{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T15:27:58Z","timestamp":1793978878496,"version":"4.8.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100017413","name":"Innovation Fund","doi-asserted-by":"publisher","award":["2022-I2M-2-002"],"award-info":[{"award-number":["2022-I2M-2-002"]}],"id":[{"id":"10.13039\/100017413","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017413","name":"Innovation Fund","doi-asserted-by":"publisher","award":["2021-I2M-3-001"],"award-info":[{"award-number":["2021-I2M-3-001"]}],"id":[{"id":"10.13039\/100017413","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017413","name":"Innovation Fund","doi-asserted-by":"publisher","award":["2019-I2M-5-074"],"award-info":[{"award-number":["2019-I2M-5-074"]}],"id":[{"id":"10.13039\/100017413","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017413","name":"Innovation Fund","doi-asserted-by":"publisher","award":["2021-I2M-1-026"],"award-info":[{"award-number":["2021-I2M-1-026"]}],"id":[{"id":"10.13039\/100017413","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018621","name":"Program for Changjiang Scholars and Innovative Research Team in University","doi-asserted-by":"publisher","award":["IRT_15R27"],"award-info":[{"award-number":["IRT_15R27"]}],"id":[{"id":"10.13039\/501100018621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173678"],"award-info":[{"award-number":["82173678"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773564"],"award-info":[{"award-number":["81773564"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82404438"],"award-info":[{"award-number":["82404438"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.ejmech.2026.119272","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:52:59Z","timestamp":1787755979000},"page":"119272","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A new short template-designed peptide with good antitumor potential by an alternative modification of threonine and its phosphorylation"],"prefix":"10.1016","volume":"319","author":[{"given":"Linfeng","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengzhan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixuan","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanhu","family":"Gou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4262-5354","authenticated-orcid":false,"given":"Yun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingman","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.ejmech.2026.119272_bib1","first-page":"308","article-title":"Cancer treatment and survivorship statistics","volume":"75","author":"Wagle","year":"2025","journal-title":"CA Cancer J. Clin."},{"issue":"4","key":"10.1016\/j.ejmech.2026.119272_bib2","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.gendis.2022.02.007","article-title":"Cancer chemotherapy and beyond: current status, drug candidates, associated risks and progress in targeted therapeutics","volume":"10","author":"Anand","year":"2022","journal-title":"Genes Dis."},{"issue":"19","key":"10.1016\/j.ejmech.2026.119272_bib3","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.3390\/cancers16193254","article-title":"Short peptides as powerful arsenal for smart fighting cancer","volume":"16","author":"Bojarska","year":"2024","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ejmech.2026.119272_bib4","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.3389\/fphar.2018.01534","article-title":"A review of resveratrol as a potent chemoprotective and synergistic agent in cancer chemotherapy","volume":"9","author":"Xiao","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"6","key":"10.1016\/j.ejmech.2026.119272_bib5","first-page":"3297","article-title":"Challenges and opportunities in cancer drug resistance, chemical","volume":"121","author":"Ward","year":"2021","journal-title":"Rev."},{"key":"10.1016\/j.ejmech.2026.119272_bib6","doi-asserted-by":"crossref","first-page":"100796","DOI":"10.1016\/j.drup.2021.100796","article-title":"Anticancer drug resistance: an update and perspective","volume":"59","author":"Nussinov","year":"2021","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.ejmech.2026.119272_bib7","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.2147\/IJN.S445333","article-title":"Anticancer mechanisms and potential anticancer applications of antimicrobial peptides and their nano agents","volume":"19","author":"Dong","year":"2024","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.ejmech.2026.119272_bib8","doi-asserted-by":"crossref","first-page":"114996","DOI":"10.1016\/j.biopha.2023.114996","article-title":"Current research status of anti-cancer peptides: mechanism of action, production, and clinical