{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:41:52Z","timestamp":1792644112415,"version":"4.5.0"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010769","name":"Axencia Galega de Innovaci\u00f3n","doi-asserted-by":"publisher","award":["IN607D2021\/01"],"award-info":[{"award-number":["IN607D2021\/01"]}],"id":[{"id":"10.13039\/501100010769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010769","name":"Axencia Galega de Innovaci\u00f3n","doi-asserted-by":"publisher","award":["IN607A2023\/04"],"award-info":[{"award-number":["IN607A2023\/04"]}],"id":[{"id":"10.13039\/501100010769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["PRTR-C17.I1"],"award-info":[{"award-number":["PRTR-C17.I1"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.ejmech.2026.119361","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:37:17Z","timestamp":1790177837000},"page":"119361","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The oxidative and carbonyl stress axis in anti-vascular endothelial growth factor-refractory neovascular age-related macular degeneration: Implications for therapeutic repurposing"],"prefix":"10.1016","volume":"320","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5281-5694","authenticated-orcid":false,"given":"Diana Carolina","family":"Castro-Fern\u00e1ndez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2492-0266","authenticated-orcid":false,"given":"Antonio","family":"Ca\u00f1izo-Outeiri\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1595-3459","authenticated-orcid":false,"given":"Ant\u00f3n L.","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3717-5693","authenticated-orcid":false,"given":"Andrea","family":"Cuartero-Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9604-6833","authenticated-orcid":false,"given":"Lorena","family":"Rodr\u00edguez-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Gonz\u00e1lez-Barcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Isabel","family":"Fern\u00e1ndez-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Rodr\u00edguez-Cid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximino Jos\u00e9","family":"Abraldes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4186-641X","authenticated-orcid":false,"given":"Pablo","family":"Almui\u00f1a-Varela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Purificaci\u00f3n","family":"Mera-Y\u00e1\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bego\u00f1a","family":"de Domingo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Gil-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda del Pilar","family":"M\u00e9ndez-Cepeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belen","family":"Pazos-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Gom\u00e9z-Ulla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Isabel","family":"Loza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8917-5525","authenticated-orcid":false,"given":"Ignacio","family":"Ortea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5523-1979","authenticated-orcid":false,"given":"Jos\u00e9","family":"Brea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1782-6779","authenticated-orcid":false,"given":"Jes\u00fas","family":"Mateos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7348-7337","authenticated-orcid":false,"given":"Anxo","family":"Fern\u00e1ndez-Ferreiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.ejmech.2026.119361_bib1","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.mayocpiqo.2024.05.003","article-title":"Recent updates on the diagnosis and management of age-related macular degeneration","volume":"8","author":"Boopathiraj","year":"2024","journal-title":"Mayo Clin Proc Innov Qual Outcomes"},{"issue":"7","key":"10.1016\/j.ejmech.2026.119361_bib2","doi-asserted-by":"crossref","first-page":"e1175","DOI":"10.1016\/S2214-109X(25)00143-3","article-title":"Global burden of vision impairment due to age-related macular degeneration, 1990\u20132021, with forecasts to 2050: a systematic analysis for the global burden of Disease Study 2021","volume":"13","author":"Jeong","year":"2025","journal-title":"Lancet Glob Health"},{"issue":"8","key":"10.1016\/j.ejmech.2026.119361_bib3","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.3390\/ijms26083463","article-title":"Role of oxidative stress and inflammation in age related macular degeneration: insights into the retinal pigment epithelium (RPE)","volume":"26","author":"Ochoa Hern\u00e1ndez","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.ejmech.2026.119361_bib4","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.3390\/antiox14101251","article-title":"Title oxidative stress in age-related macular degeneration: from molecular mechanisms to emerging therapeutic targets","volume":"14","author":"Mimura","year":"2025","journal-title":"Antioxidants"},{"key":"10.1016\/j.ejmech.2026.119361_bib5","first-page":"1","article-title":"Oxidative stress and 4-hydroxy-2-nonenal (4-HNE): implications in the pathogenesis and treatment of aging-related diseases","volume":"2022","author":"Li","year":"2022","journal-title":"J. Immunol. Res."