overlap and precision","volume":"3","author":"Holliday","year":"2011","journal-title":"J. Cheminformatics"},{"key":"10.1016\/j.ejmech.2026.119070_bib100","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.ejmech.2026.119070_bib101","doi-asserted-by":"crossref","first-page":"5718","DOI":"10.1021\/acs.jcim.5c00942","article-title":"Identifying potent compounds using pairwise consensus methods","volume":"65","author":"Xu","year":"2025","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.ejmech.2026.119070_bib102","doi-asserted-by":"crossref","DOI":"10.1002\/minf.2445","article-title":"Enhancing the reliability of integrated consensus strategies to boost docking-based screening campaigns using publicly available docking programs","volume":"44","author":"Scardino","year":"2025","journal-title":"Mol. Inf."},{"key":"10.1016\/j.ejmech.2026.119070_bib103","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1021\/ci300411b","article-title":"Current assessment of docking into GPCR Crystal structures and homology Models: successes, Challenges, and Guidelines","volume":"52","author":"Beuming","year":"2012","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.ejmech.2026.119070_bib104","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2022.879212","article-title":"Essential dynamics ensemble docking for structure-based GPCR drug discovery","volume":"9","author":"McKay","year":"2022","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.ejmech.2026.119070_bib105","author":"Pant"},{"key":"10.1016\/j.ejmech.2026.119070_bib106","doi-asserted-by":"crossref","first-page":"4736","DOI":"10.1021\/acs.jcim.2c00788","article-title":"Intermolecular interactions in G protein-coupled receptor allosteric sites at the membrane interface from molecular dynamics simulations and quantum chemical calculations","volume":"62","author":"Ding","year":"2022","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.ejmech.2026.119070_bib107","doi-asserted-by":"crossref","first-page":"6522","DOI":"10.2174\/13816128113199990440","article-title":"Non-Covalent interactions with aromatic rings: current understanding and implications for rational drug design","volume":"19","author":"Li","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.ejmech.2026.119070_bib108","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1002\/prot.25894","article-title":"Energetic contributions of amino acid residues and its cross\u2010talk to delineate ligand\u2010binding mechanism","volume":"88","author":"Kumar","year":"2020","journal-title":"Proteins: Struct., Funct., Bioinf."},{"key":"10.1016\/j.ejmech.2026.119070_bib109","doi-asserted-by":"crossref","first-page":"3862","DOI":"10.1038\/s41467-020-17618-2","article-title":"Mapping allosteric communications within individual proteins","volume":"11","author":"Wang","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2026.119070_bib110","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2024.109245","article-title":"A review on description dynamics and conformational changes of proteins using combination of principal component analysis and molecular dynamics simulation","volume":"183","author":"Moradi","year":"2024","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.ejmech.2026.119070_bib111","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s12859-015-0567-3","article-title":"Quantifying conformational changes in GPCRs: glimpse of a common functional mechanism","volume":"16","author":"Dalton","year":"2015","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.ejmech.2026.119070_bib112","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adq3971","article-title":"Structure and dynamics determine G protein coupling specificity at a class A GPCR","volume":"11","author":"Casiraghi","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ejmech.2026.119070_bib113","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1038\/s41467-023-38985-6","article-title":"Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84","volume":"14","author":"Liu","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2026.119070_bib114","doi-asserted-by":"crossref","first-page":"16341","DOI":"10.1074\/jbc.M109.094870","article-title":"Ligand-specific conformation of extracellular loop-2 in the angiotensin II type 1 receptor","volume":"285","author":"Unal","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejmech.2026.119070_bib115","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.mce.2016.11.023","article-title":"Understanding the common themes and diverse roles of the second extracellular loop (ECL2) of the GPCR super-family","volume":"449","author":"Woolley","year":"2017","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.ejmech.2026.119070_bib116","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nchembio806","article-title":"A clinical drug library screen identifies astemizole as an antimalarial agent","volume":"2","author":"Chong","year":"2006","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.ejmech.2026.119070_bib117","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1021\/acsptsci.4c00051","article-title":"Structural insights into partial activation of the prototypic G protein-coupled adenosine A2A receptor","volume":"7","author":"Claff","year":"2024","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"10.1016\/j.ejmech.2026.119070_bib118","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1021\/ci3001277","article-title":"ZINC: a free tool to discover chemistry for biology","volume":"52","author":"Irwin","year":"2012","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.ejmech.2026.119070_bib119","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.addr.2012.09.019","article-title":"Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings","volume":"64","author":"Lipinski","year":"2012","journal-title":"MOST CITED Pap. Hist. Adv. DRUG Deliv. Rev. TRIBUTE 25TH Anniv. J."