{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T22:13:04Z","timestamp":1761171184413,"version":"build-2065373602"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","physicamedica.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physica Medica"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.ejmp.2020.07.012","type":"journal-article","created":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T23:10:42Z","timestamp":1596323442000},"page":"327-336","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Mixed-beam approach for high-risk prostate cancer: Carbon-ion boost followed by photon intensity-modulated radiotherapy. Dosimetric and geometric evaluations (AIRC IG-14300)"],"prefix":"10.1016","volume":"76","author":[{"given":"Simone Giovanni","family":"Gugliandolo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5339-8038","authenticated-orcid":false,"given":"Giulia","family":"Marvaso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Comi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1338-9556","authenticated-orcid":false,"given":"Matteo","family":"Pepa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Roman\u00f2","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Zerini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Augugliaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Russo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Vischioni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Valvo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3191-2750","authenticated-orcid":false,"given":"Tommaso","family":"Giandini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Avuzzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Valdagni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delia","family":"Ciardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ottavio","family":"De Cobelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara Alicja","family":"Jereczek-Fossa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Cattani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Orecchia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ejmp.2020.07.012_b0005","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00223-017-0369-x","article-title":"Cancer treatment and bone health","volume":"102","author":"Handforth","year":"2018","journal-title":"Calcif Tissue Int"},{"issue":"1","key":"10.1016\/j.ejmp.2020.07.012_b0010","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nrurol.2009.237","article-title":"Treatment strategies for high-risk locally advanced prostate cancer","volume":"7","author":"Rosenthal","year":"2010","journal-title":"Nat Rev Urol"},{"key":"10.1016\/j.ejmp.2020.07.012_b0015","unstructured":"National Comprehensive Cancer Network (NCCN). Prostate cancer. In: National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology, version 2.2019-April 24, 2019. Available at: https:\/\/www.nccn.org\/professionals\/physician_gls\/default.aspx Accessed: May 28, 2019."},{"key":"10.1016\/j.ejmp.2020.07.012_b0020","unstructured":"EAU Guidelines. Edn. presented at the EAU Annual Congress Barcelona 2019. ISBN 978-94-92671-04-2. Available at: http:\/\/uroweb.org\/guidelines\/compilations-of-all-guidelines\/ Accessed: May 28, 2019."},{"key":"10.1016\/j.ejmp.2020.07.012_b0025","doi-asserted-by":"crossref","first-page":"330","DOI":"10.3389\/fonc.2013.00330","article-title":"Radiotherapy for thymic carcinoma: adjuvant, inductive, and definitive","volume":"3","author":"Komaki","year":"2014","journal-title":"Front Oncol"},{"issue":"6","key":"10.1016\/j.ejmp.2020.07.012_b0030","doi-asserted-by":"crossref","first-page":"189","DOI":"10.5306\/wjco.v6.i6.189","article-title":"Current role of spacers for prostate cancer radiotherapy","volume":"6","author":"Pinkawa","year":"2015","journal-title":"World J Clin Oncol"},{"issue":"12","key":"10.1016\/j.ejmp.2020.07.012_b0035","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1080\/0284186X.2018.1502467","article-title":"Dosimetric comparison of advanced radiotherapy approaches using photon techniques and particle therapy in the postoperative management of thymoma","volume":"57","author":"Haefner","year":"2018","journal-title":"Acta Oncol"},{"issue":"6","key":"10.1016\/j.ejmp.2020.07.012_b0040","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3390\/cancers9060066","article-title":"Carbon ion radiotherapy: a review of clinical experiences and preclinical research, with an emphasis on DNA damage\/repair","volume":"9","author":"Mohamad","year":"2017","journal-title":"Cancers"},{"issue":"3","key":"10.1016\/j.ejmp.2020.07.012_b0045","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.clgc.2017.01.007","article-title":"High-Risk prostate cancer and radiotherapy: the past and the future. A benchmark for a New Mixed beam radiotherapy approach","volume":"15","author":"Marvaso","year":"2017","journal-title":"Clin Genitourinary Cancer"},{"issue":"3","key":"10.1016\/j.ejmp.2020.07.012_b0050","doi-asserted-by":"crossref","first-page":"314","DOI":"10.5301\/tj.5000587","article-title":"Phase II multi-institutional clinical trial on a new mixed beam RT scheme of IMRT on pelvis combined with a carbon ion