},{"issue":"5","key":"10.1016\/j.ejmech.2026.119361_bib6","doi-asserted-by":"crossref","first-page":"653","DOI":"10.3390\/antiox10050653","article-title":"Oxidative and nitrosative stress in age-related macular degeneration: a review of their role in different stages of disease","volume":"10","author":"Toma","year":"2021","journal-title":"Antioxidants"},{"issue":"2","key":"10.1016\/j.ejmech.2026.119361_bib7","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1001\/jama.2023.26074","article-title":"Age-related macular degeneration: a review","volume":"331","author":"Fleckenstein","year":"2024","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.ejmech.2026.119361_bib8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1471-2415-10-31","article-title":"Clinical risk factors for age-related macular degeneration: a systematic review and meta-analysis","volume":"10","author":"Chakravarthy","year":"2010","journal-title":"BMC Ophthalmol."},{"issue":"2","key":"10.1016\/j.ejmech.2026.119361_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0016722","article-title":"Cigarette smoke-related hydroquinone dysregulates MCP-1, VEGF and PEDF expression in retinal pigment epithelium in vitro and in vivo","volume":"6","author":"Pons","year":"2011","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.ejmech.2026.119361_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003119","article-title":"Chronic cigarette smoke causes oxidative damage and apoptosis to retinal pigmented epithelial cells in mice. Blagosklonny MV","volume":"3","author":"Fujihara","year":"2008","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.ejmech.2026.119361_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0182420","article-title":"Cigarette smoke induced autophagy-impairment regulates AMD pathogenesis mechanisms in ARPE-19 cells","volume":"12","author":"Govindaraju","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.ejmech.2026.119361_bib12","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.freeradbiomed.2024.10.307","article-title":"The complement factor H (Y402H) risk polymorphism for age-related macular degeneration affects metabolism and response to oxidative stress in the retinal pigment epithelium","volume":"225","author":"Shang","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejmech.2026.119361_bib13","article-title":"Cigarette smoke and biological age induce degenerative heterogeneity in retinal pigment epithelium","author":"Singh","year":"2025","journal-title":"Neuroscience"},{"issue":"6","key":"10.1016\/j.ejmech.2026.119361_bib14","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/eye.2015.48","article-title":"Defining response to anti-VEGF therapies in neovascular AMD","volume":"29","author":"Amoaku","year":"2015","journal-title":"Eye"},{"issue":"6","key":"10.1016\/j.ejmech.2026.119361_bib15","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.oret.2024.01.004","article-title":"European unmet needs in the management of neovascular age-related macular degeneration in daily practice","volume":"8","author":"Boudousq","year":"2024","journal-title":"Ophthalmol Retina"},{"issue":"6","key":"10.1016\/j.ejmech.2026.119361_bib16","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1007\/s12272-024-01503-3","article-title":"Challenges and opportunities of developing small-molecule therapies for age-related macular degeneration","volume":"47","author":"Fei","year":"2024","journal-title":"Arch Pharm. Res. (Seoul)"},{"issue":"23","key":"10.1016\/j.ejmech.2026.119361_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232314759","article-title":"Recent advances in proteomics-based approaches to studying age-related macular degeneration: a systematic review","volume":"23","author":"Garc\u00eda-Quintanilla","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2026.119361_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fddsv.2024.1460100","article-title":"How