{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T14:51:35Z","timestamp":1774277495561,"version":"3.50.1"},"reference-count":55,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medical Genetics"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.ejmg.2022.104468","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T11:56:19Z","timestamp":1646135779000},"page":"104468","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Next step in molecular genetics of hereditary breast\/ovarian cancer: Multigene panel testing in clinical actionably genes and prioritization algorithms in the study of variants of uncertain significance"],"prefix":"10.1016","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0122-4116","authenticated-orcid":false,"given":"Ver\u00f3nica","family":"Castillo-Guardiola","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Rosado-Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Desamparados","family":"Sarabia-Meseguer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Mar\u00edn-Vera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Antonio","family":"Mac\u00edas-Cerrolaza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosario","family":"Garc\u00eda-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Zafra-Poves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"S\u00e1nchez-Henarejos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda \u00c1ngeles","family":"Moreno-Locubiche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Encarnaci\u00f3n","family":"Cuevas-Tortosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7443-546X","authenticated-orcid":false,"given":"Mar\u00eda","family":"Arnaldos-Carrillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6311-920X","authenticated-orcid":false,"given":"Francisco","family":"Ayala de la Pe\u00f1a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Luis","family":"Alonso-Romero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6786-4864","authenticated-orcid":false,"given":"Jos\u00e9 Antonio","family":"Noguera-Velasco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Ruiz-Espejo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmg.2022.104468_bib1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/j.1365-2559.2006.02538.x","article-title":"Histopathological features of breast cancer in carriers of ATM gene variants","volume":"49","author":"Balleine","year":"2006","journal-title":"Histopathology"},{"key":"10.1016\/j.ejmg.2022.104468_bib2","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1007\/s00432-018-2763-9","article-title":"Multigene panel testing beyond BRCA1\/2 in breast\/ovarian cancer Spanish families and clinical actionability of findings","volume":"144","author":"Bonache","year":"2018","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.ejmg.2022.104468_bib3","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1136\/jcp.54.7.512","article-title":"Ataxia telangiectasia gene mutations in leukaemia and lymphoma","volume":"54","author":"Boultwood","year":"2001","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.ejmg.2022.104468_bib4","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA A Cancer J. Clin."},{"key":"10.1016\/j.ejmg.2022.104468_bib5","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1399-0004.2008.00987.x","article-title":"ATM germline mutations in Spanish early-onset breast cancer patients negative for BRCA1\/BRCA2 mutations","volume":"73","author":"Brunet","year":"2008","journal-title":"Clin. Genet."},{"key":"10.1016\/j.ejmg.2022.104468_bib6","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1002\/cncr.30498","article-title":"A study of over 35,000 women with breast cancer tested with a 25-gene panel of hereditary cancer genes","volume":"123","author":"Buys","year":"2017","journal-title":"Cancer"},{"key":"10.1016\/j.ejmg.2022.104468_bib7","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/humu.22972","article-title":"Prioritizing variants in complete hereditary breast and ovarian cancer genes in patients lacking known BRCA mutations","volume":"37","author":"Caminsky","year":"2016","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.ejmg.2022.104468_bib14","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1038\/s41436-018-0005-9","article-title":"Landscape of pathogenic variations in a panel of 34 genes and cancer risk estimation from 5131 HBOC families","volume":"20","author":"Cast\u00e9ra","year":"2018","journal-title":"Genet. Med."},{"key":"10.1016\/j.ejmg.2022.104468_bib8","first-page":"1","article-title":"New insights into the performance of multigene panel testing: two novel nonsense variants in BRIP1 and TP53 in a young woman with breast cancer","volume":"228\u2013229","author":"Castillo-Guardiola","year":"2018","journal-title":"Cancer Gene."},{"key":"10.1016\/j.ejmg.2022.104468_bib9","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1001\/jamaoncol.2017.0424","article-title":"Associations between cancer predisposition testing panel genes and breast cancer","volume":"3","author":"Couch","year":"2017","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.ejmg.2022.104468_bib10","series-title":"NCCN Clinical Practice Guidelines in Oncology. Genetic\/Familial High-Risk Assessment: Breast and Ovarian","author":"Daly","year":"2019"},{"key":"10.1016\/j.ejmg.2022.104468_bib11","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1136\/jmedgenet-2017-104588","article-title":"Rare, protein-truncating variants in ATM, CHEK2 and PALB2, but not XRCC2, are associated with increased breast cancer risks","volume":"54","author":"Decker","year":"2017","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.ejmg.2022.104468_bib12","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.18632\/oncotarget.12699","article-title":"The transfer of multigene