{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T07:12:35Z","timestamp":1793517155365,"version":"4.5.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medical Genetics"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.ejmg.2018.05.010","type":"journal-article","created":{"date-parts":[[2018,5,10]],"date-time":"2018-05-10T05:02:37Z","timestamp":1525928557000},"page":"483-488","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"title":["Epidemiology of septo-optic dysplasia with focus on prevalence and maternal age \u2013 A EUROCAT study"],"prefix":"10.1016","volume":"61","author":[{"given":"Ester","family":"Garne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9437-2790","authenticated-orcid":false,"given":"Anke","family":"Rissmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Claude","family":"Addor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingeborg","family":"Barisic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3929-3619","authenticated-orcid":false,"given":"Jorieke","family":"Bergman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Braz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4858-6456","authenticated-orcid":false,"given":"Clara","family":"Cavero-Carbonell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth S.","family":"Draper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Gatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Haeusler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari","family":"Klungsoyr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer J.","family":"Kurinczuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Lelong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Luyt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary T.","family":"O'Mahony","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3831-6089","authenticated-orcid":false,"given":"Olatz","family":"Mokoroa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Nelen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda J.","family":"Neville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3321-9343","authenticated-orcid":false,"given":"Anna","family":"Pierini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanitra","family":"Randrianaivo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Rankin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Rouget","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2726-3471","authenticated-orcid":false,"given":"Bruno","family":"Schaub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Tucker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Verellen-Dumoulin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Wellesley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Awi","family":"Wiesel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nataliia","family":"Zymak-Zakutnia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Lanzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7164-612X","authenticated-orcid":false,"given":"Joan K.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ejmg.2018.05.010_bib1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000341148","article-title":"Septo-optic dysplasia: antenatal risk factors and clinical features in a regional study","volume":"78","author":"Atapattu","year":"2012","journal-title":"Horm. Res. Paediatr."},{"key":"10.1016\/j.ejmg.2018.05.010_bib2","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1002\/bdra.20780","article-title":"The EUROCAT network: organisation and processes","volume":"91","author":"Boyd","year":"2011","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"10.1016\/j.ejmg.2018.05.010_bib3","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0022-3476(79)80392-3","article-title":"Maternal age re septo-optic dysplasia","volume":"94","author":"Elster","year":"1979","journal-title":"J. Pediatr."},{"key":"10.1016\/j.ejmg.2018.05.010_bib4","series-title":"EUROCAT Guide 1.4","year":"2017"},{"key":"10.1016\/j.ejmg.2018.05.010_bib5","first-page":"18","article-title":"Septo-optic dysplasia","volume":"8","author":"Fard","year":"2010","journal-title":"Ped. Endocrinol. Rev."},{"issue":"Suppl. 1","key":"10.1016\/j.ejmg.2018.05.010_bib6","first-page":"S44","article-title":"Paper 5: surveillance of multiple congenital anomalies: implementation of a computer algorithm in European registers for classification of cases","volume":"91","author":"Garne","year":"2011","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"issue":"1","key":"10.1016\/j.ejmg.2018.05.010_bib7","first-page":"e15","article-title":"Gastroschisis complicated by septo-optic dysplasia: two distinct anomalies with a common origin","volume":"6","author":"Garvin","year":"2016","journal-title":"AJP Rep."},{"issue":"2","key":"10.1016\/j.ejmg.2018.05.010_bib8","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/ICB.0000000000000113","article-title":"Septo-optic dysplasia associated with congenital persistent fetal vasculature, retinal detachment, and gastroschisis","volume":"9","author":"Jordan","year":"2015","journal-title":"Retin. Cases Brief Rep."},{"issue":"6","key":"10.1016\/j.ejmg.2018.05.010_bib9","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/bdra.20663","article-title":"Septo-optic dysplasia and associations with amyoplasia and gastroschisis","volume":"88","author":"Kamien","year":"2010","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"issue":"6","key":"10.1016\/j.ejmg.2018.05.010_bib10","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1515\/JPM.2007.132","article-title":"The relationship between congenital malformations and preterm birth","volume":"35","author":"Kase","year":"2007","journal-title":"J. Perinat. Med."