{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T01:14:59Z","timestamp":1788052499735,"version":"build-2784847793"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004271","name":"Sapienza University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.ejmech.2026.119170","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T15:20:50Z","timestamp":1784388050000},"page":"119170","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Targeting Fusobacterium nucleatum in cancer therapy: A new frontier in solid tumor treatment"],"prefix":"10.1016","volume":"318","author":[{"given":"Francesco","family":"Vallini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Salvucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariangela","family":"Biava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Carradori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7466-8861","authenticated-orcid":false,"given":"Giovanna","family":"Poce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Tammaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2026.119170_bib1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.ejmech.2026.119170_bib2","first-page":"2330","article-title":"Interaction between gut microbiota and tumour chemotherapy","volume":"24","author":"Liu","year":"2022","journal-title":"Clin. Transl. Oncol. Off. Publ. Fed. Span. Oncol. Soc. Natl. Cancer Inst. Mex."},{"key":"10.1016\/j.ejmech.2026.119170_bib3","doi-asserted-by":"crossref","first-page":"e180","DOI":"10.1016\/S2214-109X(19)30488-7","article-title":"Global burden of cancer attributable to infections in 2018: a worldwide incidence analysis","volume":"8","author":"de Martel","year":"2020","journal-title":"Lancet Glob. Health"},{"key":"10.1016\/j.ejmech.2026.119170_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.neo.2023.100878","article-title":"The influence of the microbiome on the innate immune microenvironment of solid tumors","volume":"37","author":"Charles","year":"2023","journal-title":"Neoplasia"},{"key":"10.1016\/j.ejmech.2026.119170_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1051987","article-title":"The effect of the intratumoral microbiome on tumor occurrence, progression, prognosis and treatment","volume":"13","author":"Gao","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejmech.2026.119170_bib6","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202405331","article-title":"Intratumoral microbiota as a target for advanced cancer therapeutics","volume":"36","author":"Peng","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ejmech.2026.119170_bib7","doi-asserted-by":"crossref","DOI":"10.1126\/science.abc4552","article-title":"The microbiome and human cancer","volume":"371","author":"Sepich-Poore","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2026.119170_bib8","article-title":"Current understanding of the intratumoral microbiome in various tumors","volume":"4","author":"Xue","year":"2023","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.ejmech.2026.119170_bib9","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1053\/j.gastro.2022.10.018","article-title":"Gut microbiota modulation of efficacy and toxicity of cancer chemotherapy and immunotherapy","volume":"164","author":"Chrysostomou","year":"2023","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejmech.2026.119170_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112537","article-title":"Potential role of the intratumoral microbiota in colorectal cancer immunotherapy","volume":"137","author":"Fan","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"2000","key":"10.1016\/j.ejmech.2026.119170_bib11","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/prd.12426","article-title":"Fusobacterium nucleatum and cancer","volume":"89","author":"Alon-Maimon","year":"2022","journal-title":"Periodontol"},{"key":"10.1016\/j.ejmech.2026.119170_bib12","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.chom.2013.07.012","article-title":"Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-Cadherin\/\u03b2-Catenin signaling via its FadA adhesin","volume":"14","author":"Rubinstein","year":"2013","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.ejmech.2026.119170_bib13","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1128\/IAI.73.2.1171-1179.2005","article-title":"Fusobacterium nucleatum increases collagenase 3 production and migration of epithelial cells","volume":"73","author":"Uitto","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ejmech.2026.119170_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003933","article-title":"Oral bacteria and cancer","volume":"10","author":"Whitmore","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ejmech.2026.119170_bib15","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.cell.2017.07.008","article-title":"Fusobacterium nucleatum promotes chemoresistance to colorectal cancer by modulating autophagy","volume":"170","author":"Yu","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.ejmech.2026.119170_bib16","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41586-024-07182-w","article-title":"A distinct Fusobacterium nucleatum clade dominates the colorectal cancer niche","volume":"628","author":"Zepeda-Rivera","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2026.119170_bib17","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1101\/gr.126516.111","article-title":"Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma","volume":"22","author":"Castellarin","year":"2012","journal-title":"Genome Res."