{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:58:20Z","timestamp":1791424700915,"version":"4.3.3"},"reference-count":63,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medical Genetics"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1016\/j.ejmg.2009.05.005","type":"journal-article","created":{"date-parts":[[2009,5,22]],"date-time":"2009-05-22T08:14:32Z","timestamp":1242980072000},"page":"281-286","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["The etiology of congenital diaphragmatic hernia: Still largely unknown?"],"prefix":"10.1016","volume":"52","author":[{"given":"M.","family":"Klaassens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"de Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Tibboel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmg.2009.05.005_bib1","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1086\/513442","article-title":"Genetic factors in congenital diaphragmatic hernia","volume":"80","author":"Holder","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ejmg.2009.05.005_bib2","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1086\/429842","article-title":"Congenital diaphragmatic hernia and chromosome 15q26: determination of a candidate region by use of fluorescent in situ hybridization and array-based comparative genomic hybridization","volume":"76","author":"Klaassens","year":"2005","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ejmg.2009.05.005_bib3","doi-asserted-by":"crossref","DOI":"10.1038\/sj.ejhg.5201652","article-title":"Array comparative genomic hybridization in patients with congenital diaphragmatic hernia: mapping of four CDH-critical regions and sequencing of candidate genes at 15q26.1-15q26.2","author":"Slavotinek","year":"2006","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.ejmg.2009.05.005_bib4","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1371\/journal.pgen.0010010","article-title":"Fog2 is required for normal diaphragm and lung development in mice and humans","volume":"1","author":"Ackerman","year":"2005","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ejmg.2009.05.005_bib5","doi-asserted-by":"crossref","first-page":"16351","DOI":"10.1073\/pnas.0507832102","article-title":"Mouse lacking COUP-TFII as an animal model of Bochdalek-type congenital diaphragmatic hernia","volume":"102","author":"You","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejmg.2009.05.005_bib6","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1159\/000082595","article-title":"The molecular basis for abnormal human lung development","volume":"87","author":"Groenman","year":"2005","journal-title":"Biol. Neonate"},{"key":"10.1016\/j.ejmg.2009.05.005_bib7","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0012-1606(02)00026-X","article-title":"Transcriptional activation of BMP-4 and regulation of mammalian organogenesis by GATA-4 and -6","volume":"254","author":"Nemer","year":"2003","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ejmg.2009.05.005_bib8","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0378-1119(00)00364-4","article-title":"Regulation of the promoters for the human bone morphogenetic protein 2 and 4 genes","volume":"256","author":"Helvering","year":"2000","journal-title":"Gene"},{"key":"10.1016\/j.ejmg.2009.05.005_bib9","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1242\/dev.127.14.3057","article-title":"Regulation of retinoic acid signaling during lung morphogenesis","volume":"127","author":"Malpel","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.ejmg.2009.05.005_bib10","doi-asserted-by":"crossref","first-page":"L141","DOI":"10.1152\/ajplung.00148.2004","article-title":"Distal angiogenesis: a new concept for lung vascular morphogenesis","volume":"288","author":"Parera","year":"2005","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.ejmg.2009.05.005_bib11","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/ijc.11060","article-title":"Von Hippel-Lindau gene alterations in sporadic benign and malignant pheochromocytomas","volume":"105","author":"Dannenberg","year":"2003","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ejmg.2009.05.005_bib12","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1002\/ijc.21888","article-title":"The von Hippel-Lindau tumor suppressor gene expression level has prognostic value in neuroblastoma","volume":"119","author":"Hoebeeck","year":"2006","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ejmg.2009.05.005_bib13","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/978-0-387-46954-6_5","article-title":"Neural crest cell plasticity. Size matters","volume":"589","author":"Sandell","year":"2006","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.ejmg.2009.05.005_bib14","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/S0022-3468(03)00183-0","article-title":"Gene expression of fibroblast growth factors 10 and 7 is downregulated in the lung of nitrofen-induced diaphragmatic hernia in rats","volume":"38","author":"Teramoto","year":"2003","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.ejmg.2009.05.005_bib15","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.jpedsurg.2004.02.015","article-title":"VEGF