{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:50:41Z","timestamp":1792104641404,"version":"4.4.0"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020581","name":"AIRC Foundation for Cancer Research","doi-asserted-by":"publisher","award":["IG23150"],"award-info":[{"award-number":["IG23150"]}],"id":[{"id":"10.13039\/100020581","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","physicamedica.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physica Medica"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.ejmp.2026.105904","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T19:31:30Z","timestamp":1784662290000},"page":"105904","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Limited impact of CT-based breast tissue composition on skin toxicity, fibrosis, edema and liponecrosis prediction after moderately hypofractionated whole-breast radiotherapy"],"prefix":"10.1016","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1015-5762","authenticated-orcid":false,"given":"A.","family":"Belardo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9285-4390","authenticated-orcid":false,"given":"A.","family":"Fodor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9184-7720","authenticated-orcid":false,"given":"M.M.","family":"Vincenzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Mangili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Palazzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.G.Ubeira","family":"Gabellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Giannini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Tummineri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Torrisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.Del","family":"Vecchio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.G.Di","family":"Muzio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Fiorino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"22","key":"10.1016\/j.ejmp.2026.105904_b0005","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1056\/NEJM199306033282202","article-title":"Radiotherapy after breast-preserving surgery in women with localized cancer of the breast","volume":"328","author":"Veronesi","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejmp.2026.105904_b0010","first-page":"15","article-title":"Randomized clinical trial to assess the value of breast-conserving therapy in stage I and II breast cancer, EORTC 10801 trial","volume":"11","author":"van Dongen","year":"1992","journal-title":"J Natl Cancer Inst Monogr"},{"issue":"3","key":"10.1016\/j.ejmp.2026.105904_b0015","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1075-122X.2004.21323.x","article-title":"Quality of life following breast-conserving therapy or mastectomy: results of a 5-year prospective study","volume":"10","author":"Engel","year":"2004","journal-title":"Breast J"},{"key":"10.1016\/j.ejmp.2026.105904_b0020","doi-asserted-by":"crossref","unstructured":"START Trialists' Group; Bentzen SM, Agrawal RK, Aird EG, Barrett JM, Barrett-Lee PJ, et al. Standardisation of Breast Radiotherapy (START) Trial A of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial. Lancet Oncol. 2008 Apr;9(4):331-41. doi: 10.1016\/S1470-2045(08)70077-9. Epub 2008 Mar 19. PMID: 18356109; PMCID: PMC2323709.","DOI":"10.1016\/S1470-2045(08)70077-9"},{"key":"10.1016\/j.ejmp.2026.105904_b0025","doi-asserted-by":"crossref","unstructured":"Bartelink H, Maingon P, Poortmans P, Weltens C, Fourquet A, Jager J, et al. Whole-breast irradiation with or without a boost for patients treated with breast-conserving surgery for early breast cancer: 20-year follow-up of a randomised phase 3 trial. Lancet Oncol. 2015 Jan;16(1):47-56. doi: 10.1016\/S1470-2045(14)71156-8. Epub 2014 Dec 9. Erratum in: Lancet Oncol. 2015 Jan;16(1):e6. PMID: 25500422.","DOI":"10.1016\/S1470-2045(14)71156-8"},{"issue":"3","key":"10.1016\/j.ejmp.2026.105904_b0030","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s10549-017-4118-7","article-title":"Hypofractionated whole breast radiotherapy in breast conservation for early-stage breast cancer: a systematic review and meta-analysis of randomized trials","volume":"162","author":"Valle","year":"2017","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.ejmp.2026.105904_b0035","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.breast.2019.08.001","article-title":"Meta-analysis of long-term efficacy and safety of hypofractionated radiotherapy in the treatment of early breast cancer","volume":"48","author":"Andrade","year":"2019","journal-title":"Breast"},{"key":"10.1016\/j.ejmp.2026.105904_b0040","unstructured":"Office for National Statistics. Cancer survival in England. In: Patients diagnosed between 2010 and 2014 and followed up to 2015. London: Office for National Statistics (2016)."