{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T22:27:39Z","timestamp":1773959259945,"version":"3.50.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100011019","name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011019","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005881","name":"Ministry of Culture and Innovation","doi-asserted-by":"publisher","award":["TKP2021-EGA-02"],"award-info":[{"award-number":["TKP2021-EGA-02"]}],"id":[{"id":"10.13039\/501100005881","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","physicamedica.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physica Medica"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.ejmp.2026.105714","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:46:04Z","timestamp":1767660364000},"page":"105714","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Risk estimations of radiation induced malignancies in rectum and bladder following radiotherapy of prostate carcinoma"],"prefix":"10.1016","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8921-9049","authenticated-orcid":false,"given":"Brigitta Timea","family":"Herczeg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6529-1636","authenticated-orcid":false,"given":"\u00c1kos","family":"Sud\u00e1r","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Ortutay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter","family":"\u00c1goston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4672-6910","authenticated-orcid":false,"given":"Tibor","family":"Major","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u00e1n","family":"Tak\u00e1csi-Nagy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5815-0974","authenticated-orcid":false,"given":"Csilla","family":"Peszny\u00e1k","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ejmp.2026.105714_b0005","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.ejmp.2026.105714_b0010","unstructured":"Howlader N, et al. SEER Cancer Statistics Review, 1975-2018, National Cancer Institute. Bethesda, MD, https:\/\/seer.cancer.gov\/csr\/1975_2018\/, based on November 2020 SEER data submission, posted to the SEER web site, April 2021."},{"key":"10.1016\/j.ejmp.2026.105714_b0015","unstructured":"Curtis RE, et al. New malignancies among cancer survivors: seer cancer registries, 1973-2000. National Cancer Institute. NIH Publ. No. 05-5302. Bethesda, MD, 2006."},{"issue":"3","key":"10.1016\/j.ejmp.2026.105714_b0020","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1177\/1756287210374462","article-title":"Secondary malignancies following radiotherapy for prostate cancer","volume":"2","author":"Sountoulides","year":"2010","journal-title":"Ther Adv Urol"},{"key":"10.1016\/j.ejmp.2026.105714_b0025","doi-asserted-by":"crossref","unstructured":"Cakir A, Akgun Z, Fayda M, Agaoglu F. Comparison of three dimensional conformal radiation therapy, intensity modulated radiation therapy and volumetric modulated arc therapy for low radiation exposure of normal tissue in patients with prostate cancer [Internet]. Vol. 16, Asian Pacific Journal of Cancer Prevention. Asian Pacific Organization for Cancer Prevention; 2015. p. 3365\u201370. Available from: http:\/\/dx.doi.org\/10.7314\/APJCP.2015.16.8.3365.","DOI":"10.7314\/APJCP.2015.16.8.3365"},{"key":"10.1016\/j.ejmp.2026.105714_b0030","doi-asserted-by":"crossref","first-page":"203","DOI":"10.4236\/ijmpcero.2018.72018","article-title":"Influence of dosimetric considerations in evaluating second cancer risks in prostate cancer","volume":"7","author":"Elgendy","year":"2018","journal-title":"Int J Med Phys, Clin Eng Radiat Oncol"},{"key":"10.1016\/j.ejmp.2026.105714_b0035","series-title":"Molecular & Diagnostic Imaging in Prostate Cancer: Clinical Applications and Treatment Strategies","first-page":"31","article-title":"Advances in radiotherapy for prostate cancer treatment","author":"Podder","year":"2018"},{"key":"10.1016\/j.ejmp.2026.105714_b0040","doi-asserted-by":"crossref","first-page":"S4271","DOI":"10.1016\/S0167-8140(24)01961-3","article-title":"1592: Dosimetric comparison of adaptive and scheduled plans in adaptive teletherapy of prostate cancer","volume":"194","author":"Herein","year":"2024","journal-title":"Radiother Oncol"},{"issue":"1","key":"10.1016\/j.ejmp.2026.105714_b0045","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0360-3016(03)00073-7","article-title":"Radiation-induced second cancers: the impact of 3D-CRT and