applications","volume":"164","author":"Chinnadurai","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejmech.2026.119272_bib9","doi-asserted-by":"crossref","first-page":"178086","DOI":"10.1016\/j.ejphar.2025.178086","article-title":"Unveiling anticancer peptides; from the mechanisms of action to their development through artificial intelligence","volume":"1005","author":"Collins","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejmech.2026.119272_bib10","doi-asserted-by":"crossref","first-page":"1310443","DOI":"10.3389\/fimmu.2024.1310443","article-title":"Bioactive peptides: an alternative therapeutic approach for cancer management","volume":"15","author":"Ghadiri","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejmech.2026.119272_bib11","doi-asserted-by":"crossref","first-page":"170600","DOI":"10.1016\/j.cej.2025.170600","article-title":"Microfluidic-synthesized anticancer peptide loaded bimetallic MOF complexes enhance tumor immunotherapy via pyroptosis","volume":"526","author":"Zhang","year":"2025","journal-title":"Chem. Eng. J."},{"issue":"32","key":"10.1016\/j.ejmech.2026.119272_bib12","doi-asserted-by":"crossref","first-page":"2404937","DOI":"10.1002\/advs.202404937","article-title":"A lipid-sensitive spider peptide toxin exhibits selective anti-leukemia efficacy through multimodal mechanisms","volume":"11","author":"Zhang","year":"2024","journal-title":"Adv. Sci."},{"issue":"1","key":"10.1016\/j.ejmech.2026.119272_bib13","doi-asserted-by":"crossref","first-page":"11685","DOI":"10.1038\/s41467-025-66748-y","article-title":"A scalable reinforcement learning approach for screening large peptide libraries for bioactive peptide discovery","volume":"16","author":"Pandey","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2026.119272_bib14","doi-asserted-by":"crossref","first-page":"112165","DOI":"10.1016\/j.colsurfb.2021.112165","article-title":"Correlation between the secondary structure and surface activity of \u03b2-sheet forming cationic amphiphilic peptides and their anticancer activity","volume":"209","author":"Hadianamrei","year":"2022","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"16","key":"10.1016\/j.ejmech.2026.119272_bib15","doi-asserted-by":"crossref","first-page":"7283","DOI":"10.1021\/jacs.2c00452","article-title":"Heterochiral \u03b2-Peptide polymers combating multidrug-resistant cancers effectively without inducing drug resistance","volume":"144","author":"Shao","year":"2022","journal-title":"J. Am. Chem. Soc."},{"issue":"17","key":"10.1016\/j.ejmech.2026.119272_bib16","doi-asserted-by":"crossref","first-page":"7857","DOI":"10.1021\/acs.jmedchem.9b00634","article-title":"Monosaccharide analogues of anticancer peptide R-Lycosin-I: role of monosaccharide conjugation in complexation and the potential of lung cancer targeting and therapy","volume":"62","author":"Zhang","year":"2019","journal-title":"J. Med. Chem."},{"issue":"5","key":"10.1016\/j.ejmech.2026.119272_bib17","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.1021\/acs.jmedchem.3c02232","article-title":"Three rounds of stability-guided optimization and systematical evaluation of oncolytic peptide LTX-315","volume":"67","author":"Fu","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119272_bib18","doi-asserted-by":"crossref","first-page":"108344","DOI":"10.1016\/j.bioorg.2025.108344","article-title":"Efficient synthesis, stability-guided optimization and anticancer evaluation of bee venom peptide Melittin","volume":"159","author":"Liu","year":"2025","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2026.119272_bib19","doi-asserted-by":"crossref","first-page":"122483","DOI":"10.1016\/j.ijpharm.2022.122483","article-title":"Plasma metabolites-based design of long-acting peptides and their anticancer evaluation","volume":"631","author":"Zhang","year":"2023","journal-title":"Int. J. Pharm."},{"issue":"15","key":"10.1016\/j.ejmech.2026.119272_bib20","doi-asserted-by":"crossref","first-page":"11483","DOI":"10.1021\/acs.jmedchem.1c00805","article-title":"Glucose-lipopeptide conjugates reveal the role of glucose modification position in complexation and the potential of malignant melanoma therapy","volume":"64","author":"Zhao","year":"2021","journal-title":"J. Med. Chem."},{"issue":"39","key":"10.1016\/j.ejmech.2026.119272_bib21","doi-asserted-by":"crossref","first-page":"13706","DOI":"10.1002\/anie.201902470","article-title":"De novo design of selective membrane-active peptides by enzymatic control of their conformational bias on the cell surface","volume":"58","author":"Shi","year":"2019","journal-title":"Angew. Chem. Int. Ed. Engl"},{"issue":"45","key":"10.1016\/j.ejmech.2026.119272_bib22","doi-asserted-by":"crossref","first-page":"8204","DOI":"10.1039\/D5CC00660K","article-title":"Triphenyl phosphonium functionalized amphiphilic peptides as promising antibacterial and anticancer agents","volume":"61","author":"Mondal","year":"2025","journal-title":"Chem. Commun."