{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T10:53:48Z","timestamp":1782989628435,"version":"3.54.5"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["2021-2027"],"award-info":[{"award-number":["2021-2027"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medical Genetics"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.ejmg.2025.105017","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T19:18:07Z","timestamp":1745867887000},"page":"105017","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Comparison of bilateral tibial lengthening with circular external fixator and simultaneous deformity correction with hexapod external fixator in Achondroplasia"],"prefix":"10.1016","volume":"75","author":[{"given":"Maria Beatrice","family":"Bocchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osvaldo","family":"Palmacci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Vitiello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Giuli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Ziranu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Maccauro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmg.2025.105017_bib1","first-page":"238","article-title":"Limb lengthening in short stature patients","volume":"10","author":"Aldegheri","year":"2001","journal-title":"J. Pediatr. Orthop. B"},{"key":"10.1016\/j.ejmg.2025.105017_bib2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.berh.2007.12.008","article-title":"Achondroplasia","volume":"22","author":"Baujat","year":"2008","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.ejmg.2025.105017_bib4","first-page":"368","article-title":"Achondroplasia is defined by recurrent G380R mutations of FGFR3","volume":"56","author":"Bellus","year":"1995","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ejmg.2025.105017_bib5","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1002\/ajmg.a.61787","article-title":"Birth prevalence of achondroplasia: a systematic literature review and meta-analysis","volume":"182","author":"Foreman","year":"2020","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.ejmg.2025.105017_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2021.115872","article-title":"Lifetime impact of achondroplasia: current evidence and perspectives on the natural history","volume":"146","author":"Hoover-Fong","year":"2021","journal-title":"Bone"},{"key":"10.1016\/j.ejmg.2025.105017_bib7","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1097\/01.bpo.0000217712.42115.e6","article-title":"Dynamic lower extremity alignment in children with achondroplasia","volume":"26","author":"Inan","year":"2006","journal-title":"J. Pediatr. Orthop."},{"key":"10.1016\/j.ejmg.2025.105017_bib8","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jphys.2023.05.006","article-title":"Appraisal of Clinical Practice Guideline: international Consensus Statement on the diagnosis, multidisciplinary management and lifelong care of individuals with achondroplasia","volume":"69","author":"Johnston","year":"2023","journal-title":"J. Physiother."},{"key":"10.1016\/j.ejmg.2025.105017_bib9","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3109\/17453674.2014.899856","article-title":"The etiology of short stature affects the clinical outcome of lower limb lengthening using external fixation","volume":"85","author":"Kim","year":"2014","journal-title":"Acta Orthop."},{"key":"10.1016\/j.ejmg.2025.105017_bib10","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1097\/00003086-199001000-00016","article-title":"Psychologic, vascular, and physiologic aspects of lower limb lengthening in achondroplastics","author":"Lavini","year":"1990","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.ejmg.2025.105017_bib11","doi-asserted-by":"crossref","first-page":"575","DOI":"10.5312\/wjo.v12.i8.575","article-title":"Limb lengthening with PRECICE magnetic nail in pediatric patients: a systematic review","volume":"12","author":"Masci","year":"2021","journal-title":"World J. Orthoped."},{"key":"10.1016\/j.ejmg.2025.105017_bib12","series-title":"StatPearls","article-title":"Achondroplasia","author":"McDonald","year":"2023"},{"key":"10.1016\/j.ejmg.2025.105017_bib13","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1007\/s12325-023-02549-3","article-title":"Burden and treatment of achondroplasia: a systematic literature review","volume":"40","author":"Murton","year":"2023","journal-title":"Adv. Ther."},{"key":"10.1016\/j.ejmg.2025.105017_bib14","first-page":"8","article-title":"Skeletal growth and development of the achondroplastic dwarf","author":"Nehme","year":"1976","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.ejmg.2025.105017_bib15","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/ajmg.a.61974","article-title":"Clinical charts for surveillance of growth and body proportion development in achondroplasia and examples of their use","volume":"185","author":"Neumeyer","year":"2021","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.ejmg.2025.105017_bib16","doi-asserted-by":"crossref","first-page":"540","DOI":"10.3390\/children8070540","article-title":"Extensive limb lengthening for achondroplasia and hypochondroplasia","volume":"8","author":"Paley","year":"2021","journal-title":"Children"},{"key":"10.1016\/j.ejmg.2025.105017_bib17","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/00003086-199001000-00011","article-title":"Problems, obstacles, and complications of limb lengthening by the Ilizarov technique","author":"Paley","year":"1990","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.ejmg.2025.105017_bib18","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/01241398-198801000-00018","article-title":"Current techniques of limb lengthening","volume":"8","author":"Paley","year":"1988","journal-title":"J. Pediatr. Orthop."},{"key":"10.1016\/j.ejmg.2025.105017_bib19","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1097\/01202412-199504010-00009","article-title":"Staged lengthening in the prevention of dwarfism in achondroplastic children: a preliminary report","volume":"4","author":"Peretti","year":"1995","journal-title":"J. Pediatr. Orthop. B"},{"key":"10.1016\/j.ejmg.2025.105017_bib20","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.otsr.2017.03.015","article-title":"Evaluation of the external fixator TrueLok Hexapod System for tibial deformity correction in children","volume":"103","author":"Pesenti","year":"2017","journal-title":"Orthop Traumatol Surg Res"},{"key":"10.1016\/j.ejmg.2025.105017_bib21","doi-asserted-by":"crossref","first-page":"5957","DOI":"10.3390\/jcm10245957","article-title":"Comparison of intramedullary magnetic nail, monolateral external distractor, and spatial external fixator in femur lengthening in adolescents with congenital diseases","volume":"10","author":"Pietrzak","year":"2021","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.ejmg.2025.105017_bib22","doi-asserted-by":"crossref","first-page":"749","DOI":"10.3390\/children8090749","article-title":"Simultaneous bilateral femoral and tibial lengthening in achondroplasia","volume":"8","author":"Shabtai","year":"2021","journal-title":"Children"},{"key":"10.1016\/j.ejmg.2025.105017_bib23","doi-asserted-by":"crossref","first-page":"231","DOI":"10.5435\/00124635-200904000-00004","article-title":"Achondroplasia: manifestations and treatment","volume":"17","author":"Shirley","year":"2009","journal-title":"J. Am. Acad. Orthop. Surg."},{"key":"10.1016\/j.ejmg.2025.105017_bib24","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/01241398-199603000-00006","article-title":"Results of tibial lengthening with the Ilizarov technique","volume":"16","author":"Stanitski","year":"1996","journal-title":"J. Pediatr. Orthop."},{"key":"10.1016\/j.ejmg.2025.105017_bib25","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1097\/01.bpo.0000242429.83866.97","article-title":"Bifocal tibial corrective osteotomy with lengthening in achondroplasia: an analysis of results and complications","volume":"26","author":"Vaidya","year":"2006","journal-title":"J. Pediatr. Orthop."},{"key":"10.1016\/j.ejmg.2025.105017_bib26","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1136\/adc.2010.189092","article-title":"Clinical management of achondroplasia","volume":"97","author":"Wright","year":"2012","journal-title":"Arch. Dis. Child."}],"container-title":["European Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1769721225000242?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1769721225000242?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T23:33:32Z","timestamp":1762558412000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1769721225000242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":25,"alternative-id":["S1769721225000242"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmg.2025.105017","relation":{},"ISSN":["1769-7212"],"issn-type":[{"value":"1769-7212","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of bilateral tibial lengthening with circular external fixator and simultaneous deformity correction with hexapod external fixator in Achondroplasia","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medical Genetics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmg.2025.105017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"105017"}}