{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:26:27Z","timestamp":1791195987498,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","physicamedica.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physica Medica"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.ejmp.2024.103386","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T17:23:35Z","timestamp":1716830615000},"page":"103386","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Quantification of deformable image registration uncertainties for dose accumulation on head and neck cancer proton treatments"],"prefix":"10.1016","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1416-8093","authenticated-orcid":false,"given":"Florian","family":"Amstutz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter G","family":"D\u2019Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Albertini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Bachtiary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien C","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Unkelbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antony J.","family":"Lomax","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1608-4467","authenticated-orcid":false,"given":"Ye","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmp.2024.103386_b0005","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.radonc.2018.07.009","article-title":"Anatomical change during radiotherapy for head and neck cancer, and its effect on delivered dose to the spinal cord","volume":"130","author":"Noble","year":"2019","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ejmp.2024.103386_b0010","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.ijrobp.2003.12.024","article-title":"Quantification of volumetric and geometric changes occurring during fractionated radiotherapy for head-and-neck cancer using an integrated CT\/linear accelerator system","volume":"59","author":"Barker","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ejmp.2024.103386_b0015","doi-asserted-by":"crossref","first-page":"711","DOI":"10.3109\/0284186X.2012.731524","article-title":"Weight loss in patients with head and neck cancer during and after conventional and accelerated radiotherapy","volume":"52","author":"Ottosson","year":"2013","journal-title":"Acta Oncol"},{"key":"10.1016\/j.ejmp.2024.103386_b0020","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.ijrobp.2005.07.957","article-title":"Repeat CT imaging and replanning during the course of IMRT for head-and-neck cancer","volume":"64","author":"Hansen","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ejmp.2024.103386_b0025","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.ijrobp.2007.01.030","article-title":"Spatial and dosimetric variability of organs at risk in head-and-neck intensity-modulated radiotherapy","volume":"68","author":"Robar","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ejmp.2024.103386_b0030","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.radonc.2017.04.008","article-title":"Delivered dose can be a better predictor of rectal toxicity than planned dose in prostate radiotherapy","volume":"123","author":"Shelley","year":"2017","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ejmp.2024.103386_b0035","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/acm2.12189","article-title":"Potential proton and photon dose degradation in advanced head and neck cancer patients by intratherapy changes","volume":"18","author":"St\u00fctzer","year":"2017","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.ejmp.2024.103386_b0040","first-page":"5","article-title":"Adaptive radiotherapy for head and neck cancer. Cancers","author":"Morgan","year":"2020","journal-title":"Head Neck"},{"key":"10.1016\/j.ejmp.2024.103386_b0045","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.semradonc.2019.02.008","article-title":"Head and neck cancer adaptive radiation therapy (ART): conceptual considerations for the informed clinician","volume":"29","author":"Heukelom","year":"2019","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.ejmp.2024.103386_b0050","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.radonc.2012.10.010","article-title":"Adaptive radiotherapy for head and neck cancer - Dosimetric results from a prospective clinical trial","volume":"106","author":"Schwartz","year":"2013","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ejmp.2024.103386_b0055","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.radonc.2021.03.008","article-title":"Anatomic changes in head and neck intensity-modulated proton therapy: Comparison between robust optimization and online adaptation","volume":"159","author":"Lalonde","year":"2021","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ejmp.2024.103386_b0060","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1080\/0284186X.2019.1620331","article-title":"Deformable image registration for radiation therapy: principle, methods, applications and evaluation","volume":"58","author":"Rigaud","year":"2019","journal-title":"Acta Oncol"},{"key":"10.1016\/j.ejmp.2024.103386_b0065","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/acm2.12957","article-title":"An international survey on the clinical use of rigid and deformable image registration in radiotherapy","volume":"21","author":"Yuen","year":"2020","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.ejmp.2024.103386_b0070","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.ijrobp.2017.04.023","article-title":"Online adaptive radiation therapy","volume":"99","author":"Lim-Reinders","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ejmp.2024.103386_b0075","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3857\/roj.2017.00325","article-title":"Deformable image registration in radiation therapy","volume":"35","author":"Oh","year":"2017","journal-title":"Radiat Oncol J"},{"key":"10.1016\/j.ejmp.2024.103386_b0080","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.semradonc.2019.02.002","article-title":"Deformable registration for dose accumulation","volume":"29","author":"Chetty","year":"2019","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.ejmp.2024.103386_b0085","first-page":"182","article-title":"Applicability and usage of dose mapping\/accumulation in radiotherapy","author":"Murr","year":"2023","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ejmp.2024.103386_b0090","doi-asserted-by":"crossref","unstructured":"Brock KK, Mutic S, McNutt TR, Li H, Kessler ML. Use of image registration and fusion algorithms and techniques in radiotherapy: Report of the AAPM Radiation Therapy Committee Task Group No. 132: Report. Med Phys 2017;44:e43\u201376. 