},{"key":"10.1016\/j.ejmp.2026.105904_b0045","series-title":"Priorities for research on cancer survivorship","author":"National Cancer Institute","year":"2010"},{"issue":"18","key":"10.1016\/j.ejmp.2026.105904_b0050","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1016\/j.ejca.2011.06.039","article-title":"Frequency and severity of skin reactions in patients with breast cancer undergoing adjuvant radiotherapy, the usefulness of two assessment instruments - a pilot study","volume":"47","author":"Sharp","year":"2011","journal-title":"Eur J Cancer"},{"issue":"3","key":"10.1016\/j.ejmp.2026.105904_b0055","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/jso.23804","article-title":"Postmastectomy radiation therapy and immediate autologous breast reconstruction: integrating perspectives from surgical oncology, radiation oncology, and plastic and reconstructive surgery","volume":"111","author":"Rochlin","year":"2015","journal-title":"J Surg Oncol"},{"issue":"11","key":"10.1016\/j.ejmp.2026.105904_b0060","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/S1470-2045(13)70386-3","article-title":"The UK Standardisation of Breast Radiotherapy (START) trials of radiotherapy hypofractionation for treatment of early breast cancer: 10-year follow-up results of two randomised controlled trials","volume":"14","author":"Haviland","year":"2013","journal-title":"Lancet Oncol"},{"issue":"3","key":"10.1016\/j.ejmp.2026.105904_b0065","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.canrad.2017.10.004","article-title":"Evaluation at 3years of concurrent bevacizumab and radiotherapy for breast cancer: results of a prospective study","volume":"22","author":"Dautruche","year":"2018","journal-title":"Cancer Radiother"},{"issue":"13","key":"10.1016\/j.ejmp.2026.105904_b0070","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1200\/JCO.2007.15.2488","article-title":"A multicenter randomized trial of breast intensity-modulated radiation therapy to reduce acute radiation dermatitis","volume":"26","author":"Pignol","year":"2008","journal-title":"J Clin Oncol"},{"issue":"6","key":"10.1016\/j.ejmp.2026.105904_b0075","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1056\/NEJMoa0906260","article-title":"Long-term results of hypofractionated radiation therapy for breast cancer","volume":"362","author":"Whelan","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejmp.2026.105904_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2024.110183","article-title":"Skin dose-volume predictors of moderate-severe late side effects after whole breast radiotherapy","volume":"194","author":"Cicchetti","year":"2024","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ejmp.2026.105904_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2024.110700","article-title":"Training and temporally validating an NTCP model of acute toxicity after whole breast radiotherapy, including the impact of advanced delivery techniques","volume":"204","author":"Vincenzi","year":"2025","journal-title":"Radiother Oncol"},{"issue":"5","key":"10.1016\/j.ejmp.2026.105904_b0090","doi-asserted-by":"crossref","first-page":"934","DOI":"10.3390\/cancers16050934","article-title":"Comparing performances of predictive models of toxicity after radiotherapy for breast cancer using different machine learning approaches","volume":"16","author":"Ubeira-Gabellini","year":"2024","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ejmp.2026.105904_b0095","doi-asserted-by":"crossref","unstructured":"Collette S, Collette L, Budiharto T, Horiot JC, Poortmans PM, Struikmans H, et al. Predictors of the risk of fibrosis at 10 years after breast conserving therapy for early breast cancer: a study based on the EORTC Trial 22881-10882 'boost versus no boost'. Eur J Cancer. 2008 Nov;44(17):2587-99. doi: 10.1016\/j.ejca.2008.07.032. Epub 2008 Aug 29. Erratum in: Eur J Cancer. 