IMRT","volume":"56","author":"Hall","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"6","key":"10.1016\/j.ejmp.2026.105714_b0050","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1120\/jacmp.v17i6.6464","article-title":"Dosimetric comparison of intensity-modulated radiotherapy and volumetric-modulated arc radiotherapy in patients with prostate cancer: a meta-analysis","volume":"17","author":"Ren","year":"2016","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.ejmp.2026.105714_b0055","doi-asserted-by":"crossref","first-page":"e391","DOI":"10.1002\/mp.12462","article-title":"AAPM TG 158: Measurement and calculation of doses outside the treated volume from external-beam radiation therapy","volume":"44","author":"Kry","year":"2017","journal-title":"Med Phys"},{"key":"10.1016\/j.ejmp.2026.105714_b0060","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ejmp.2019.09.076","article-title":"External photon radiation treatment for prostate cancer: Uncomplicated and cancer-free control probability assessment of 36 plans","volume":"66","author":"S\u00e1nchez-Nieto","year":"2019","journal-title":"Phys Med"},{"issue":"1","key":"10.1016\/j.ejmp.2026.105714_b0065","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1078\/0939-3889-00242","article-title":"A simple dose-response relationship for modeling secondary cancer incidence after radiotherapy","volume":"15","author":"Schneider","year":"2005","journal-title":"Zeitschrift F\u00fcr Medizinische Physik"},{"issue":"5","key":"10.1016\/j.ejmp.2026.105714_b0070","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/j.ijrobp.2004.12.040","article-title":"Estimation of radiation-induced cancer from three-dimensional dose distributions: concept of organ equivalent dose","volume":"61","author":"Schneider","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"10.1016\/j.ejmp.2026.105714_b0075","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1742-4682-8-27","article-title":"Site-specific dose-response relationships for cancer induction from the combined Japanese A-bomb and Hodgkin cohorts for doses relevant to radiotherapy","volume":"8","author":"Schneider","year":"2011","journal-title":"Theor Biol Med Model"},{"key":"10.1016\/j.ejmp.2026.105714_b0080","unstructured":"Pesznyak C and Safrany G (2017). Sug\u00e1rbiol\u00f3gia. In None. Typotex Kiad\u00f3. ISBN: 978-963-2799-52-0, https:\/\/www.typotex.hu\/book\/8898\/sugarbiologia."},{"issue":"3 Suppl","key":"10.1016\/j.ejmp.2026.105714_b0085","article-title":"Use of normal tissue complication probability models in the clinic","volume":"76","author":"Marks","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2_suppl","key":"10.1016\/j.ejmp.2026.105714_b0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1200\/jco.2016.34.2_suppl.1","article-title":"NRG Oncology RTOG 0415: a randomized phase III non-inferiority study comparing two fractionation schedules in patients with low-risk prostate cancer","volume":"34","author":"Lee","year":"2024","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejmp.2026.105714_b0095","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ejmp.2017.02.015","article-title":"Models for the risk of secondary cancers from radiation therapy","volume":"42","author":"Dasu","year":"2017","journal-title":"Phys Med: Eur J Med Phys"},{"key":"10.1016\/j.ejmp.2026.105714_b0100","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ejmp.2021.09.005","article-title":"Out-of-field organ doses and associated risk of cancer development following radiation therapy with photons","volume":"90","author":"Mazonakis","year":"2021","journal-title":"Phys Med: Eur J Med Phys"},{"issue":"2","key":"10.1016\/j.ejmp.2026.105714_b0105","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ijrobp.2012.09.001","article-title":"Second solid cancers after radiation therapy: a systematic review of the epidemiologic studies of the radiation dose-response relationship","volume":"86","author":"Berrington de Gonzalez","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"6","key":"10.1016\/j.ejmp.2026.105714_b0110","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1088\/0031-9155\/53\/6\/012","article-title":"Equivalent dose and effective dose from stray radiation during passively scattered proton radiotherapy for prostate cancer","volume":"53","author":"Fontenot","year":"2008","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ejmp.2026.105714_b0115","doi-asserted-by":"crossref","unstructured":"Berrington de Gonzalez A, et al. RadRAT: a radiation risk assessment tool for lifetime cancer risk projection. J Radiol Prot. 2012 Sep;32(3):205-22. doi: 10.1088\/0952-4746\/32\/3\/205. Epub 2012 Jul 19. PMID: 22810503; PMCID: PMC3816370.","DOI":"10.1088\/0952-4746\/32\/3\/205"},{"key":"10.1016\/j.ejmp.2026.105714_b0120","doi-asserted-by":"crossref","unstructured":"Mishra P, Pandey CM, Singh U, Gupta A, Sahu C, Keshri A. Descriptive statistics and normality tests for statistical data. Ann Card Anaesth. 