{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T12:28:17Z","timestamp":1793968097079,"version":"4.8.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","award":["2024-02726"],"award-info":[{"award-number":["2024-02726"]}],"id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.ejmech.2026.119346","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T15:39:54Z","timestamp":1789745994000},"page":"119346","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P1","title":["Harnessing chirality for enhanced stability: An all-D protease resistant antimicrobial peptide active against drug-resistant skin bacteria"],"prefix":"10.1016","volume":"321","author":[{"given":"Anna","family":"Dziuba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Ausiello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annarita","family":"Del Gatto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanyukta","family":"Darnal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia Maria","family":"Pedone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Kerr","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"Notomista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Ferraz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Contursi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Cafaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annelie","family":"Brauner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2026.119346_bib1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3389\/fphar.2018.00281","article-title":"Antimicrobial peptides and their therapeutic potential for bacterial skin infections and wounds","volume":"9","author":"Pfalzgraff","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejmech.2026.119346_bib2","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3390\/antibiotics12030557","article-title":"Clinical impact of Staphylococcus aureus skin and soft tissue infections","volume":"12","author":"Linz","year":"2023","journal-title":"Antibiotics"},{"key":"10.1016\/j.ejmech.2026.119346_bib3","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2165\/11539770-000000000-00000","article-title":"Pseudomonas skin infection: clinical features, epidemiology, and management","volume":"12","author":"Wu","year":"2011","journal-title":"Am. J. Clin. Dermatol."},{"key":"10.1016\/j.ejmech.2026.119346_bib4","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jgar.2021.05.010","article-title":"Challenges in the management of chronic wound infections","volume":"26","author":"Falcone","year":"2021","journal-title":"J. Glob. Antimicrob. Resist."},{"key":"10.1016\/j.ejmech.2026.119346_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2021.609584","article-title":"Distribution and antibiotic resistance patterns of pathogenic bacteria in patients with chronic cutaneous wounds in China","volume":"8","author":"Guan","year":"2021","journal-title":"Front. Med."},{"key":"10.1016\/j.ejmech.2026.119346_bib6","article-title":"Effective alternative strategies to combat challenges associated with MDR bacterial infections: drug repurposing, role of artificial intelligence, and novel therapeutic options","author":"El-Sayed","year":"2025","journal-title":"J. Infect. Public Health"},{"key":"10.1016\/j.ejmech.2026.119346_bib7","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jgar.2020.12.025","article-title":"Exploring the future of infectious disease treatment in a post-antibiotic era: a comparative review of alternative therapeutics","volume":"24","author":"Streicher","year":"2021","journal-title":"J. Glob. Antimicrob. Resist."},{"key":"10.1016\/j.ejmech.2026.119346_bib8","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/bip.22250","article-title":"Peptide design for antimicrobial and immunomodulatory applications","volume":"100","author":"Haney","year":"2013","journal-title":"Pept. Sci."},{"key":"10.1016\/j.ejmech.2026.119346_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.116072","article-title":"Antimicrobial peptides: an alternative to traditional antibiotics","volume":"265","author":"Ji","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119346_bib10","doi-asserted-by":"crossref","first-page":"4584","DOI":"10.3390\/molecules27144584","article-title":"Lights and shadows on the therapeutic use of antimicrobial peptides","volume":"27","author":"Bellotti","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2026.119346_bib11","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1186\/s12967-025-06321-9","article-title":"Antimicrobial peptide biological activity, delivery systems and clinical translation status and challenges","volume":"23","author":"Zheng","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.ejmech.2026.119346_bib12","doi-asserted-by":"crossref","first-page":"4538","DOI":"10.1038\/s41467-019-12364-6","article-title":"Integrated evolutionary analysis reveals antimicrobial peptides with limited resistance","volume":"10","author":"Spohn","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2026.119346_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2024.127822","article-title":"Antimicrobial peptides: opportunities and challenges in overcoming resistance","volume":"286","author":"Bucataru","year":"2024","journal-title":"Microbiol. Res."