2009 Jul;45(11):2061. PMID: 18757193.","DOI":"10.1016\/j.ejca.2008.07.032"},{"issue":"2","key":"10.1016\/j.ejmp.2026.105904_b0100","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.radonc.2005.12.013","article-title":"Influence of connective tissue diseases on the expression of radiation side effects: a systematic review","volume":"78","author":"H\u00f6lscher","year":"2006","journal-title":"Radiother Oncol"},{"issue":"1","key":"10.1016\/j.ejmp.2026.105904_b0105","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jaad.2005.08.054","article-title":"Radiation dermatitis: clinical presentation, pathophysiology, and treatment 2006","volume":"54","author":"Hymes","year":"2006","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"10.1016\/j.ejmp.2026.105904_b0110","first-page":"33","article-title":"Factors influencing the severity of radiation skin and oral mucosal reactions: development of a conceptual framework","volume":"11","author":"Porock","year":"2002","journal-title":"Eur J Cancer Care (Engl)"},{"issue":"9","key":"10.1016\/j.ejmp.2026.105904_b0115","doi-asserted-by":"crossref","first-page":"473","DOI":"10.2147\/CCID.S94320","article-title":"Chronic radiation-induced dermatitis: challenges and solutions","volume":"9","author":"Spa\u0142ek","year":"2016","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"6","key":"10.1016\/j.ejmp.2026.105904_b0120","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1002\/cncr.24120","article-title":"Increased risk of high-grade dermatologic toxicities with radiation plus epidermal growth factor receptor inhibitor therapy","volume":"115","author":"Tejwani","year":"2009","journal-title":"Cancer"},{"key":"10.1016\/j.ejmp.2026.105904_b0125","doi-asserted-by":"crossref","unstructured":"Toledano A, Garaud P, Serin D, Fourquet A, Bosset JF, Miny-Buffet J, et al. La chimioth\u00e9rapie concomitante de la radioth\u00e9rapie augmente la toxicit\u00e9 tardive apr\u00e8s chirurgie conservatrice du cancer du sein [Concurrent administration of adjuvant chemotherapy and radiotherapy after breast-conservative surgery enhances late toxicities]. Cancer Radiother. 2006 Jun;10(4):158-67. French. doi: 10.1016\/j.canrad.2006.03.001. Epub 2006 Apr 24. PMID: 16632399.","DOI":"10.1016\/j.canrad.2006.03.001"},{"issue":"10","key":"10.1016\/j.ejmp.2026.105904_b0130","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.clon.2011.04.011","article-title":"The Cambridge Breast Intensity-modulated Radiotherapy Trial: patient- and treatment-related factors that influence late toxicity","volume":"23","author":"Barnett","year":"2011","journal-title":"Clin Oncol (R Coll Radiol)"},{"issue":"9","key":"10.1016\/j.ejmp.2026.105904_b0135","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1748-717X-9-97","article-title":"Toxicity and cosmetic outcome of hypofractionated whole-breast radiotherapy: predictive clinical and dosimetric factors","volume":"24","author":"Ciammella","year":"2014","journal-title":"Radiat Oncol"},{"issue":"4","key":"10.1016\/j.ejmp.2026.105904_b0140","doi-asserted-by":"crossref","first-page":"e480","DOI":"10.1016\/j.clbc.2021.11.008","article-title":"Toxicity of hypofractionated whole breast radiotherapy without boost and timescale of late skin responses in a large cohort of early-stage breast cancer patients","volume":"22","author":"Fodor","year":"2022","journal-title":"Clin Breast Cancer"},{"issue":"6","key":"10.1016\/j.ejmp.2026.105904_b0145","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.tranon.2015.10.002","article-title":"Imaging breast density: established and emerging modalities","volume":"8","author":"Chen","year":"2015","journal-title":"Transl Oncol"},{"key":"10.1016\/j.ejmp.2026.105904_b0150","doi-asserted-by":"crossref","unstructured":"Boyd NF, Martin LJ, Yaffe MJ, Minkin S. Mammographic density and breast cancer risk: current understanding and future prospects. Breast Cancer Res. 2011;13(6):223. doi: 10.1186\/bcr2942. Epub 2011 Nov 1. PMID: 22114898; PMCID: PMC3326547.","DOI":"10.1186\/bcr2942"},{"key":"10.1016\/j.ejmp.2026.105904_b0155","doi-asserted-by":"crossref","unstructured":"Kanbayti IH, Rae WID, McEntee MF, Ekpo EU. Are mammographic density phenotypes associated with breast cancer treatment response and clinical outcomes? A systematic review and meta-analysis. Breast. 