{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T18:56:36Z","timestamp":1775933796790,"version":"3.50.1"},"reference-count":13,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","physicamedica.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physica Medica"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.ejmp.2024.104863","type":"journal-article","created":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T10:30:02Z","timestamp":1732962602000},"page":"104863","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Exploring the dosimetric impact of systematic and random setup uncertainties in robust optimization of head and neck IMPT plans"],"prefix":"10.1016","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2377-8678","authenticated-orcid":false,"given":"Suresh","family":"Rana","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3125-6343","authenticated-orcid":false,"given":"Noufal Manthala","family":"Padannayil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youssef","family":"Zeidan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shyam","family":"Pokharel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Richter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Kasper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hina","family":"Saeed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmp.2024.104863_b0005","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.oraloncology.2018.11.015","article-title":"Intensity modulated proton therapy (IMPT) \u2013 The future of IMRT for head and neck cancer","volume":"88","author":"Moreno","year":"2019","journal-title":"Oral Oncol"},{"issue":"2","key":"10.1016\/j.ejmp.2024.104863_b0010","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1016\/j.meddos.2020.10.006","article-title":"Investigating the utilization of beam-specific apertures for the intensity-modulated proton therapy (IMPT) head and neck cancer plans","volume":"46","author":"Rana","year":"2021","journal-title":"Med Dosim"},{"issue":"3","key":"10.1016\/j.ejmp.2024.104863_b0015","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1118\/1.3556559","article-title":"Minimax optimization for handling range and setup uncertainties in proton therapy","volume":"38","author":"Fredriksson","year":"2011","journal-title":"Med Phys"},{"issue":"1","key":"10.1016\/j.ejmp.2024.104863_b0020","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ijrobp.2016.02.016","article-title":"Evaluation of robustness to setup and range uncertainties for head and neck patients treated with pencil beam scanning proton therapy","volume":"95","author":"Malyapa","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"6","key":"10.1016\/j.ejmp.2024.104863_b0025","article-title":"Robustly optimized hybrid intensity-modulated proton therapy for craniospinal irradiation","volume":"18","author":"Sharma","year":"2022","journal-title":"J Cancer Res Ther"},{"issue":"2","key":"10.1016\/j.ejmp.2024.104863_b0030","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1118\/1.3679340","article-title":"Robust optimization of intensity modulated proton therapy","volume":"39","author":"Liu","year":"2012","journal-title":"Med Phys"},{"issue":"3","key":"10.1016\/j.ejmp.2024.104863_b0035","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/acm2.13183","article-title":"Investigating volumetric repainting to mitigate interplay effect on 4D robustly optimized lung cancer plans in pencil beam scanning proton therapy","volume":"22","author":"Rana","year":"2021","journal-title":"J Appl Clin Med Phys"},{"issue":"6","key":"10.1016\/j.ejmp.2024.104863_b0040","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1088\/0031-9155\/53\/6\/013","article-title":"Worst case optimization: a method to account for uncertainties in the optimization of intensity modulated proton therapy","volume":"53","author":"Pflugfelder","year":"2008","journal-title":"Phys Med Biol"},{"issue":"1","key":"10.1016\/j.ejmp.2024.104863_b0045","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1118\/1.3021139","article-title":"Reducing the sensitivity of IMPT treatment plans to setup errors and range uncertainties via probabilistic treatment planning","volume":"36","author":"Unkelbach","year":"2008","journal-title":"Med Phys"},{"issue":"5","key":"10.1016\/j.ejmp.2024.104863_b0050","doi-asserted-by":"crossref","DOI":"10.1118\/1.4801899","article-title":"Effectiveness of robust optimization in intensity\u2010modulated proton therapy planning for head and neck cancers","volume":"40","author":"Liu","year":"2013","journal-title":"Med Phys"},{"issue":"20","key":"10.1016\/j.ejmp.2024.104863_b0055","doi-asserted-by":"crossref","first-page":"8178","DOI":"10.1088\/1361-6560\/aa8c58","article-title":"A robust optimisation approach accounting for the effect of fractionation on setup uncertainties","volume":"62","author":"Lowe","year":"2017","journal-title":"Phys Med Biol"},{"issue":"1","key":"10.1016\/j.ejmp.2024.104863_b0060","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.radonc.2016.04.038","article-title":"The price of robustness; impact of worst-case optimization on organ-at-risk dose and complication probability in intensity-modulated proton therapy for oropharyngeal cancer patients","volume":"120","author":"van de Water","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ejmp.2024.104863_b0065","unstructured":"RaySearch Laboratories RSL-D-RS-12A-REF-EN-1.0-2022-06-23 Raystation 12A Reference Manual; 2022."}],"container-title":["Physica Medica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1120179724013310?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1120179724013310?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T15:29:21Z","timestamp":1733498961000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1120179724013310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":13,"alternative-id":["S1120179724013310"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmp.2024.104863","relation":{},"ISSN":["1120-1797"],"issn-type":[{"value":"1120-1797","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring the dosimetric impact of systematic and random setup uncertainties in robust optimization of head and neck IMPT plans","name":"articletitle","label":"Article Title"},{"value":"Physica Medica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmp.2024.104863","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Associazione Italiana di Fisica Medica e Sanitaria. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104863"}}