},{"key":"10.1016\/j.ejmech.2026.119170_bib18","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1038\/s41467-020-16967-2","article-title":"Breast cancer colonization by Fusobacterium nucleatum accelerates tumor growth and metastatic progression","volume":"11","author":"Parhi","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2026.119170_bib19","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.70273","article-title":"Integrated spatial multi-omics profiling of Fusobacterium nucleatum in breast cancer unveils its role in tumour microenvironment modulation and cancer progression","volume":"15","author":"Zhao","year":"2025","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.ejmech.2026.119170_bib20","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1111\/cas.15901","article-title":"Intratumor Fusobacterium nucleatum promotes the progression of pancreatic cancer via the CXCL1-CXCR2 axis","volume":"114","author":"Hayashi","year":"2023","journal-title":"Cancer Sci."},{"key":"10.1016\/j.ejmech.2026.119170_bib21","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.abn4948","article-title":"Fusobacterium nucleatum induces proliferation and migration in pancreatic cancer cells through host autocrine and paracrine signaling","volume":"15","author":"Udayasuryan","year":"2022","journal-title":"Sci. Signal."},{"key":"10.1016\/j.ejmech.2026.119170_bib22","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1111\/cas.15787","article-title":"Fusobacterium nucleatum promotes the early occurrence of esophageal cancer through upregulation of IL-32\/PRTN3 expression","volume":"114","author":"Lei","year":"2023","journal-title":"Cancer Sci."},{"key":"10.1016\/j.ejmech.2026.119170_bib23","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2197836","article-title":"Fusobacterium nucleatum promotes esophageal squamous cell carcinoma progression and chemoresistance by enhancing the secretion of chemotherapy-induced senescence-associated secretory phenotype via activation of DNA damage response pathway","volume":"15","author":"Zhang","year":"2023","journal-title":"Gut Microbes"},{"key":"10.1016\/j.ejmech.2026.119170_bib24","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41392-023-01693-0","article-title":"Intratumoural microbiota: a new frontier in cancer development and therapy","volume":"9","author":"Cao","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.ejmech.2026.119170_bib25","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1126\/science.aal5240","article-title":"Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer","volume":"358","author":"Bullman","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2026.119170_bib26","doi-asserted-by":"crossref","first-page":"5041","DOI":"10.1002\/cam4.3870","article-title":"Antibiotic use influences outcomes in advanced pancreatic adenocarcinoma patients","volume":"10","author":"Mohindroo","year":"2021","journal-title":"Cancer Med."},{"key":"10.1016\/j.ejmech.2026.119170_bib27","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.chom.2023.04.010","article-title":"Fusobacterium nucleatum-derived succinic acid induces tumor resistance to immunotherapy in colorectal cancer","volume":"31","author":"Jiang","year":"2023","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.ejmech.2026.119170_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111625","article-title":"The cancer chemotherapeutic 5-fluorouracil is a potent Fusobacterium nucleatum inhibitor and its activity is modified by intratumoral microbiota","volume":"41","author":"LaCourse","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.ejmech.2026.119170_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/iid3.1067","article-title":"Effects of metronidazole on colorectal cancer occurrence and colorectal cancer liver metastases by regulating Fusobacterium nucleatum in mice","volume":"11","author":"Wang","year":"2023","journal-title":"Immun. Inflamm. Dis."},{"key":"10.1016\/j.ejmech.2026.119170_bib30","article-title":"Preoperative metronidazole treatment to evaluate its efficacy in reducing Fusobacterium nucleatum colonisation in colorectal cancer patients: a proof-of-concept trial, ESMO gastrointest","volume":"8","author":"De Dosso","year":"2025","journal-title":"Oncol"},{"key":"10.1016\/j.ejmech.2026.119170_bib31","doi-asserted-by":"crossref","first-page":"836","DOI":"10.7326\/M16-0577","article-title":"Aspirin use for the primary prevention of cardiovascular disease and colorectal cancer: U.S. preventive services task force recommendation statement","volume":"164","author":"Bibbins-Domingo","year":"2016","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.ejmech.2026.119170_bib32","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1053\/j.gastro.2020.05.004","article-title":"Aspirin