drug repurposing can advance drug discovery: challenges and opportunities","volume":"4","author":"Pinzi","year":"2024","journal-title":"Front Drug Discov"},{"issue":"41","key":"10.1016\/j.ejmech.2026.119361_bib19","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2102975118","article-title":"Identification of fluoxetine as a direct NLRP3 inhibitor to treat atrophic macular degeneration","volume":"118","author":"Ambati","year":"2021","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"9","key":"10.1016\/j.ejmech.2026.119361_bib20","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1177\/15353702231181188","article-title":"Repurposing medications for treatment of age-related macular degeneration: insights from novel approaches to data mining","volume":"248","author":"Moir","year":"2023","journal-title":"Exp Biol Med"},{"issue":"2","key":"10.1016\/j.ejmech.2026.119361_bib21","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1006\/exer.1996.0020","article-title":"ARPE-19, A human retinal pigment epithelial cell line with differentiated properties","volume":"62","author":"Dunn","year":"1996","journal-title":"Exp. Eye Res."},{"issue":"1","key":"10.1016\/j.ejmech.2026.119361_bib22","doi-asserted-by":"crossref","DOI":"10.1002\/cpns.14","article-title":"Cigarette smoke extract: a preclinical model of tobacco dependence","volume":"77","author":"Gellner","year":"2016","journal-title":"Curr Protoc Neurosci"},{"issue":"2","key":"10.1016\/j.ejmech.2026.119361_bib23","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1177\/1087057107312628","article-title":"Quantitative assessment of hit detection and confirmation in single and duplicate high-throughput screenings","volume":"13","author":"Wu","year":"2008","journal-title":"SLAS Discov"},{"key":"10.1016\/j.ejmech.2026.119361_bib24","series-title":"Assay Guidance Manual [Internet]","article-title":"HTS assay validation","author":"Iversen","year":"2004"},{"issue":"2","key":"10.1016\/j.ejmech.2026.119361_bib25","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.molimm.2015.06.008","article-title":"Diverse cellular and organismal functions of the lysosomal thiol reductase GILT","volume":"68","author":"Rausch","year":"2015","journal-title":"Mol. Immunol."},{"issue":"2","key":"10.1016\/j.ejmech.2026.119361_bib26","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1073\/pnas.97.2.745","article-title":"Enzymatic reduction of disulfide bonds in lysosomes: characterization of a gamma-interferon-inducible lysosomal thiol reductase (GILT)","volume":"97","author":"Arunachalam","year":"2000","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"14","key":"10.1016\/j.ejmech.2026.119361_bib27","doi-asserted-by":"crossref","first-page":"4866","DOI":"10.3390\/ijms21144866","article-title":"ROS in platelet biology: functional aspects and methodological insights","volume":"21","author":"Masselli","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.ejmech.2026.119361_bib28","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1182\/blood-2005-03-1047","article-title":"Platelet NAD(P)H-oxidase\u2013generated ROS production regulates \u03b1IIb\u03b23-integrin activation independent of the NO\/cGMP pathway","volume":"106","author":"Begonja","year":"2005","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.ejmech.2026.119361_bib29","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/s42255-023-00781-3","article-title":"The GAPDH redox switch safeguards reductive capacity and enables survival of stressed tumour cells","volume":"5","author":"Talwar","year":"2023","journal-title":"Nat. Metab."},{"issue":"2","key":"10.1016\/j.ejmech.2026.119361_bib30","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/nchembio.1720","article-title":"A proton relay enhances H2O2 sensitivity of GAPDH to facilitate metabolic adaptation","volume":"11","author":"Peralta","year":"2015","journal-title":"Nat. Chem. Biol."},{"issue":"5","key":"10.1016\/j.ejmech.2026.119361_bib31","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1128\/JVI.02744-14","article-title":"Interferon-induced ifit proteins: their role in viral pathogenesis","volume":"89","author":"Fensterl","year":"2015","journal-title":"J. Virol."},{"key":"10.1016\/j.ejmech.2026.119361_bib32","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.redox.2017.07.016","article-title":"Regulation of type I interferon responses by mitochondria-derived reactive oxygen species in plasmacytoid dendritic cells","volume":"13","author":"Agod","year":"2017","journal-title":"Redox Biol."