{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T12:20:49Z","timestamp":1773750049629,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","award":["7373"],"award-info":[{"award-number":["7373"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","physicamedica.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physica Medica"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.ejmp.2019.04.003","type":"journal-article","created":{"date-parts":[[2019,4,28]],"date-time":"2019-04-28T04:46:20Z","timestamp":1556426780000},"page":"64-69","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Dose-response relationship and normal-tissue complication probability of conductive hearing loss in patients undergoing head-and-neck or cranial radiotherapy: A prospective study including 70 ears"],"prefix":"10.1016","volume":"61","author":[{"given":"Mohammad Amin","family":"Mosleh-Shirazi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2038-1528","authenticated-orcid":false,"given":"Azadeh","family":"Amraee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fathollah","family":"Mohaghegh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmp.2019.04.003_b0005","series-title":"Perez & Brady\u2019s principles and practice of radiation oncology","author":"Halperin","year":"2013"},{"key":"10.1016\/j.ejmp.2019.04.003_b0010","first-page":"53","article-title":"Radiotherapy techniques for intracranial tumours","volume":"4","author":"Mosleh-Shirazi","year":"2006","journal-title":"Iranian J Radiat Res"},{"key":"10.1016\/j.ejmp.2019.04.003_b0015","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3109\/00206098909081617","article-title":"Postirradiation hearing loss","volume":"28","author":"Talmi","year":"1989","journal-title":"Audiology"},{"key":"10.1016\/j.ejmp.2019.04.003_b0020","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S0360-3016(01)02810-3","article-title":"Late radiation effects on hearing, vestibular function, and taste in brain tumor patients","volume":"53","author":"Johannesen","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ejmp.2019.04.003_b0025","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0360-3016(96)00346-X","article-title":"Postirradiation sensorineural hearing loss: a common but ignored late radiation complication","volume":"36","author":"Grau","year":"1996","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ejmp.2019.04.003_b0030","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1097\/00007611-196207000-00018","article-title":"The effects of radiation therapy on the ear: with particular reference to radiation otitis media","volume":"55","author":"Borsanyi","year":"1962","journal-title":"South Med J"},{"key":"10.1016\/j.ejmp.2019.04.003_b0035","first-page":"1066","article-title":"Hearing loss after therapy with radiation","volume":"135","author":"Coplan","year":"1981","journal-title":"Am J Dis Child"},{"key":"10.1016\/j.ejmp.2019.04.003_b0040","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/0360-3016(91)90692-W","article-title":"Sensori-neural hearing loss in patients treated with irradiation for nasopharyngeal carcinoma","volume":"21","author":"Grau","year":"1991","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ejmp.2019.04.003_b0045","first-page":"22","article-title":"Otological complications following radiotherapy in head and neck cancers","volume":"10","author":"Bhagat","year":"2004","journal-title":"Indian J Otol"},{"key":"10.1016\/j.ejmp.2019.04.003_b0050","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1016\/j.ijrobp.2009.04.096","article-title":"Radiation therapy and hearing loss","volume":"76","author":"Bhandare","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ejmp.2019.04.003_b0055","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s40463-014-0030-x","article-title":"Cochlea sparing effects of intensity modulated radiation therapy in head and neck cancers patients: a long-term follow-up study","volume":"43","author":"Theunissen","year":"2014","journal-title":"J Otolaryngol Head Neck Surgery"},{"key":"10.1016\/j.ejmp.2019.04.003_b0060","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.2307\/3576626","article-title":"Complication probability as assessed from dose-volume histograms","volume":"104","author":"Lyman","year":"1985","journal-title":"Radiat Res"},{"key":"10.1016\/j.ejmp.2019.04.003_b0065","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0360-3016(91)90173-2","article-title":"Histogram reduction method for calculating complication probabilities for three-dimensional treatment planning evaluations","volume":"21","author":"Kutcher","year":"1991","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ejmp.2019.04.003_b0070","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0360-3016(91)90171-Y","article-title":"Tolerance of normal tissue to therapeutic irradiation","volume":"21","author":"Emami","year":"1991","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ejmp.2019.04.003_b0075","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0360-3016(91)90172-Z","article-title":"Fitting of normal tissue tolerance data to an analytic function","volume":"21","author":"Burman","year":"1991","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ejmp.2019.04.003_b0080","first-page":"11","article-title":"The effect of radiation therapy on hearing loss in patients with head and neck cancer","author":"Chaibakhsh","year":"2018","journal-title":"Int J Cancer Manage"},{"key":"10.1016\/j.ejmp.2019.04.003_b0085","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0305-7372(03)00066-5","article-title":"Radiotherapy-induced ear