reduces colorectal tumor development in mice and gut microbes reduce its bioavailability and chemopreventive effects","volume":"159","author":"Zhao","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejmech.2026.119170_bib33","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1146\/annurev-med-060319-120913","article-title":"Aspirin in the prevention of colorectal neoplasia","volume":"72","author":"Drew","year":"2021","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.ejmech.2026.119170_bib34","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00547-21","article-title":"Aspirin modulation of the colorectal cancer-associated microbe Fusobacterium nucleatum","volume":"12","author":"Brennan","year":"2021","journal-title":"mBio"},{"key":"10.1016\/j.ejmech.2026.119170_bib35","first-page":"321","article-title":"Phase 2 trial of metformin combined with 5-fluorouracil in patients with refractory metastatic colorectal cancer","volume":"15","author":"Miranda","year":"2016","journal-title":"Clin. Colorectal Cancer"},{"key":"10.1016\/j.ejmech.2026.119170_bib36","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41416-022-02044-6","article-title":"Metformin abrogates Fusobacterium nucleatum-induced chemoresistance in colorectal cancer by inhibiting miR-361-5p\/sonic hedgehog signaling-regulated stemness","volume":"128","author":"Hong","year":"2023","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ejmech.2026.119170_bib37","doi-asserted-by":"crossref","first-page":"15699","DOI":"10.1021\/acs.jmedchem.3c00281","article-title":"Discovery of new Fusobacterium nucleatum inhibitors to attenuate migratory capability of Colon cancer cells by the drug repositioning strategy","volume":"66","author":"Pan","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119170_bib38","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1021\/acsinfecdis.3c00710","article-title":"Evaluation of Fusobacterium nucleatum Enoyl-ACP Reductase (FabK) as a narrow-spectrum drug target","volume":"10","author":"Rutherford","year":"2024","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.ejmech.2026.119170_bib39","article-title":"Vanillin derivatives reverse fusobacterium nucleatum-induced proliferation and migration of colorectal cancer through E-Cadherin\/\u03b2-Catenin pathway","volume":"13","author":"Zhou","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejmech.2026.119170_bib40","article-title":"Optimized antimicrobial peptide jelleine-I derivative Br-J-I inhibits Fusobacterium nucleatum to suppress colorectal cancer progression","volume":"24","author":"Jia","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2026.119170_bib41","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.apsb.2025.01.002","article-title":"Locally producing antibacterial peptide to deplete intratumoral pathogen for preventing metastatic breast cancer","volume":"15","author":"Geng","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.ejmech.2026.119170_bib42","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/s13020-024-01032-7","article-title":"Potential of natural products and gut microbiome in tumor immunotherapy","volume":"19","author":"Cao","year":"2024","journal-title":"Chin. Med."},{"key":"10.1016\/j.ejmech.2026.119170_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12082272","article-title":"Targeting gut microbial biofilms\u2014a key to hinder colon carcinogenesis?","volume":"12","author":"Chew","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.ejmech.2026.119170_bib44","doi-asserted-by":"crossref","first-page":"6111","DOI":"10.3390\/cancers14246111","article-title":"Sodium new Houttuyfonate inhibits cancer-promoting Fusobacterium nucleatum (Fn) to reduce colorectal cancer progression","volume":"14","author":"Jia","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.ejmech.2026.119170_bib45","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3892\/ol.2020.12404","article-title":"L-fucose ameliorates the carcinogenic properties of Fusobacterium nucleatum in colorectal cancer","volume":"21","author":"Duan","year":"2020","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.ejmech.2026.119170_bib46","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s12029-021-00654-6","article-title":"Microbial azurin immobilized on nano-chitosan as anticancer and antibacterial agent against gastrointestinal cancers and related bacteria","volume":"53","author":"Al-Hazmi","year":"2022","journal-title":"J. Gastrointest. Cancer"},{"key":"10.1016\/j.ejmech.2026.119170_bib47","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1154818","article-title":"Tubeimuside I improves the efficacy of a therapeutic Fusobacterium nucleatum dendritic cell-based vaccine against colorectal cancer","volume":"14","author":"Tong","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejmech.2026.119170_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117932","article-title":"Banxia Xiexin Decoction delays colitis-to-cancer transition by inhibiting E-cadherin\/\u03b2-catenin pathway via Fusobacterium nucleatum