expression is downregulated in nitrofen-induced congenital diaphragmatic hernia","volume":"39","author":"Chang","year":"2004","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.ejmg.2009.05.005_bib16","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0002-9440(10)63848-5","article-title":"Down-regulation of sonic hedgehog expression in pulmonary hypoplasia is associated with congenital diaphragmatic hernia","volume":"162","author":"Unger","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ejmg.2009.05.005_bib17","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1007\/s10024-003-0109-2","article-title":"Expression of angiogenesis-related factors in lungs of patients with congenital diaphragmatic hernia and pulmonary hypoplasia of other causes","volume":"7","author":"de Rooij","year":"2004","journal-title":"Pediatr. Dev. Pathol."},{"key":"10.1016\/j.ejmg.2009.05.005_bib18","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s003830100597","article-title":"Neural crest-derived defects in experimental congenital diaphragmatic hernia","volume":"17","author":"Yu","year":"2001","journal-title":"Pediatr. Surg. Int."},{"key":"10.1016\/j.ejmg.2009.05.005_bib19","doi-asserted-by":"crossref","first-page":"L1310","DOI":"10.1152\/ajplung.00257.2002","article-title":"Diaphragm defects occur in a CDH hernia model independently of myogenesis and lung formation","volume":"283","author":"Babiuk","year":"2002","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.ejmg.2009.05.005_bib20","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0301-2115(00)00436-X","article-title":"Hormonal modulation of fetal pulmonary development: relevance for the fetus with diaphragmatic hernia","volume":"92","author":"Keijzer","year":"2000","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.ejmg.2009.05.005_bib21","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/ajmg.a.30320","article-title":"Comments on \u201ccongenital diaphragmatic hernia: is 15q26.1-26.2 a candidate locus?\u201d","volume":"131","author":"Tonnies","year":"2004","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.ejmg.2009.05.005_bib22","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/ajmg.a.20464","article-title":"Congenital diaphragmatic hernia: is 15q26.1-26.2 a candidate locus?","volume":"126A","author":"Biggio","year":"2004","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.ejmg.2009.05.005_bib23","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S1043-2760(01)00424-6","article-title":"Physiological function of the orphans GCNF and COUP-TF","volume":"12","author":"Cooney","year":"2001","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.ejmg.2009.05.005_bib24","first-page":"229","article-title":"Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age","volume":"18","author":"Tsai","year":"1997","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ejmg.2009.05.005_bib25","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1101\/gad.13.8.1037","article-title":"The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development","volume":"13","author":"Pereira","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.ejmg.2009.05.005_bib26","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0960-0760(95)00225-1","article-title":"Chicken ovalbumin upstream promoter-transcription factors and their regulation","volume":"56","author":"Qiu","year":"1996","journal-title":"J. Steroid. Steroid. Biochem. Mol. Biol."},{"key":"10.1016\/j.ejmg.2009.05.005_bib27","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.ydbio.2006.05.019","article-title":"Retinoic acid regulates morphogenesis and patterning of posterior foregut derivatives","volume":"297","author":"Wang","year":"2006","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ejmg.2009.05.005_bib28","doi-asserted-by":"crossref","DOI":"10.1086\/512203","article-title":"Mutations in STRA6 cause a broad spectrum of malformations including anophthalmia, congenital heart defects, diaphragmatic hernia, alveolar capillary dysplasia, lung hypoplasia and mental retardation","author":"Pasutto","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ejmg.2009.05.005_bib29","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1086\/518177","article-title":"Matthew-Wood syndrome is caused by truncating mutations in the retinol-binding protein receptor gene STRA6","volume":"80","author":"Golzio","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ejmg.2009.05.005_bib30","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1093\/hmg\/ddm016","article-title":"Characterization of a recurrent 15q24 microdeletion syndrome","volume":"16","author":"Sharp","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ejmg.2009.05.005_bib31","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1042\/cs1030613","article-title":"Retinoid receptors in the developing human lung","volume":"103","author":"Kimura","year":"2002","journal-title":"Clin. Sci. (Lond)"},{"key":"10.1016\/j.ejmg.2009.05.005_bib32","doi-asserted-by":"crossref","first-page":"4309","DOI":"10.1210\/jc.2005-0556","article-title":"Expression of glucocorticoid, retinoid, and thyroid hormone receptors during human lung development","volume":"90","author":"Rajatapiti","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ejmg.2009.05.005_bib33","first-page":"888","article-title":"Incidence of congenital diaphragmatic hernia in the young of rats bred on a diet deficient in vitamin A","volume":"62","author":"Anderson","year":"1941","journal-title":"Am. J. Dis. Child."