},{"key":"10.1016\/j.ejmech.2026.119070_bib120","doi-asserted-by":"crossref","DOI":"10.1021\/jm020017n","article-title":"Molecular properties that influence the oral bioavailability of drug candidates","volume":"45","author":"Veber","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119070_bib121","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/nature10361","article-title":"Crystal structure of the \u03b22 adrenergic receptor-Gs protein complex","volume":"477","author":"Rasmussen","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2026.119070_bib122","doi-asserted-by":"crossref","first-page":"48471","DOI":"10.1021\/acsomega.4c07071","article-title":"A high-throughput method for screening peptide activators of G-Protein-Coupled receptors","volume":"9","author":"Paudel","year":"2024","journal-title":"ACS Omega"},{"key":"10.1016\/j.ejmech.2026.119070_bib123","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.csbj.2022.11.057","article-title":"Evaluating GPCR modeling and docking strategies in the era of deep learning-based protein structure prediction","volume":"21","author":"Lee","year":"2023","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.ejmech.2026.119070_bib124","doi-asserted-by":"crossref","DOI":"10.1016\/j.crfs.2024.100710","article-title":"Free fatty acid receptors beyond fatty acids: a computational journey to explore peptides as possible binders of GPR120","volume":"8","author":"Pedroni","year":"2024","journal-title":"Curr. Res. Food Sci."},{"key":"10.1016\/j.ejmech.2026.119070_bib125","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.104389","article-title":"New insight into enzymatic hydrolysis of peptides with site-specific amino acid d-isomerization","volume":"105","author":"Yan","year":"2020","journal-title":"Bioorganic Chem"},{"key":"10.1016\/j.ejmech.2026.119070_bib126","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.02828-24","article-title":"Oral delivery of GLP-1 peptide using recombinant Lactobacillus gasseri for the treatment of type 2 diabetes mellitus","volume":"13","author":"Ke","year":"2025","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.ejmech.2026.119070_bib127","article-title":"Navigating the complexity of oral peptide delivery: challenges and strategies to enhance oral bioavailability, Front","volume":"6","author":"Khalid","year":"2026","journal-title":"Drug Deliv."},{"key":"10.1016\/j.ejmech.2026.119070_bib128","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ymeth.2020.06.016","article-title":"Machine learning and AI-based approaches for bioactive ligand discovery and GPCR-ligand recognition","volume":"180","author":"Raschka","year":"2020","journal-title":"Methods"},{"key":"10.1016\/j.ejmech.2026.119070_bib129","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.eng.2023.09.011","article-title":"The application of artificial intelligence accelerates G protein-coupled receptor ligand discovery","volume":"32","author":"Chen","year":"2024","journal-title":"Engineering"},{"key":"10.1016\/j.ejmech.2026.119070_bib130","doi-asserted-by":"crossref","first-page":"903","DOI":"10.3390\/molecules29040903","article-title":"Machine learning empowering drug discovery: applications, opportunities and challenges","volume":"29","author":"Qi","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2026.119070_bib131","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s44386-025-00019-0","article-title":"AI meets physics in computational structure-based drug discovery for GPCRs","volume":"2","author":"Michino","year":"2025","journal-title":"Npj Drug Discov."},{"key":"10.1016\/j.ejmech.2026.119070_bib132","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbae338","article-title":"A survey of generative AI for de novo drug design: new frontiers in molecule and protein generation","volume":"25","author":"Tang","year":"2024","journal-title":"Brief. Bioinform."},{"key":"10.1016\/j.ejmech.2026.119070_bib133","doi-asserted-by":"crossref","DOI":"10.1113\/EP087877","article-title":"Elucidation of the roles of brown and brite fat genes: GPR120 is a modulator of brown adipose tissue function","volume":"105","author":"Christian","year":"2020","journal-title":"Exp. Physiol."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523426005155?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523426005155?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T08:06:14Z","timestamp":1787040374000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523426005155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":133,"alternative-id":["S0223523426005155"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2026.119070","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"GPR120\/free fatty acid receptor 4 (FFAR-4) agonists, antagonists, allosteric modulators: Computational drug design and discovery review","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2026.119070","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119070"}}