{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:58:21Z","timestamp":1789628301571,"version":"build-2803163510"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.ejmech.2026.119130","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T20:06:43Z","timestamp":1783627603000},"page":"119130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Design and synthesis of substituted pyrimidines with potent antiviral activity against dengue"],"prefix":"10.1016","volume":"317","author":[{"given":"Dimitrios","family":"Kiousis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Kalyva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Despoina","family":"Giannioti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantina","family":"Katsigianni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasiliki","family":"Zogali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maharah Binte Abdul","family":"Mahid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kitti Wing Ki","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minos-Timotheos","family":"Matsoukas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhash G.","family":"Vasudevan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8937-4986","authenticated-orcid":false,"given":"Gerasimos","family":"Rassias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2026.119130_bib1","unstructured":"Genus: Orthoflavivirus | ICTV; https:\/\/ictv.global\/report\/chapter\/flaviviridae\/flaviviridae\/orthoflavivirus (accessed 18 May 2026)."},{"key":"10.1016\/j.ejmech.2026.119130_bib2","series-title":"Dengue Virus Evolution: from Emergence to a Global Health Crisis","year":"2025"},{"key":"10.1016\/j.ejmech.2026.119130_bib3","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/s41564-020-0714-0","article-title":"The continued threat of emerging flaviviruses","volume":"6","author":"Pierson","year":"2020","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.ejmech.2026.119130_bib4","article-title":"Current status of the development of dengue vaccines","volume":"22","author":"Lee","year":"2024","journal-title":"Vaccine X"},{"key":"10.1016\/j.ejmech.2026.119130_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2020.572681","article-title":"Antibody-dependent enhancement: a challenge for developing a safe Dengue vaccine","volume":"10","author":"Shukla","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.ejmech.2026.119130_bib6","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jclinepi.2017.11.019","article-title":"Controversy and debate on dengue vaccine series-paper 1. Review of a licensed dengue vaccine: inappropriate subgroup analyses and selective reporting may cause harm in mass vaccination programs","volume":"95","author":"Dans","year":"2018","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.ejmech.2026.119130_bib7","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3390\/v17020212","article-title":"Current dengue virus vaccine developments and future directions","volume":"17","author":"Anumanthan","year":"2025","journal-title":"Viruses"},{"key":"10.1016\/j.ejmech.2026.119130_bib8","doi-asserted-by":"crossref","first-page":"4448","DOI":"10.1021\/acs.chemrev.7b00719","article-title":"Biochemistry and molecular biology of flaviviruses","volume":"118","author":"Barrows","year":"2018","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejmech.2026.119130_bib9","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3390\/membranes12020231","article-title":"Structures and dynamics of dengue virus nonstructural membrane proteins","volume":"12","author":"Li","year":"2022","journal-title":"Membranes"},{"key":"10.1016\/j.ejmech.2026.119130_bib10","doi-asserted-by":"crossref","first-page":"5622","DOI":"10.1021\/acs.jmedchem.5b01653","article-title":"The medicinal chemistry of dengue virus","volume":"59","author":"Behnam","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119130_bib11","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1016\/j.molcel.2023.06.023","article-title":"Structures of dengue virus RNA replicase complexes","volume":"83","author":"Osawa","year":"2023","journal-title":"Mol. Cell."},{"key":"10.1016\/j.ejmech.2026.119130_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.nmni.2025.101614","article-title":"Novel and repurposed antiviral molecules for arbovirus infections with epidemic potential: a systematic review","volume":"66","author":"Logiudice","year":"2025","journal-title":"New Microbes New Infect."},{"key":"10.1016\/j.ejmech.2026.119130_bib13","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12985-025-02622-z","article-title":"Advances in antiviral strategies targeting mosquito-borne viruses: cellular, viral, and immune-related approaches","volume":"22","author":"Khan","year":"2025","journal-title":"Virol. J."},{"key":"10.1016\/j.ejmech.2026.119130_bib14","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3390\/v17010074","article-title":"A comprehensive review of the development and therapeutic use of antivirals in flavivirus infection","volume":"17","author":"Tripathi","year":"2025","journal-title":"Viruses"},{"key":"10.1016\/j.ejmech.2026.119130_bib15","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.3390\/pathogens14111156","article-title":"Antiviral compounds from natural sources against human arboviruses: an updated review including illustrative in silico analysis","volume":"14","author":"Aguiar-Pech","year":"2025","journal-title":"Pathogens"},{"key":"10.1016\/j.ejmech.2026.119130_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.coviro.2023.101305","article-title":"Flavivirus nonstructural proteins and replication complexes as antiviral drug targets","volume":"59","author":"van den