{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:44:55Z","timestamp":1791121495215,"version":"4.1.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medical Genetics"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1016\/j.ejmg.2011.06.003","type":"journal-article","created":{"date-parts":[[2011,7,5]],"date-time":"2011-07-05T18:17:46Z","timestamp":1309889866000},"page":"1-7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Limb skeletal malformations \u2013 What the HOX is going on?"],"prefix":"10.1016","volume":"55","author":[{"given":"Nathalie","family":"Brison","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Przemko","family":"Tylzanowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Debeer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmg.2011.06.003_bib1","first-page":"1","article-title":"The genetics of hand malformations","volume":"14","author":"Temtamy","year":"1978","journal-title":"Birth Defects Orig. Artic. Ser."},{"key":"10.1016\/j.ejmg.2011.06.003_bib2","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1399-0004.2007.00935.x","article-title":"Synpolydactyly: clinical and molecular advances","volume":"73","author":"Malik","year":"2008","journal-title":"Clin. Genet."},{"key":"10.1016\/j.ejmg.2011.06.003_bib3","doi-asserted-by":"crossref","first-page":"7458","DOI":"10.1073\/pnas.94.14.7458","article-title":"Synpolydactyly phenotypes correlate with size of expansions in HOXD13 polyalanine tract","volume":"94","author":"Goodman","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejmg.2011.06.003_bib4","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1136\/jmg.39.11.852","article-title":"Severe digital abnormalities in a patient heterozygous for both a novel missense mutation in HOXD13 and a polyalanine tract expansion in HOXA13","volume":"39","author":"Debeer","year":"2002","journal-title":"J.\u00a0Med. Genet."},{"key":"10.1016\/j.ejmg.2011.06.003_bib5","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1086\/302070","article-title":"Deletions in HOXD13 segregate with an identical, novel foot malformation in two unrelated families","volume":"63","author":"Goodman","year":"1998","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ejmg.2011.06.003_bib6","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/ajmg.a.20103","article-title":"An acceptor splice site mutation in HOXD13 results in variable hand, but consistent foot malformations","volume":"121A","author":"Kan","year":"2003","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.ejmg.2011.06.003_bib7","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0092-8674(94)90290-9","article-title":"Hox genes in vertebrate development","volume":"78","author":"Krumlauf","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.ejmg.2011.06.003_bib8","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1126\/science.272.5261.548","article-title":"Altered growth and branching patterns in synpolydactyly caused by mutations in HOXD13","volume":"272","author":"Muragaki","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.ejmg.2011.06.003_bib9","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/ng0297-179","article-title":"Mutation of HOXA13 in hand-foot-genital syndrome","volume":"15","author":"Mortlock","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ejmg.2011.06.003_bib10","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/ajmg.10776","article-title":"Limb malformations and the human HOX genes","volume":"112","author":"Goodman","year":"2002","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.ejmg.2011.06.003_bib11","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1086\/511387","article-title":"Mutations in HOXD13 underlie syndactyly type V and a novel brachydactyly-syndactyly syndrome","volume":"80","author":"Zhao","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ejmg.2011.06.003_bib12","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1093\/hmg\/5.7.945","article-title":"Genomic structure of HOXD13 gene: a nine polyalanine duplication causes synpolydactyly in two unrelated families","volume":"5","author":"Akarsu","year":"1996","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ejmg.2011.06.003_bib13","first-page":"259","article-title":"Synpolydactyly: unusual features and variable expression in 5 generations of an Italian family","volume":"12","author":"Chessa","year":"1990","journal-title":"Pediatr. Med. Chir."