2019 Oct;47:62-76. doi: 10.1016\/j.breast.2019.07.002. Epub 2019 Jul 18. PMID: 31352313.","DOI":"10.1016\/j.breast.2019.07.002"},{"issue":"12","key":"10.1016\/j.ejmp.2026.105904_b0160","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1056\/NEJMoa013390","article-title":"Heritability of mammographic density, a risk factor for breast cancer","volume":"347","author":"Boyd","year":"2002","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.ejmp.2026.105904_b0165","doi-asserted-by":"crossref","first-page":"R7","DOI":"10.1186\/bcr3378","article-title":"Mammographic density as a predictor of breast cancer survival: the Multiethnic Cohort","volume":"15","author":"Maskarinec","year":"2013","journal-title":"Breast Cancer Res"},{"issue":"12","key":"10.1016\/j.ejmp.2026.105904_b0170","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1158\/1055-9965.EPI-07-0458","article-title":"National cancer institute breast cancer surveillance consortium. association between breast density and subsequent breast cancer following treatment for ductal carcinoma in situ","volume":"16","author":"Hwang","year":"2007","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.ejmp.2026.105904_b0175","doi-asserted-by":"crossref","unstructured":"Mori M, Belardo A, Vincenzi MM, Fodor A, Mangili P, Palazzo G, Gabellini MU, Tummineri R, Torrisi M, Vecchio AD, Muzio ND, Fiorino C. Breast density histogram analysis: the role of fat in outcome prediction after Whole Breast Radiotherapy. Pract Radiat Oncol. 2025 Dec 13:S1879-8500(25)00319-4. doi: 10.1016\/j.prro.2025.12.004. Epub ahead of print. PMID: 41397616.","DOI":"10.2139\/ssrn.5240655"},{"issue":"10","key":"10.1016\/j.ejmp.2026.105904_b0180","first-page":"955","article-title":"Reproductive and hormonal factors associated with mammographic breast density by age (United States)","volume":"11","author":"El-Bastawissi","year":"2000","journal-title":"Cancer Causes Control"},{"issue":"2","key":"10.1016\/j.ejmp.2026.105904_b0185","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1023\/A:1006326432340","article-title":"Mammographic density changes in perimenopausal and postmenopausal women: is effect of hormone replacement therapy predictable?","volume":"59","author":"Sterns","year":"2000","journal-title":"Breast Cancer Res Treat"},{"issue":"2","key":"10.1016\/j.ejmp.2026.105904_b0190","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/00008469-200004000-00006","article-title":"Parity and mammographic breast density in relation to breast cancer risk: indication of interaction","volume":"9","author":"van Gils","year":"2000","journal-title":"Eur J Cancer Prev"},{"issue":"7","key":"10.1016\/j.ejmp.2026.105904_b0195","first-page":"653","article-title":"Association of mammographically defined percent breast density with epidemiologic risk factors for breast cancer (United States)","volume":"11","author":"Vachon","year":"2000","journal-title":"Cancer Causes Control"},{"issue":"1","key":"10.1016\/j.ejmp.2026.105904_b0200","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1054\/bjoc.2000.1151","article-title":"High risk mammographic parenchymal patterns and diet: a case-control study","volume":"83","author":"Sala","year":"2000","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ejmp.2026.105904_b0205","doi-asserted-by":"crossref","unstructured":"Greendale GA, Reboussin BA, Sie A, Singh HR, Olson LK, Gatewood O, et al. Effects of estrogen and estrogen-progestin on mammographic parenchymal density. Postmenopausal Estrogen\/Progestin Interventions (PEPI) Investigators. Ann Intern Med. 1999 Feb 16;130(4 Pt 1):262-9. doi: 10.7326\/0003-4819-130-4_part_1-199902160-00003. PMID: 10068383.","DOI":"10.7326\/0003-4819-130-4_Part_1-199902160-00003"},{"issue":"4","key":"10.1016\/j.ejmp.2026.105904_b0210","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S1028-4559(10)60091-5","article-title":"Factors that influence changes in mammographic density with postmenopausal hormone therapy","volume":"49","author":"Chen","year":"2010","journal-title":"Taiwan J Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.ejmp.2026.105904_b0215","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1158\/1055-9965.EPI-06-1047","article-title":"Longitudinal trends in mammographic percent density and breast cancer risk","volume":"16","author":"Vachon","year":"2007","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"4","key":"10.1016\/j.ejmp.2026.105904_b0220","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1158\/1055-9965.EPI-05-0798","article-title":"A