},{"key":"10.1016\/j.ejmech.2026.119346_bib14","article-title":"Antimicrobial peptides: from discovery to developmental applications","author":"Zhang","year":"2025","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ejmech.2026.119346_bib15","doi-asserted-by":"crossref","DOI":"10.1093\/jambio\/lxae290","article-title":"Harnessing bacterial antimicrobial peptides: a comprehensive review on properties, mechanisms, applications, and challenges in combating antimicrobial resistance","volume":"136","author":"Erriah","year":"2025","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.ejmech.2026.119346_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2025.1553693","article-title":"Broad-spectrum antimicrobial activity and in vivo efficacy of SK1260 against bacterial pathogens","volume":"16","author":"Kavela","year":"2025","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ejmech.2026.119346_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2025.1528583","article-title":"Unlocking the power of antimicrobial peptides: advances in production, optimization, and therapeutics","volume":"15","author":"Sadeeq","year":"2025","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.ejmech.2026.119346_bib18","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.actbio.2023.04.030","article-title":"Boosting stability and therapeutic potential of proteolysis-resistant antimicrobial peptides by end-tagging \u03b2-naphthylalanine","volume":"164","author":"He","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ejmech.2026.119346_bib19","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1080\/07388551.2020.1796576","article-title":"Antimicrobial peptides as therapeutic agents: opportunities and challenges","volume":"40","author":"Mahlapuu","year":"2020","journal-title":"Crit. Rev. Biotechnol."},{"key":"10.1016\/j.ejmech.2026.119346_bib20","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.jtbi.2017.02.012","article-title":"Antimicrobial potency of cationic antimicrobial peptides can be predicted from their amino acid composition: application to the detection of \"cryptic\" antimicrobial peptides","volume":"419","author":"Pane","year":"2017","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.ejmech.2026.119346_bib21","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s12934-015-0302-9","article-title":"The identification of a novel Sulfolobus islandicus CAMP-like peptide points to archaeal microorganisms as cell factories for the production of antimicrobial molecules","volume":"14","author":"Notomista","year":"2015","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.ejmech.2026.119346_bib22","doi-asserted-by":"crossref","first-page":"5993","DOI":"10.1093\/nar\/gku215","article-title":"Structural and functional studies of Stf76 from the Sulfolobus islandicus plasmid-virus pSSVx: a novel peculiar member of the winged helix-turn-helix transcription factor family","volume":"42","author":"Contursi","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejmech.2026.119346_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-35530-0","article-title":"Antifungal and anti-biofilm activity of the first cryptic antimicrobial peptide from an archaeal protein against candida spp. clinical isolates","volume":"8","author":"Roscetto","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2026.119346_bib24","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1021\/acsptsci.4c00503","article-title":"Comparison of protocols to test peptide stability in blood plasma and cell culture supernatants","volume":"7","author":"Kohler","year":"2024","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"10.1016\/j.ejmech.2026.119346_bib25","first-page":"583","article-title":"Chapter 32 - modes of action of antibacterial agents","author":"Allison","year":"2015"},{"key":"10.1016\/j.ejmech.2026.119346_bib26","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.nmni.2015.06.003","article-title":"Fatal necrotizing fasciitis due to necrotic toxin-producing Escherichia coli strain","volume":"8","author":"Gallois","year":"2015","journal-title":"New Microbes New Infect."},{"key":"10.1016\/j.ejmech.2026.119346_bib27","doi-asserted-by":"crossref","first-page":"8671","DOI":"10.3390\/ijms21228671","article-title":"Pseudomonas aeruginosa biofilms","volume":"21","author":"Thi","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2026.119346_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.microb.2025.100356","article-title":"Bacterial biofilm and its role in antibiotic resistance","volume":"7","author":"Sharif","year":"2025","journal-title":"Microbe"},{"key":"10.1016\/j.ejmech.2026.119346_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fmedt.2020.610997","article-title":"Mode-of-Action of antimicrobial peptides: membrane disruption vs. intracellular mechanisms","volume":"2","author":"Benfield","year":"2020","journal-title":"Front Med Technol"},{"key":"10.1016\/j.ejmech.2026.119346_bib30","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.jiph.2016.08.007","article-title":"Antibiotic