},{"key":"10.1016\/j.ejmg.2011.06.003_bib14","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1002\/ajmg.a.32426","article-title":"Identification of a HOXD13 mutation in a VACTERL patient","volume":"146A","author":"Garcia-Barcelo","year":"2008","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.ejmg.2011.06.003_bib15","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/ajmg.a.30971","article-title":"A\u00a072-year-old Danish puzzle resolved-comparative analysis of phenotypes in families with different-sized HOXD13 polyalanine expansions","volume":"138","author":"Kjaer","year":"2005","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.ejmg.2011.06.003_bib16","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1136\/jmg.32.6.421","article-title":"A\u00a0large Turkish kindred with syndactyly type II (synpolydactyly). 1. Field investigation, clinical and pedigree data","volume":"32","author":"Sayli","year":"1995","journal-title":"J.\u00a0Med. Genet."},{"key":"10.1016\/j.ejmg.2011.06.003_bib17","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/j.1399-0004.2009.01213.x","article-title":"Polyalanine repeat expansion mutations in the HOXD13 gene in Pakistani families with synpolydactyly","volume":"76","author":"Wajid","year":"2009","journal-title":"Clin. Genet."},{"key":"10.1016\/j.ejmg.2011.06.003_bib18","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ejmg.2010.10.007","article-title":"Polyalanine repeat expansion mutation of the HOXD13gene in a Chinese family with unusual clinical manifestations of synpolydactyly","volume":"54","author":"Gong","year":"2011","journal-title":"Eur. J. Med. Genet."},{"key":"10.1016\/j.ejmg.2011.06.003_bib19","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.ejmg.2006.01.004","article-title":"Clinical phenotype associated with homozygosity for a HOXD13 7-residue polyalanine tract expansion","volume":"49","author":"Horsnell","year":"2006","journal-title":"Eur. J. Med. Genet."},{"key":"10.1016\/j.ejmg.2011.06.003_bib20","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1126\/science.275.5298.408","article-title":"Polyalanine expansion in synpolydactyly might result from unequal crossing-over of HOXD13","volume":"275","author":"Warren","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.ejmg.2011.06.003_bib21","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1136\/jmg.32.6.435","article-title":"A\u00a0large Turkish kindred with syndactyly type II (synpolydactyly). 2. Homozygous phenotype?","volume":"32","author":"Akarsu","year":"1995","journal-title":"J.\u00a0Med. Genet."},{"key":"10.1016\/j.ejmg.2011.06.003_bib22","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1073\/pnas.93.4.1560","article-title":"Trinucleotide repeats and long homopeptides in genes and proteins associated with nervous system disease and development","volume":"93","author":"Karlin","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejmg.2011.06.003_bib23","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1101\/gad.7.3.491","article-title":"Transcriptional repression by the Drosophila even-skipped protein \u2013 definition of a minimal repression domain","volume":"7","author":"Han","year":"1993","journal-title":"Genes Dev."},{"key":"10.1016\/j.ejmg.2011.06.003_bib24","first-page":"4057","article-title":"Mapping and mutagenesis of the amino-terminal transcriptional repression domain of the Drosophila Kruppel protein","volume":"14","author":"Licht","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ejmg.2011.06.003_bib25","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1006\/dbio.2001.0382","article-title":"The mouse Hoxd13(spdh) mutation, a polyalanine expansion similar to human type II synpolydactyly (SPD), disrupts the function but not the expression of other Hoxd genes","volume":"237","author":"Bruneau","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ejmg.2011.06.003_bib26","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/384069a0","article-title":"Synpolydactyly in mice with a targeted deficiency in the HoxD complex","volume":"384","author":"Zakany","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.ejmg.2011.06.003_bib27","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1093\/hmg\/ddh277","article-title":"A\u00a0molecular pathogenesis for transcription factor associated poly-alanine tract expansions","volume":"13","author":"Albrecht","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ejmg.2011.06.003_bib28","first-page":"146","article-title":"Mutant Hoxd13 induces extra digits in a mouse model of synpolydactyly directly and by decreasing retinoic acid synthesis","volume":"119","author":"Kuss","year":"2009","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.ejmg.2011.06.003_bib29","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1172\/JCI41554","article-title":"Homeobox genes d11-d13 and a13 control mouse autopod cortical bone and joint formation","volume":"120","author":"Villavicencio-Lorini","year":"2010","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.ejmg.2011.06.003_bib30","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/1471-2350-8-78","article-title":"Synpolydactyly and HOXD13 polyalanine repeat: addition of 2 alanine residues is without clinical consequences","volume":"8","author":"Malik","year":"2007","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.ejmg.2011.06.003_bib31","first-page":"287","article-title":"Novel mutations of the HOXD13 gene in hand and foot malformations","volume":"92","author":"Nakano","year":"2007","journal-title":"Int. Surg."