},{"issue":"12","key":"10.1016\/j.ejmech.2026.119272_bib23","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1038\/s41589-025-01946-9","article-title":"A class of benzofuranoindoline-bearing heptacyclic fungal RiPPs with anticancer activities","volume":"21","author":"Nie","year":"2025","journal-title":"Nat. Chem. Boil."},{"issue":"1","key":"10.1016\/j.ejmech.2026.119272_bib24","first-page":"201","article-title":"The hybrid oncolytic peptide NTP-385 potently inhibits adherent cancer cells by targeting the nucleus, Acta","volume":"44","author":"Yin","year":"2023","journal-title":"Pharmacol. Sin."},{"issue":"9","key":"10.1016\/j.ejmech.2026.119272_bib25","doi-asserted-by":"crossref","first-page":"5802","DOI":"10.1021\/acs.jmedchem.0c02237","article-title":"Stapled wasp Venom-Derived oncolytic peptides with side chains induce rapid membrane lysis and prolonged immune responses in melanoma","volume":"64","author":"Wu","year":"2021","journal-title":"J. Med. Chem."},{"issue":"19","key":"10.1016\/j.ejmech.2026.119272_bib26","doi-asserted-by":"crossref","first-page":"17893","DOI":"10.1021\/acs.jmedchem.4c01939","article-title":"Design, synthesis, and biological evaluation of lysine-stapled peptide inhibitors of p53-MDM2\/MDMX interactions with potent antitumor activity in vivo","volume":"67","author":"Xu","year":"2024","journal-title":"J. Med. Chem."},{"issue":"Pt 2","key":"10.1016\/j.ejmech.2026.119272_bib27","doi-asserted-by":"crossref","first-page":"118339","DOI":"10.1016\/j.ejmech.2025.118339","article-title":"KLAK peptide in anticancer therapy: achieving cancer cell apoptosis via mitochondrial membrane disruption using homing domains introduction and other modifications","volume":"302","author":"Kotal\u00edk","year":"2026","journal-title":"Eur. J. Med. Chem."},{"issue":"7","key":"10.1016\/j.ejmech.2026.119272_bib28","doi-asserted-by":"crossref","first-page":"4491","DOI":"10.1016\/j.apsb.2026.01.006","article-title":"Discovery of novel tumor-targeting peptideoncolytic peptide based conjugates (PPCs): a new paradigm for targeted oncolytic-immunotherapy","volume":"16","author":"Yu","year":"2026","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.ejmech.2026.119272_bib29","doi-asserted-by":"crossref","first-page":"114660","DOI":"10.1016\/j.jconrel.2026.114660","article-title":"pH-responsive polymeric-peptide complex enhances tumor immunogenic cell death by membrane disruption","volume":"392","author":"Jin","year":"2026","journal-title":"J. Control. Release."},{"issue":"8","key":"10.1016\/j.ejmech.2026.119272_bib30","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1016\/j.biomaterials.2010.11.054","article-title":"Synthetic cationic amphiphilic \u03b1-helical peptides as antimicrobial agents","volume":"32","author":"Wiradharma","year":"2011","journal-title":"Biomaterials"},{"issue":"34","key":"10.1016\/j.ejmech.2026.119272_bib31","doi-asserted-by":"crossref","first-page":"8841","DOI":"10.1016\/j.biomaterials.2012.08.026","article-title":"Cationic amphiphilic alpha-helical peptides for the treatment of carbapenem-resistant Acinetobacter baumannii infection","volume":"33","author":"Huang","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejmech.2026.119272_bib32","doi-asserted-by":"crossref","first-page":"116519","DOI":"10.1016\/j.ejmech.2024.116519","article-title":"Rational design of a new short anticancer peptide with good potential for cancer treatment","volume":"273","author":"Wu","year":"2024","journal-title":"Eur. J. Med. Chem."},{"issue":"22","key":"10.1016\/j.ejmech.2026.119272_bib33","doi-asserted-by":"crossref","first-page":"6387","DOI":"10.1039\/D0BM00629G","article-title":"Branched \u03b1-helical peptides enhanced antitumor efficacy and selectivity","volume":"8","author":"Wang","year":"2020","journal-title":"Biomater. Sci."},{"issue":"19","key":"10.1016\/j.ejmech.2026.119272_bib34","doi-asserted-by":"crossref","first-page":"16529","DOI":"10.1021\/am504973d","article-title":"High cell selectivity and low level antibacterial resistance of designed amphiphilic peptide G(IIKK)(3)I-NH2","volume":"6","author":"Chen","year":"2014","journal-title":"Acs. Appl. Mater. Inter."},{"issue":"42","key":"10.1016\/j.ejmech.2026.119272_bib35","doi-asserted-by":"crossref","first-page":"49713","DOI":"10.1021\/acsami.1c14761","article-title":"Designed antitumor peptide for targeted siRNA delivery into cancer spheroids","volume":"13","author":"Cirillo","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ejmech.2026.119272_bib36","doi-asserted-by":"crossref","first-page":"131355","DOI":"10.1016\/j.colsurfa.2023.131355","article-title":"de Novo-designed antimicrobial peptides with broad-spectrum antimicrobial potency and rapid wound disinfection","volume":"667","author":"Zheng","year":"2023","journal-title":"Colloid. Surface. A"},{"key":"10.1016\/j.ejmech.2026.119272_bib37","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.jcis.2021.08.200","article-title":"Rationally designed short cationic \u03b1-helical peptides with selective anticancer activity","volume":"607","author":"Hadianamrei","year":"2022","journal-title":"J. Colloid Interface Sci."