{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T05:19:21Z","timestamp":1792387161935,"version":"4.4.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of War","doi-asserted-by":"publisher","award":["W81XWH-22-1-0369"],"award-info":[{"award-number":["W81XWH-22-1-0369"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006710","name":"Wayne State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI161570"],"award-info":[{"award-number":["R01AI161570"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA247370"],"award-info":[{"award-number":["R01CA247370"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008296","name":"Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008296","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017453","name":"Institute for Prostate Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017302","name":"Barbara Ann Karmanos Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017302","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.ejmech.2026.119108","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T23:33:16Z","timestamp":1782948796000},"page":"119108","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Structure-guided design of potent and selective covalent inhibitors of SARS-CoV-1 and SARS-CoV-2 papain-like proteases with antiviral activity"],"prefix":"10.1016","volume":"317","author":[{"given":"Abdullah I.","family":"Al-Homoudi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narva Deshwar","family":"Kushwaha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hariprasad","family":"Aruri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Galarza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel J.","family":"Moorman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark T.","family":"Heise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Tartamella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipankar","family":"Ray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2047-5535","authenticated-orcid":false,"given":"Ladislau C.","family":"Kovari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2413-0235","authenticated-orcid":false,"given":"Navnath S.","family":"Gavande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2026.119108_bib1","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.28008","article-title":"Incubation period of COVID-19 caused by unique SARS-CoV-2 strains: a systematic review and meta-analysis","volume":"5","author":"Wu","year":"2022","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.ejmech.2026.119108_bib3","first-page":"162","article-title":"SARS-CoV-2 variant biology: immune escape, transmission and fitness","volume":"21","author":"Carabelli","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ejmech.2026.119108_bib4","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1056\/NEJMoa2007764","article-title":"Remdesivir for the treatment of Covid-19 \u2013 final report","volume":"383","author":"Beigel","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejmech.2026.119108_bib5","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1056\/NEJMoa2116044","article-title":"Molnupiravir for oral treatment of Covid-19 in nonhospitalized patients","volume":"386","author":"Jayk Bernal","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejmech.2026.119108_bib6","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1126\/science.abl4784","article-title":"An oral SARS-CoV-2 mpro inhibitor clinical candidate for the treatment of COVID-19","volume":"374","author":"Owen","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2026.119108_bib7","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1056\/NEJMoa2023184","article-title":"Repurposed antiviral drugs for Covid-19 \u2013 interim WHO solidarity trial results","volume":"384","author":"Pan","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejmech.2026.119108_bib8","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S1473-3099(21)00485-0","article-title":"Remdesivir plus standard of care versus standard of care alone for the treatment of patients admitted to hospital with COVID-19 (DisCoVeRy): a phase 3 randomized controlled open-label trial","volume":"22","author":"Ader","year":"2022","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.ejmech.2026.119108_bib9","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/s41594-021-00651-0","article-title":"Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis","volume":"28","author":"Kabinger","year":"2021","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.ejmech.2026.119108_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.100770","article-title":"Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template","volume":"297","author":"Gordon","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejmech.2026.119108_bib11","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0140-6736(21)02657-X","article-title":"Caution required with use of ritonavir-boosted PF-07321332 in COVID-19 management","volume":"399","author":"Heskin","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.ejmech.2026.119108_bib12","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1038\/s41591-024-03173-6","article-title":"Long COVID science, research and policy","volume":"30","author":"Al-Aly","year":"2024","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejmech.2026.119108_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens11091008","article-title":"Association between mutations in papain-like protease (PLpro) of SARS-CoV-2 with COVID-19 clinical outcomes","volume":"11","author":"Tan","year":"2022","journal-title":"Pathogens"},{"key":"10.1016\/j.ejmech.2026.119108_bib14","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.00869-22","article-title":"Genetic