panel testing for hereditary breast and ovarian cancer to healthcare: what are the implications for the management of patients and families?","volume":"8","author":"Eliade","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejmg.2022.104468_bib13","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","article-title":"Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012","volume":"136","author":"Ferlay","year":"2015","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ejmg.2022.104468_bib15","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s10689-017-9985-x","article-title":"Molecular characterization and clinical interpretation of BRCA1\/BRCA2 variants in families from Murcia (south-eastern Spain) with hereditary breast and ovarian cancer: clinical-pathological features in BRCA carriers and non-carriers","volume":"16","author":"Gabald\u00f3 Barrios","year":"2017","journal-title":"Fam. Cancer"},{"key":"10.1016\/j.ejmg.2022.104468_bib16","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s12094-016-1607-9","article-title":"Cancer incidence in Spain, 2015","volume":"19","author":"Galceran","year":"2017","journal-title":"Clin. Transl. Oncol."},{"key":"10.1016\/j.ejmg.2022.104468_bib17","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1038\/s41431-017-0021-2","article-title":"Contribution of germline deleterious variants in the RAD51 paralogs to breast and ovarian cancers","volume":"25","author":"Golmard","year":"2017","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.ejmg.2022.104468_bib18","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1089\/dna.2013.1970","article-title":"The effect of CHEK2 variant I157T on cancer susceptibility: evidence from a meta-analysis","volume":"32","author":"Han","year":"2013","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.ejmg.2022.104468_bib19","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1093\/carcin\/23.10.1617","article-title":"Deficiency in the repair of UV-induced DNA damage in human skin fibroblasts compromised for the ATM gene","volume":"23","author":"Hannan","year":"2002","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.ejmg.2022.104468_bib20","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.ajhg.2016.08.016","article-title":"REVEL: an ensemble method for predicting the pathogenicity of rare missense variants","volume":"99","author":"Ioannidis","year":"2016","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ejmg.2022.104468_bib21","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/ijc.30428","article-title":"Gene panel sequencing in familial breast\/ovarian cancer patients identifies multiple novel mutations also in genes others than BRCA1\/2","volume":"140","author":"Kraus","year":"2017","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ejmg.2022.104468_bib22","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1038\/gim.2014.40","article-title":"Utilization of multigene panels in hereditary cancer predisposition testing: analysis of more than 2,000 patients","volume":"16","author":"LaDuca","year":"2014","journal-title":"Genet. Med."},{"key":"10.1016\/j.ejmg.2022.104468_bib23","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1007\/s12094-015-1435-3","article-title":"SEOM clinical guidelines in Hereditary Breast and ovarian cancer","volume":"17","author":"Llort","year":"2015","journal-title":"Clin. Transl. Oncol."},{"key":"10.1016\/j.ejmg.2022.104468_bib24","series-title":"Consensus Guideline on Genetic Testing for Hereditary Breast Cancer","author":"Manahan","year":"2019"},{"key":"10.1016\/j.ejmg.2022.104468_bib25","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ygyno.2015.01.537","article-title":"Hereditary predisposition to ovarian cancer, looking beyond BRCA1\/BRCA2","volume":"137","author":"Minion","year":"2015","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ejmg.2022.104468_bib26","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12920-016-0178-5","article-title":"A unified analytic framework for prioritization of non-coding variants of uncertain significance in heritable breast and ovarian cancer","volume":"9","author":"Mucaki","year":"2016","journal-title":"BMC Med. Genom."},{"key":"10.1016\/j.ejmg.2022.104468_bib27","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/gim.2017.37","article-title":"Sherloc: a comprehensive refinement of the ACMG-AMP variant classification criteria","volume":"19","author":"Nykamp","year":"2017","journal-title":"Genet. Med."},{"key":"10.1016\/j.ejmg.2022.104468_bib28","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s10549-009-0396-z","article-title":"ATM germline mutations in women with familial breast cancer and a relative with haematological malignancy","volume":"119","author":"Paglia","year":"2010","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.ejmg.2022.104468_bib29","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1001\/jamaoncol.2016.5194","article-title":"Prevalence and spectrum of germline cancer susceptibility gene mutations among patients with early-onset colorectal cancer","volume":"3","author":"Pearlman","year":"2017","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.ejmg.2022.104468_bib30","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djv214","article-title":"Germline mutations in the BRIP1, BARD1, PALB2, and NBN genes in women with ovarian cancer","volume":"107","author":"Ramus","year":"2015","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.ejmg.2022.104468_bib31","doi-asserted-by":"crossref","first-page":"9","DOI":"10.20892\/j.issn.2095-3941.2016.0084","article-title":"Epidemiology of ovarian cancer: a review","volume":"14","author":"Reid","year":"2017","journal-title":"Cancer Biol. Med."