},{"issue":"9","key":"10.1016\/j.ejmech.2026.119272_bib38","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1016\/j.bpj.2011.03.018","article-title":"Tryptophan-lipid interactions in membrane protein folding probed by ultraviolet resonance Raman and fluorescence spectroscopy","volume":"100","author":"Sanchez","year":"2011","journal-title":"Biophys. J."},{"key":"10.1016\/j.ejmech.2026.119272_bib39","doi-asserted-by":"crossref","first-page":"117662","DOI":"10.1016\/j.ejmech.2025.117662","article-title":"A new short pH-responsive anticancer peptide derived by intramolecular charge shielding strategy","volume":"291","author":"Chang","year":"2025","journal-title":"Eur. J. Med. Chem."},{"issue":"13","key":"10.1016\/j.ejmech.2026.119272_bib40","doi-asserted-by":"crossref","first-page":"3408","DOI":"10.1021\/acs.jpcb.5c00680","article-title":"How does an anti-cancer peptide passively permeate the plasma membrane of a cancer cell and not a normal cell?","volume":"129","author":"Cardenas","year":"2025","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.ejmech.2026.119272_bib41","doi-asserted-by":"crossref","first-page":"1463088","DOI":"10.3389\/fonc.2024.1463088","article-title":"From defense to offense: antimicrobial peptides as promising therapeutics for cancer","volume":"14","author":"Zare-Zardini","year":"2024","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ejmech.2026.119272_bib42","doi-asserted-by":"crossref","first-page":"109782","DOI":"10.1016\/j.bioorg.2026.109782","article-title":"Novel pH-responsive anticancer lipopeptide exhibiting superior antitumor performance by the smart intramolecular charge shielding and lipidation modification","volume":"175","author":"Tian","year":"2026","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2026.119272_bib43","first-page":"557","article-title":"The design of cell-selective tryptophan and arginine-rich antimicrobial peptides by introducing hydrophilic uncharged residues, Acta","volume":"153","author":"Zhu","year":"2022","journal-title":"Biomater"},{"key":"10.1016\/j.ejmech.2026.119272_bib44","doi-asserted-by":"crossref","first-page":"117321","DOI":"10.1016\/j.ejmech.2025.117321","article-title":"Single or double lipid-modified ultra-short antimicrobial peptides for treating infections caused by resistant bacteria","volume":"287","author":"Ouyang","year":"2025","journal-title":"Eur. J. Med. Chem."},{"issue":"13","key":"10.1016\/j.ejmech.2026.119272_bib45","doi-asserted-by":"crossref","first-page":"13772","DOI":"10.1021\/acs.jmedchem.5c00665","article-title":"Leucine\/Isoleucine substitution scanning of tryptophan residues to reduce the toxicity of \u03b2-Hairpin peptide N2W2","volume":"68","author":"Li","year":"2025","journal-title":"J. Med. Chem."},{"issue":"21","key":"10.1016\/j.ejmech.2026.119272_bib46","doi-asserted-by":"crossref","first-page":"e202500316","DOI":"10.1002\/cmdc.202500316","article-title":"Optimizing amphipathic antimicrobial peptides via helical wheel rotation","volume":"20","author":"Phuong","year":"2025","journal-title":"ChemMedChem"},{"issue":"6","key":"10.1016\/j.ejmech.2026.119272_bib47","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1080\/1061186X.2021.1873351","article-title":"New designed pH-responsive histidine-rich peptides with antitumor activity","volume":"29","author":"Chang","year":"2021","journal-title":"J. Drug Target."},{"key":"10.1016\/j.ejmech.2026.119272_bib48","doi-asserted-by":"crossref","first-page":"1321386","DOI":"10.3389\/fmicb.2023.1321386","article-title":"Anticancer activities of natural antimicrobial peptides from animals","volume":"14","author":"Qu","year":"2023","journal-title":"Front. Microbiol."},{"issue":"1","key":"10.1016\/j.ejmech.2026.119272_bib49","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2174\/1389557514666141107120954","article-title":"Alpha-helical cationic anticancer peptides: a promising candidate for novel anticancer drugs","volume":"15","author":"Huang","year":"2015","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119272_bib50","doi-asserted-by":"crossref","first-page":"106156","DOI":"10.1016\/j.biocel.2022.106156","article-title":"Effect of hydrophobicity on distinct anticancer mechanism of antimicrobial peptide chensinin-1b and its lipoanalog PA-C1b in breast cancer cells","volume":"143","author":"Guo","year":"2022","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"21","key":"10.1016\/j.ejmech.2026.119272_bib51","doi-asserted-by":"crossref","first-page":"18807","DOI":"10.1021\/acs.jmedchem.4c01179","article-title":"Phosphorylation as an effective tool to improve stability and reduce toxicity of antimicrobial peptides","volume":"67","author":"Ba","year":"2024","journal-title":"J. Med. Chem."