{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:16:42Z","timestamp":1762175802402,"version":"build-2065373602"},"reference-count":28,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medical Genetics"],"published-print":{"date-parts":[[2006,1]]},"DOI":"10.1016\/j.ejmg.2005.01.023","type":"journal-article","created":{"date-parts":[[2005,4,18]],"date-time":"2005-04-18T13:29:14Z","timestamp":1113830954000},"page":"63-69","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["A different approach to telomere analysis with ddPRINS in chronic lymphocytic leukemia"],"prefix":"10.1016","volume":"49","author":[{"given":"Sukru","family":"Palanduz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nedime","family":"Serakinci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kivanc","family":"Cefle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melih","family":"Aktan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulcin","family":"Tutkan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukru","family":"Ozturk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gokay","family":"Bozkurt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guncag","family":"Dincol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuksel","family":"Pekcelen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f8rn","family":"Koch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmg.2005.01.023_bib1","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/350569a0","article-title":"Structure and function of telomeres","volume":"350","author":"Blackburn","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.ejmg.2005.01.023_bib2","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1146\/annurev.bi.61.070192.000553","article-title":"Telomerases","volume":"61","author":"Blackburn","year":"1992","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.ejmg.2005.01.023_bib3","first-page":"4918","article-title":"Telomer length and telomerase activity predict survival in patients with B cell chronic lymphocytic leukaemia","volume":"58","author":"Bechter","year":"1998","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejmg.2005.01.023_bib4","doi-asserted-by":"crossref","first-page":"9082","DOI":"10.1073\/pnas.92.20.9082","article-title":"Telomerase activity in normal and malignant hematopoietic cells","volume":"92","author":"Broccoli","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejmg.2005.01.023_bib5","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/sj.neo.7900092","article-title":"Mapping of the gene for the human telomerase reverse transcriptase, hTERT, to chromosome 5p15.33 by fluorescence in situ hybridization","volume":"2","author":"Bryce","year":"2000","journal-title":"Neoplasia"},{"key":"10.1016\/j.ejmg.2005.01.023_bib6","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/stem.140239","article-title":"Differential expression of telomerase activity in hematopoietic progenitors from adult human bone marrow","volume":"14","author":"Chiu","year":"1996","journal-title":"Stem Cell"},{"key":"10.1016\/j.ejmg.2005.01.023_bib7","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1182\/blood.V85.9.2315.bloodjournal8592315","article-title":"Telomerase activity in normal leukocytes and in hermatologic malignancies","volume":"85","author":"Counter","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.ejmg.2005.01.023_bib8","first-page":"610","article-title":"Telomerase activity and telomer length in acute and chronic leukemia, pre and post-ex vivo culture","volume":"60","author":"Engelhardt","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejmg.2005.01.023_bib9","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1146\/annurev.bi.65.070196.002005","article-title":"Telomer length regulation","volume":"65","author":"Greider","year":"1996","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.ejmg.2005.01.023_bib10","series-title":"ACT Cytogenetics Laboratory Manuel, second ed","first-page":"245","article-title":"Chromosome stains","author":"Gustashaw","year":"1991"},{"key":"10.1016\/j.ejmg.2005.01.023_bib11","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0531-5565(92)90068-B","article-title":"The telomere hypothesis of cellular ageing","volume":"27","author":"Harley","year":"1992","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.ejmg.2005.01.023_bib12","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/0014-4827(65)90211-9","article-title":"The limited in vitro lifespan of human diploid cell strains","volume":"37","author":"Hayflick","year":"1965","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ejmg.2005.01.023_bib13","doi-asserted-by":"crossref","first-page":"3711","DOI":"10.4049\/jimmunol.155.8.3711","article-title":"Activation of telomerase in human lymphocytes and hematopoietic progenitors","volume":"15","author":"Hiyama","year":"1995","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejmg.2005.01.023_bib14","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1126\/science.7605428","article-title":"Specific