},{"key":"10.1016\/j.ejmg.2009.05.005_bib34","first-page":"163","article-title":"Effect of diet during pregnancy upon the incidence of congenital hereditary diaphragmatic hernia in the rat","volume":"25","author":"Anderson","year":"1949","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ejmg.2009.05.005_bib35","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/aja.1000920202","article-title":"An analysis of the syndrome of malformations induced by maternal vitamin A deficiency. Effects of restoration of vitamin A at various times during gestation","volume":"92","author":"Wilson","year":"1953","journal-title":"Am. J. Anat."},{"key":"10.1016\/j.ejmg.2009.05.005_bib36","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0002-9440(10)63861-8","article-title":"Retinal dehydrogenase-2 is inhibited by compounds that induce congenital diaphragmatic hernias in rodents","volume":"162","author":"Mey","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ejmg.2009.05.005_bib37","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1096\/fasebj.10.9.8801178","article-title":"Embryonic development and pattern formation","volume":"10","author":"Morriss-Kay","year":"1996","journal-title":"Faseb J."},{"key":"10.1016\/j.ejmg.2009.05.005_bib38","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s003830050399","article-title":"Retinol status of newborn infants with congenital diaphragmatic hernia","volume":"13","author":"Major","year":"1998","journal-title":"Pediatr. Surg. Int."},{"key":"10.1016\/j.ejmg.2009.05.005_bib39","doi-asserted-by":"crossref","first-page":"28029","DOI":"10.1074\/jbc.M103577200","article-title":"Friend of GATA 2 physically interacts with chicken ovalbumin upstream promoter-TF2 (COUP-TF2) and COUP-TF3 and represses COUP-TF2-dependent activation of the atrial natriuretic factor promoter","volume":"276","author":"Huggins","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejmg.2009.05.005_bib40","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.semcdb.2004.10.006","article-title":"Coregulation of GATA factors by the friend of GATA (FOG) family of multitype zinc finger proteins","volume":"16","author":"Cantor","year":"2005","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.ejmg.2009.05.005_bib41","doi-asserted-by":"crossref","first-page":"L665","DOI":"10.1152\/ajplung.00027.2008","article-title":"Gene expression in the developing diaphragm: significance for congenital diaphragmatic hernia","volume":"294","author":"Clugston","year":"2008","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.ejmg.2009.05.005_bib42","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.ydbio.2006.09.050","article-title":"Impaired mesenchymal cell function in Gata4 mutant mice leads to diaphragmatic hernias and primary lung defects","volume":"301","author":"Jay","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ejmg.2009.05.005_bib43","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1006\/dbio.1998.9139","article-title":"Retinoid signaling required for normal heart development regulates GATA-4 in a pathway distinct from cardiomyocyte differentiation","volume":"206","author":"Kostetskii","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ejmg.2009.05.005_bib44","doi-asserted-by":"crossref","first-page":"15062","DOI":"10.1073\/pnas.251407098","article-title":"Inadequate lung development and bronchial hyperplasia in mice with a targeted deletion in the Dutt1\/Robo1 gene","volume":"98","author":"Xian","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejmg.2009.05.005_bib45","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/S0925-4773(03)00161-8","article-title":"Congenital diaphragmatic hernia, kidney agenesis and cardiac defects associated with Slit3-deficiency in mice","volume":"120","author":"Liu","year":"2003","journal-title":"Mech. Dev."},{"key":"10.1016\/j.ejmg.2009.05.005_bib46","doi-asserted-by":"crossref","first-page":"5217","DOI":"10.1073\/pnas.0730709100","article-title":"A genetic model for a central (septum transversum) congenital diaphragmatic hernia in mice lacking Slit3","volume":"100","author":"Yuan","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejmg.2009.05.005_bib47","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0022-3468(76)80206-0","article-title":"Bilateral congenital diaphragmatic defects in two siblings","volume":"11","author":"Thomas","year":"1976","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.ejmg.2009.05.005_bib48","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0022-3468(95)90589-8","article-title":"Embryonic cell death patterns associated with nitrofen-induced congenital diaphragmatic