boost for high-risk prostate cancer patients","volume":"103","author":"Marvaso","year":"2017","journal-title":"Tumori J"},{"key":"10.1016\/j.ejmp.2020.07.012_b0055","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ejmp.2020.05.016","article-title":"Influence of different urinary bladder filling levels and controlling regions of interest selection on deformable image registration algorithms","volume":"75","author":"Roman\u00f2","year":"2020","journal-title":"Phys Med"},{"key":"10.1016\/j.ejmp.2020.07.012_b0060","doi-asserted-by":"crossref","first-page":"e93","DOI":"10.1016\/S1470-2045(14)70412-7","article-title":"Carbon ion radiotherapy in Japan: an assessment of 20 years of clinical experience","volume":"16","author":"Kamada","year":"2015","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ejmp.2020.07.012_b0065","first-page":"288","article-title":"A multi-institutional analysis of prospective studies of carbon ion radiotherapy for prostate cancer: a report from the Japan Carbon ion Radiation Oncology Study Group (J-CROS) Radiother","volume":"121","author":"Nomiya","year":"2016","journal-title":"Oncol."},{"issue":"2","key":"10.1016\/j.ejmp.2020.07.012_b0070","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3857\/roj.2017.00325","article-title":"Deformable image registration in radiation therapy","volume":"35","author":"Oh","year":"2017","journal-title":"Radiat Oncol J"},{"issue":"10","key":"10.1016\/j.ejmp.2020.07.012_b0075","doi-asserted-by":"crossref","first-page":"e908","DOI":"10.1002\/mp.13162","article-title":"Patient-specific validation of deformable image registration in radiation therapy: overview and caveats","volume":"45","author":"Paganelli","year":"2018","journal-title":"Med Phys"},{"issue":"11","key":"10.1016\/j.ejmp.2020.07.012_b0080","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1088\/0031-9155\/45\/11\/313","article-title":"Treatment planning for heavy-ion radiotherapy: physical beam model and dose optimization","volume":"45","author":"Kr\u00e4mer","year":"2000","journal-title":"Phys Med Biol"},{"issue":"12","key":"10.1016\/j.ejmp.2020.07.012_b0085","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1088\/0031-9155\/57\/12\/3759","article-title":"Monte Carlo simulations to support start-up and treatment planning of scanned proton and carbon ion therapy at a synchrotron-based facility","volume":"57","author":"Parodi","year":"2012","journal-title":"Phys Med Biol"},{"issue":"suppl 1","key":"10.1016\/j.ejmp.2020.07.012_b0090","doi-asserted-by":"crossref","first-page":"i91","DOI":"10.1093\/jrr\/rrt051","article-title":"Monte Carlo-based parametrization of the lateral dose spread for clinical treatment planning of scanned proton and carbon ion beams","volume":"54","author":"Parodi","year":"2013","journal-title":"J Radiat Res"},{"key":"10.1016\/j.ejmp.2020.07.012_b0095","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.ejmp.2016.03.017","article-title":"What can particle therapy add to the treatment of prostate cancer?","volume":"32","author":"Schwarz","year":"2016","journal-title":"Phys Med"},{"issue":"1","key":"10.1016\/j.ejmp.2020.07.012_b0100","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s12032-018-1233-1","article-title":"Impact of image guidance on toxicity and tumour outcome in moderately hypofractionated external-beam radiotherapy for prostate cancer","volume":"36","author":"Jereczek-Fossa","year":"2019","journal-title":"Med Oncol"},{"issue":"3","key":"10.1016\/j.ejmp.2020.07.012_b0105","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1016\/j.ijrobp.2009.07.1754","article-title":"Use of normal tissue complication probability models in the clinic","volume":"76","author":"Marks","year":"2010","journal-title":"Int J Rad Oncol*Biol*Phys."},{"issue":"7","key":"10.1016\/j.ejmp.2020.07.012_b0110","doi-asserted-by":"crossref","first-page":"e43","DOI":"10.1002\/mp.12256","article-title":"Use of image registration and fusion algorithms and techniques in radiotherapy: report of the AAPM Radiation Therapy Committee Task Group No. 132","volume":"44","author":"Brock","year":"2017","journal-title":"Med Phys"},{"issue":"985","key":"10.1016\/j.ejmp.2020.07.012_b0115","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1259\/bjr\/27674581","article-title":"A novel algorithm for the morphometric assessment of radiotherapy treatment planning volumes","volume":"83","author":"Jena","year":"2010","journal-title":"British J Radiol"},{"issue":"3","key":"10.1016\/j.ejmp.2020.07.012_b0120","doi-asserted-by":"crossref","first-page":"297","DOI":"10.2307\/1932409","article-title":"Measures of the amount of ecologic association between species","volume":"26","author":"Dice","year":"1945","journal-title":"Ecology"},{"issue":"4","key":"10.1016\/j.ejmp.2020.07.012_b0125","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1120\/jacmp.v17i4.6051","article-title":"The feasibility of atlas-based automatic segmentation of MRI for H&N radiotherapy planning","volume":"17","author":"Wardman","year":"2016","journal-title":"J Appl Clin Med Phys"},{"issue":"5","key":"10.1016\/j.ejmp.2020.07.012_b0130","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.compeleceng.2011.07.012","article-title":"A