},{"issue":"13","key":"10.1016\/j.ejmech.2026.119272_bib52","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/0024-3205(96)00057-4","article-title":"Phosphorylation of enkephalins enhances their proteolytic stability","volume":"58","author":"Dass","year":"1996","journal-title":"Life Sci."},{"key":"10.1016\/j.ejmech.2026.119272_bib53","first-page":"11254","article-title":"Reversing anticancer drug resistance by synergistic combination of chemotherapeutics and membranolytic antitumor \u03b2-Peptide polymer","volume":"146","author":"Shao","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2026.119272_bib54","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.jconrel.2022.03.034","article-title":"Drug-free neutrally charged polypeptide nanoparticles as anticancer agents","volume":"345","author":"Yang","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejmech.2026.119272_bib55","doi-asserted-by":"crossref","first-page":"1028600","DOI":"10.3389\/fonc.2022.1028600","article-title":"Hybrid peptide NTP-217 triggers ROS-mediated rapid necrosis in liver cancer cells by induction of mitochondrial leakage","volume":"12","author":"Yin","year":"2023","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ejmech.2026.119272_bib56","doi-asserted-by":"crossref","first-page":"10488","DOI":"10.1038\/s41467-025-65449-w","article-title":"An antimicrobial peptide as a potential therapy for bacterial pneumonia that alleviates antimicrobial resistance","volume":"16","author":"Zhong","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2026.119272_bib57","doi-asserted-by":"crossref","first-page":"10382","DOI":"10.1038\/s41467-024-54854-2","article-title":"MMP-2-triggered, mitochondria-targeted PROTAC-PDT therapy of breast cancer and brain metastases inhibition","volume":"15","author":"Tong","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2026.119272_bib58","doi-asserted-by":"crossref","first-page":"118802","DOI":"10.1016\/j.ejmech.2026.118802","article-title":"Engineering \u03b2-amino acid antimicrobial peptides with enhanced stability and potential efficacy against gram-negative bacterial infections","volume":"310","author":"Zhu","year":"2026","journal-title":"Eur. J. Med. Chem."},{"issue":"19","key":"10.1016\/j.ejmech.2026.119272_bib59","doi-asserted-by":"crossref","first-page":"20081","DOI":"10.1021\/acs.jmedchem.5c00922","article-title":"Fluorinated modification as a simple strategy that effectively enhances the stability and activity of antimicrobial peptides","volume":"68","author":"Ouyang","year":"2025","journal-title":"J. Med. Chem."},{"issue":"9","key":"10.1016\/j.ejmech.2026.119272_bib60","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1080\/1061186X.2022.2070627","article-title":"Constructing new acid-activated anticancer peptide by attaching a desirable anionic binding partner peptide","volume":"30","author":"Zhang","year":"2022","journal-title":"J. Drug Target."},{"issue":"1","key":"10.1016\/j.ejmech.2026.119272_bib61","first-page":"100890","article-title":"Design of pH-responsive antimicrobial peptide melittin analog-camptothecin conjugates for tumor therapy","volume":"19","author":"Huang","year":"2024","journal-title":"Asian J. Pharm. Sci."},{"issue":"1","key":"10.1016\/j.ejmech.2026.119272_bib62","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1080\/10717544.2016.1247927","article-title":"Preparation of endostatin-loaded chitosan nanoparticles and evaluation of the antitumor effect of such nanoparticles on the Lewis lung cancer model","volume":"24","author":"Ding","year":"2017","journal-title":"Drug Deliv."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523426007178?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523426007178?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T15:03:09Z","timestamp":1793977389000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523426007178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":62,"alternative-id":["S0223523426007178"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2026.119272","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A new short template-designed peptide with good antitumor potential by an alternative modification of threonine and its phosphorylation","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2026.119272","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119272"}}