2019 Jan-Mar;22(1):67-72. doi: 10.4103\/aca.ACA_157_18. PMID: 30648682; PMCID: PMC6350423.","DOI":"10.4103\/aca.ACA_157_18"},{"issue":"1136","key":"10.1016\/j.ejmp.2026.105714_b0125","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20201289","article-title":"Volumetric modulated arc therapy (VMAT): a review of clinical outcomes\u2014what is the clinical evidence for the most effective implementation?","volume":"95","author":"Hunte","year":"2022","journal-title":"Br J Radiol"},{"issue":"5","key":"10.1016\/j.ejmp.2026.105714_b0130","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1016\/j.ijrobp.2010.10.024","article-title":"Assessing the role of volumetric modulated arc therapy (vmat) relative to imrt and helical tomotherapy in the management of localized, locally advanced, and post-operative prostate cancer","volume":"80","author":"Davidson","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"10.1016\/j.ejmp.2026.105714_b0135","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/jmrs.311","article-title":"The role of volumetric modulated arc therapy (VMAT) in gynaecological radiation therapy: a dosimetric comparison of intensity modulated radiation therapy versus VMAT","volume":"66","author":"Knapp","year":"2019","journal-title":"J Med Radiat Sci"},{"issue":"1","key":"10.1016\/j.ejmp.2026.105714_b0140","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.rpor.2019.11.001","article-title":"Normal tissue sparing using different techniques for prostate irradiation","volume":"25","author":"Melles-Bencsik","year":"2020","journal-title":"Rep Pract Oncol Radiother"},{"key":"10.1016\/j.ejmp.2026.105714_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmp.2017.02.018","article-title":"The risk of second primary cancers due to peripheral photon and neutron doses received during prostate cancer external beam radiation therapy","volume":"42","author":"Bezak","year":"2017","journal-title":"Phys Med"},{"key":"10.1016\/j.ejmp.2026.105714_b0150","article-title":"Estimation of the risk of secondary cancer in rectum and bladder after radiation therapy for prostate cancer using a feasibility dose\u2013volume histogram","volume":"27","author":"Aoyama","year":"2023","journal-title":"Phys Imaging Radiat Oncol"},{"key":"10.1016\/j.ejmp.2026.105714_b0155","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.586401","article-title":"Risk and prognosis of secondary bladder cancer after radiation therapy for rectal cancer: a large population-based cohort study","volume":"10","author":"Guan","year":"2021","journal-title":"Front Oncol"},{"key":"10.1016\/j.ejmp.2026.105714_b0160","doi-asserted-by":"crossref","first-page":"S186","DOI":"10.1016\/S0167-8140(15)31675-3","article-title":"EP-1557: Comparison of normal tissue dosimetry for 3D-CRT and IMRT techniques in prostate irradiation","volume":"111","author":"Pesznyak","year":"2014","journal-title":"Radiother Oncol"},{"issue":"4","key":"10.1016\/j.ejmp.2026.105714_b0165","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.ijrobp.2011.09.015","article-title":"A comprehensive comparison of IMRT and VMAT plan quality for prostate cancer treatment","volume":"83","author":"Quan","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ejmp.2026.105714_b0170","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/978-3-319-99286-0_2","article-title":"Advances in radiotherapy for prostate cancer treatment","volume":"1096","author":"Podder","year":"2018","journal-title":"Adv Exp Med Biol"},{"issue":"7","key":"10.1016\/j.ejmp.2026.105714_b0175","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/acm2.13274","article-title":"Risk for second bladder and rectal malignancies from cervical cancer irradiation","volume":"22","author":"Mazonakis","year":"2021","journal-title":"J Appl Clin Med Phys"},{"issue":"9","key":"10.1016\/j.ejmp.2026.105714_b0180","doi-asserted-by":"crossref","DOI":"10.3390\/jpm12091442","article-title":"Assessment of radiation-induced bladder and bowel cancer risks after