{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:40:47Z","timestamp":1792615247108,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.ejmech.2026.119448","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:24:03Z","timestamp":1792509843000},"page":"119448","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P2","title":["Discovery of benzoxazole derivatives as novel \u03b1-synuclein aggregate ligands with potential for PET tracer development"],"prefix":"10.1016","volume":"321","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6739-4398","authenticated-orcid":false,"given":"Yuanlong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2433-9938","authenticated-orcid":false,"given":"Jiale","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4634-4877","authenticated-orcid":false,"given":"YiKun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YongKang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9672-6441","authenticated-orcid":false,"given":"Bin","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2026.119448_bib1","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.amjmed.2019.03.001","article-title":"Parkinson's disease and parkinsonism","volume":"132","author":"Hayes","year":"2019","journal-title":"Am. J. Med."},{"key":"10.1016\/j.ejmech.2026.119448_bib2","article-title":"Alpha-synuclein pathophysiology in neurodegenerative disorders: a review focusing on molecular mechanisms and treatment advances in parkinson's disease | cellular and molecular neurobiology | springer nature link","volume":"45","author":"Shakila","year":"2025","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.ejmech.2026.119448_bib3","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ncl.2024.12.005","article-title":"Biomarkers in parkinson's disease","volume":"43","author":"Brooker","year":"2025","journal-title":"Neurol. Clin."},{"key":"10.1016\/j.ejmech.2026.119448_bib4","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s10571-025-01560-2","article-title":"Exploring \u03b1-syn\u2019s functions through ablation models: physiological and pathological implications","volume":"45","author":"Praveen","year":"2025","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.ejmech.2026.119448_bib5","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.1016\/S1353-8020(13)70017-8","article-title":"\u03b1-synucleinopathy phenotypes","volume":"20","author":"McCann","year":"2014","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.ejmech.2026.119448_bib6","first-page":"891","article-title":"\u03b1-synuclein misfolding and aggregation: implications in parkinson's disease pathogenesis","volume":"1867","author":"Mehra","year":"2019","journal-title":"Biochim. Biophys. Acta BBA - Proteins Proteomics"},{"key":"10.1016\/j.ejmech.2026.119448_bib7","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S1474-4422(21)00030-2","article-title":"Challenges in the diagnosis of parkinson's disease","volume":"20","author":"Tolosa","year":"2021","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ejmech.2026.119448_bib8","doi-asserted-by":"crossref","unstructured":"K. Kulcsarova, M. Skorvanek, R.B. Postuma, D. Berg, Defining parkinson's disease: past and future, J. Park. Dis. 14 (n.d) S257\u2013S271. https:\/\/doi.org\/10.3233\/JPD-230411.","DOI":"10.3233\/JPD-230411"},{"key":"10.1016\/j.ejmech.2026.119448_bib9","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1001\/jama.2019.22360","article-title":"Diagnosis and treatment of parkinson disease: a review","volume":"323","author":"Armstrong","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.ejmech.2026.119448_bib10","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S1474-4422(21)00061-2","article-title":"Progress towards therapies for disease modification in parkinson's disease","volume":"20","author":"Vijiaratnam","year":"2021","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ejmech.2026.119448_bib11","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.cca.2022.02.006","article-title":"\u03b1-synuclein in parkinson's disease and advances in detection","volume":"529","author":"Chen","year":"2022","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.ejmech.2026.119448_bib12","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jagp.2013.03.001","article-title":"Amyloid PET imaging in lewy body disorders","volume":"23","author":"Donaghy","year":"2015","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.ejmech.2026.119448_bib13","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcad305","article-title":"A review of the flortaucipir literature for positron emission tomography imaging of tau neurofibrillary tangles","volume":"6","author":"Burnham","year":"2023","journal-title":"Brain Commun"},{"key":"10.1016\/j.ejmech.2026.119448_bib14","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1016\/S0140-6736(26)00417-4","article-title":"Comparison of [18F]flortaucipir and [18F]MK6240 for the detection of tau pathology in alzheimer's disease (HEAD): a multicentre, prospective, cross-sectional, within-participant study","volume":"407","author":"Povala","year":"2026","journal-title":"Lancet"},{"key":"10.1016\/j.ejmech.2026.119448_bib15","doi-asserted-by":"crossref","first-page":"847","DOI":"10.3390\/ph14090847","article-title":"Alpha-synuclein PET tracer development\u2014an overview about current efforts","volume":"14","author":"Korat","year":"2021","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.ejmech.2026.119448_bib16","doi-asserted-by":"crossref","first-page":"4211","DOI":"10.1007\/s00259-025-07695-0","article-title":"PET