},{"key":"10.1016\/j.ejmg.2022.104468_bib32","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13058-018-0951-9","article-title":"Morphology and genomic hallmarks of breast tumours developed by ATM deleterious variant carriers","volume":"20","author":"Renault","year":"2018","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.ejmg.2022.104468_bib33","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of medical genetics and genomics and the association for molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet. Med."},{"key":"10.1016\/j.ejmg.2022.104468_bib34","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1007\/s12094-016-1588-8","article-title":"SEOM Clinical Guideline in ovarian cancer (2016)","volume":"18","author":"Santaballa","year":"2016","journal-title":"Clin. Transl. Oncol."},{"key":"10.1016\/j.ejmg.2022.104468_bib35","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s10549-015-3429-9","article-title":"HBOC multi-gene panel testing: comparison of two sequencing centers","volume":"152","author":"Schroeder","year":"2015","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.ejmg.2022.104468_bib36","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ejca.2018.10.007","article-title":"Genetic counselling and testing of susceptibility genes for therapeutic decision-making in breast cancer-an European consensus statement and expert recommendations","volume":"106","author":"Singer","year":"2019","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.ejmg.2022.104468_bib37","series-title":"n.d. Cifras del c\u00e1ncer en Espa\u00f1a","year":"2020"},{"key":"10.1016\/j.ejmg.2022.104468_bib38","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/pcmr.12466","article-title":"A novel ATM-dependent checkpoint defect distinct from loss of function mutation promotes genomic instability in melanoma","volume":"29","author":"Spoerri","year":"2016","journal-title":"Pigment Cell Melanoma Res."},{"key":"10.1016\/j.ejmg.2022.104468_bib39","first-page":"463","article-title":"A review on role of ATM gene in hereditary transfer of colorectal cancer","volume":"89","author":"Sriramulu","year":"2019","journal-title":"Acta Biomed."},{"key":"10.1016\/j.ejmg.2022.104468_bib40","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.ygyno.2006.05.040","article-title":"CHEK2 variants predispose to benign, borderline and low-grade invasive ovarian tumors","volume":"102","author":"Szymanska-Pasternak","year":"2006","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ejmg.2022.104468_bib41","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s10549-016-4058-7","article-title":"Almost 2% of Spanish breast cancer families are associated to germline pathogenic mutations in the ATM gene","volume":"161","author":"Tavera-Tapia","year":"2017","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.ejmg.2022.104468_bib42","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1038\/gim.2017.210","article-title":"Modeling the ACMG\/AMP variant classification guidelines as a Bayesian classification framework","volume":"20","author":"Tavtigian","year":"2018","journal-title":"Genet. Med."},{"key":"10.1016\/j.ejmg.2022.104468_bib43","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1002\/humu.24088","article-title":"Fitting a naturally scaled point system to the ACMG\/AMP variant classification guidelines","volume":"41","author":"Tavtigian","year":"2020","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.ejmg.2022.104468_bib44","first-page":"3325","article-title":"Contributions of ATM mutations to familial breast and ovarian cancer","volume":"63","author":"Thorstenson","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejmg.2022.104468_bib45","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/humu.20811","article-title":"Intronic variants in BRCA1 and BRCA2 that affect RNA splicing can be reliably selected by splice-site prediction programs","volume":"30","author":"Vreeswijk","year":"2009","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.ejmg.2022.104468_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.pmbts.2017.07.002","article-title":"Breast cancer epidemiology, prevention, and screening","volume":"151","author":"Winters","year":"2017","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.ejmg.2022.104468_bib48","author":"ClinVar"},{"key":"10.1016\/j.ejmg.2022.104468_bib52","author":"Align"},{"key":"10.1016\/j.ejmg.2022.104468_bib53","author":"Varsome"},{"key":"10.1016\/j.ejmg.2022.104468_bib55","author":"MaxEntScan"},{"key":"10.1016\/j.ejmg.2022.104468_bib56","author":"NNSplice"},{"key":"10.1016\/j.ejmg.2022.104468_bib57","author":"Splicer"},{"key":"10.1016\/j.ejmg.2022.104468_bib58","author":"Mutalyzer"},{"key":"10.1016\/j.ejmg.2022.104468_bib61","author":"LitVar"},{"key":"10.1016\/j.ejmg.2022.104468_bib62","author":"ExPASy"}],"container-title":["European Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1769721222000490?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1769721222000490?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:52:09Z","timestamp":1761709929000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1769721222000490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":55,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["S1769721222000490"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmg.2022.104468","relation":{},"ISSN":["1769-7212"],"issn-type":[{"value":"1769-7212","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Next step in molecular genetics of hereditary breast\/ovarian cancer: Multigene panel testing in clinical actionably genes and prioritization algorithms in the study of variants of uncertain significance","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medical Genetics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmg.2022.104468","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104468"}}