FadA","volume":"328","author":"Jiang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejmech.2026.119170_bib49","doi-asserted-by":"crossref","first-page":"9710","DOI":"10.3390\/ijms26199710","article-title":"Fusobacterium nucleatum in colorectal cancer: relationship among immune modulation, potential biomarkers and therapeutic implications","volume":"26","author":"Incognito","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2026.119170_bib50","doi-asserted-by":"crossref","first-page":"12916","DOI":"10.3390\/molecules181012916","article-title":"The anti-lung cancer activities of steroidal saponins of p. polyphylla smith var. chinensis (Franch.) Hara through enhanced immunostimulation in experimental Lewis Tumor-Bearing C57BL\/6 Mice and induction of apoptosis in the A549 cell line","volume":"18","author":"Li","year":"2013","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2026.119170_bib51","doi-asserted-by":"crossref","first-page":"4081","DOI":"10.3390\/molecules26134081","article-title":"The fruits of Paris polyphylla inhibit colorectal cancer cell migration induced by Fusobacterium nucleatum-derived extracellular vesicles","volume":"26","author":"Lin","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2026.119170_bib52","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3390\/biomedicines14010252","article-title":"Microbiota-derived proteins shape t cell responses in healthy and colorectal cancer subjects","volume":"14","author":"Niccolai","year":"2026","journal-title":"Biomedicines"},{"key":"10.1016\/j.ejmech.2026.119170_bib53","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.chom.2022.11.014","article-title":"Oncomicrobial vaccines: the potential for a Fusobacterium nucleatum vaccine to improve colorectal cancer outcomes","volume":"31","author":"Holt","year":"2023","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.ejmech.2026.119170_bib54","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1016\/j.scib.2024.06.016","article-title":"An emerging antibacterial nanovaccine for enhanced chemotherapy by selectively eliminating tumor-colonizing bacteria","volume":"69","author":"Chen","year":"2024","journal-title":"Sci. Bull."},{"key":"10.1016\/j.ejmech.2026.119170_bib55","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adt0341","article-title":"A polyvalent vaccine for selectively killing tumor-associated bacteria to prevent cancer metastasis","volume":"11","author":"Kang","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ejmech.2026.119170_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2025.101277","article-title":"Engineering nanoplatforms of bacterial outer membrane vesicles to overcome cancer therapy resistance","volume":"83","author":"Chai","year":"2025","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.ejmech.2026.119170_bib57","doi-asserted-by":"crossref","first-page":"24593","DOI":"10.1021\/acsnano.3c10212","article-title":"Advanced generation therapeutics: biomimetic nanodelivery system for tumor immunotherapy","volume":"17","author":"Li","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.ejmech.2026.119170_bib58","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.jconrel.2024.07.045","article-title":"Nano-mupirocin as tumor-targeted antibiotic: physicochemical, immunotoxicological and pharmacokinetic characterization, and effect on gut microbiome","volume":"373","author":"Cern","year":"2024","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.ejmech.2026.119170_bib59","doi-asserted-by":"crossref","first-page":"11466","DOI":"10.1021\/acsnano.3c01308","article-title":"Modulation of intratumoral Fusobacterium nucleatum to enhance sonodynamic therapy for colorectal cancer with reduced phototoxic skin injury","volume":"17","author":"Qu","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.ejmech.2026.119170_bib60","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1038\/s41587-023-01957-8","article-title":"Killing tumor-associated bacteria with a liposomal antibiotic generates neoantigens that induce anti-tumor immune responses","volume":"42","author":"Wang","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ejmech.2026.119170_bib61","doi-asserted-by":"crossref","first-page":"7335","DOI":"10.1021\/acsnano.2c11305","article-title":"Synergistic target of intratumoral microbiome and tumor by metronidazole\u2013fluorouridine nanoparticles","volume":"17","author":"Gao","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.ejmech.2026.119170_bib62","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202306281","article-title":"Antibacterial Fusobacterium nucleatum \u2010mimicking nanomedicine to selectively eliminate tumor\u2010colonized bacteria and enhance immunotherapy against colorectal cancer","volume":"35","author":"Chen","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ejmech.2026.119170_bib63","doi-asserted-by":"crossref","first-page":"8971","DOI":"10.1021\/acsnano.3c12687","article-title":"Biomimetic nanovehicle-enabled targeted depletion of intratumoral Fusobacterium nucleatum synergizes with PD-L1 blockade against breast