{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T03:50:15Z","timestamp":1773892215745,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medical Genetics"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.ejmg.2016.03.005","type":"journal-article","created":{"date-parts":[[2016,4,5]],"date-time":"2016-04-05T03:46:53Z","timestamp":1459828013000},"page":"269-273","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Neoplasia in Turner syndrome. The importance of clinical and screening practices during follow-up"],"prefix":"10.1016","volume":"59","author":[{"given":"Daniela","family":"Larizza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Albanesi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalisa","family":"De Silvestri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Accordino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Brazzelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella Carnevale","family":"Maff\u00e8","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Calcaterra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmg.2016.03.005_bib1","doi-asserted-by":"crossref","first-page":"3303e10","DOI":"10.1016\/j.ejca.2013.05.026","article-title":"Hormone replacement therapy increases the risk of cranial meningioma","volume":"49","author":"Andersen","year":"2013","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.ejmg.2016.03.005_bib2","unstructured":"Associazione Italiana registri tumori. http:\/\/www.registri-tumori.it\/cms\/."},{"key":"10.1016\/j.ejmg.2016.03.005_bib3","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.canlet.2008.11.009","article-title":"A\u00a0common repertoire of autoantibodies is shared by cancer and autoimmune disease patients: inflammation in their induction and impact on tumour growth","volume":"281","author":"Bei","year":"2009","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ejmg.2016.03.005_bib4","first-page":"1113","article-title":"Detection of hidden Y mosaicism in Turner's syndrome: importance in the prevention of gonadoblastoma","volume":"19","author":"Bianco","year":"2006","journal-title":"J.\u00a0Pediatr. Endocrinol. Metab."},{"key":"10.1016\/j.ejmg.2016.03.005_bib5","doi-asserted-by":"crossref","first-page":"8859","DOI":"10.1016\/0140-6736(93)90636-U","article-title":"Effects of human growth hormone therapy on melanocytic naevi","volume":"341","author":"Bourguignon","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.ejmg.2016.03.005_bib6","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1530\/eje.1.01988","article-title":"Papillary thyroid carcinoma after recombinant GH therapy for Turner syndrome","volume":"153","author":"Cabanas","year":"2005","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.ejmg.2016.03.005_bib7","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1586\/eem.10.73","article-title":"Role of the growth hormone\u2013IGF-1 axis in cancer","volume":"6","author":"Chhabra","year":"2011","journal-title":"Expert. Rev. Endocrinol. Metab."},{"key":"10.1016\/j.ejmg.2016.03.005_bib8","first-page":"649e56","article-title":"Exogenous hormone use, reproductive factors, and risk of intracranial meningioma in females","volume":"118","author":"Claus","year":"2013","journal-title":"J.\u00a0Neurosurg."},{"key":"10.1016\/j.ejmg.2016.03.005_bib9","first-page":"6107","article-title":"Oncogenic inflammation and autoimmune disease","author":"Eisenlohr","year":"2006","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.ejmg.2016.03.005_bib10","first-page":"120","article-title":"Turner syndrome in adulthood","volume":"23","author":"Elsheikh","year":"2002","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ejmg.2016.03.005_bib11","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1159\/000051977","article-title":"Hepatic adenoma associated with recombinant human growth hormone therapy in a patient with Turner's syndrome","volume":"17","author":"Espat","year":"2000","journal-title":"Dig. Surg."},{"key":"10.1016\/j.ejmg.2016.03.005_bib12","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1016\/j.ejca.2011.04.023","article-title":"Hormonal and reproductive factors in relation to melanoma in women: current review and meta-analysis","volume":"47","author":"Gandini","year":"2011","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.ejmg.2016.03.005_bib13","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/ncpendmet0024","article-title":"Clinical practice in Turner syndrome","volume":"1","author":"Gravholt","year":"2005","journal-title":"Nat. Clin. Pract. Endocrinol. Metab."},{"key":"10.1016\/j.ejmg.2016.03.005_bib14","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0895-4356(97)00237-0","article-title":"Morbidity in Turner syndrome","volume":"51","author":"Gravholt","year":"1998","journal-title":"J.\u00a0Clin. Epidemiol."},{"key":"10.1016\/j.ejmg.2016.03.005_bib15","first-page":"3199","article-title":"Occurrence of gonadoblastoma in females with Turner syndrome and Y chromosome material: a population study","volume":"85","author":"Gravholt","year":"2000","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ejmg.2016.03.005_bib16","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1038\/bjc.1996.222","article-title":"Occurrence of cancer in women with Turner syndrome","volume":"73","author":"Hasle","year":"1996","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ejmg.2016.03.005_bib17","first-page":"534","article-title":"Cytogenetic and molecular analysis of sex chromosome monosomy","volume":"42","author":"Hassold","year":"1998","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ejmg.2016.03.005_bib18","first-page":"471","article-title":"Turner syndrome: a cytogenetic and molecular study","volume":"6","author":"Jacobs","year":"1995","journal-title":"Ann. Hum. Genet."},{"key":"10.1016\/j.ejmg.2016.03.005_bib19","doi-asserted-by":"crossref","first-page":"698e705","DOI":"10.1111\/j.1365-2265.2005.02282.x","article-title":"Adult growth hormone replacement therapy and neuroimaging surveillance in brain tumour survivors","volume":"62","author":"Jostel","year":"2005","journal-title":"Clin. Endocrinol. (Oxf)"},{"key":"10.1016\/j.ejmg.2016.03.005_bib20","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.autrev.2009.07.004","article-title":"Malignancies in systemic lupus erythematosus","volume":"9","author":"Kiss","year":"2010","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.ejmg.2016.03.005_bib21","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jaut.2009.03.002","article-title":"Autoimmune stigmata in Turner syndrome: when lacks an X chromosome","volume":"33","author":"Larizza","year":"2009","journal-title":"J.