hernia","volume":"30","author":"Alles","year":"1995","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.ejmg.2009.05.005_bib49","series-title":"The Developing Human","author":"Moore","year":"1993"},{"key":"10.1016\/j.ejmg.2009.05.005_bib50","series-title":"Inborn Errors of Development: The Molecular Basis of Clinical Disorders of Morphogenesis","first-page":"67","article-title":"Neural crest formation and craniofacial development","author":"Lang","year":"2004"},{"key":"10.1016\/j.ejmg.2009.05.005_bib51","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.ydbio.2005.03.021","article-title":"Slit\/Robo signaling is necessary to confine early neural crest cells to the ventral migratory pathway in the trunk","volume":"282","author":"Jia","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ejmg.2009.05.005_bib52","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/tera.1420470204","article-title":"Nitrofen-induced congenital diaphragmatic defects in CD1 mice","volume":"47","author":"Wickman","year":"1993","journal-title":"Teratology"},{"key":"10.1016\/j.ejmg.2009.05.005_bib53","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.gde.2004.07.012","article-title":"Retinoic acid signalling in the development of branchial arches","volume":"14","author":"Mark","year":"2004","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.ejmg.2009.05.005_bib54","series-title":"Smiths' Recognizable Patterns of Human Malformation","author":"Jones","year":"2005"},{"key":"10.1016\/j.ejmg.2009.05.005_bib55","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ijcard.2006.02.002","article-title":"Cardiovascular anomalies associated with chromosome 22q11.2 deletion","volume":"114","author":"Momma","year":"2007","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ejmg.2009.05.005_bib56","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/ajmg.c.30131","article-title":"Congenital diaphragmatic hernia and associated cardiovascular malformations: type, frequency, and impact on management","volume":"145C","author":"Lin","year":"2007","journal-title":"Am. J. Med. Genet. C Semin. Med. Genet."},{"key":"10.1016\/j.ejmg.2009.05.005_bib57","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.jpedsurg.2005.03.025","article-title":"Cardiac anomalies in patients with congenital diaphragmatic hernia and their prognosis: a report from the Congenital Diaphragmatic Hernia Study Group","volume":"40","author":"Graziano","year":"2005","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.ejmg.2009.05.005_bib58","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1056\/NEJM198510033131401","article-title":"Retinoic acid embryopathy","volume":"313","author":"Lammer","year":"1985","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejmg.2009.05.005_bib59","doi-asserted-by":"crossref","first-page":"4789","DOI":"10.1242\/dev.02031","article-title":"Retinoic acid-dependent eye morphogenesis is orchestrated by neural crest cells","volume":"132","author":"Matt","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.ejmg.2009.05.005_bib60","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1242\/dev.02204","article-title":"Retinaldehyde dehydrogenase 2 (RALDH2)-mediated retinoic acid synthesis regulates early mouse embryonic forebrain development by controlling FGF and sonic hedgehog signaling","volume":"133","author":"Ribes","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.ejmg.2009.05.005_bib61","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1126\/science.1132292","article-title":"Gene regulatory networks in the evolution and development of the heart","volume":"313","author":"Olson","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.ejmg.2009.05.005_bib62","first-page":"505","article-title":"Treatment evolution in high-risk congenital diaphragmatic hernia: ten years' experience with diaphragmatic agenesis","volume":"244","author":"Lally","year":"2006","journal-title":"Ann. Surg."},{"key":"10.1016\/j.ejmg.2009.05.005_bib63","doi-asserted-by":"crossref","first-page":"e651","DOI":"10.1542\/peds.2006-3040","article-title":"Defect size determines survival in infants with congenital diaphragmatic hernia","volume":"120","author":"Lally","year":"2007","journal-title":"Pediatrics"}],"container-title":["European Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1769721209000627?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1769721209000627?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:36:36Z","timestamp":1761708996000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1769721209000627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":63,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["S1769721209000627"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmg.2009.05.005","relation":{},"ISSN":["1769-7212"],"issn-type":[{"value":"1769-7212","type":"print"}],"subject":[],"published":{"date-parts":[[2009,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The etiology of congenital diaphragmatic hernia: Still largely unknown?","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medical Genetics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmg.2009.05.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}