conventionally and hypo-fractionated radiotherapy for the preoperative management of rectal carcinoma","volume":"12","author":"Matsali","year":"2022","journal-title":"J Pers Med"},{"issue":"7","key":"10.1016\/j.ejmp.2026.105714_b0185","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1002\/mp.14169","article-title":"Secondary bladder and rectal cancer risk estimates following standard fractionated and moderately hypofractionated VMAT for prostate carcinoma","volume":"47","author":"Mazonakis","year":"2020","journal-title":"Med Phys"},{"key":"10.1016\/j.ejmp.2026.105714_b0190","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.2147\/CMAR.S244901","article-title":"Comparison of radiation-induced secondary malignancy risk between sequential and simultaneous integrated boost for the treatment of nasopharyngeal carcinoma: intensity-modulated radiotherapy versus volumetric-modulated arc therapy","volume":"12","author":"Haciislamoglu","year":"2020","journal-title":"Cancer Manag Res"},{"key":"10.1016\/j.ejmp.2026.105714_b0195","article-title":"Benefits of adopting hypofractionated radiotherapy as a standard of care in low-and middle-income countries","volume":"8","author":"Kraus","year":"2022","journal-title":"JCO Glob Oncol"},{"issue":"9","key":"10.1016\/j.ejmp.2026.105714_b0200","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/acm2.12972","article-title":"Estimation of secondary cancer risk after radiotherapy in high-risk prostate cancer patients with pelvic irradiation","volume":"21","author":"Haciislamoglu","year":"2020","journal-title":"J Appl Clin Med Phys"},{"issue":"3","key":"10.1016\/j.ejmp.2026.105714_b0205","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s00411-009-0231-2","article-title":"A new view of radiation-induced cancer: integrating short- and long-term processes. Part II: second cancer risk estimation","volume":"48","author":"Shuryak","year":"2009","journal-title":"Radiat Environ Biophys"},{"issue":"2","key":"10.1016\/j.ejmp.2026.105714_b0210","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/(SICI)1097-0142(20000115)88:2<398::AID-CNCR22>3.0.CO;2-V","article-title":"Second malignancies in prostate carcinoma patients after radiotherapy compared with surgery","volume":"88","author":"Brenner","year":"2000","journal-title":"Cancer"},{"issue":"2","key":"10.1016\/j.ejmp.2026.105714_b0215","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3857\/roj.2020.00857","article-title":"Risk of second cancer among young prostate cancer survivors","volume":"39","author":"Zhang","year":"2021","journal-title":"Radiat Oncol J"},{"issue":"8","key":"10.1016\/j.ejmp.2026.105714_b0220","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/S1470-2045(16)30102-4","article-title":"Conventional versus hypofractionated high-dose intensity-modulated radiotherapy for prostate cancer: 5-year outcomes of the randomised, non-inferiority, phase 3 CHHiP trial","volume":"17","author":"Dearnaley","year":"2016","journal-title":"Lancet Oncol"},{"issue":"8","key":"10.1016\/j.ejmp.2026.105714_b0225","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/S1470-2045(16)30070-5","article-title":"Hypofractionated versus conventionally fractionated radiotherapy for patients with localised prostate cancer (HYPRO): final efficacy results from a randomised, multicentre, open-label, phase 3 trial","volume":"17","author":"Incrocci","year":"2016","journal-title":"Lancet Oncol"}],"container-title":["Physica Medica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1120179726000013?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1120179726000013?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T18:59:29Z","timestamp":1773946769000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1120179726000013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":45,"alternative-id":["S1120179726000013"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmp.2026.105714","relation":{},"ISSN":["1120-1797"],"issn-type":[{"value":"1120-1797","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk estimations of radiation induced malignancies in rectum and bladder following radiotherapy of prostate carcinoma","name":"articletitle","label":"Article Title"},{"value":"Physica Medica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmp.2026.105714","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Associazione Italiana di Fisica Medica e Sanitaria. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105714"}}