\u00a0Autoimmun."},{"key":"10.1016\/j.ejmg.2016.03.005_bib22","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1136\/jcp.48.10.965","article-title":"Papillary mucinous adenoma arising in adenomyomatous hyperplasia of the gall bladder","volume":"8","author":"Lauwers","year":"1995","journal-title":"J.\u00a0Clin. Pathol."},{"key":"10.1016\/j.ejmg.2016.03.005_bib23","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.jaad.2003.07.031","article-title":"Turner's syndrome in dermatology","volume":"50","author":"Lowenstein","year":"2004","journal-title":"J.\u00a0Am. Acad. Dermatol."},{"key":"10.1016\/j.ejmg.2016.03.005_bib24","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/ajmg.a.30569","article-title":"Gonadoblastoma in Turner syndrome and Y-chromosome-derived material","volume":"135A","author":"Mazzanti","year":"2005","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.ejmg.2016.03.005_bib25","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1055\/s-2007-991518","article-title":"Hepatocellular carcinoma and congenital absence of the portal vein in a child receiving growth hormone therapy for Turner syndrome","volume":"27","author":"Morotti","year":"2007","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.ejmg.2016.03.005_bib26","series-title":"Turner syndrome in a Lifespan Perspective: Reasearch and Clinical Aspects)","article-title":"Mortality in Turner syndrome","author":"Naeraa","year":"1995"},{"key":"10.1016\/j.ejmg.2016.03.005_bib27","first-page":"1366","article-title":"Demonstration and localization of growth hormone receptor in human skin and skin fibroblasts","volume":"75","author":"Oakes","year":"1992","journal-title":"F.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ejmg.2016.03.005_bib28","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/BF00209476","article-title":"Turner syndrome and female sex chromosome aberrations: deduction of the principal factors involved in the development of clinical features","volume":"95","author":"Ogata","year":"1995","journal-title":"Hum. Genet."},{"key":"10.1016\/j.ejmg.2016.03.005_bib29","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.ejmg.2014.03.005","article-title":"Turner syndrome and meningioma: support for a possible increased risk of neoplasia in Turner syndrome","volume":"57","author":"Pier","year":"2014","journal-title":"Eur. J. Med. Genet."},{"key":"10.1016\/j.ejmg.2016.03.005_bib30","doi-asserted-by":"crossref","first-page":"215e6","DOI":"10.3109\/13697137.2010.533615","article-title":"Hormone therapy and brain tumors","volume":"14","author":"Pines","year":"2011","journal-title":"Climacteric"},{"key":"10.1016\/j.ejmg.2016.03.005_bib31","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.ijscr.2013.09.003","article-title":"Pancreatic mucinous cystic tumor in Turner syndrome: how a tumor bends to a genetic disease","volume":"4","author":"Pizzi","year":"2013","journal-title":"Int. J. Surg. Case Rep."},{"key":"10.1016\/j.ejmg.2016.03.005_bib32","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1590\/S1516-31802009000600010","article-title":"Y\u00a0chromosome in Turner syndrome: review of the literature","volume":"127","author":"Rocco de Oliveira","year":"2009","journal-title":"Sao Paulo Med. J."},{"key":"10.1016\/j.ejmg.2016.03.005_bib33","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0022-3476(98)70452-4","article-title":"Growth hormone therapy of Turner's syndrome: beneficial effect on adult height","volume":"132","author":"Rosenfeld","year":"1998","journal-title":"J.\u00a0Pediatr."},{"key":"10.1016\/j.ejmg.2016.03.005_bib34","first-page":"297","article-title":"Clinical review 48: the current status of diagnosis and therapeutic intervention in Turner's syndrome","volume":"77","author":"Saenger","year":"1993","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ejmg.2016.03.005_bib35","first-page":"4345","article-title":"Growth-promoting strategies in Turner's syndrome","volume":"84","author":"Saenger","year":"1999","journal-title":"J.\u00a0Clin. Endocrinol. Meta"},{"key":"10.1016\/j.ejmg.2016.03.005_bib36","first-page":"3061","article-title":"Fifth international symposium on Turner syndrome. Recommendations for the diagnosis and management of Turner syndrome","volume":"86","author":"Saenger","year":"2001","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ejmg.2016.03.005_bib37","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S1470-2045(08)70033-0","article-title":"Cancer incidence in women with Turner syndrome in Great Britain: a national cohort study","volume":"9","author":"Schoemaker","year":"2008","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.ejmg.2016.03.005_bib38","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/s00431-005-0074-z","article-title":"Primitive neuroectodermal tumor of the brain in a girl with Turner syndrome diagnosed after 4 years of growth hormone therapy","volume":"165","author":"Shih-Hsiang","year":"2006","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.ejmg.2016.03.005_bib39","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0140-6736(02)09519-3","article-title":"Risk of cancer in patients treated with human pituitary growth hormone in the UK, 1959\u201385: a cohort study","volume":"360","author":"Swerdlow","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.ejmg.2016.03.005_bib40","first-page":"1400","article-title":"Gonadoblastoma: molecular definition of the susceptibility region on the Y chromosome","volume":"57","author":"Tsuchiya","year":"1995","journal-title":"Am. J. Hum. Genet."}],"container-title":["European Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1769721216300477?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1769721216300477?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:42:59Z","timestamp":1761709379000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1769721216300477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["S1769721216300477"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmg.2016.03.005","relation":{},"ISSN":["1769-7212"],"issn-type":[{"value":"1769-7212","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neoplasia in Turner syndrome. The importance of clinical and screening practices during follow-up","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medical Genetics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmg.2016.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}