},{"issue":"22","key":"10.1016\/j.ejmech.2026.119361_bib33","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abe7548","article-title":"Elevated type I interferon responses potentiate metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice","volume":"7","author":"Lei","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ejmech.2026.119361_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1065967","article-title":"Paraoxonase 1 and atherosclerosis","volume":"10","author":"Durrington","year":"2023","journal-title":"Front. Cardiovasc. Med."},{"issue":"2","key":"10.1016\/j.ejmech.2026.119361_bib35","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/nm1709","article-title":"Oxidative damage\u2013induced inflammation initiates age-related macular degeneration","volume":"14","author":"Hollyfield","year":"2008","journal-title":"Nat Med"},{"issue":"23","key":"10.1016\/j.ejmech.2026.119361_bib36","doi-asserted-by":"crossref","first-page":"14682","DOI":"10.1073\/pnas.222551899","article-title":"Drusen proteome analysis: an approach to the etiology of age-related macular degeneration","volume":"99","author":"Crabb","year":"2002","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"12","key":"10.1016\/j.ejmech.2026.119361_bib37","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1167\/iovs.65.12.20","article-title":"Aberrant lipid metabolism and complement activation in age-related macular degeneration","volume":"65","author":"Tang","year":"2024","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"7367","key":"10.1016\/j.ejmech.2026.119361_bib38","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/nature10449","article-title":"Complement factor H binds malondialdehyde epitopes and protects from oxidative stress","volume":"478","author":"Weismann","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2026.119361_bib39","doi-asserted-by":"crossref","first-page":"473","DOI":"10.34133\/research.0473","article-title":"Inhibition of ALOX12\u201312-HETE alleviates lung ischemia\u2013reperfusion injury by reducing endothelial ferroptosis-mediated neutrophil extracellular trap formation","volume":"7","author":"Li","year":"2024","journal-title":"Research"},{"issue":"5","key":"10.1016\/j.ejmech.2026.119361_bib40","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/s41556-019-0305-6","article-title":"ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway","volume":"21","author":"Chu","year":"2019","journal-title":"Nat. Cell Biol."},{"issue":"10","key":"10.1016\/j.ejmech.2026.119361_bib41","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.2337\/diabetes.49.10.1627","article-title":"Identification, cloning, and heterologous expression of a Mammalian fructosamine-3-kinase","volume":"49","author":"Delpierre","year":"2000","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.ejmech.2026.119361_bib42","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/s41540-024-00390-0","article-title":"Multi-omics reveals new links between Fructosamine-3-Kinase (FN3K) and core metabolic pathways","volume":"10","author":"Shrestha","year":"2024","journal-title":"npj Syst. Biol. Appl."},{"issue":"5","key":"10.1016\/j.ejmech.2026.119361_bib47","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1165\/rcmb.2007-0130OC","article-title":"\u03b1,\u03b2-Unsaturated aldehydes in cigarette smoke release inflammatory mediators from human macrophages","volume":"37","author":"Facchinetti","year":"2007","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"1","key":"10.1016\/j.ejmech.2026.119361_bib48","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1167\/iovs.06-0248","article-title":"Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-\u03b1-Lipoic acid","volume":"48","author":"Jia","year":"2007","journal-title":"Investig Opthalmology Vis Sci"},{"issue":"11","key":"10.1016\/j.ejmech.2026.119361_bib49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0048501","article-title":"Biological effects of cigarette smoke in cultured human retinal pigment epithelial cells","volume":"7","author":"Yu","year":"2012","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.ejmech.2026.119361_bib50","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0005304","article-title":"Changes in retinal pigment epithelium related to cigarette smoke: possible relevance to smoking as a risk factor for age-related macular degeneration","volume":"4","author":"Wang","year":"2009","journal-title":"PLoS One"},{"issue":"5\u20136","key":"10.1016\/j.ejmech.2026.119361_bib51","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1017\/S0952523810000246","article-title":"Evidence of alpha 7 nicotinic acetylcholine receptor expression in retinal pigment epithelial cells","volume":"27","author":"Maneu","year":"2010","journal-title":"Vis. Neurosci."