imaging of alpha-synuclein: from radiotracer design through in vitro and in vivo translation","volume":"53","author":"Pees","year":"2026","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.ejmech.2026.119448_bib17","doi-asserted-by":"crossref","first-page":"907","DOI":"10.3390\/cells14120907","article-title":"Development of positron emission tomography radiotracers for imaging \u03b1-synuclein aggregates","volume":"14","author":"Guo","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.ejmech.2026.119448_bib18","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.1021\/acs.molpharmaceut.8b00229","article-title":"In silico, in vitro, and in vivo evaluation of new candidates for \u03b1-synuclein PET imaging","volume":"15","author":"Verdurand","year":"2018","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejmech.2026.119448_bib19","doi-asserted-by":"crossref","unstructured":"T.S. Chisholm, C.A. Hunter, Ligands for protein fibrils of amyloid-\u03b2, \u03b1-synuclein, and tau, Chem. Rev. 125 (n.d) 5282\u20135348. https:\/\/doi.org\/10.1021\/acs.chemrev.4c00838.","DOI":"10.1021\/acs.chemrev.4c00838"},{"key":"10.1016\/j.ejmech.2026.119448_bib20","doi-asserted-by":"crossref","first-page":"12185","DOI":"10.1021\/acs.jmedchem.3c00779","article-title":"A novel brain PET radiotracer for imaging alpha synuclein fibrils in multiple system atrophy (MSA)","volume":"66","author":"Kim","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119448_bib21","doi-asserted-by":"crossref","first-page":"3350","DOI":"10.1016\/j.cell.2023.06.004","article-title":"Development of an \u03b1-synuclein positron emission tomography tracer for imaging synucleinopathies","volume":"186","author":"Xiang","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.ejmech.2026.119448_bib22","doi-asserted-by":"crossref","DOI":"10.1177\/1536012118796297","article-title":"The binding of BF-227-like benzoxazoles to human \u03b1-synuclein and amyloid \u03b2 peptide fibrils","volume":"17","author":"Josephson","year":"2018","journal-title":"Mol. Imaging"},{"key":"10.1016\/j.ejmech.2026.119448_bib23","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1007\/s00259-020-05133-x","article-title":"[11C]MODAG-001\u2014towards a PET tracer targeting \u03b1-synuclein aggregates","volume":"48","author":"Kuebler","year":"2021","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.ejmech.2026.119448_bib24","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1002\/anie.201805501","article-title":"Chemistry for positron emission tomography: recent advances in 11C-, 18F-, 13N-, and 15O-labeling reactions","volume":"58","author":"Deng","year":"2019","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.ejmech.2026.119448_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113887","article-title":"Discovery of styrylaniline derivatives as novel alpha-synuclein aggregates ligands","volume":"226","author":"Bian","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119448_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2020.115358","article-title":"Design, synthesis and identification of N, N-dibenzylcinnamamide (DBC) derivatives as novel ligands for \u03b1-synuclein fibrils by SPR evaluation system","volume":"28","author":"Chen","year":"2020","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119448_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116490","article-title":"Novel 4-triazole phenyl amide (4-TPA) molecules: potent promoters of \u03b1-synuclein fibril disassembly","volume":"273","author":"Qiu","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2026.119448_bib28","doi-asserted-by":"crossref","first-page":"6750","DOI":"10.1038\/s41467-023-42305-3","article-title":"The \u03b1-synuclein PET tracer [18F] ACI-12589 distinguishes multiple system atrophy from other neurodegenerative diseases","volume":"14","author":"Smith","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2026.119448_bib29","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ejphar.2009.06.042","article-title":"In vitro characterisation of BF227 binding to \u03b1-synuclein\/lewy bodies","volume":"617","author":"Fodero-Tavoletti","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejmech.2026.119448_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2021.105009","article-title":"Biochemical characterization of proliferative and differentiated SH-SY5Y cell line as a model for parkinson's disease","volume":"145","author":"Alrashidi","year":"2021","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ejmech.2026.119448_bib31","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1517\/17460441.3.6.677","article-title":"Strategies to assess blood\u2013brain barrier penetration","volume":"3","author":"Di","year":"2008","journal-title":"Expert Opin. Drug Discov."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523426008937?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523426008937?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:48:26Z","timestamp":1792612106000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523426008937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":31,"alternative-id":["S0223523426008937"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2026.119448","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of benzoxazole derivatives as novel \u03b1-synuclein aggregate ligands with potential for PET tracer development","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2026.119448","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119448"}}