resistance","volume":"10","author":"Frieri","year":"2017","journal-title":"J. Infect. Public Health"},{"key":"10.1016\/j.ejmech.2026.119346_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.145923","article-title":"Enhancing the stability of antimicrobial peptides: from design strategies to applications","volume":"475","author":"Xu","year":"2023","journal-title":"Chem Eng J"},{"key":"10.1016\/j.ejmech.2026.119346_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.915368","article-title":"Antimicrobial peptide mimics for clinical use: does size matter?","volume":"13","author":"Svenson","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejmech.2026.119346_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2024.107398","article-title":"LL-37, the master antimicrobial peptide, its multifaceted role from combating infections to cancer immunity","volume":"65","author":"Keshri","year":"2025","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.ejmech.2026.119346_bib34","doi-asserted-by":"crossref","first-page":"396","DOI":"10.3390\/pharmaceutics17040396","article-title":"New temporin A analogues modified in positions 1 and 10-synthesis and biological studies","volume":"17","author":"Dimitrova","year":"2025","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejmech.2026.119346_bib35","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/j.bbamem.2008.10.009","article-title":"Structure, membrane orientation, mechanism, and function of pexiganan--a highly potent antimicrobial peptide designed from magainin","volume":"1788","author":"Gottler","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejmech.2026.119346_bib36","doi-asserted-by":"crossref","first-page":"17856","DOI":"10.1021\/acsomega.3c00850","article-title":"Interaction of pexiganan (MSI-78)-derived analogues reduces inflammation and TLR4-mediated cytokine secretion: a comparative study","volume":"8","author":"Cohen","year":"2023","journal-title":"ACS Omega"},{"key":"10.1016\/j.ejmech.2026.119346_bib37","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.cbpa.2014.09.019","article-title":"Mirror image proteins","volume":"22","author":"Zhao","year":"2014","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.ejmech.2026.119346_bib38","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s13568-016-0295-8","article-title":"Antimicrobial activity and stability of the d-amino acid substituted derivatives of antimicrobial peptide polybia-MPI","volume":"6","author":"Zhao","year":"2016","journal-title":"AMB Express"},{"key":"10.1016\/j.ejmech.2026.119346_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamem.2023.184160","article-title":"Analyzing mechanisms of action of antimicrobial peptides on bacterial membranes requires multiple complimentary assays and different bacterial strains","volume":"1865","author":"Wang","year":"2023","journal-title":"BBA - Biomembranes"},{"key":"10.1016\/j.ejmech.2026.119346_bib40","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.resmic.2012.10.020","article-title":"Offense and defense: microbial membrane vesicles play both ways","volume":"163","author":"MacDonald","year":"2012","journal-title":"Res. Microbiol."},{"key":"10.1016\/j.ejmech.2026.119346_bib41","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1021\/acsinfecdis.3c00491","article-title":"Mechanism of protease resistance of d-amino acid residue containing cationic antimicrobial heptapeptides","volume":"10","author":"Sarkar","year":"2024","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.ejmech.2026.119346_bib42","doi-asserted-by":"crossref","DOI":"10.1002\/cbic.202200537","article-title":"D-peptide and D-protein technology: recent advances, challenges, and opportunities","volume":"24","author":"Lander","year":"2023","journal-title":"Chembiochem"},{"key":"10.1016\/j.ejmech.2026.119346_bib43","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.1021\/acs.biochem.5c00101","article-title":"\u03b1-helical structure of antimicrobial peptides enhances their activity through molecular surface signatures","volume":"64","author":"Quagliata","year":"2025","journal-title":"Biochemistry"},{"key":"10.1016\/j.ejmech.2026.119346_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.microb.2024.100078","article-title":"Biofilm formation and antibiotic resistance in Pseudomonas aeruginosa","volume":"3","author":"Haidar","year":"2024","journal-title":"Microbe"},{"key":"10.1016\/j.ejmech.2026.119346_bib45","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1021\/acsinfecdis.2c00598","article-title":"A synthetic cyclized antimicrobial peptide with potent effects against drug-resistant skin pathogens","volume":"9","author":"White","year":"2023","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.ejmech.2026.119346_bib46","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S1389-1723(00)88949-5","article-title":"Enzymes acting on peptides containing d-amino acid","volume":"89","author":"Asano","year":"2000","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.ejmech.2026.119346_bib47","doi-asserted-by":"crossref","first-page":"29","DOI":"10.2174\/1573395052952941","article-title":"Innate immunity in the skin: how keratinocytes fight against pathogens","volume":"1","author":"Pivarcsi","year":"2005","journal-title":"Curr. Immunol. Rev."