},{"issue":"1","key":"10.1016\/j.ejmech.2026.119361_bib52","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.1038\/s41598-017-03283-x","article-title":"Disruption of retinal pigment epithelial cell properties under the exposure of cotinine","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.ejmech.2026.119361_bib53","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1124\/mol.105.018168","article-title":"Hydralazine inhibits rapid acrolein-Induced protein oligomerization: role of aldehyde scavenging and adduct trapping in cross-link blocking and cytoprotection","volume":"69","author":"Burcham","year":"2006","journal-title":"Mol. Pharmacol."},{"issue":"3","key":"10.1016\/j.ejmech.2026.119361_bib54","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1124\/mol.65.3.655","article-title":"Protein adduct-trapping by hydrazinophthalazine drugs: mechanisms of cytoprotection against Acrolein-mediated toxicity","volume":"65","author":"Burcham","year":"2004","journal-title":"Mol. Pharmacol."},{"issue":"1","key":"10.1016\/j.ejmech.2026.119361_bib55","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1179\/rer.2000.5.1.47","article-title":"The antihypertensive hydralazine is an efficient scavenger of acrolein","volume":"5","author":"Burcham","year":"2000","journal-title":"Redox Rep."},{"key":"10.1016\/j.ejmech.2026.119361_bib56","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0300-483X(02)00287-1","article-title":"Aldehyde-sequestering drugs: tools for studying protein damage by lipid peroxidation products","volume":"181\u2013182","author":"Burcham","year":"2002","journal-title":"Toxicology"},{"issue":"3","key":"10.1016\/j.ejmech.2026.119361_bib57","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1124\/jpet.104.067330","article-title":"Strong protein adduct trapping accompanies abolition of acrolein-mediated hepatotoxicity by hydralazine in mice","volume":"310","author":"Kaminskas","year":"2004","journal-title":"J. Pharmacol. Exp. Therapeut."},{"issue":"4","key":"10.1016\/j.ejmech.2026.119361_bib58","doi-asserted-by":"crossref","first-page":"319","DOI":"10.2174\/138955708783955953","article-title":"Carbonyl-scavenging drugs & protection against carbonyl stress-associated cell injury","volume":"8","author":"Burcham","year":"2008","journal-title":"Mini-Rev Med Chem"},{"issue":"18","key":"10.1016\/j.ejmech.2026.119361_bib59","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1039\/b408796h","article-title":"Reactivity of hydrazinophthalazine drugs with the lipid peroxidation products acrolein and crotonaldehyde","volume":"2","author":"Kaminskas","year":"2004","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.ejmech.2026.119361_bib60","series-title":"Process for the Preparation of 1-carboethoxyhydrazinophthalazine Hydrochloride","author":"Paradowski","year":"1971"},{"issue":"1","key":"10.1016\/j.ejmech.2026.119361_bib61","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1089\/zeb.2014.0992","article-title":"Todralazine protects zebrafish from lethal effects of ionizing radiation: role of hematopoietic cell expansion","volume":"12","author":"Dimri","year":"2015","journal-title":"Zebrafish"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523426008068?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523426008068?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:24:26Z","timestamp":1792643066000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523426008068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":57,"alternative-id":["S0223523426008068"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2026.119361","relation":{"is-supplemented-by":[{"id-type":"uri","id":"https:\/\/massive.ucsd.edu\/proteosafe\/static\/massive.jsp","asserted-by":"subject"}]},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The oxidative and carbonyl stress axis in anti-vascular endothelial growth factor-refractory neovascular age-related macular degeneration: Implications for therapeutic repurposing","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2026.119361","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"119361"}}