Elsen","year":"2023","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.ejmech.2026.119130_bib17","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.3390\/microorganisms11102427","article-title":"Vector-transmitted flaviviruses: an antiviral molecules overview","volume":"11","author":"Diani","year":"2023","journal-title":"Microorganisms"},{"key":"10.1016\/j.ejmech.2026.119130_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114753","article-title":"Recent two-year advances in anti-dengue small-molecule inhibitors","volume":"243","author":"Yang","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119130_bib19","article-title":"Dengue virus NS4B protein as a target for developing antivirals","volume":"12","author":"Li","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.ejmech.2026.119130_bib20","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.3390\/v13101981","article-title":"Precursors of viral proteases as distinct drug targets","volume":"13","author":"Majerov\u00e1","year":"2021","journal-title":"Viruses"},{"issue":"5","key":"10.1016\/j.ejmech.2026.119130_bib21","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1039\/D0MD00052C","article-title":"Recent progress on phenotype-based discovery of dengue inhibitors","volume":"11","author":"Yokokawa","year":"2020","journal-title":"RSC Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119130_bib22","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02839-20","article-title":"A targeted computational screen of the SWEETLEAD database reveals FDA-approved compounds with anti-dengue viral activity","volume":"11","author":"Moshiri","year":"2020","journal-title":"mBio"},{"key":"10.1016\/j.ejmech.2026.119130_bib23","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.ejmech.2019.05.010","article-title":"Recent update on anti-dengue drug discovery","volume":"176","author":"Dighe","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119130_bib24","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1039\/D4MD00240G","article-title":"Discovery and structure-activity relationship study of novel isoxazole-based small molecules targeting Zika virus infections","volume":"15","author":"Girmay","year":"2024","journal-title":"RSC Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119130_bib25","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1007\/s12272-022-01380-8","article-title":"Discovery and synthesis of 1,2,4-oxadiazole derivatives as novel inhibitors of Zika, dengue, Japanese encephalitis, and classical swine fever virus infections","volume":"45","author":"Nam","year":"2022","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.ejmech.2026.119130_bib26","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s11262-022-01898-5","article-title":"A review on structural genomics approach applied for drug discovery against three vector-borne viral diseases: dengue, Chikungunya and Zika","volume":"58","author":"Sundar","year":"2022","journal-title":"Virus Genes"},{"key":"10.1016\/j.ejmech.2026.119130_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113767","article-title":"Synthesis, structure-activity relationship and antiviral activity of indole-containing inhibitors of Flavivirus NS2B-NS3 protease","volume":"225","author":"Nie","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119130_bib28","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1021\/acsmedchemlett.1c00515","article-title":"Nanoparticular inhibitors of flavivirus proteases from Zika, west nile and dengue virus are cell-permeable antivirals","volume":"12","author":"Schroeder","year":"2021","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2026.119130_bib29","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1021\/acsmedchemlett.9b00629","article-title":"Catching a moving target: comparative modeling of flaviviral NS2B-NS3 reveals small molecule zika protease inhibitors","volume":"11","author":"Pach","year":"2020","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2026.119130_bib30","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1021\/acs.jmedchem.6b01021","article-title":"Peptide\u2013boronic acid inhibitors of flaviviral proteases: medicinal chemistry and structural biology","volume":"60","author":"Nitsche","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119130_bib31","doi-asserted-by":"crossref","first-page":"4047","DOI":"10.3390\/molecules29174047","article-title":"Orthoflaviviral inhibitors in clinical trials, preclinical in vivo efficacy targeting NS2B-NS3 and cellular antiviral activity via competitive protease inhibition","volume":"29","author":"Cavina","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2026.119130_bib32","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20240134","article-title":"Dengue virus: pathogenesis and potential for small molecule inhibitors","volume":"44","author":"Chauhan","year":"2024","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.ejmech.2026.119130_bib33","doi-asserted-by":"crossref","unstructured":"Kesteleyn B, Bonfanti JF, Bardiot D, De Boeck B, Goethals O, Kaptein SJF, Stoops B, Coesemans E, Fortin J, Muller P, Doublet F, Carlens G, Koukni M, Smets W, Raboisson P, Chaltin P, Simmen K, Loock MV, Neyts J, Marchand A, Jonckers THM. Discovery of JNJ-1802, a first-in-class pan-serotype dengue virus NS4B inhibitor. J. Med. Chem. 67, 4063-4082. doi:10.1021\/acs.jmedchem.3c02336.","DOI":"10.1021\/acs.jmedchem.3c02336"},{"key":"10.1016\/j.ejmech.2026.119130_bib34","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/s41586-023-05790-6","article-title":"Blocking NS3-NS4B interaction inhibits dengue virus in non-human primates","volume":"615","author":"Goethals","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2026.119130_bib35","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1093\/cid\/ciad284","article-title":"Safety, tolerability, and