},{"key":"10.1016\/j.ejmech.2026.119346_bib48","doi-asserted-by":"crossref","first-page":"8856","DOI":"10.1073\/pnas.97.16.8856","article-title":"The role of antimicrobial peptides in animal defenses","volume":"97","author":"Hancock","year":"2000","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ejmech.2026.119346_bib49","doi-asserted-by":"crossref","first-page":"17180","DOI":"10.1021\/jacs.1c07492","article-title":"Dendritic hydrogels induce immune modulation in human keratinocytes and effectively eradicate bacterial pathogens","volume":"143","author":"Fan","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2026.119346_bib50","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0137753","article-title":"Staphylococcus aureus inhibits IL-8 responses induced by Pseudomonas aeruginosa in airway epithelial cells","volume":"10","author":"Chekabab","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ejmech.2026.119346_bib51","doi-asserted-by":"crossref","first-page":"840","DOI":"10.3390\/antibiotics9120840","article-title":"Antibacterial and anti-inflammatory activity of an antimicrobial peptide synthesized with d-amino acids","volume":"9","author":"Brunetti","year":"2020","journal-title":"Antibiotics"},{"key":"10.1016\/j.ejmech.2026.119346_bib52","doi-asserted-by":"crossref","first-page":"26279","DOI":"10.1016\/S0021-9258(19)74312-9","article-title":"Antigenicity and immunogenicity of modified synthetic peptides containing d-amino acid residues. Antibodies to a d-enantiomer do recognize the parent l-hexapeptide and reciprocally","volume":"268","author":"Benkirane","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejmech.2026.119346_bib53","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1007\/s11095-015-1791-2","article-title":"Pharmacokinetic properties of a novel d-peptide developed to be therapeutically active against toxic \u03b2-amyloid oligomers","volume":"33","author":"Leithold","year":"2016","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejmech.2026.119346_bib54","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.3390\/ph16101386","article-title":"The antimicrobial, antibiofilm and anti-inflammatory activities of P13#1, a cathelicidin-like achiral peptoid","volume":"16","author":"Cafaro","year":"2023","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.ejmech.2026.119346_bib55","article-title":"Antimicrobial properties and membrane-active mechanism of a potential \u03b1-Helical antimicrobial derived from cathelicidin PMAP-36","volume":"9","author":"Lv","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ejmech.2026.119346_bib56","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1128\/AAC.44.12.3317-3321.2000","article-title":"Interactions of bacterial cationic peptide antibiotics with outer and cytoplasmic membranes of Pseudomonas aeruginosa","volume":"44","author":"Zhang","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2026.119346_bib57","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.3390\/ijms24032914","article-title":"Optimization of the hemolysis assay for the assessment of cytotoxicity","volume":"24","author":"S\u00e6b\u00f8","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2026.119346_bib58","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0146552","article-title":"Rational design of a carrier protein for the production of recombinant toxic peptides in Escherichia coli","volume":"11","author":"Pane","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ejmech.2026.119346_bib59","doi-asserted-by":"crossref","first-page":"8914","DOI":"10.3390\/ijms26188914","article-title":"Exploring the antimicrobial and antiviral properties of cryptic peptides from human fibrinogen","volume":"26","author":"Bosso","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2026.119346_bib60","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1007\/s00018-022-04440-w","article-title":"A stable cyclized antimicrobial peptide derived from LL-37 with host immunomodulatory effects and activity against uropathogens","volume":"79","author":"White","year":"2022","journal-title":"Cell. Mol. Life Sci."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523426007919?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523426007919?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T11:57:20Z","timestamp":1793966240000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523426007919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":60,"alternative-id":["S0223523426007919"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2026.119346","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Harnessing chirality for enhanced stability: An all-D protease resistant antimicrobial peptide active against drug-resistant skin bacteria","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2026.119346","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"119346"}}