surveillance of SARS-CoV-2 Mpro reveals high sequence and structural conservation prior to the introduction of protease inhibitor paxlovid","volume":"13","author":"Lee","year":"2022","journal-title":"mBio"},{"key":"10.1016\/j.ejmech.2026.119108_bib15","doi-asserted-by":"crossref","first-page":"32208","DOI":"10.1074\/jbc.M704870200","article-title":"Regulation of IRF-3-dependent innate immunity by the papain-like protease domain of the severe acute respiratory syndrome coronavirus","volume":"282","author":"Devaraj","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejmech.2026.119108_bib16","doi-asserted-by":"crossref","first-page":"4550","DOI":"10.1128\/JVI.79.7.4550-4551.2005","article-title":"Deubiquitination, a new function of the severe acute respiratory syndrome coronavirus papain-like protease?","volume":"79","author":"Sulea","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.ejmech.2026.119108_bib17","doi-asserted-by":"crossref","first-page":"15199","DOI":"10.1128\/JVI.79.24.15199-15208.2005","article-title":"The papain-like protease from the severe acute respiratory syndrome coronavirus is a deubiquitinating enzyme","volume":"79","author":"Lindner","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.ejmech.2026.119108_bib18","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1038\/s41590-021-01056-3","article-title":"ISG15 secretion exacerbates inflammation in SARS-CoV-2 infection","volume":"22","author":"Cao","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ejmech.2026.119108_bib19","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1038\/s41590-021-01035-8","article-title":"Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection","volume":"22","author":"Munnur","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ejmech.2026.119108_bib20","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abd4596","article-title":"Activity profiling and structures of inhibitor-bound SARS-CoV-2-PLpro protease provides a framework for anti-COVID-19 drug design","volume":"6","author":"Rut","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ejmech.2026.119108_bib21","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41586-020-2601-5","article-title":"Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity","volume":"587","author":"Shin","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2026.119108_bib22","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1021\/acsinfecdis.0c00168","article-title":"Characterization and noncovalent inhibition of the deubiquitinase and deISGylase activity of SARS-CoV-2 papain-like protease","volume":"6","author":"Freitas","year":"2020","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.ejmech.2026.119108_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/srep40292","article-title":"X-ray structure and enzymatic activity profile of a core papain-like protease of MERS coronavirus with utility for structure-based drug design","volume":"7","author":"Clasman","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2026.119108_bib24","doi-asserted-by":"crossref","first-page":"7561","DOI":"10.1021\/acs.jmedchem.2c00303","article-title":"Progress and challenges in targeting the SARS-CoV-2 papain-like protease","volume":"65","author":"Tan","year":"2022","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119108_bib25","doi-asserted-by":"crossref","first-page":"16119","DOI":"10.1073\/pnas.0805240105","article-title":"A noncovalent class of papain-like protease\/deubiquitinase inhibitors blocks SARS virus replication","volume":"105","author":"Ratia","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejmech.2026.119108_bib26","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1038\/s41467-023-37254-w","article-title":"Potent and selective covalent inhibition of the papain-like protease from SARS-CoV-2","volume":"14","author":"Sanders","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2026.119108_bib27","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1126\/science.adm9724","article-title":"Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model","volume":"383","author":"Tan","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2026.119108_bib30","doi-asserted-by":"crossref","first-page":"20399","DOI":"10.1021\/acs.jmedchem.4c01872","article-title":"Structure-based design of covalent SARS-CoV-2 papain-like protease inhibitors","volume":"67","author":"Tan","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119108_bib28","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1021\/acs.jmedchem.1c01307","article-title":"Design of SARS-CoV-2 PLpro inhibitors for COVID-19 antiviral therapy leveraging binding cooperativity","volume":"65","author":"Shen","year":"2022","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119108_bib29","article-title":"Potent novel SARS-CoV-2 PLpro inhibitors block viral replication in monkey and human cell cultures","author":"Shen","year":"2021","journal-title":"bioRxiv preprint"},{"key":"10.1016\/j.ejmech.2026.119108_bib34","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020106275","article-title":"Mechanism and inhibition of the papain-like protease PLpro of SARS-CoV-2","volume":"39","author":"Klemm","year":"2020","journal-title":"EMBO J."},{"key":"10.1016\/j.ejmech.2026.119108_bib32","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1038\/s41467-023-38031-5","article-title":"Dual domain recognition determines SARS-CoV-2 PLpro selectivity for human ISG15 and K48-linked di-ubiquitin","volume":"14","author":"Wydorski","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2026.119108_bib31","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.ade1985","article-title":"The substrate selectivity of papain-like proteases from human-infecting coronaviruses correlates with innate immune suppression","volume":"16","author":"Xiong","year":"2023","journal-title":"Sci. Signal."