{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T09:51:24Z","timestamp":1793613084055,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","physicamedica.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physica Medica"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.ejmp.2024.103368","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T04:34:16Z","timestamp":1714019656000},"page":"103368","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Evaluation of safety margins for cone beam CT-based adaptive prostate radiotherapy"],"prefix":"10.1016","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1010-4092","authenticated-orcid":false,"given":"Florian","family":"Dupont","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8038-4889","authenticated-orcid":false,"given":"David","family":"Dechambre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmond","family":"Sterpin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.ejmp.2024.103368_b0005","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/0360-3016(95)00116-6","article-title":"Quantification of organ motion during conformal radiotherapy of the prostate by three dimensional image registration","volume":"33","author":"Van Herk","year":"1995","journal-title":"J Radiation Oncol Biol Phys"},{"issue":"1","key":"10.1016\/j.ejmp.2024.103368_b0010","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1053\/j.semradonc.2003.10.003","article-title":"Errors and Margins in Radiotherapy","volume":"14","author":"Van Herk","year":"2004","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.ejmp.2024.103368_b0015","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/S0360-3016(01)02805-X","article-title":"Inclusion of geometric uncertainties in treatment plan evaluation","volume":"52","author":"Van Herk","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ejmp.2024.103368_b0020","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1259\/bjr\/20582161","article-title":"An analysis of geometric uncertainty calculations for prostate radiotherapy in clinical practice","volume":"82","author":"McGarry","year":"2009","journal-title":"Br J Radiol"},{"issue":"4","key":"10.1016\/j.ejmp.2024.103368_b0025","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/S0360-3016(00)00518-6","article-title":"The probability of correct target dosage: dose-population histograms for deriving treatment margins in radiotherapy","volume":"47","author":"Van Herk","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"10.1016\/j.ejmp.2024.103368_b0030","doi-asserted-by":"crossref","first-page":"pp","DOI":"10.1118\/1.4794502","article-title":"Evaluation of multiple image-based modalities for image-guided radiation therapy (IGRT) of prostate carcinoma: A prospective study","volume":"40","author":"Mayyas","year":"2013","journal-title":"Med Phys"},{"key":"10.1016\/j.ejmp.2024.103368_b0035","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1118\/1.2405325","article-title":"Dosimetric evaluation of daily rigid and nonrigid geometric correction strategies during on-line image-guided radiation therapy (IGRT) of prostate cancer","volume":"34","author":"Song","year":"2007","journal-title":"Med Phys"},{"key":"10.1016\/j.ejmp.2024.103368_b0040","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0167-8140(02)00140-8","article-title":"Geometrical uncertainties, radiotherapy planning margins, and the ICRU-62 report","volume":"64","author":"Stroom","year":"2002","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ejmp.2024.103368_b0045","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.semradonc.2019.02.004","article-title":"Practical Clinical Workflows for Online and Offline Adaptive Radiation Therapy","volume":"29","author":"Green","year":"2019","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.ejmp.2024.103368_b0050","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.ijrobp.2020.10.021","article-title":"Adaptive Radiation Therapy (ART) Strategies and Technical Considerations: A State of the ART Review From NRG Oncology","volume":"109","author":"Glide-Hurst","year":"2021","journal-title":"Int J Radiat Oncol*Biol*Phys"},{"key":"10.1016\/j.ejmp.2024.103368_b0055","article-title":"Intrafraction Motion and Margin Assessment for Ethos Online Adaptive Radiotherapy Treatments of the Prostate and Seminal Vesicles","volume":"9","author":"Byrne","year":"2024","journal-title":"Adv Radiat Oncol"},{"key":"10.1016\/j.ejmp.2024.103368_b0060","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/acm2.13399","article-title":"Prospects for daily online adaptive radiotherapy via ethos for prostate cancer patients without nodal involvement using unedited CBCT auto-segmentation","volume":"22","author":"Moazzezi","year":"2021","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.ejmp.2024.103368_b0065","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/j.ijrobp.2011.10.009","article-title":"First Clinical Release of an Online, Adaptive, Aperture-Based Image-Guided Radiotherapy Strategy in Intensity-Modulated Radiotherapy to Correct for Inter- and Intrafractional Rotations of the Prostate","volume":"83","author":"Deutschmann","year":"2012","journal-title":"Int J Radiat Oncol*Biol*Phys"},{"key":"10.1016\/j.ejmp.2024.103368_b0070","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.phro.2019.02.002","article-title":"Clinical implementation of magnetic resonance imaging guided adaptive radiotherapy for localized prostate cancer","volume":"9","author":"Tetar","year":"2019","journal-title":"Phys Imaging Radiat Oncol"},{"key":"10.1016\/j.ejmp.2024.103368_b0075","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.radonc.2021.12.013","article-title":"Online adaptive radiotherapy potentially reduces toxicity for high-risk prostate cancer treatment","volume":"167","author":"Christiansen","year":"2022","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ejmp.2024.103368_b0080","doi-asserted-by":"crossref","first-page":"4429","DOI":"10.1088\/0031-9155\/60\/11\/4429","article-title":"Contouring variability