longitudinal investigation of mammographic density: the multiethnic cohort","volume":"15","author":"Maskarinec","year":"2006","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"5","key":"10.1016\/j.ejmp.2026.105904_b0225","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1093\/jnci\/djk066","article-title":"Longitudinal measurement of clinical mammographic breast density to improve estimation of breast cancer risk","volume":"99","author":"Kerlikowske","year":"2007","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ejmp.2026.105904_b0230","doi-asserted-by":"crossref","unstructured":"Guthrie JR, Milne RL, Hopper JL, Cawson J, Dennerstein L, Burger HG. Mammographic densities during the menopausal transition: a longitudinal study of Australian-born women. Menopause. 2007 Mar-Apr;14(2):208-15. doi: 10.1097\/01.gme.0000232278.82218.1f. PMID: 17091098.","DOI":"10.1097\/01.gme.0000232278.82218.1f"},{"key":"10.1016\/j.ejmp.2026.105904_b0235","doi-asserted-by":"crossref","unstructured":"Fodor A, Brombin C, Mangili P, Borroni F, Pasetti M, Tummineri R, et al. Impact of molecular subtype on 1325 early-stage breast cancer patients homogeneously treated with hypofractionated radiotherapy without boost: Should the indications for radiotherapy be more personalized? Breast. 2021 Feb;55:45-54. doi: 10.1016\/j.breast.2020.12.004. Epub 2020 Dec 9. PMID: 33326894; PMCID: PMC7736720.","DOI":"10.1016\/j.breast.2020.12.004"},{"key":"10.1016\/j.ejmp.2026.105904_b0240","doi-asserted-by":"crossref","unstructured":"Mornex F, Pavy JJ, Denekamp J, Bolla M. Syst\u00e8me d'\u00e9valuation des effets tardifs des radiations sur les tissus normaux: l'\u00e9chelle SOMA-LENT. Groupe de travail des effets tardifs de l'EORTC [Scoring system of late effects of radiations on normal tissues: the SOMA-LENT scale]. Cancer Radiother. 1997;1(6):622-68. French. doi: 10.1016\/s1278-3218(97)82941-1. PMID: 9614880.","DOI":"10.1016\/S1278-3218(97)82941-1"},{"issue":"4","key":"10.1016\/j.ejmp.2026.105904_b0245","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/S0360-3016(02)04202-5","article-title":"Increasing the rate of late toxicity by changing the score? a comparison of RTOG\/EORTC and LENT\/SOMA scores","volume":"55","author":"Hoeller","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ejmp.2026.105904_b0250","doi-asserted-by":"crossref","unstructured":"Collins GS, Reitsma JB, Altman DG, Moons KG. Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): the TRIPOD statement. Br J Cancer. 2015 Jan 20;112(2):251-9. doi: 10.1038\/bjc.2014.639. Epub 2015 Jan 6. PMID: 25562432; PMCID: PMC4454817..","DOI":"10.1038\/bjc.2014.639"},{"issue":"19","key":"10.1016\/j.ejmp.2026.105904_b0255","doi-asserted-by":"crossref","first-page":"4938","DOI":"10.3390\/cancers13194938","article-title":"Prediction of early distant recurrence in upfront resectable pancreatic adenocarcinoma: a multidisciplinary, machine learning-based approach","volume":"13","author":"Palumbo","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"2","key":"10.1016\/j.ejmp.2026.105904_b0260","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/0167-8140(94)90063-9","article-title":"The influence of breast size on late radiation effects and association with radiotherapy dose inhomogeneity","volume":"33","author":"Moody","year":"1994","journal-title":"Radiother Oncol"},{"issue":"1","key":"10.1016\/j.ejmp.2026.105904_b0265","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.clon.2003.08.005","article-title":"Impact of radiation therapy on acute toxicity in breast conservation therapy for early breast cancer","volume":"16","author":"Back","year":"2004","journal-title":"Clin Oncol (R Coll Radiol)"},{"issue":"3","key":"10.1016\/j.ejmp.2026.105904_b0270","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.ijrobp.2011.03.015","article-title":"Standardized Total Average Toxicity score: a scale- and grade-independent measure of late radiotherapy toxicity to facilitate pooling of data from different studies","volume":"82","author":"Barnett","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ejmp.2026.105904_b0275","article-title":"Tumour bed boost radiotherapy for women after breast-conserving