{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T12:11:41Z","timestamp":1788783101362,"version":"build-2803163510"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001777","name":"University of Wollongong","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001777","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001043","name":"CASS Foundation Ltd","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001043","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022084","name":"Peter MacCallum Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022084","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004224","name":"Peter MacCallum Cancer Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004224","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","physicamedica.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physica Medica"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ejmp.2026.105910","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:15:37Z","timestamp":1786493737000},"page":"105910","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Blood dosimetry during volumetric modulated arc therapy for non-small cell lung cancer: A time-resolved model of circulating particles"],"prefix":"10.1016","volume":"149","author":[{"given":"Mathieu","family":"Gaudreault","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2919-2040","authenticated-orcid":false,"given":"Anson","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippa","family":"Johnstone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9411-153X","authenticated-orcid":false,"given":"Katrina","family":"Woodford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1965-0885","authenticated-orcid":false,"given":"Kenton","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Hardcastle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"MacManus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Panettieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmp.2026.105910_b0005","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1201500","article-title":"A review on lymphocyte radiosensitivity and its impact on radiotherapy","volume":"13","author":"Paganetti","year":"2023","journal-title":"Front Oncol"},{"key":"10.1016\/j.ejmp.2026.105910_b0010","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.bbcan.2014.04.009","article-title":"Radiation sensitivity of human and murine peripheral blood lymphocytes, stem and progenitor cells","volume":"1846","author":"Heylmann","year":"2014","journal-title":"Biochim et Biophys Acta (BBA) - Rev Cancer"},{"key":"10.1016\/j.ejmp.2026.105910_b0015","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.adro.2018.08.014","article-title":"Field size effects on the risk and severity of treatment-induced lymphopenia in patients undergoing radiation therapy for solid tumors","volume":"3","author":"Ellsworth","year":"2018","journal-title":"Adv Radiat Oncol"},{"key":"10.1016\/j.ejmp.2026.105910_b0020","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1038\/s41419-018-1095-7","article-title":"Sensitivity of CD3\/CD28-stimulated versus non-stimulated lymphocytes to ionizing radiation and genotoxic anticancer drugs: key role of ATM in the differential radiation response","volume":"9","author":"Heylmann","year":"2018","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.ejmp.2026.105910_b0025","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.4049\/jimmunol.139.10.3199","article-title":"Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes","volume":"139","author":"Sellins","year":"1987","journal-title":"J Immunol"},{"key":"10.1016\/j.ejmp.2026.105910_b0030","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.ijrobp.2021.07.1695","article-title":"The influence of severe radiation-induced lymphopenia on overall survival in solid tumors: a systematic review and meta-analysis","volume":"111","author":"Damen","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ejmp.2026.105910_b0035","doi-asserted-by":"crossref","DOI":"10.1002\/acm2.70341","article-title":"Dynamic blood dose estimates in radiotherapy and correlations with adverse clinical outcomes in brain, head\u2010and\u2010neck, and lung cancer patients","volume":"27","author":"Tattenberg","year":"2026","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.ejmp.2026.105910_b0040","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.radonc.2022.10.019","article-title":"Lymphocyte sparing normal tissue effects in the clinic (LymphoTEC): a systematic review of dose constraint considerations to mitigate radiation-related lymphopenia in the era of immunotherapy","volume":"177","author":"Venkatesulu","year":"2022","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ejmp.2026.105910_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2023.110041","article-title":"Modeling frameworks for radiation induced lymphopenia: a critical review","volume":"190","author":"Cella","year":"2024","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ejmp.2026.105910_b0050","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.ijrobp.2025.07.1429","article-title":"Radiation-induced lymphopenia: from mathematical modeling toward mechanistic learning","volume":"124","author":"de Kermenguy","year":"2026","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ejmp.2026.105910_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmp.2026.105771","article-title":"BLOOD: a fast, customizable, and patient-specific computational framework for assessing whole-body lymphocyte dose, survival, and replenishment after radiotherapy treatments","volume":"145","author":"L\u00f3pez-Mart\u00ednez","year":"2026","journal-title":"Phys Med"},{"key":"10.1016\/j.ejmp.2026.105910_b0060","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/ac16ea","article-title":"HEDOS\u2014a computational tool to assess radiation dose to circulating blood cells during external beam radiotherapy based on whole-body blood flow simulations","volume":"66","author":"Shin","year":"2021","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ejmp.2026.105910_b0065","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/ad02d6","article-title":"A stochastic model of blood flow to calculate blood dose during radiotherapy","volume":"68","author":"Beekman","year":"2023","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ejmp.2026.105910_b0070","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.ijrobp.2023.01.054","article-title":"Predicting severity of radiation induced lymphopenia in individual proton therapy patients for varying dose rate and fractionation using dynamic 4-dimensional blood flow