},{"key":"10.1016\/j.ejmech.2026.119108_bib33","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/s41467-020-20718-8","article-title":"The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery","volume":"12","author":"Fu","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2026.119108_bib35","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s41564-021-00884-1","article-title":"ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity","volume":"6","author":"Liu","year":"2021","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.ejmech.2026.119108_bib36","series-title":"Schr\u00f6dinger Release 2025-3: Maestro and Glide","year":"2025"},{"key":"10.1016\/j.ejmech.2026.119108_bib37","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1021\/ci500118s","article-title":"Docking covalent inhibitors: a parameter-free approach to pose prediction and scoring","volume":"54","author":"Zhu","year":"2014","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.ejmech.2026.119108_bib38","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ado4288","article-title":"Discovery of SARS-CoV-2 papain-like protease inhibitors with efficacy in a murine infection model","volume":"10","author":"Garnsey","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ejmech.2026.119108_bib39","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1021\/tx970061j","article-title":"Evidence of quinone metabolites of naphthalene covalently bound to sulfur nucleophiles of proteins of murine clara cells after exposure to naphthalene","volume":"10","author":"Zheng","year":"1997","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.ejmech.2026.119108_bib40","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.freeradbiomed.2009.07.020","article-title":"Depurinating naphthalene-DNA adducts in mouse skin related to cancer initiation","volume":"47","author":"Saeed","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejmech.2026.119108_bib41","unstructured":"International Agency for Research on Cancer, List of Classifications, World Health Organization, https:\/\/monographs.iarc.who.int\/list-of-classifications, n.d. (accessed 25 August 2025)."},{"key":"10.1016\/j.ejmech.2026.119108_bib42","doi-asserted-by":"crossref","first-page":"28.29.1","DOI":"10.1002\/0471140864.ps2809s79","article-title":"Analysis of protein stability and ligand interactions by thermal shift assay","volume":"79","author":"Huynh","year":"2015","journal-title":"Curr. Protoc. Protein Sci."},{"key":"10.1016\/j.ejmech.2026.119108_bib43","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/s41573-022-00542-z","article-title":"Advances in covalent drug discovery","volume":"21","author":"Boike","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejmech.2026.119108_bib44","doi-asserted-by":"crossref","first-page":"14693","DOI":"10.1021\/acs.jmedchem.4c01721","article-title":"Demystifying functional parameters for irreversible enzyme inhibitors","volume":"67","author":"Heppner","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119108_bib45","first-page":"1","article-title":"Evaluation of enzyme inhibitors in drug discovery: a guide for medicinal chemists and pharmacologists","volume":"46","author":"Copeland","year":"2005","journal-title":"Methods Biochem. Anal."},{"key":"10.1016\/j.ejmech.2026.119108_bib46","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.antiviral.2014.12.015","article-title":"The SARS-coronavirus papain-like protease: structure, function and inhibition by designed antiviral compounds","volume":"115","author":"B\u00e1ez-Santos","year":"2015","journal-title":"Antivir. Res."},{"key":"10.1016\/j.ejmech.2026.119108_bib47","article-title":"Human structural homologues of SARS-CoV-2 PLpro as anti-targets: a strategic panel analysis","author":"Al-Homoudi","year":"2025","journal-title":"MicroPubl. Biol."},{"key":"10.1016\/j.ejmech.2026.119108_bib48","first-page":"66","article-title":"Thiol-reactive or redox-active: revising a repurposing screen led to a new invalidation pipeline and identified a true noncovalent inhibitor against papain-like protease from SARS-CoV-2","author":"Kuzikov","year":"2025","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119108_bib49","series-title":"Schr\u00f6dinger Release 2025-3: Qikprop [Software]","year":"2025"},{"issue":"1","key":"10.1016\/j.ejmech.2026.119108_bib50","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1006\/prep.2001.1603","article-title":"A new vector for high-throughput, ligation-independent cloning encoding a tobacco etch virus protease cleavage site","volume":"25","author":"Stols","year":"2002","journal-title":"Protein Expr. Purif."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523426005532?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523426005532?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T08:00:13Z","timestamp":1787040013000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523426005532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":49,"alternative-id":["S0223523426005532"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2026.119108","relation":{"has-preprint":[{"id-type":"doi","id":"10.26434\/chemrxiv-2025-69806","asserted-by":"object"}]},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structure-guided design of potent and selective covalent inhibitors of SARS-CoV-1 and SARS-CoV-2 papain-like proteases with antiviral activity","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2026.119108","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119108"}}