{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:10:35Z","timestamp":1792509035155,"version":"4.5.0"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T00:00:00Z","timestamp":1695254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","physicamedica.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physica Medica"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.ejmp.2023.102681","type":"journal-article","created":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T06:38:30Z","timestamp":1695451110000},"page":"102681","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Simulation of breast lesions based upon fractal Perlin noise"],"prefix":"10.1016","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2914-883X","authenticated-orcid":false,"given":"Hanna","family":"Tomic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur C.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3775-2876","authenticated-orcid":false,"given":"Anna","family":"Bjerk\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6038-7740","authenticated-orcid":false,"given":"Marcelo A.C.","family":"Vieira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Zackrisson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Tingberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pontus","family":"Timberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Dustler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7087-0915","authenticated-orcid":false,"given":"Predrag R.","family":"Bakic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ejmp.2023.102681_b0005","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s13244-015-0394-0","article-title":"Medical imaging in personalised medicine: a white paper of the research committee of the European Society of Radiology (ESR)","volume":"6","author":"European Society of Radiology (ESR).","year":"2015","journal-title":"Insights Imaging."},{"issue":"1","key":"10.1016\/j.ejmp.2023.102681_b0010","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/med.21846","article-title":"A review in radiomics: making personalized medicine a reality via routine imaging","volume":"42","author":"Guiot","year":"2022","journal-title":"Med Res Rev."},{"issue":"4","key":"10.1016\/j.ejmp.2023.102681_b0015","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1002\/mp.14045","article-title":"Physical imaging phantoms for simulation of tumor heterogeneity in PET, CT, and MRI: an overview of existing designs","volume":"47","author":"Valladares","year":"2020","journal-title":"Med Phys"},{"issue":"4","key":"10.1016\/j.ejmp.2023.102681_b0020","doi-asserted-by":"crossref","DOI":"10.1117\/1.JMI.7.4.042805","article-title":"Virtual clinical trials in medical imaging: a review","volume":"7","author":"Abadi","year":"2020","journal-title":"J Med Imaging"},{"issue":"3-4","key":"10.1016\/j.ejmp.2023.102681_b0025","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1093\/rpd\/ncab080","article-title":"Virtual clinical trials in medical imaging system evaluation and optimisation","volume":"195","author":"Barufaldi","year":"2021","journal-title":"Radiat Prot Dosim."},{"key":"10.1016\/j.ejmp.2023.102681_b0030","doi-asserted-by":"crossref","unstructured":"Bakic P, Barufaldi B, Pokrajac D, Weinstein S, Maidment A. Optimized simulation of breast anatomy for virtual clinical trials. Proceedings of the 14th International Workshop on Breast Imaging(10718); 2018 8-11 July; Atlanta, US. SPIE; 2018. doi:10.1117\/12.2318525.","DOI":"10.1117\/12.2318525"},{"issue":"2","key":"10.1016\/j.ejmp.2023.102681_b0035","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1118\/1.4905232","article-title":"A computational model to generate simulated three-dimensional breast masses","volume":"42","author":"De Sisternes","year":"2015","journal-title":"Med Phys."},{"key":"10.1016\/j.ejmp.2023.102681_b0040","doi-asserted-by":"crossref","DOI":"10.1118\/1.4890590","article-title":"The simulation of 3D mass models in 2D digital mammography and breast tomosynthesis","volume":"41","author":"Shaheen","year":"2014","journal-title":"Med Phys."},{"issue":"1","key":"10.1016\/j.ejmp.2023.102681_b0045","doi-asserted-by":"crossref","first-page":"012003","DOI":"10.1088\/2516-1091\/acc4fc","article-title":"The creation of breast lesion models for mammographic virtual clinical trials: a topical review","volume":"5","author":"Van Camp","year":"2023","journal-title":"Prog Biomed Eng."},{"key":"10.1016\/j.ejmp.2023.102681_b0050","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.breast.2019.10.018","article-title":"Overview of radiomics in breast cancer diagnosis and prognostication","volume":"49","author":"Tagliafico","year":"2020","journal-title":"Breast."},{"issue":"3","key":"10.1016\/j.ejmp.2023.102681_b0055","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1145\/325165.325247","article-title":"An image synthesizer","volume":"19","author":"Perlin","year":"1985","journal-title":"ACM SIGGRAPH Comput Graph."