pharmacokinetics of JNJ-1802, a pan-serotype dengue direct antiviral small molecule, in a phase 1, double-blind, randomized, dose-escalation study in healthy volunteers","volume":"77","author":"Ackaert","year":"2023","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ejmech.2026.119130_bib36","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abb2181","article-title":"NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models","volume":"13","author":"Moquin","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ejmech.2026.119130_bib37","article-title":"Mechanistic insights into dengue virus inhibition by a clinical trial compound NITD-688","volume":"122","author":"Wang","year":"2025","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejmech.2026.119130_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2025.110451","article-title":"Subcellular determinants of orthoflavivirus protease activity","volume":"301","author":"Corliss","year":"2025","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejmech.2026.119130_bib39","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.antiviral.2015.03.014","article-title":"The flavivirus NS2B\u2013NS3 protease\u2013helicase as a target for antiviral drug development","volume":"118","author":"Luo","year":"2015","journal-title":"Antiviral Res"},{"key":"10.1016\/j.ejmech.2026.119130_bib40","doi-asserted-by":"crossref","first-page":"11348","DOI":"10.1021\/cr500233q","article-title":"Biochemistry and medicinal chemistry of the dengue virus protease","volume":"114","author":"Nitsche","year":"2014","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejmech.2026.119130_bib41","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3390\/v14010044","article-title":"Potential role of flavivirus NS2B-NS3 proteases in viral pathogenesis and anti-Flavivirus drug discovery employing animal cells and models: a review","volume":"14","author":"Wahaab","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.ejmech.2026.119130_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2026.118779","article-title":"Medicinal chemistry strategies targeting viral proteases: from classical design to next-generation therapeutics","volume":"310","author":"Alturki","year":"2026","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119130_bib43","doi-asserted-by":"crossref","DOI":"10.1002\/ejoc.70408","volume":"29","author":"Ingaladal","year":"2026","journal-title":"Eur. J. Org. Chem."},{"key":"10.1016\/j.ejmech.2026.119130_bib44","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.virs.2025.05.009","article-title":"Eltrombopag, an FDA-approved drug, inhibits dengue virus type 2 by targeting NS2B-NS3 protease","volume":"40","author":"Zhu","year":"2025","journal-title":"Virol. Sin."},{"issue":"8","key":"10.1016\/j.ejmech.2026.119130_bib45","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1021\/acsmedchemlett.5c00219","article-title":"Discovery of Pyrazole-3-Carboxylic acid derivatives as dengue virus protease inhibitors with antiviral activity","volume":"16","author":"Lang","year":"2025","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2026.119130_bib46","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3390\/pathogens11030293","article-title":"Antiviral agents against flavivirus protease: Prospect and future direction","volume":"11","author":"Samrat","year":"2022","journal-title":"Pathogens"},{"key":"10.1016\/j.ejmech.2026.119130_bib47","series-title":"Dengue and Zika: Control and Antiviral Treatment Strategies","first-page":"175","article-title":"Strategies towards protease inhibitors for emerging flaviviruses","author":"Nitsche","year":"2018"},{"key":"10.1016\/j.ejmech.2026.119130_bib48","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.ejmech.2019.07.007","article-title":"Cell-active carbazole derivatives as inhibitors of the zika virus protease","volume":"180","author":"Rassias","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119130_bib49","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1128\/JVI.06225-11","article-title":"Ligand-bound structures of the dengue virus protease reveal the active conformation","volume":"86","author":"Noble","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.ejmech.2026.119130_bib50","article-title":"Dengue virus NS2B\/NS3 protease inhibitors exploiting the prime side","volume":"91","author":"L","year":"2017","journal-title":"J. Virol."},{"key":"10.1016\/j.ejmech.2026.119130_bib51","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1002\/cmdc.202100246","article-title":"Ligand accessibility insights to the dengue virus NS3-NS2B protease assessed by long-timescale molecular dynamics simulations","volume":"16","author":"Kronenberger","year":"2021","journal-title":"ChemMedChem"},{"key":"10.1016\/j.ejmech.2026.119130_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.105306","article-title":"The mitochondrial amidoxime reducing component-from prodrug-activation mechanism to drug-metabolizing enzyme and onward to drug target","volume":"299","author":"Struwe","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejmech.2026.119130_bib53","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1016\/j.bmc.2011.01.066","article-title":"Synthesis and biological evaluation of L-valine-amidoximeesters as double prodrugs of amidines","volume":"19","author":"Kotthaus","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119130_bib54","doi-asserted-by":"crossref","first-page":"8173","DOI":"10.1021\/jm8010417","article-title":"The fourth molybdenum containing enzyme mARC: cloning and involvement in the activation of N-hydroxylated prodrugs","volume":"51","author":"Gruenewald","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119130_bib55","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0049-3848(00)00399-6","article-title":"The direct thrombin inhibitor melagatran and its oral prodrug H 376\/95: intestinal absorption properties, biochemical and pharmacodynamic effects","volume":"101","author":"Gustafsson","year":"2001","journal-title":"Thromb. Res."