},{"key":"10.1016\/j.ejmg.2018.05.010_bib11","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1093\/pch\/pxx118","article-title":"Increasing incidence of optic nerve hypoplasia\/septo-optic dysplasia spectrum: geographical clustering in Northern Canada","author":"Khaper","year":"2017","journal-title":"Paediatr. Child Health"},{"key":"10.1016\/j.ejmg.2018.05.010_bib12","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S0140-6736(79)90138-7","article-title":"Septo-optic dysplasia and maternal age","volume":"2","author":"Lippe","year":"1979","journal-title":"Lancet"},{"key":"10.1016\/j.ejmg.2018.05.010_bib14","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1111\/j.1471-0528.2009.02227.x","article-title":"Maternal age-specific risk of non-chromosomal anomalies","volume":"116","author":"Loane","year":"2009","journal-title":"BJOG"},{"issue":"4","key":"10.1016\/j.ejmg.2018.05.010_bib15","first-page":"363","article-title":"Increasing prevalence of gastroschisis in Europe 1980-2002: a phenomenon restricted to younger mothers?","volume":"21","author":"Loane","year":"2007","journal-title":"PPE"},{"key":"10.1016\/j.ejmg.2018.05.010_bib16","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/(SICI)1096-8628(19970331)69:3<235::AID-AJMG4>3.0.CO;2-K","article-title":"Hypothesis: septo-optic dysplasia is a vascular disruption sequence","volume":"69","author":"Lubinsky","year":"1997","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.ejmg.2018.05.010_bib17","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1515\/JPEM.2005.18.5.471","article-title":"Maternal age in patients with septo-optic dysplasia","volume":"18","author":"Murray","year":"2005","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"10.1016\/j.ejmg.2018.05.010_bib18","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jpeds.2005.07.031","article-title":"Geographical distribution of optic nerve hypoplasia and septo-optic dysplasia in Northwest England","volume":"148","author":"Patel","year":"2006","journal-title":"J. Pediatr."},{"key":"10.1016\/j.ejmg.2018.05.010_bib19","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.pediatrneurol.2005.07.004","article-title":"Septo-optic dysplasia complex: a heterogenous malformation syndrome","volume":"34","author":"Polizzi","year":"2006","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.ejmg.2018.05.010_bib20","first-page":"61","article-title":"Congenital absence of the septum pellucidum","author":"Reeves","year":"1941","journal-title":"Bull. Johns Hopkins Hosp."},{"key":"10.1016\/j.ejmg.2018.05.010_bib21","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1007\/s00431-007-0666-x","article-title":"Refining clinical phenotypes in septo-optic dysplasia based on MRI findings","volume":"167","author":"Riedl","year":"2008","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.ejmg.2018.05.010_bib22","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/ajmg.a.20417","article-title":"Septo-optic dysplasia and amniotic bands: further evidence for a vascular pathogenesis","volume":"125A","author":"Stevens","year":"2004","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.ejmg.2018.05.010_bib23","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1034\/j.1600-0420.2002.800313.x","article-title":"Optic nerve hypoplasia: risk factors and epidemiology","volume":"80","author":"Tornqvist","year":"2002","journal-title":"Acta Ophthalmol. Scand."},{"key":"10.1016\/j.ejmg.2018.05.010_bib24","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1093\/humupd\/dmp052","article-title":"Teratogenic mechanisms of medical drugs","volume":"16","author":"Van Gelden","year":"2010","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.ejmg.2018.05.010_bib25","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/ejhg.2009.125","article-title":"Septo-optic dysplasia","author":"Webb","year":"2010","journal-title":"Eur. J. Hum. Genet."},{"issue":"11","key":"10.1016\/j.ejmg.2018.05.010_bib26","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1111\/1471-0528.12281","article-title":"Preterm birth time trends in Europe: a study of 19 countries","volume":"120","author":"Zeitlin","year":"2013","journal-title":"BJOG"}],"container-title":["European Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1769721218301496?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1769721218301496?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:46:09Z","timestamp":1761709569000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1769721218301496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":25,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["S1769721218301496"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmg.2018.05.010","relation":{},"ISSN":["1769-7212"],"issn-type":[{"value":"1769-7212","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epidemiology of septo-optic dysplasia with focus on prevalence and maternal age \u2013 A EUROCAT study","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medical Genetics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmg.2018.05.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}