surgery","volume":"11(11):CD011987","author":"Kindts","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"issue":"7","key":"10.1016\/j.ejmp.2026.105904_b0280","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1186\/1748-717X-7-217","article-title":"Factors of influence on acute skin toxicity of breast cancer patients treated with standard three-dimensional conformal radiotherapy (3D-CRT) after breast conserving surgery (BCS)","volume":"18","author":"Kraus-Tiefenbacher","year":"2012","journal-title":"Radiat Oncol"},{"issue":"12","key":"10.1016\/j.ejmp.2026.105904_b0285","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1016\/0360-3016(86)90005-2","article-title":"Arm lymphedema in patients treated conservatively for breast cancer: relationship to patient age and axillary node dissection technique","volume":"12","author":"Pezner","year":"1986","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"10.1016\/j.ejmp.2026.105904_b0290","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0936-6555(05)81031-3","article-title":"The influence of breast size on late radiation reaction following excision and radiotherapy for early breast cancer","volume":"3","author":"Brierley","year":"1991","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"10.1016\/j.ejmp.2026.105904_b0295","doi-asserted-by":"crossref","unstructured":"C\u00f3rdoba EE, Lacunza E, G\u00fcerci AM. Clinical factors affecting the determination of radiotherapy-induced skin toxicity in breast cancer. Radiat Oncol J. 2021 Dec;39(4):315-323. doi: 10.3857\/roj.2020.00395. Epub 2021 Dec 24. PMID: 34986553; PMCID: PMC8743461.","DOI":"10.3857\/roj.2020.00395"},{"issue":"10","key":"10.1016\/j.ejmp.2026.105904_b0300","first-page":"2260","article-title":"The effects of radiation therapy on quality of life of women with breast carcinoma: results of a randomized trial","volume":"88","author":"Whelan","year":"2000","journal-title":"Ontario Clin Oncol Group Cancer"},{"issue":"5","key":"10.1016\/j.ejmp.2026.105904_b0305","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.clbc.2024.03.002","article-title":"Quality of Life Outcomes Associated with Optimization of Treatment by Omitting Radiotherapy in Early Breast Cancer","volume":"24","author":"Stafford","year":"2024","journal-title":"Clin Breast Cancer"},{"key":"10.1016\/j.ejmp.2026.105904_b0310","doi-asserted-by":"crossref","unstructured":"Bodewes FTH, van Asselt AA, Dorrius MD, Greuter MJW, de Bock GH. Mammographic breast density and the risk of breast cancer: A systematic review and meta-analysis. Breast. 2022 Dec;66:62-68. doi: 10.1016\/j.breast.2022.09.007. Epub 2022 Sep 26. PMID: 36183671; PMCID: PMC9530665.","DOI":"10.1016\/j.breast.2022.09.007"},{"issue":"1","key":"10.1016\/j.ejmp.2026.105904_b0315","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s12282-018-0901-5","article-title":"Fat necrosis after breast-conserving oncoplastic surgery","volume":"26","author":"Nakada","year":"2019","journal-title":"Breast Cancer"},{"issue":"7","key":"10.1016\/j.ejmp.2026.105904_b0320","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.clon.2012.05.003","article-title":"Members of the IMRT Indications Expert Panel. Intensity-modulated radiotherapy in the treatment of breast cancer","volume":"24","author":"Dayes","year":"2012","journal-title":"Clin Oncol (R Coll Radiol)"}],"container-title":["Physica Medica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1120179726001912?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1120179726001912?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:43:00Z","timestamp":1792104180000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1120179726001912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":64,"alternative-id":["S1120179726001912"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmp.2026.105904","relation":{},"ISSN":["1120-1797"],"issn-type":[{"value":"1120-1797","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Limited impact of CT-based breast tissue composition on skin toxicity, fibrosis, edema and liponecrosis prediction after moderately hypofractionated whole-breast radiotherapy","name":"articletitle","label":"Article Title"},{"value":"Physica Medica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmp.2026.105904","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Associazione Italiana di Fisica Medica e Sanitaria. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105904"}}