},{"key":"10.1016\/j.ejmp.2023.102681_b0060","doi-asserted-by":"crossref","unstructured":"Dustler M, Bakic P, Petersson H, Timberg P, Tingberg A, Zackrisson S. Application of the fractal Perlin noise algorithm for the generation of simulated breast tissue. Proceedings of SPIE Med Imaging, Physics of Medical Imaging(9412); 2015 Feb 21-26; Orlando, US. SPIE; 2015. doi:10.1117\/12.2081856.","DOI":"10.1117\/12.2081856"},{"key":"10.1016\/j.ejmp.2023.102681_b0065","doi-asserted-by":"crossref","unstructured":"Dustler M, F\u00f6rnvik H, L\u00e5ng K. Binary implementation of fractal Perlin noise to simulate fibroglandular breast tissue. Proceedings of SPIE Med Imaging, Physics of Medical Imaging(10573); 2018 10-15 Feb; Houston, US. SPIE; 2018. doi:10.1117\/12.2293234.","DOI":"10.1117\/12.2293234"},{"key":"10.1016\/j.ejmp.2023.102681_b0070","series-title":"Atlas for breast imaging reporting and data system","year":"2013"},{"issue":"17","key":"10.1016\/j.ejmp.2023.102681_b0075","doi-asserted-by":"crossref","first-page":"6920","DOI":"10.1088\/1361-6560\/aa7cd0","article-title":"The compressed breast during mammography and breast tomosynthesis: in vivo shape characterization and modeling","volume":"62","author":"Rodr\u00edguez-Ruiz","year":"2017","journal-title":"Phys Med Biol"},{"issue":"6","key":"10.1016\/j.ejmp.2023.102681_b0080","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1002\/mp.12186","article-title":"Improvements of an objective model of compressed breasts undergoing mammography: Generation and characterization of breast shapes","volume":"44","author":"Rodr\u00edguez-Ruiz","year":"2017","journal-title":"Med Phys."},{"key":"10.1016\/j.ejmp.2023.102681_b0085","doi-asserted-by":"crossref","unstructured":"Barufaldi B, Higginbotham D, Bakic P, Maidment AD. OpenVCT: a GPU-accelerated virtual clinical trial pipeline for mammography and digital breast tomosynthesis. Proceedings of SPIE Med Imaging, Physics of Medical Imaging(10573); 2018 10-15 Feb; Houston (US). SPIE; 2018. doi:10.1117\/12.2294935.","DOI":"10.1117\/12.2294935"},{"issue":"3\u20134","key":"10.1016\/j.ejmp.2023.102681_b0090","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1093\/rpd\/ncab014","article-title":"ViewDEX 3.0\u2014 Recent development of a software application facilitating assessment of image quality and observer performance","volume":"195","author":"Svalkvist","year":"2021","journal-title":"Radiat Prot Dosim."},{"issue":"1\u20134","key":"10.1016\/j.ejmp.2023.102681_b0095","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1093\/rpd\/ncv543","article-title":"ViewDEX: A status report","volume":"169","author":"Svalkvist","year":"2016","journal-title":"Radiat Prot Dosim."},{"issue":"1\u20133","key":"10.1016\/j.ejmp.2023.102681_b0100","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1093\/rpd\/ncq057","article-title":"ViewDEX: an efficient and easy-to-use software for observer performance studies","volume":"139","author":"H\u00e5kansson","year":"2010","journal-title":"Radiat Prot Dosim"},{"issue":"1\u20133","key":"10.1016\/j.ejmp.2023.102681_b0105","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/rpd\/nch550","article-title":"A software tool for increased efficiency in observer performance studies in radiology","volume":"114","author":"B\u00f6rjesson","year":"2005","journal-title":"Radiat Prot Dosim"},{"issue":"10","key":"10.1016\/j.ejmp.2023.102681_b0110","doi-asserted-by":"crossref","first-page":"5303","DOI":"10.1118\/1.3633905","article-title":"On the orientation of mammographic structure","volume":"38","author":"Reiser","year":"2011","journal-title":"Med Phys."},{"issue":"03","key":"10.1016\/j.ejmp.2023.102681_b0115","doi-asserted-by":"crossref","DOI":"10.1117\/1.JMI.9.3.033503","article-title":"Development and evaluation of a method for tumor growth simulation in virtual clinical trials of breast cancer screening","volume":"9","author":"Tomic","year":"2022","journal-title":"J Med Imaging."}],"container-title":["Physica Medica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1120179723001588?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1120179723001588?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T03:55:32Z","timestamp":1761105332000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1120179723001588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":23,"alternative-id":["S1120179723001588"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmp.2023.102681","relation":{},"ISSN":["1120-1797"],"issn-type":[{"value":"1120-1797","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Simulation of breast lesions based upon fractal Perlin noise","name":"articletitle","label":"Article Title"},{"value":"Physica Medica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmp.2023.102681","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Associazione Italiana di Fisica Medica e Sanitaria. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102681"}}