},{"key":"10.1016\/j.ejmech.2026.119130_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113695","article-title":"Amidoxime prodrugs convert to potent cell-active multimodal inhibitors of the dengue virus protease","volume":"224","author":"Swarbrick","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119130_bib57","doi-asserted-by":"crossref","first-page":"10136","DOI":"10.1073\/pnas.1805195115","article-title":"Targeting intramolecular proteinase NS2B\/3 cleavages for trans-dominant inhibition of dengue virus","volume":"115","author":"Constant","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejmech.2026.119130_bib58","doi-asserted-by":"crossref","first-page":"593","DOI":"10.2217\/fvl.10.39","article-title":"Structural and functional parameters of the flaviviral protease: a promising antiviral drug target","volume":"5","author":"Shiryaev","year":"2010","journal-title":"Future Virol."},{"key":"10.1016\/j.ejmech.2026.119130_bib59","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1099\/0022-1317-78-2-337","article-title":"Internal proteolysis of the NS3 protein specified by dengue virus 2","volume":"78","author":"Teo","year":"1997","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.ejmech.2026.119130_bib60","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1006\/viro.1993.1198","article-title":"Dengue 2 virus NS2B and NS3 form a stable complex that can cleave NS3 within the helicase domain","volume":"193","author":"Arias","year":"1993","journal-title":"Virology"},{"key":"10.1016\/j.ejmech.2026.119130_bib61","doi-asserted-by":"crossref","first-page":"7549","DOI":"10.1128\/jvi.66.12.7549-7554.1992","article-title":"Processing and localization of dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5","volume":"66","author":"Zhang","year":"1992","journal-title":"J. Virol."},{"key":"10.1016\/j.ejmech.2026.119130_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116213","article-title":"Carbazole to indolazepinone scaffold morphing leads to potent cell-active dengue antivirals","volume":"268","author":"Zogali","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119130_bib63","series-title":"Design and Synthesis of a Potent, Cell Active Purine-based Amidoxime Towards the Development of a Dengue Antiviral Treatment","author":"Kiousis","year":"2026"},{"issue":"20","key":"10.1016\/j.ejmech.2026.119130_bib64","article-title":"An improved focus-forming assay for determination of the dengue virus titer","volume":"14","author":"Mahid","year":"2024","journal-title":"Bio. Protoc."},{"key":"10.1016\/j.ejmech.2026.119130_bib65","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1128\/JCM.43.7.3267-3272.2005","article-title":"Flow cytometry-based assay for titrating dengue virus","volume":"43","author":"Lambeth","year":"2005","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.ejmech.2026.119130_bib66","doi-asserted-by":"crossref","first-page":"6548","DOI":"10.1128\/JVI.02510-10","article-title":"Inhibition of dengue virus through suppression of host pyrimidine biosynthesis","volume":"85","author":"Wang","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.ejmech.2026.119130_bib67","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1758-2946-3-33","article-title":"An open chemical toolbox","volume":"3","author":"O'Boyle","year":"2011","journal-title":"J. Cheminf."},{"key":"10.1016\/j.ejmech.2026.119130_bib68","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13321-025-00973-x","article-title":"GNINA 1.3: the next increment in molecular docking with deep learning","volume":"17","author":"McNutt","year":"2025","journal-title":"J. Cheminf."},{"key":"10.1016\/j.ejmech.2026.119130_bib69","doi-asserted-by":"crossref","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2026.119130_bib70","doi-asserted-by":"crossref","DOI":"10.2174\/0113816128393399251021101651","article-title":"Integrative approaches to uncover the therapeutic action of Huaiqihuang in myocarditis: network pharmacology, molecular docking, and molecular dynamics","author":"Du","year":"2026","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.ejmech.2026.119130_bib71","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1021\/acs.orglett.3c04065","article-title":"Norbornene derivatives-controlled palladium-catalyzed divergent synthesis of dibenzo[a,c]cycloheptenones and fluorenones from aryl iodides and \u03b1-Oxocarboxylic acids","volume":"26","author":"Zhou","year":"2024","journal-title":"Org. Lett."},{"key":"10.1016\/j.ejmech.2026.119130_bib72","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adl0026","article-title":"Late-stage modification of complex drug: base-controlled Pd-catalyzed regioselective synthesis and bioactivity of arylated osimertinibs","volume":"10","author":"Feng","year":"2024","journal-title":"Sci. Adv."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523426005751?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523426005751?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T08:07:07Z","timestamp":1787040427000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523426005751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":72,"alternative-id":["S0223523426005751"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2026.119130","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design and synthesis of substituted pyrimidines with potent antiviral activity against dengue","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2026.119130","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"119130"}}