simulations","volume":"116","author":"McCullum","year":"2023","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ejmp.2026.105910_b0075","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/ad8ea5","article-title":"FLIP: a novel method for patient-specific dose quantification in circulating blood in large vessels during proton or photon external beam radiotherapy treatments","volume":"69","author":"Garc\u00eda-Cardosa","year":"2024","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ejmp.2026.105910_b0080","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/ae6015","article-title":"FLIP-HEDOS: a patient-specific blood dose quantification model during radiotherapy treatments","volume":"71","author":"Garc\u00eda-Cardosa","year":"2026","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ejmp.2026.105910_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmp.2024.104845","article-title":"The BeamSplitter \u2013 An algorithm providing the dose per control point of radiation therapy treatment plans","volume":"128","author":"Gaudreault","year":"2024","journal-title":"Phys Med"},{"key":"10.1016\/j.ejmp.2026.105910_b0090","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/acdcdc","article-title":"4D dosimetric-blood flow model: impact of prolonged fraction delivery times of IMRT on the dose to the circulating lymphocytes","volume":"68","author":"Hammi","year":"2023","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ejmp.2026.105910_b0095","doi-asserted-by":"crossref","DOI":"10.1002\/mp.17961","article-title":"Implementations of modulation complexity scores and their correlations with treatment plan quality in stereotactic radiation therapy","volume":"52","author":"Gaudreault","year":"2025","journal-title":"Med Phys"},{"key":"10.1016\/j.ejmp.2026.105910_b0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0146-6453(03)00002-2","article-title":"Basic anatomical and physiological data for use in radiological protection: reference values","volume":"32","author":"Valentin","year":"2002","journal-title":"Ann ICRP"},{"key":"10.1016\/j.ejmp.2026.105910_b0105","doi-asserted-by":"crossref","DOI":"10.1148\/ryai.230024","article-title":"TotalSegmentator: robust segmentation of 104 anatomic structures in CT images","volume":"5","author":"Wasserthal","year":"2023","journal-title":"Radiol Artif Intell"},{"key":"10.1016\/j.ejmp.2026.105910_b0110","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1177\/0146645319893605","article-title":"ICRP publication 145: adult mesh-type reference computational phantoms","volume":"49","author":"Kim","year":"2020","journal-title":"Ann ICRP"},{"key":"10.1016\/j.ejmp.2026.105910_b0115","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/acm2.13215","article-title":"On the reduction of aperture complexity in kidney SABR","volume":"22","author":"Gaudreault","year":"2021","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.ejmp.2026.105910_b0120","doi-asserted-by":"crossref","first-page":"e144","DOI":"10.1016\/j.ijrobp.2025.06.3609","article-title":"Comparative study of HEDOS and EDIC for predicting 2-year survival in locally advanced NSCLC patients undergoing radiotherapy","volume":"123","author":"Catalano","year":"2025","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ejmp.2026.105910_b0125","doi-asserted-by":"crossref","first-page":"3900","DOI":"10.21037\/tlcr-2025-547","article-title":"Prognostic impact of dose to circulating blood cells in non-small cell lung cancer patients after chemoradiotherapy","volume":"14","author":"Ha","year":"2025","journal-title":"Transl Lung Cancer Res"},{"key":"10.1016\/j.ejmp.2026.105910_b0130","doi-asserted-by":"crossref","first-page":"S2699","DOI":"10.1016\/S0167-8140(25)01672-X","article-title":"3387 A novel patient-specific method combined with a stochastic hemodynamic model to quantify the dose in circulating blood during radiotherapy treatments","volume":"206","author":"Garc\u00eda-Cardosa","year":"2025","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ejmp.2026.105910_b0135","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/ab6c41","article-title":"4D blood flow model for dose calculation to circulating blood and lymphocytes","volume":"65","author":"Hammi","year":"2020","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ejmp.2026.105910_b0140","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/ad69f9","article-title":"Inter-subject cerebrovascular variability: a source of uncertainty for dose calculation to circulating blood cells for glioblastoma patients treated with modern radiotherapy techniques","volume":"69","author":"Hammi","year":"2024","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ejmp.2026.105910_b0145","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/acb198","article-title":"Comparison of dual-energy CT with positron emission tomography for lung perfusion imaging in patients with non-small cell lung cancer","volume":"68","author":"Gaudreault","year":"2023","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ejmp.2026.105910_b0150","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.ijrobp.2023.10.038","article-title":"Dose-response relationship between radiation therapy and loss of lung perfusion comparing positron emission tomography and dual-energy computed tomography in non-small cell lung cancer","volume":"118","author":"Gaudreault","year":"2024","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ejmp.2026.105910_b0155","doi-asserted-by":"crossref","first-page":"4048","DOI":"10.1088\/0031-9155\/61\/11\/4048","article-title":"Dose rate mapping of VMAT treatments","volume":"61","author":"Podesta","year":"2016","journal-title":"Phys Med Biol"}],"container-title":["Physica Medica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1120179726001973?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1120179726001973?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:25:03Z","timestamp":1788780303000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1120179726001973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":31,"alternative-id":["S1120179726001973"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmp.2026.105910","relation":{},"ISSN":["1120-1797"],"issn-type":[{"value":"1120-1797","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Blood dosimetry during volumetric modulated arc therapy for non-small cell lung cancer: A time-resolved model of circulating particles","name":"articletitle","label":"Article Title"},{"value":"Physica Medica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmp.2026.105910","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Associazione Italiana di Fisica Medica e Sanitaria. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"105910"}}