cancer","volume":"18","author":"Geng","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.ejmech.2026.119170_bib64","doi-asserted-by":"crossref","first-page":"4977","DOI":"10.1016\/j.apsb.2024.09.015","article-title":"Colon-specific controlled release of oral liposomes for enhanced chemo-immunotherapy against colorectal cancer","volume":"14","author":"Niu","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.ejmech.2026.119170_bib65","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.actbio.2025.02.013","article-title":"Multifunctional nanodrug for simultaneously combating chemoresistance and immunosuppression in Fusobacterium nucleatum-associated colorectal cancer","volume":"195","author":"Li","year":"2025","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ejmech.2026.119170_bib66","article-title":"Tumor-targeting nanoassembly for enhanced colorectal cancer therapy by eliminating intratumoral Fusobacterium nucleatum","author":"Li","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ejmech.2026.119170_bib67","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.actbio.2024.06.042","article-title":"Antibacterial tellurium-containing polycarbonate drug carriers to eliminate intratumor bacteria for synergetic chemotherapy against colorectal cancer","volume":"185","author":"Hu","year":"2024","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ejmech.2026.119170_bib68","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.add2789","article-title":"Nitroreductase-instructed supramolecular assemblies for microbiome regulation to enhance colorectal cancer treatments","volume":"8","author":"Chen","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ejmech.2026.119170_bib69","doi-asserted-by":"crossref","first-page":"9594","DOI":"10.1039\/D1TB02134F","article-title":"A dendritic polyamidoamine supramolecular system composed of pillar[5]arene and azobenzene for targeting drug-resistant colon cancer","volume":"9","author":"Liu","year":"2021","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.ejmech.2026.119170_bib70","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2022.2100203","article-title":"Effect of a bacteriocin-producing Streptococcus salivarius on the pathogen Fusobacterium nucleatum in a model of the human distal colon","volume":"14","author":"Lawrence","year":"2022","journal-title":"Gut Microbes"},{"key":"10.1016\/j.ejmech.2026.119170_bib71","doi-asserted-by":"crossref","first-page":"924","DOI":"10.3390\/ijms21030924","article-title":"Potential use of Biotherapeutic bacteria to target colorectal cancer-associated taxa","volume":"21","author":"Lawrence","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2026.119170_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.125993","article-title":"Hyaluronic acid-based prodrug nanomedicines for enhanced tumor targeting and therapy: a review","volume":"249","author":"Zhang","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejmech.2026.119170_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2024.121797","article-title":"Fabrication of hyaluronic acid-inulin coated Enterococcus faecium for colon-targeted delivery to fight Fusobacterium nucleatum","volume":"329","author":"Zhu","year":"2024","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ejmech.2026.119170_bib74","doi-asserted-by":"crossref","first-page":"7136","DOI":"10.3390\/molecules26237136","article-title":"Antimicrobial properties of chitosan and chitosan derivatives in the treatment of enteric infections","volume":"26","author":"Yan","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2026.119170_bib75","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.3389\/fmicb.2019.02101","article-title":"Chitooligosaccharides prevents the development of colitis-associated colorectal cancer by modulating the intestinal microbiota and mycobiota","volume":"10","author":"Wu","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ejmech.2026.119170_bib76","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.00524-25","article-title":"An antisense oligomer conjugate with unpredicted bactericidal activity against Fusobacterium nucleatum","volume":"16","author":"Cosi","year":"2025","journal-title":"mBio"},{"key":"10.1016\/j.ejmech.2026.119170_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173459","article-title":"Both endogenous and exogenous miR-139\u20135p inhibit Fusobacterium nucleatum-related colorectal cancer development","volume":"888","author":"Zhao","year":"2020","journal-title":"Eur. J. Pharmacol."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S022352342600615X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S022352342600615X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:20:01Z","timestamp":1788049201000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S022352342600615X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":77,"alternative-id":["S022352342600615X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2026.119170","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting Fusobacterium nucleatum in cancer therapy: A new frontier in solid tumor treatment","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2026.119170","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"119170"}}