},{"key":"10.1016\/j.ejmg.2011.06.003_bib32","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1086\/338921","article-title":"A\u00a0117-kb microdeletion removing HOXD9-HOXD13 and EVX2 causes synpolydactyly","volume":"70","author":"Goodman","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ejmg.2011.06.003_bib33","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1399-0004.2008.01147.x","article-title":"A\u00a0novel microdeletion at chromosome 2q31.1-31.2 in a three-generation family presenting duplication of great toes with clinodactyly","volume":"75","author":"Tsai","year":"2009","journal-title":"Clin. Genet."},{"key":"10.1016\/j.ejmg.2011.06.003_bib34","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1136\/jmg.2010.079491","article-title":"2q31.1 microdeletion syndrome: redefining the associated clinical phenotype","volume":"48","author":"Dimitrov","year":"2011","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.ejmg.2011.06.003_bib35","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1242\/dev.00396","article-title":"An I47L substitution in the HOXD13 homeodomain causes a novel human limb malformation by producing a selective loss of function","volume":"130","author":"Caronia","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.ejmg.2011.06.003_bib36","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/1382","article-title":"Comparison of X-ray and NMR structures for the Antennapedia homeodomain-DNA complex","volume":"5","author":"Fraenkel","year":"1998","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.ejmg.2011.06.003_bib37","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0092-8674(94)90292-5","article-title":"Homeodomain-DNA recognition","volume":"78","author":"Gehring","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.ejmg.2011.06.003_bib38","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1086\/374721","article-title":"Missense mutations in the homeodomain of HOXD13 are associated with brachydactyly types D and E","volume":"72","author":"Johnson","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ejmg.2011.06.003_bib39","first-page":"847","article-title":"A\u00a0G220V substitution within the N-terminal transcription regulating domain of HOXD13 causes a variant synpolydactyly phenotype","volume":"18","author":"Fantini","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ejmg.2011.06.003_bib40","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1093\/hmg\/7.6.1033","article-title":"A\u00a0new spontaneous mouse mutation of Hoxd13 with a polyalanine expansion and phenotype similar to human synpolydactyly","volume":"7","author":"Johnson","year":"1998","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ejmg.2011.06.003_bib41","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1242\/dev.122.4.1175","article-title":"A\u00a0mutational analysis of the 5\u2032 HoxD genes: dissection of genetic interactions during limb development in the mouse","volume":"122","author":"Davis","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.ejmg.2011.06.003_bib42","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/0092-8674(93)90378-4","article-title":"Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs","volume":"75","author":"Dolle","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.ejmg.2011.06.003_bib43","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/molbev\/msl161","article-title":"Morphological change caused by loss of the taxon-specific polyalanine tract in Hoxd-13","volume":"24","author":"Anan","year":"2007","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.ejmg.2011.06.003_bib44","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1242\/dev.124.3.627","article-title":"Analysis of Hoxd-13 and Hoxd-11 misexpression in chick limb buds reveals that Hox genes affect both bone condensation and growth","volume":"124","author":"Goff","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.ejmg.2011.06.003_bib45","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1101\/gad.9.20.2509","article-title":"Misexpression of Hoxa-13 induces cartilage homeotic transformation and changes cell adhesiveness in chick limb buds","volume":"9","author":"Yokouchi","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/j.ejmg.2011.06.003_bib46","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/978-1-60327-483-8_27","article-title":"Electroporation in avian embryos","volume":"461","author":"Funahashi","year":"2008","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ejmg.2011.06.003_bib47","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0091-679X(08)00212-4","article-title":"Gain- and loss-of-function approaches in the chick embryo","volume":"87","author":"Sauka-Spengler","year":"2008","journal-title":"Methods Cell Biol."