association of telomerase activity with immortal cells and cancer","volume":"266","author":"Kim","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.ejmg.2005.01.023_bib15","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/BF00327311","article-title":"Oligonucleotide-priming methods for the chromosome-specific labelling of alpha satellite DNA in situ","volume":"98","author":"Koch","year":"1989","journal-title":"Chromosoma"},{"key":"10.1016\/j.ejmg.2005.01.023_bib16","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1006\/geno.1999.5809","article-title":"An in situ study of variant telomeric repeats in human chromosomes","volume":"58","author":"Krejci","year":"1999","journal-title":"Genomics"},{"key":"10.1016\/j.ejmg.2005.01.023_bib17","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/s004120050297","article-title":"Improved detection and comparative sizing of human chromosomal telomeres in situ","volume":"107","author":"Krejci","year":"1998","journal-title":"Chromosoma"},{"key":"10.1016\/j.ejmg.2005.01.023_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10428199609045709","article-title":"Telomeres and telomerase in normal and malignant haemotologic cells","volume":"24","author":"Leber","year":"2000","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.ejmg.2005.01.023_bib19","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/0022-2836(92)90096-3","article-title":"Telomere end-replication problem and cell aging","volume":"225","author":"Levy","year":"1992","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.ejmg.2005.01.023_bib20","first-page":"3043","article-title":"Telomerase activity in human malignant hematopoitec cells","volume":"9","author":"Nilsson","year":"1994","journal-title":"Oncogene"},{"key":"10.1016\/j.ejmg.2005.01.023_bib21","first-page":"3557","article-title":"Telomere shortening associated with disease evolution patterns in myelodysplastic syndromes","volume":"54","author":"Ohyashiki","year":"1994","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejmg.2005.01.023_bib22","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/0165-4608(94)90047-7","article-title":"Telomere shortening in leukemic cells is related to their genetic alterations but not replicative capacity","volume":"78","author":"Ohyashiki","year":"1994","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/j.ejmg.2005.01.023_bib23","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0165-4608(96)00277-4","article-title":"Telomere dynamics and cytogenetic changes in human hematologic neoplasias: a working hypothesis","volume":"94","author":"Ohyashiki","year":"1997","journal-title":"Cancer Genet. Cytogenet."},{"issue":"Suppl 1","key":"10.1016\/j.ejmg.2005.01.023_bib24","first-page":"1","article-title":"Chronic lymphocytic leukaemia","volume":"105","author":"Oscier","year":"1999","journal-title":"Br. J. Hematol."},{"key":"10.1016\/j.ejmg.2005.01.023_bib25","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3109\/10428199809057538","article-title":"Regulation of B-CLL apoptosis through membrane receptors and Bcl-2 family proteins","volume":"30","author":"Osorio","year":"1998","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.ejmg.2005.01.023_bib26","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/6209","article-title":"Detection and sizing of telomeric repeat DNA in situ","volume":"17","author":"Serakinci","year":"1999","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ejmg.2005.01.023_bib27","first-page":"197","article-title":"Origin of concatameric T7 DNA","volume":"239","author":"Watson","year":"1972","journal-title":"Nature"},{"key":"10.1016\/j.ejmg.2005.01.023_bib28","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1172\/JCI117759","article-title":"Telomeric DNA in normal and leukemic blood cells","volume":"95","author":"Yamada","year":"1995","journal-title":"J. Clin. Invest."}],"container-title":["European Journal of Medical Genetics"],"original-title":[],"language":"fr","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1769721205000297?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1769721205000297?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:34:10Z","timestamp":1761708850000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1769721205000297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["S1769721205000297"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmg.2005.01.023","relation":{},"ISSN":["1769-7212"],"issn-type":[{"type":"print","value":"1769-7212"}],"subject":[],"published":{"date-parts":[[2006,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A different approach to telomere analysis with ddPRINS in chronic lymphocytic leukemia","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medical Genetics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmg.2005.01.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Published by Elsevier Masson SAS","name":"copyright","label":"Copyright"}]}}