10.1002\/mp.12256.","DOI":"10.1002\/mp.12256"},{"key":"10.1016\/j.ejmp.2024.103386_b0095","doi-asserted-by":"crossref","first-page":"e908","DOI":"10.1002\/mp.13162","article-title":"Patient-specific validation of deformable image registration in radiation therapy: Overview and caveats","volume":"45","author":"Paganelli","year":"2018","journal-title":"Med Phys"},{"key":"10.1016\/j.ejmp.2024.103386_b0100","doi-asserted-by":"crossref","first-page":"24TR01","DOI":"10.1088\/1361-6560\/ad0d8a","article-title":"Review and recommendations on deformable image registration uncertainties for radiotherapy applications","volume":"68","author":"Nenoff","year":"2023","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ejmp.2024.103386_b0105","doi-asserted-by":"crossref","first-page":"20210001","DOI":"10.1259\/bjr.20210001","article-title":"Clinical use, challenges, and barriers to implementation of deformable image registration in radiotherapy - the need for guidance and QA tools","volume":"94","author":"Hussein","year":"2021","journal-title":"Br J Radiol"},{"key":"10.1016\/j.ejmp.2024.103386_b0110","doi-asserted-by":"crossref","first-page":"9493","DOI":"10.3390\/app12199493","article-title":"Evaluating the quality of patient-specific deformable image registration in adaptive radiotherapy using a digitally enhanced head and neck phantom","volume":"12","author":"Cagni","year":"2022","journal-title":"Appl Sci"},{"key":"10.1016\/j.ejmp.2024.103386_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2020.04.046","article-title":"Deformable image registration uncertainty for inter-fractional dose accumulation of lung cancer proton therapy","author":"Nenoff","year":"2020","journal-title":"Radiother Oncol J Eur Soc Ther Radiol Oncol"},{"key":"10.1016\/j.ejmp.2024.103386_b0120","first-page":"66","article-title":"An approach for estimating dosimetric uncertainties in deformable dose accumulation in pencil beam scanning proton therapy for lung cancer","author":"Amstutz","year":"2021","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ejmp.2024.103386_b0125","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.ijrobp.2016.11.013","article-title":"Effect of anatomic changes on pencil beam scanned proton dose distributions for cranial and extracranial tumors","volume":"97","author":"Placidi","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ejmp.2024.103386_b0130","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.radonc.2019.12.009","article-title":"Quantifying the dose accumulation uncertainty after deformable image registration in head-and-neck radiotherapy","volume":"143","author":"Lowther","year":"2020","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ejmp.2024.103386_b0135","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s13246-022-01125-3","article-title":"MIRSIG position paper: the use of image registration and fusion algorithms in radiotherapy","volume":"45","author":"Lowther","year":"2022","journal-title":"Phys Eng Sci Med"},{"key":"10.1016\/j.ejmp.2024.103386_b0140","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1002\/mp.16564","article-title":"Patient-specific quality assurance for deformable IMRT\/IMPT dose accumulation: Proposition and validation of energy conservation based validation criterion","volume":"50","author":"Wu","year":"2023","journal-title":"Med Phys"},{"key":"10.1016\/j.ejmp.2024.103386_b0145","unstructured":"Sharp G, Li R, Wolfgang J, Chen G, Peroni M, Spadea MF, et al. Plastimatch: an open source software suite for radiotherapy image processing. Proc XVI\u2019th Int Conf Use Comput Radiother ICCR 2010."},{"key":"10.1016\/j.ejmp.2024.103386_b0150","unstructured":"Plastimatch.org. Plastimatch Webpage 2021. http:\/\/plastimatch.org\/ (accessed November 13, 2019)."},{"key":"10.1016\/j.ejmp.2024.103386_b0155","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1109\/TMI.2009.2035616","article-title":"Elastix: A toolbox for intensity-based medical image registration","volume":"29","author":"Klein","year":"2010","journal-title":"IEEE Trans Med Imaging"},{"key":"10.1016\/j.ejmp.2024.103386_b0160","first-page":"1","article-title":"Fast parallel image registration on CPU and GPU for diagnostic classification of Alzheimer\u2019s disease","volume":"7","author":"Shamonin","year":"2014","journal-title":"Front Neuroinf"},{"key":"10.1016\/j.ejmp.2024.103386_b0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1748-717X-9-169","article-title":"The effects of computed tomography image characteristics and knot spacing on the spatial accuracy of B-spline deformable image registration in the head and neck geometry","volume":"9","author":"Brouwer","year":"2014","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ejmp.2024.103386_b0170","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.cmpb.2009.09.002","article-title":"Fast free-form deformation using graphics processing units","volume":"98","author":"Modat","year":"2010","journal-title":"Comput Methods Programs Biomed"},{"key":"10.1016\/j.ejmp.2024.103386_b0175","doi-asserted-by":"crossref","first-page":"4399","DOI":"10.1088\/0031-9155\/56\/14\/011","article-title":"Is it necessary to plan with safety margins for actively scanned proton therapy?","volume":"56","author":"Albertini","year":"2011","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ejmp.2024.103386_b0180","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1118\/1.3302141","article-title":"Analysis of deformable image registration accuracy using computational modeling","volume":"37","author":"Zhong","year":"2010","journal-title":"Med Phys"}],"container-title":["Physica Medica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1120179724001819?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1120179724001819?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T10:21:11Z","timestamp":1720261271000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1120179724001819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":36,"alternative-id":["S1120179724001819"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmp.2024.103386","relation":{},"ISSN":["1120-1797"],"issn-type":[{"value":"1120-1797","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantification of deformable image registration uncertainties for dose accumulation on head and neck cancer proton treatments","name":"articletitle","label":"Article Title"},{"value":"Physica Medica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmp.2024.103386","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Associazione Italiana di Fisica Medica e Sanitaria. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103386"}}