toxicity","volume":"29","author":"Jereczek-Fossa","year":"2003","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.ejmp.2019.04.003_b0090","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.clon.2007.12.011","article-title":"An evaluation of conformal and intensity-modulated radiotherapy in whole ventricular radiotherapy for localised primary intracranial germinomas","volume":"20","author":"Raggi","year":"2008","journal-title":"Clin Oncol"},{"key":"10.1016\/j.ejmp.2019.04.003_b0095","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.clon.2006.11.007","article-title":"Otological toxicity after postoperative radiotherapy for parotid tumours","volume":"19","author":"Bhide","year":"2007","journal-title":"Clin Oncol"},{"key":"10.1016\/j.ejmp.2019.04.003_b0100","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1177\/000348940511400413","article-title":"Hearing loss as a late complication of radiotherapy in children with brain tumors","volume":"114","author":"Williams","year":"2005","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"10.1016\/j.ejmp.2019.04.003_b0105","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1088\/0031-9155\/52\/6\/011","article-title":"EUCLID: an outcome analysis tool for high-dimensional clinical studies","volume":"52","author":"Gayou","year":"2007","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ejmp.2019.04.003_b0110","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0360-3016(96)00447-6","article-title":"Necrosis following radiotherapy for carcinoma of the pinna","volume":"36","author":"Hayter","year":"1996","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ejmp.2019.04.003_b0115","first-page":"6","article-title":"Noise-induced and age-related hearing loss: new perspectives and potential therapies","author":"Liberman","year":"2017","journal-title":"F1000Research"},{"key":"10.1016\/j.ejmp.2019.04.003_b0120","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.ijrobp.2008.01.050","article-title":"Hearing loss after radiotherapy for pediatric brain tumors: effect of cochlear dose","volume":"72","author":"Hua","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ejmp.2019.04.003_b0125","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S0360-3016(02)03408-9","article-title":"What is the cost of cochlear avoidance in pediatric medulloblastoma? Evaluation of 3D conformal planning techniques for the posterior fossa boost","volume":"54","author":"Soomal","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ejmp.2019.04.003_b0130","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1002\/cncr.21683","article-title":"Sensorineural hearing loss in combined modality treatment of nasopharyngeal carcinoma","volume":"106","author":"Chen","year":"2006","journal-title":"Cancer"},{"key":"10.1016\/j.ejmp.2019.04.003_b0135","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s12070-011-0142-9","article-title":"Ototoxic effects of irradiation","volume":"63","author":"Upadhya","year":"2011","journal-title":"Indian J Otolaryngol Head Neck Surgery"},{"key":"10.1016\/j.ejmp.2019.04.003_b0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/1115-3474.124989","article-title":"Post irradiation hearing loss in head\/neck patients in Lagos, Nigeria","volume":"12","author":"Somefun","year":"2005","journal-title":"West African J Radiol"},{"key":"10.1016\/j.ejmp.2019.04.003_b0145","doi-asserted-by":"crossref","first-page":"20140413","DOI":"10.1259\/bjr.20140413","article-title":"Use of gEUD for predicting ear and pituitary gland damage following proton and photon radiation therapy","volume":"88","author":"De Marzi","year":"2015","journal-title":"Br J Radiol"},{"key":"10.1016\/j.ejmp.2019.04.003_b0150","series-title":"Delineating Organs at Risk in Radiation Therapy","author":"Cefaro","year":"2013"},{"key":"10.1016\/j.ejmp.2019.04.003_b0155","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0360-3016(87)90266-5","article-title":"Optimization of radiation therapy, III: a method of assessing complication probabilities from dose-volume histograms","volume":"13","author":"Lyman","year":"1987","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ejmp.2019.04.003_b0160","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1080\/09553009214552071","article-title":"Tumour and normal tissue responses to fractionated non-uniform dose delivery","volume":"62","author":"K\u00e4llman","year":"1992","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.ejmp.2019.04.003_b0165","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1259\/0007-1285-58-690-515","article-title":"The application of the linear-quadratic dose-effect equation to fractionated and protracted radiotherapy","volume":"58","author":"Dale","year":"1985","journal-title":"Br J Radiol"}],"container-title":["Physica Medica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1120179719300791?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1120179719300791?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T03:34:16Z","timestamp":1761104056000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1120179719300791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":33,"alternative-id":["S1120179719300791"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmp.2019.04.003","relation":{},"ISSN":["1120-1797"],"issn-type":[{"value":"1120-1797","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dose-response relationship and normal-tissue complication probability of conductive hearing loss in patients undergoing head-and-neck or cranial radiotherapy: A prospective study including 70 ears","name":"articletitle","label":"Article Title"},{"value":"Physica Medica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmp.2019.04.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}