non-reference image fusion metric based on mutual information of image features","volume":"37","author":"Haghighat","year":"2011","journal-title":"Comput Electr Eng"},{"key":"10.1016\/j.ejmp.2020.07.012_b0135","doi-asserted-by":"crossref","unstructured":"Haghighat M, Razian MA, (2014, October). Fast-FMI: non-reference image fusion metric. In 2014 IEEE 8th International Conference on Application of Information and Communication Technologies (AICT) (pp. 1\u20133). IEEE.","DOI":"10.1109\/ICAICT.2014.7036000"},{"key":"10.1016\/j.ejmp.2020.07.012_b0140","doi-asserted-by":"crossref","unstructured":"Lowe, D. G. (1999, September). Object recognition from local scale-invariant features. In iccv (Vol. 99, No. 2, pp. 1150-1157).","DOI":"10.1109\/ICCV.1999.790410"},{"issue":"2","key":"10.1016\/j.ejmp.2020.07.012_b0145","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1023\/B:VISI.0000029664.99615.94","article-title":"Distinctive image features from scale-invariant keypoints","volume":"60","author":"Lowe","year":"2004","journal-title":"Int J Comput Vision"},{"key":"10.1016\/j.ejmp.2020.07.012_b0150","unstructured":"http:\/\/plastimatch.org\/."},{"issue":"11","key":"10.1016\/j.ejmp.2020.07.012_b0155","doi-asserted-by":"crossref","first-page":"e1096","DOI":"10.1002\/mp.12506","article-title":"Radiobiological issues in prospective carbon ion therapy trials","volume":"45","author":"Fossati","year":"2018","journal-title":"Med Phys"},{"issue":"12","key":"10.1016\/j.ejmp.2020.07.012_b0160","doi-asserted-by":"crossref","DOI":"10.1118\/1.4901409","article-title":"Deformable image registration based automatic CT-to-CT contour propagation for head and neck adaptive radiotherapy in the routine clinical setting","volume":"41","author":"Kumarasiri","year":"2014","journal-title":"Med Phys"},{"issue":"4","key":"10.1016\/j.ejmp.2020.07.012_b0165","doi-asserted-by":"crossref","first-page":"e317","DOI":"10.1016\/j.prro.2015.01.008","article-title":"Target and organ dose estimation from intensity modulated head and neck radiation therapy using 3 deformable image registration algorithms","volume":"5","author":"Kumarasiri","year":"2015","journal-title":"Practical Radiat Oncol"},{"key":"10.1016\/j.ejmp.2020.07.012_b0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/726268","article-title":"Evaluation of deformable image registration methods for dose monitoring in head and neck radiotherapy","volume":"2015","author":"Rigaud","year":"2015","journal-title":"Biomed Res Int"},{"issue":"1","key":"10.1016\/j.ejmp.2020.07.012_b0175","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1186\/s13014-018-1162-3","article-title":"Assessing the impact of choosing different deformable registration algorithms on cone-beam CT enhancement by histogram matching","volume":"13","author":"Kidar","year":"2018","journal-title":"Radiation Oncol"},{"key":"10.1016\/j.ejmp.2020.07.012_b0180","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ejmp.2017.03.016","article-title":"Dose warping performance in deformable image registration in lung","volume":"37","author":"Moriya","year":"2017","journal-title":"Physica Med"},{"issue":"1","key":"10.1016\/j.ejmp.2020.07.012_b0185","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1186\/s13014-014-0293-4","article-title":"Assessing cumulative dose distributions in combined radiotherapy for cervical cancer using deformable image registration with pre-imaging preparations","volume":"9","author":"Abe","year":"2014","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ejmp.2020.07.012_b0190","series-title":"International Conference on Medical Image Computing and Computer-Assisted Intervention","first-page":"554","article-title":"Summarizing and visualizing uncertainty in non-rigid registration","author":"Risholm","year":"2010"},{"issue":"4","key":"10.1016\/j.ejmp.2020.07.012_b0195","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.ijrobp.2014.12.013","article-title":"Magnetic resonance imaging\u2013guided versus surrogate-based motion tracking in liver radiation therapy: a prospective comparative study","volume":"91","author":"Paganelli","year":"2015","journal-title":"Int J Radiat Oncol*Biol*Phys"}],"container-title":["Physica Medica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1120179720301721?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1120179720301721?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T03:42:40Z","timestamp":1761104560000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1120179720301721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":39,"alternative-id":["S1120179720301721"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmp.2020.07.012","relation":{},"ISSN":["1120-1797"],"issn-type":[{"type":"print","value":"1120-1797"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mixed-beam approach for high-risk prostate cancer: Carbon-ion boost followed by photon intensity-modulated radiotherapy. Dosimetric and geometric evaluations (AIRC IG-14300)","name":"articletitle","label":"Article Title"},{"value":"Physica Medica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmp.2020.07.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}