of human- and deformable-generated contours in radiotherapy for prostate cancer","volume":"60","author":"Gardner","year":"2015","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ejmp.2024.103368_b0085","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.radonc.2019.04.006","article-title":"Interobserver variability in delineation of target volumes in head and neck cancer","volume":"137","author":"van der Veen","year":"2019","journal-title":"Radiother Oncol"},{"issue":"6","key":"10.1016\/j.ejmp.2024.103368_b0090","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1118\/1.598485","article-title":"A general methodology for three-dimensional analysis of variation in target volume delineation","volume":"26","author":"Remeijer","year":"1999","journal-title":"Med Phys"},{"key":"10.1016\/j.ejmp.2024.103368_b0095","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ejmp.2022.03.006","article-title":"Minimum non-isotropic and asymmetric margins for taking into account intrafraction prostate motion during moderately hypofractionated radiotherapy","volume":"96","author":"Di Franco","year":"2022","journal-title":"Phys Med"},{"key":"10.1016\/j.ejmp.2024.103368_b0100","doi-asserted-by":"crossref","DOI":"10.1177\/1533033819883641","article-title":"Dosimetric Characterization of the Dual Layer MLC System for an O-Ring Linear Accelerator","volume":"18","author":"Kim","year":"2019","journal-title":"Technol Cancer Res Treat"},{"issue":"3","key":"10.1016\/j.ejmp.2024.103368_b0105","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.radonc.2016.04.014","article-title":"MRI-guided prostate adaptive radiotherapy \u2013 A systematic review","volume":"119","author":"McPartlin","year":"2016","journal-title":"Radiother Oncol"},{"issue":"3","key":"10.1016\/j.ejmp.2024.103368_b0110","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.semradonc.2005.01.005","article-title":"Target definition in prostate, head, and neck","volume":"15","author":"Rasch","year":"2005","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.ejmp.2024.103368_b0115","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20160312","article-title":"Target margins in radiotherapy of prostate cancer","volume":"89","author":"Yartsev","year":"2016","journal-title":"Br J Radiol"},{"key":"10.1016\/j.ejmp.2024.103368_b0120","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1080\/02841860802244190","article-title":"Optimal treatment margins for radiotherapy of prostate cancer based on interfraction imaging","volume":"47","author":"Arnesen","year":"2008","journal-title":"Acta Oncol"},{"key":"10.1016\/j.ejmp.2024.103368_b0125","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ijrobp.2007.05.046","article-title":"Adaptive Radiotherapy for Prostate Cancer Using Kilovoltage Cone-Beam Computed Tomography: First Clinical Results","volume":"70","author":"Nijkamp","year":"2008","journal-title":"Int J Radiat Oncol*Biol*Phys"},{"issue":"4","key":"10.1016\/j.ejmp.2024.103368_b0130","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.meddos.2012.02.006","article-title":"Interfraction rotation of the prostate as evaluated by kilovoltage X-ray fiducial marker imaging in intensity-modulated radiotherapy of localized prostate cancer","volume":"37","author":"Graf","year":"2012","journal-title":"Med Dosim"},{"issue":"1","key":"10.1016\/j.ejmp.2024.103368_b0135","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ijrobp.2004.09.023","article-title":"Quantification of shape variation of prostate and seminal vesicles during external beam radiotherapy","volume":"61","author":"Deurloo","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ejmp.2024.103368_b0140","doi-asserted-by":"crossref","first-page":"e383","DOI":"10.1016\/j.clon.2022.03.022","article-title":"Prostate Volume Changes during Extreme and Moderately Hypofractionated Magnetic Resonance Image-guided Radiotherapy","volume":"34","author":"Alexander","year":"2022","journal-title":"Clin Oncol"},{"key":"10.1016\/j.ejmp.2024.103368_b0145","unstructured":"M. Van Herk, Margins and margin recipes, 2011."},{"key":"10.1016\/j.ejmp.2024.103368_b0150","doi-asserted-by":"crossref","first-page":"20180948","DOI":"10.1259\/bjr.20180948","article-title":"Comparison of prostate delineation on multimodality imaging for MR-guided radiotherapy","volume":"92","author":"Pathmanathan","year":"2019","journal-title":"Br J Radiol"},{"key":"10.1016\/j.ejmp.2024.103368_b0155","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ijrobp.2006.08.021","article-title":"A magnetic resonance imaging study of prostate deformation relative to implanted gold fiducial markers","volume":"67","author":"Nichol","year":"2007","journal-title":"Int J Radiat Oncol*Biol*Phys"},{"key":"10.1016\/j.ejmp.2024.103368_b0160","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ejmp.2018.09.008","article-title":"Effect of accounting for interfractional CTV shape variations in PTV margins on prostate cancer radiation treatment plans","volume":"54","author":"Hirose","year":"2018","journal-title":"Phys Med"}],"container-title":["Physica Medica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1120179724001637?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1120179724001637?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T18:56:43Z","timestamp":1760641003000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1120179724001637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":32,"alternative-id":["S1120179724001637"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmp.2024.103368","relation":{},"ISSN":["1120-1797"],"issn-type":[{"value":"1120-1797","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of safety margins for cone beam CT-based adaptive prostate radiotherapy","name":"articletitle","label":"Article Title"},{"value":"Physica Medica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmp.2024.103368","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Associazione Italiana di Fisica Medica e Sanitaria. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103368"}}