},{"key":"10.1016\/j.ejmg.2011.06.003_bib48","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/dvdy.21907","article-title":"The RCAS retroviral expression system in the study of skeletal development","volume":"238","author":"Gordon","year":"2009","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ejmg.2011.06.003_bib49","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/dvdy.10461","article-title":"Status of transgenic chicken models for developmental biology","volume":"229","author":"Mozdziak","year":"2004","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ejmg.2011.06.003_bib50","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cimid.2007.11.010","article-title":"Germ cells and transgenesis in chickens","volume":"32","author":"Han","year":"2009","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"10.1016\/j.ejmg.2011.06.003_bib51","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0925-4773(91)90067-G","article-title":"The Hox-4.8 gene is localized at the 5\u2032 extremity of the Hox-4 complex and is expressed in the most posterior parts of the body during development","volume":"36","author":"Dolle","year":"1991","journal-title":"Mech. Dev."},{"key":"10.1016\/j.ejmg.2011.06.003_bib52","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1242\/dev.122.5.1449","article-title":"Analysis of Hox gene expression in the chick limb bud","volume":"122","author":"Nelson","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.ejmg.2011.06.003_bib53","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.gde.2007.05.011","article-title":"The role of Hox genes during vertebrate limb development","volume":"17","author":"Zakany","year":"2007","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.ejmg.2011.06.003_bib54","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0091-679X(08)60629-9","article-title":"Manipulating gene expression with replication-competent retroviruses","volume":"51","author":"Morgan","year":"1996","journal-title":"Methods Cell Biol."},{"key":"10.1016\/j.ejmg.2011.06.003_bib55","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1006\/meth.1998.0595","article-title":"Targeted gene misexpression in chick limb buds using avian replication-competent retroviruses","volume":"14","author":"Logan","year":"1998","journal-title":"Methods"},{"key":"10.1016\/j.ejmg.2011.06.003_bib56","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.ydbio.2008.02.048","article-title":"Hoxd13 binds in\u00a0vivo and regulates the expression of genes acting in key pathways for early limb and skeletal patterning","volume":"317","author":"Salsi","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ejmg.2011.06.003_bib57","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1074\/jbc.M510900200","article-title":"Hoxd13 and Hoxa13 directly control the expression of the EphA7 Ephrin tyrosine kinase receptor in developing limbs","volume":"281","author":"Salsi","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ejmg.2011.06.003_bib58","doi-asserted-by":"crossref","first-page":"4475","DOI":"10.1093\/nar\/gki761","article-title":"Group 13 HOX proteins interact with the MH2 domain of R-Smads and modulate Smad transcriptional activation functions independent of HOX DNA-binding capability","volume":"33","author":"Williams","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejmg.2011.06.003_bib59","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.ydbio.2004.12.015","article-title":"Candidate downstream regulated genes of HOX group 13 transcription factors with and without monomeric DNA binding capability","volume":"279","author":"Williams","year":"2005","journal-title":"Dev. Biol."}],"container-title":["European Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1769721211000735?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1769721211000735?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:39:00Z","timestamp":1761709140000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1769721211000735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S1769721211000735"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmg.2011.06.003","relation":{},"ISSN":["1769-7212"],"issn-type":[{"value":"1769-7212","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Limb skeletal malformations \u2013 What the HOX is going on?","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medical Genetics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmg.2011.06.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Published by Elsevier Masson SAS","name":"copyright","label":"Copyright"}]}}